{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:13:20Z","timestamp":1792642400673,"version":"4.5.0"},"reference-count":144,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEMS Microbiology Reviews"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1093\/femsre\/fuw037","type":"journal-article","created":{"date-parts":[[2016,9,10]],"date-time":"2016-09-10T00:11:17Z","timestamp":1473466277000},"page":"34-48","source":"Crossref","is-referenced-by-count":214,"title":["The clinical impact of artemisinin resistance in Southeast Asia and the potential for future spread"],"prefix":"10.1093","volume":"41","author":[{"given":"Charles J.","family":"Woodrow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,9,8]]},"reference":[{"key":"2017011220551390000_41.1.34.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15162-8"},{"key":"2017011220551390000_41.1.34.2","doi-asserted-by":"crossref","first-page":"771","DOI":"10.4269\/ajtmh.1994.50.771","article-title":"Concentration and time dependency of artemisinin efficacy against Plasmodium falciparum in vitro","volume":"50","author":"Alin","year":"1994","journal-title":"Am J Trop Med Hyg"},{"key":"2017011220551390000_41.1.34.3","doi-asserted-by":"crossref","first-page":"641","DOI":"10.4269\/ajtmh.2007.76.641","article-title":"Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border","volume":"76","author":"Alker","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"2017011220551390000_41.1.34.4","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00487-9"},{"key":"2017011220551390000_41.1.34.5","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02902-14"},{"key":"2017011220551390000_41.1.34.6","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70181-0"},{"key":"2017011220551390000_41.1.34.7","doi-asserted-by":"publisher","DOI":"10.1086\/651562"},{"key":"2017011220551390000_41.1.34.8","doi-asserted-by":"publisher","DOI":"10.1038\/nature12876"},{"key":"2017011220551390000_41.1.34.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314981"},{"key":"2017011220551390000_41.1.34.10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151898"},{"key":"2017011220551390000_41.1.34.11","unstructured":"Basco LK . Field Application of In Vitro Assays for the Sensitivity of Human Malaria Parasites to Antimalarial Drugs. Geneva: WHO; 2007."},{"key":"2017011220551390000_41.1.34.12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019283"},{"key":"2017011220551390000_41.1.34.13","doi-asserted-by":"publisher","DOI":"10.1038\/nature15535"},{"key":"2017011220551390000_41.1.34.14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001984"},{"key":"2017011220551390000_41.1.34.15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026005"},{"key":"2017011220551390000_41.1.34.16","doi-asserted-by":"publisher","DOI":"10.1038\/nature10814"},{"key":"2017011220551390000_41.1.34.17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-10-4094"},{"key":"2017011220551390000_41.1.34.18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001398"},{"key":"2017011220551390000_41.1.34.19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004551"},{"key":"2017011220551390000_41.1.34.20","doi-asserted-by":"publisher","DOI":"10.1126\/science.1215966"},{"key":"2017011220551390000_41.1.34.21","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv752"},{"key":"2017011220551390000_41.1.34.22","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01924-13"},{"key":"2017011220551390000_41.1.34.23","doi-asserted-by":"publisher","DOI":"10.1086\/315718"},{"key":"2017011220551390000_41.1.34.24","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv372"},{"key":"2017011220551390000_41.1.34.25","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(86)90248-8"},{"key":"2017011220551390000_41.1.34.26","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis958"},{"key":"2017011220551390000_41.1.34.27","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3156"},{"key":"2017011220551390000_41.1.34.28","doi-asserted-by":"publisher","DOI":"10.1086\/344647"},{"key":"2017011220551390000_41.1.34.29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2006.01739.x"},{"key":"2017011220551390000_41.1.34.30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2006.01690.x"},{"key":"2017011220551390000_41.1.34.31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002132"},{"key":"2017011220551390000_41.1.34.32","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67176-0"},{"key":"2017011220551390000_41.1.34.33","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61924-1"},{"key":"2017011220551390000_41.1.34.34","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808859"},{"key":"2017011220551390000_41.1.34.35","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0539-5"},{"key":"2017011220551390000_41.1.34.36","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000199"},{"key":"2017011220551390000_41.1.34.37","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2012.12-0025"},{"key":"2017011220551390000_41.1.34.38","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-12-411"},{"key":"2017011220551390000_41.1.34.39","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-339"},{"key":"2017011220551390000_41.1.34.40","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-11-257"},{"key":"2017011220551390000_41.1.34.41","doi-asserted-by":"crossref","first-page":"240","DOI":"10.4269\/ajtmh.1989.40.240","article-title":"Stage specific actions of antimalarial drugs on Plasmodium falciparum in culture","volume":"40","author":"Geary","year":"1989","journal-title":"Am J Trop Med Hyg"},{"key":"2017011220551390000_41.1.34.42","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2925"},{"key":"2017011220551390000_41.1.34.