{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:41:45Z","timestamp":1793115705091,"version":"4.5.0"},"reference-count":248,"publisher":"Oxford University Press (OUP)","issue":"6","funder":[{"name":"AU IDEAS","award":["IVI-AUFF-2011-743-065"],"award-info":[{"award-number":["IVI-AUFF-2011-743-065"]}]},{"DOI":"10.13039\/501100004836","name":"Danish Council for Independent Research","doi-asserted-by":"crossref","award":["DFF-0602-0 1772"],"award-info":[{"award-number":["DFF-0602-0 1772"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"DOI":"10.1093\/femsre\/fux037","type":"journal-article","created":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T07:08:31Z","timestamp":1504508911000},"page":"854-879","source":"Crossref","is-referenced-by-count":94,"title":["A visual review of the human pathogen Streptococcus pneumoniae"],"prefix":"10.1093","volume":"41","author":[{"given":"Ditte H\u00f8yer","family":"Engholm","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mogens","family":"Kilian","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Goodsell","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA"},{"name":"Rutgers, the State University of New Jersey, NJ 08901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebbe Sloth","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark"},{"name":"Interdisciplinary Nanoscience Center, Aarhus University, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke Schmidt","family":"Kj\u00e6rgaard","sequence":"additional","affiliation":[{"name":"Aarhus Institute of Advanced Studies, Aarhus University, 8000 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,10,5]]},"reference":[{"key":"key\n\t\t\t\t20180328163942_bib1","doi-asserted-by":"crossref","first-page":"7856","DOI":"10.1128\/JB.00837-07","article-title":"Predicted functions and linkage specificities of the products of the Streptococcus pneumoniae capsular biosynthetic loci","volume":"189","author":"Aanensen","year":"2007","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1365-2958.2010.07199.x","article-title":"The molecular basis of glycogen breakdown and transport in Streptococcus pneumoniae","volume":"77","author":"Abbott","year":"2010","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/cei.12170","article-title":"Alveolar macrophages in pulmonary host defence the unrecognized role of apoptosis as a mechanism of intracellular bacterial killing","volume":"174","author":"Aberdein","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"key\n\t\t\t\t20180328163942_bib4","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1128\/IAI.71.1.218-225.2003","article-title":"Genetic alteration of capsule type but not PspA type affects accessibility of surface-bound complement and surface antigens of Streptococcus pneumoniae","volume":"71","author":"Abeyta","year":"2003","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180328163942_bib5","first-page":"1","article-title":"Prevention of pneumococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"46","author":"ACIP","year":"1997","journal-title":"MMWR Recomm Rep"},{"key":"key\n\t\t\t\t20180328163942_bib6","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nrmicro2198","article-title":"Bacterial cell division: assembly, maintenance and disassembly of the Z ring","volume":"7","author":"Adams","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib7","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.4049\/jimmunol.1102934","article-title":"Enolase of Streptococcus pneumoniae binds human complement inhibitor C4b-binding protein and contributes to complement evasion","volume":"189","author":"Agarwal","year":"2012","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20180328163942_bib8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1432-1033.1977.tb11596.x","article-title":"The action of lysozyme on peptidoglycan with N-unsubstituted glucosamine residues. Isolation of glycan fragments and their susceptibility to lysozyme","volume":"76","author":"Amano","year":"1977","journal-title":"Eur J Biochem\/FEBS"},{"key":"key\n\t\t\t\t20180328163942_bib9","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0968-0004(03)00162-2","article-title":"Elongation factors in protein biosynthesis","volume":"28","author":"Andersen","year":"2003","journal-title":"Trends Biochem Sci"},{"key":"key\n\t\t\t\t20180328163942_bib10","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/bioinformatics\/bti770","article-title":"The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling","volume":"22","author":"Arnold","year":"2006","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20180328163942_bib11","doi-asserted-by":"crossref","first-page":"e1002156","DOI":"10.1371\/journal.pgen.1002156","article-title":"Role of the single-stranded DNA-binding protein SsbB in pneumococcal transformation: maintenance