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As a sialic acid-binding immunoglobulin-like lectin (Siglec), CD169 recognizes sialylated gangliosides and glycoconjugates present on surface of several viral envelopes, including HIV-1, SARS-CoV-2, and Ebola virus as well as sialylated bacterial capsules such as those of Neisseria meningitidis and Campylobacter jejuni. Moreover, different viruses were shown to be captured by CD169+ cells which could play distinctive role during infections: they could enhance efficient immune responses, but also facilitate pathogen dissemination through viral capture and transfer to permissive cells. This last mechanism has been well documented for HIV-1, where CD169 mediates viral trans-infection of CD4\u207a T-cells. CD169 expression is rapidly induced by type-I interferons during acute viral infections and has emerged as a valuable biomarker to distinguish viral from bacterial infection, particularly for COVID-19 and influenza. Detectable by flow cytometry, CD169 represents a solid biomarker in clinical settings and possible target in the development of novel prophylactic and therapeutic strategies. Its dual role, protective in host defence yet exploitable by certain pathogens, highlights the need for careful consideration in future therapeutic approaches.<\/jats:p>","DOI":"10.1093\/femsre\/fuag013","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:45:25Z","timestamp":1773924325000},"source":"Crossref","is-referenced-by-count":2,"title":["Role of myeloid cells expressing CD169\/Siglec-1 in host-pathogen interactions"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2756-4839","authenticated-orcid":false,"given":"Ilona","family":"Ronco","sequence":"first","affiliation":[{"name":"Centre International de Recherche en Infectiologie, CIRI, Inserm U1111, CNRS UMR5308, Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, \u00c9cole Normale Sup\u00e9rieure de Lyon , 69007, Lyon 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