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.03.004"},{"key":"2017011220551390000_41.1.34.44","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-11-355"},{"key":"2017011220551390000_41.1.34.45","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00197-15"},{"key":"2017011220551390000_41.1.34.46","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv249"},{"key":"2017011220551390000_41.1.34.47","doi-asserted-by":"publisher","DOI":"10.1038\/srep17412"},{"key":"2017011220551390000_41.1.34.48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600459113"},{"key":"2017011220551390000_41.1.34.49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2006.01786.x"},{"key":"2017011220551390000_41.1.34.50","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu608"},{"key":"2017011220551390000_41.1.34.51","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0778-0"},{"key":"2017011220551390000_41.1.34.52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1104063108"},{"key":"2017011220551390000_41.1.34.53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217452110"},{"key":"2017011220551390000_41.1.34.54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057689"},{"key":"2017011220551390000_41.1.34.55","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00686-12"},{"key":"2017011220551390000_41.1.34.56","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00039-16"},{"key":"2017011220551390000_41.1.34.57","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00835-15"},{"key":"2017011220551390000_41.1.34.58","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/S0140-6736(84)92057-9","article-title":"Randomised comparative study of mefloquine, qinghaosu, and pyrimethamine-sulfadoxine in patients with falciparum malaria","volume":"2","author":"Li","year":"1984","journal-title":"Lancet"},{"key":"2017011220551390000_41.1.34.59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093138"},{"key":"2017011220551390000_41.1.34.60","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv414"},{"key":"2017011220551390000_41.1.34.61","doi-asserted-by":"crossref","unstructured":"MalariaGEN Plasmodium falciparum Community Project . Genomic epidemiology of artemisinin resistant malaria. Elife 2016;5.","DOI":"10.7554\/eLife.08714"},{"key":"2017011220551390000_41.1.34.62","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-8-31"},{"key":"2017011220551390000_41.1.34.63","doi-asserted-by":"publisher","DOI":"10.1038\/nature14412"},{"key":"2017011220551390000_41.1.34.64","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513137"},{"key":"2017011220551390000_41.1.34.65","doi-asserted-by":"publisher","DOI":"10.3201\/eid2110.150682"},{"key":"2017011220551390000_41.1.34.66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059192"},{"key":"2017011220551390000_41.1.34.67","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2624"},{"key":"2017011220551390000_41.1.34.68","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3189"},{"key":"2017011220551390000_41.1.34.69","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260403"},{"key":"2017011220551390000_41.1.34.70","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-9-273"},{"key":"2017011220551390000_41.1.34.71","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70064-6"},{"key":"2017011220551390000_41.1.34.72","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05085-6"},{"key":"2017011220551390000_41.1.34.73","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(15)00162-X"},{"key":"2017011220551390000_41.1.34.74","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0805011"},{"key":"2017011220551390000_41.1.34.75","doi-asserted-by":"publisher","DOI":"10.1086\/657120"},{"key":"2017011220551390000_41.1.34.76","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/170.4.971"},{"key":"2017011220551390000_41.1.34.77","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02505-8"},{"key":"2017011220551390000_41.1.34.78","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu1160"},{"key":"2017011220551390000_41.1.34.79","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.14-0605"},{"key":"2017011220551390000_41.1.34.80","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.01.013"},{"key":"2017011220551390000_41.1.34.81","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.14-0461"},{"key":"2017011220551390000_41.1.34.82","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020186"},{"key":"2017011220551390000_41.1.34.83","doi-asserted-by":"crossref","unstructured":"Phyo AP Ashley EA Anderson TJ . Declining efficacy of artemisinin combination therapy against P. falciparum malaria on the Thai-Myanmar border (2003\u20132013): the role of parasite genetic factors. Clin Infect Dis 2016a.","DOI":"10.1093\/cid\/ciw388"},{"key":"2017011220551390000_41.1.34.84","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00320-5"},{"key":"2017011220551390000_41.1.34.85","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60484-X"},{"key":"2017011220551390000_41.1.34.86","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(98)90750-7"},{"key":"2017011220551390000_41.1.34.87","doi-asserted-by":"crossref","first-page":"883","DOI":"10.4269\/ajtmh.1998.59.883","article-title":"Artesunate versus artemether for the treatment of recrudescent multidrug-resistant falciparum malaria","volume":"59","author":"Price","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"2017011220551390000_41.1.34.88","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16767-6"},{"key":"2017011220551390000_41.1.34.89","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cmi.2015.10.027","article-title":"Natural selection of K13 mutants of Plasmodium falciparum in response to artemisinin combination therapies in Thailand","volume":"22","author":"Putaporntip","year":"2016","journal-title":"Clin Microbiol Infect"},{"key":"2017011220551390000_41.1.34.90","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-8-10"},{"key":"2017011220551390000_41.1.34.91","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70322-6"},{"key":"2017011220551390000_41.1.34.92","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70826-6"},{"key":"2017011220551390000_41.1.34.93","doi-asserted-by":"publisher","DOI":"10.1126\/science.1098876"},{"key":"2017011220551390000_41.1.34.94","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193225"},{"key":"2017011220551390000_41.1.34.95","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007125"},{"key":"2017011220551390000_41.1.34.96","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006113108"},{"key":"2017011220551390000_41.1.34.97","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-11-300"},{"key":"2017011220551390000_41.1.34.98","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1403007"},{"key":"2017011220551390000_41.1.34.99","first-page":"1","article-title":"A