of a reservoir for genetic plasticity","volume":"7","author":"Attaiech","year":"2011","journal-title":"PLos Genet"},{"key":"key\n\t\t\t\t20180328163942_bib12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1471-2164-9-75","article-title":"The RAST Server: rapid annotations using subsystems technology","volume":"9","author":"Aziz","year":"2008","journal-title":"BMC Genomics"},{"key":"key\n\t\t\t\t20180328163942_bib13","doi-asserted-by":"crossref","first-page":"5480","DOI":"10.1128\/JB.00384-08","article-title":"A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells","volume":"190","author":"Bagnoli","year":"2008","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib14","doi-asserted-by":"crossref","first-page":"E758","DOI":"10.1073\/pnas.1313860111","article-title":"Secretion of a pneumococcal type II secretion system pilus correlates with DNA uptake during transformation","volume":"111","author":"Balaban","year":"2014","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180328163942_bib15","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1128\/JB.01555-10","article-title":"Characterization of mutants deficient in the L,D-carboxypeptidase (DacB) and WalRK (VicRK) regulon, involved in peptidoglycan maturation of Streptococcus pneumoniae serotype 2 strain D39","volume":"193","author":"Barendt","year":"2011","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib16","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1073\/pnas.0511017103","article-title":"A pneumococcal pilus influences virulence and host inflammatory responses","volume":"103","author":"Barocchi","year":"2006","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180328163942_bib17","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1574-6976.2008.00104.x","article-title":"Cytoplasmic steps of peptidoglycan biosynthesis","volume":"32","author":"Barreteau","year":"2008","journal-title":"FEMS Microbiol Rev"},{"key":"key\n\t\t\t\t20180328163942_bib18","doi-asserted-by":"crossref","first-page":"3842","DOI":"10.1038\/ncomms4842","article-title":"Structural basis of PcsB-mediated cell separation in Streptococcus pneumoniae","volume":"5","author":"Bartual","year":"2014","journal-title":"Nat Commun"},{"key":"key\n\t\t\t\t20180328163942_bib19","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1128\/JB.01120-08","article-title":"Synthesis of CDP-activated ribitol for teichoic acid precursors in Streptococcus pneumoniae","volume":"191","author":"Baur","year":"2009","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib20","doi-asserted-by":"crossref","first-page":"E905","DOI":"10.1073\/pnas.1119172109","article-title":"Control of cell division in Streptococcus pneumoniae by the conserved Ser\/Thr protein kinase StkP","volume":"109","author":"Beilharz","year":"2012","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180328163942_bib21","doi-asserted-by":"crossref","first-page":"6057","DOI":"10.1128\/JB.185.20.6057-6066.2003","article-title":"Positive correlation between tyrosine phosphorylation of CpsD and capsular polysaccharide production in Streptococcus pneumoniae","volume":"185","author":"Bender","year":"2003","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib22","doi-asserted-by":"crossref","first-page":"47966","DOI":"10.1074\/jbc.M105448200","article-title":"CpsB is a modulator of capsule-associated tyrosine kinase activity in Streptococcus pneumoniae","volume":"276","author":"Bender","year":"2001","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180328163942_bib23","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1371\/journal.pgen.0020031","article-title":"Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes","volume":"2","author":"Bentley","year":"2006","journal-title":"PLos Genet"},{"key":"key\n\t\t\t\t20180328163942_bib24","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1111\/j.1365-2958.2004.04446.x","article-title":"Why are pathogenic staphylococci so lysozyme resistant? The peptidoglycan O-acetyltransferase OatA is the major determinant for lysozyme resistance of Staphylococcus aureus","volume":"55","author":"Bera","year":"2005","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib25","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1046\/j.1365-2958.2002.03013.x","article-title":"Uptake of transforming DNA in Gram-positive bacteria: a view from Streptococcus pneumoniae","volume":"45","author":"Berge","year":"2002","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib26","doi-asserted-by":"crossref","first-page":"e1003596","DOI":"10.1371\/journal.ppat.1003596","article-title":"Midcell recruitment of the DNA uptake and virulence nuclease, EndA, for pneumococcal transformation","volume":"9","author":"Berge","year":"2013","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20180328163942_bib27","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1128\/IAI.72.4.2416-2419.2004","article-title":"Glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pneumoniae