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In particular, phage cocktails, which combine multiple phages, potentially offer broader antimicrobial spectra than single-phage applications and may suppress the emergence of resistant bacteria. This comprehensive review systematically examines cutting-edge technologies and effective strategies for designing phage cocktails. Special attention was given to the combination of phages recognizing different receptors, designs based on phage-bacteria infection network analysis, and synergistic effects with antibiotics. Additionally, the analysis of large-scale clinical studies has identified challenges in practical implementation, including ensuring cocktail stability and addressing immune responses. These insights are expected to contribute to the design of more effective phage cocktails and the establishment of novel therapeutic strategies to address AMR.<\/jats:p>","DOI":"10.1093\/femsre\/fuaf061","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T13:44:32Z","timestamp":1764942272000},"source":"Crossref","is-referenced-by-count":51,"title":["Phage cocktails: state-of-the-art technologies and strategies for effective design"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4857-4700","authenticated-orcid":false,"given":"Tomoyoshi","family":"Kaneko","sequence":"first","affiliation":[{"name":"Waseda University Department of Life Science and Medical Bioscience, , Tokyo, 162-8480 ,","place":["Japan"]},{"name":"Phage Therapy Institute, Comprehensive Research Organization, Waseda University , Tokyo, 162-8480 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