contribution to the problem of strains of human plasmodium","volume":"33","author":"Shute","year":"1954","journal-title":"Riv Malariol"},{"key":"2017011220551390000_41.1.34.100","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02528-15"},{"key":"2017011220551390000_41.1.34.101","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(96)89380-5"},{"key":"2017011220551390000_41.1.34.102","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70187-0"},{"key":"2017011220551390000_41.1.34.103","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)70049-6"},{"key":"2017011220551390000_41.1.34.104","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9614"},{"key":"2017011220551390000_41.1.34.105","doi-asserted-by":"publisher","DOI":"10.1086\/650301"},{"key":"2017011220551390000_41.1.34.106","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260867"},{"key":"2017011220551390000_41.1.34.107","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1211205110"},{"key":"2017011220551390000_41.1.34.108","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu491"},{"key":"2017011220551390000_41.1.34.109","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004789"},{"key":"2017011220551390000_41.1.34.110","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu467"},{"key":"2017011220551390000_41.1.34.111","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1993.1010"},{"key":"2017011220551390000_41.1.34.112","doi-asserted-by":"publisher","DOI":"10.1086\/656476"},{"key":"2017011220551390000_41.1.34.113","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02746-14"},{"key":"2017011220551390000_41.1.34.114","doi-asserted-by":"crossref","unstructured":"Tilley L Straimer J Gnadig NF . Artemisinin action and resistance in Plasmodium falciparum. Trends Parasitol 2016.","DOI":"10.1016\/j.pt.2016.05.010"},{"key":"2017011220551390000_41.1.34.115","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0982-y"},{"key":"2017011220551390000_41.1.34.116","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw029"},{"key":"2017011220551390000_41.1.34.117","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)70032-0"},{"key":"2017011220551390000_41.1.34.118","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1240-7"},{"key":"2017011220551390000_41.1.34.119","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-11-198"},{"key":"2017011220551390000_41.1.34.120","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.14-0031"},{"key":"2017011220551390000_41.1.34.121","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2005.01557.x"},{"key":"2017011220551390000_41.1.34.122","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10111"},{"key":"2017011220551390000_41.1.34.123","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01255-15"},{"key":"2017011220551390000_41.1.34.124","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4573"},{"key":"2017011220551390000_41.1.34.125","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001823"},{"key":"2017011220551390000_41.1.34.126","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200421682"},{"key":"2017011220551390000_41.1.34.127","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-8-253"},{"key":"2017011220551390000_41.1.34.128","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1315860"},{"key":"2017011220551390000_41.1.34.129","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-016-1147-3"},{"key":"2017011220551390000_41.1.34.130","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0544-6"},{"key":"2017011220551390000_41.1.34.131","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70252-4"},{"key":"2017011220551390000_41.1.34.132","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01868-12"},{"key":"2017011220551390000_41.1.34.133","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01636-09"},{"key":"2017011220551390000_41.1.34.134","unstructured":"World Health Organization . Chemotherapy of Malaria. Report of a WHO scientific group. (WHO Technical Report Series, No. 375). Geneva, Switzerland: World Health Organization; 1967."},{"key":"2017011220551390000_41.1.34.135","unstructured":"World Health Organization . Status Report on Artemisinin Resistance: September 2015. Geneva, Switzerland: World Health Organization; 2015."},{"key":"2017011220551390000_41.1.34.136","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0445-x"},{"key":"2017011220551390000_41.1.34.137","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)70024-1"},{"key":"2017011220551390000_41.1.34.138","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0301-z"},{"key":"2017011220551390000_41.1.34.139","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001564"},{"key":"2017011220551390000_41.1.34.140","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0456-7"},{"key":"2017011220551390000_41.1.34.141","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0874-1"},{"key":"2017011220551390000_41.1.34.142","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.178830"},{"key":"2017011220551390000_41.1.34.143","doi-asserted-by":"publisher","DOI":"10.1038\/srep20100"},{"key":"2017011220551390000_41.1.34.144","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-7-96"}],"container-title":["FEMS Microbiology Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/femsre\/article-pdf\/41\/1\/34\/19424503\/fuw037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T10:26:14Z","timestamp":1568370374000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femsre\/article-lookup\/doi\/10.1093\/femsre\/fuw037"}},"subtitle":[],"editor":[{"given":"Christiaan","family":"van Ooij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,9,8]]},"references-count":144,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,12]]},"published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1093\/femsre\/fuw037"],"URL":"https:\/\/doi.org\/10.1093\/femsre\/fuw037","relation":{},"ISSN":["1574-6976"],"issn-type":[{"value":"1574-6976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,8]]}}}