is a surface-displayed plasminogen-binding protein","volume":"72","author":"Bergmann","year":"2004","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180328163942_bib28","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1160\/TH05-05-0369","article-title":"The nine residue plasminogen-binding motif of the pneumococcal enolase is the major cofactor of plasmin-mediated degradation of extracellular matrix, dissolution of fibrin and transmigration","volume":"94","author":"Bergmann","year":"2005","journal-title":"Thromb Haemost"},{"key":"key\n\t\t\t\t20180328163942_bib29","doi-asserted-by":"crossref","first-page":"e33320","DOI":"10.1371\/journal.pone.0033320","article-title":"A functional genomics approach to establish the complement of carbohydrate transporters in Streptococcus pneumoniae","volume":"7","author":"Bidossi","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180328163942_bib30","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S1473-3099(04)00938-7","article-title":"Streptococcus pneumoniae colonisation: the key to pneumococcal disease","volume":"4","author":"Bogaert","year":"2004","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t20180328163942_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nprot.2008.197","article-title":"Protein structure homology modeling using SWISS-MODEL workspace","volume":"4","author":"Bordoli","year":"2009","journal-title":"Nat Protoc"},{"key":"key\n\t\t\t\t20180328163942_bib32","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1574-6976.2007.00089.x","article-title":"The biosynthesis of peptidoglycan lipid-linked intermediates","volume":"32","author":"Bouhss","year":"2008","journal-title":"FEMS Microbiol Rev"},{"key":"key\n\t\t\t\t20180328163942_bib33","doi-asserted-by":"crossref","first-page":"6394","DOI":"10.1016\/S0021-9258(19)43459-5","article-title":"Pneumococcal Forssman antigen. A choline-containing lipoteichoic acid","volume":"248","author":"Briles","year":"1973","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180328163942_bib34","first-page":"xiii","article-title":"Preface","volume-title":"Streptococcus pneumoniae - Molecular Mechanisms of Host-Pathogen Interactions","author":"Brown","year":"2015"},{"key":"key\n\t\t\t\t20180328163942_bib35","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1046\/j.1365-2958.2001.02414.x","article-title":"A Streptococcus pneumoniae pathogenicity island encoding an ABC transporter involved in iron uptake and virulence","volume":"40","author":"Brown","year":"2001","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib36","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev-micro-092412-155620","article-title":"Wall teichoic acids of gram-positive bacteria","volume":"67","author":"Brown","year":"2013","journal-title":"Annu Rev Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib37","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1042\/bj1100573","article-title":"Pneumococcal C-substance, a ribitol teichoic acid containing choline phosphate","volume":"110","author":"Brundish","year":"1968","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t20180328163942_bib38","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.tim.2012.08.008","article-title":"Pneumococcal carbohydrate transport: food for thought","volume":"20","author":"Buckwalter","year":"2012","journal-title":"Trends Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib39","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev-genet-102108-134845","article-title":"The bacterial cytoskeleton","volume":"44","author":"Cabeen","year":"2010","journal-title":"Annu Rev Genet"},{"key":"key\n\t\t\t\t20180328163942_bib40","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.celrep.2011.12.007","article-title":"DnaK functions as a central hub in the E. coli chaperone network","volume":"1","author":"Calloni","year":"2012","journal-title":"Cell Rep"},{"key":"key\n\t\t\t\t20180328163942_bib41","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S1473-3099(05)70267-X","article-title":"The global burden of group A streptococcal diseases","volume":"5","author":"Carapetis","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t20180328163942_bib42","doi-asserted-by":"crossref","first-page":"e68277","DOI":"10.1371\/journal.pone.0068277","article-title":"Pyruvate oxidase influences the sugar utilization pattern and capsule production in Streptococcus pneumoniae","volume":"8","author":"Carvalho","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180328163942_bib43","doi-asserted-by":"crossref","first-page":"e26707","DOI":"10.1371\/journal.pone.0026707","article-title":"CcpA ensures optimal metabolic fitness of Streptococcus pneumoniae","volume":"6","author":"Carvalho","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180328163942_bib44","doi-asserted-by":"crossref","first-page":"38449","DOI":"10.1074\/jbc.M112.391482","article-title":"The HtrA protease from Streptococcus pneumoniae digests both denatured proteins and the competence-stimulating peptide","volume":"287","author":"Cassone","year":"2012","journal-title":"J Biol Chem"},{"issue":"Suppl 1","key":"key\n\t\t\t\t20180328163942_bib45","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1186\/1475-2859-13-S1-S9","article-title":"Cell wall structure and function in lactic acid bacteria","volume":"13","author":"Chapot-Chartier","year":"2014","journal-title":"Microb Cell Fact"},{"key":"key\n\t\t\t\t20180328163942_bib46","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrmicro844","article-title":"DNA uptake during bacterial transformation","volume":"2","author":"Chen","year":"2004","journal-title":"Nat Rev Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib47","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/nature06971","article-title":"Mechanism of homologous recombination from the RecA-ssDNA\/dsDNA structures","volume":"453","author":"Chen","year":"2008","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180328163942_bib48","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1574-6976.2009.00164.x","article-title":"The genetic transformation machinery: composition, localization, and mechanism","volume":"33","author":"Claverys","year":"2009","journal-title":"FEMS Microbiol Rev"},{"key":"key\n\t\t\t\t20180328163942_bib49","doi-asserted-by":"crossref","first-page":"5421","DOI":"10.1038\/ncomms6421","article-title":"Structure and function of a spectrin-like regulator of bacterial cytokinesis","volume":"5","author":"Cleverley","year":"2014","journal-title":"Nat Commun"},{"key":"key\n\t\t\t\t20180328163942_bib50","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1126\/science.135.3505.722","article-title":"Cell wall replication in Streptococcus pyogenes","volume":"135","author":"Cole","year":"1962","journal-title":"Science"},{"key":"key\n\t\t\t\t20180328163942_bib51","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.sbi.2007.12.009","article-title":"Type IV pili: paradoxes in form and function","volume":"18","author":"Craig","year":"2008","journal-title":"Curr Opin Struct Biol"},{"key":"key\n\t\t\t\t20180328163942_bib52","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nrmicro885","article-title":"Type IV pilus structure and bacterial pathogenicity","volume":"2","author":"Craig","year":"2004","journal-title":"Nat Rev Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib53","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.molcel.2006.07.004","article-title":"Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions","volume":"23","author":"Craig","year":"2006","journal-title":"Mol Cell"},{"key":"key\n\t\t\t\t20180328163942_bib54","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1111\/j.1365-2958.2006.05340.x","article-title":"Attenuation of penicillin resistance in a peptidoglycan O-acetyl transferase mutant of Streptococcus pneumoniae","volume":"61","author":"Crisostomo","year":"2006","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib55","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1128\/IAI.01125-09","article-title":"Three surface exoglycosidases from Streptococcus pneumoniae, NanA, BgaA, and StrH, promote resistance to opsonophagocytic killing by human neutrophils","volume":"78","author":"Dalia","year":"2010","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180328163942_bib56","doi-asserted-by":"crossref","first-page":"7105","DOI":"10.1128\/JB.00681-07","article-title":"The essential tacF gene is responsible for the choline-dependent growth phenotype of Streptococcus pneumoniae","volume":"189","author":"Damjanovic","year":"2007","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib57","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.micpath.2006.01.007","article-title":"Capsule does not block antibody binding to PspA, a surface virulence protein of Streptococcus pneumoniae","volume":"40","author":"Daniels","year":"2006","journal-title":"Microb Pathog"},{"key":"key\n\t\t\t\t20180328163942_bib58","doi-asserted-by":"crossref","first-page":"471","DOI":"10.4049\/jimmunol.173.1.471","article-title":"Dual roles of PspC, a surface protein of Streptococcus pneumoniae, in binding human secretory IgA and factor H","volume":"173","author":"Dave","year":"2004","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20180328163942_bib59","doi-asserted-by":"crossref","first-page":"e21269","DOI":"10.1371\/journal.pone.0021269","article-title":"The Streptococcus pneumoniae pilus-1 displays a biphasic expression pattern","volume":"6","author":"De Angelis","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180328163942_bib60","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1089\/10766290152652756","article-title":"Molecular characterization of the pneumococcal teichoic acid phosphorylcholine esterase","volume":"7","author":"de las Rivas","year":"2001","journal-title":"Microb Drug Resist"},{"key":"key\n\t\t\t\t20180328163942_bib61","doi-asserted-by":"crossref","first-page":"4988","DOI":"10.1128\/JB.184.18.4988-5000.2002","article-title":"Purification and polar localization of pneumococcal LytB, a putative endo-beta-N-acetylglucosaminidase: the chain-dispersing murein hydrolase","volume":"184","author":"De Las Rivas","year":"2002","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib62","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1128\/JB.182.10.2855-2864.2000","article-title":"Biosynthesis of lipoteichoic acid in Lactobacillus rhamnosus: role of DltD in D-alanylation","volume":"182","author":"Debabov","year":"2000","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib63","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1128\/jb.178.13.3869-3876.1996","article-title":"The D-Alanyl carrier protein in Lactobacillus casei: cloning, sequencing, and expression of dltC","volume":"178","author":"Debabov","year":"1996","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib64","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1089\/mdr.2012.0026","article-title":"Biosynthesis of teichoic acids in Streptococcus pneumoniae and closely related species: lessons from genomes","volume":"18","author":"Denapaite","year":"2012","journal-title":"Microb Drug Resist"},{"key":"key\n\t\t\t\t20180328163942_bib65","first-page":"401","article-title":"Streptococcus pneumoniae interactions with macrophages and mechanisms of immune evasion","volume-title":"Streptococcus pneuminiae - Molecular Mechanisms of Host-Pathogen Interactions","author":"Dockrell","year":"2015"},{"key":"key\n\t\t\t\t20180328163942_bib66","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/j.1365-2958.2004.04430.x","article-title":"Biogenesis of a putative channel protein, ComEC, required for DNA uptake: membrane topology, oligomerization and formation of disulphide bonds","volume":"55","author":"Draskovic","year":"2005","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib67","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.bbamem.2010.08.016","article-title":"The Sec translocase","volume":"1808","author":"du Plessis","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20180328163942_bib68","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1089\/mdr.2011.0232","article-title":"Attachment of capsular polysaccharide to the cell wall in Streptococcus pneumoniae","volume":"18","author":"Eberhardt","year":"2012","journal-title":"Microb Drug Resist"},{"key":"key\n\t\t\t\t20180328163942_bib69","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.jmb.2004.08.088","article-title":"Plasmin(ogen)-binding alpha-enolase from Streptococcus pneumoniae: crystal structure and evaluation of plasmin(ogen)-binding sites","volume":"343","author":"Ehinger","year":"2004","journal-title":"J Mol Biol"},{"key":"key\n\t\t\t\t20180328163942_bib70","doi-asserted-by":"crossref","first-page":"30106","DOI":"10.1074\/jbc.M401701200","article-title":"The bacA gene of Escherichia coli encodes an undecaprenyl pyrophosphate phosphatase activity","volume":"279","author":"El Ghachi","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180328163942_bib71","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1099\/mic.0.026328-0","article-title":"Fratricide in Streptococcus pneumoniae: contributions and role of the cell wall hydrolases CbpD, LytA and LytC","volume":"155","author":"Eldholm","year":"2009","journal-title":"Microbiology"},{"key":"key\n\t\t\t\t20180328163942_bib72","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/j.1365-2958.2010.07143.x","article-title":"Pneumococcal CbpD is a murein hydrolase that requires a dual cell envelope binding specificity to kill target cells during fratricide","volume":"76","author":"Eldholm","year":"2010","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib73","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1128\/JB.01168-06","article-title":"Streptococcus pneumoniae DivIVA: localization and interactions in a MinCD-free context","volume":"189","author":"Fadda","year":"2007","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib74","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1365-2958.2008.06396.x","article-title":"Sortase-mediated assembly and surface topology of adhesive pneumococcal pili","volume":"70","author":"Falker","year":"2008","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib75","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/j.1432-1033.1993.tb18102.x","article-title":"Teichoic acid and lipoteichoic acid of Streptococcus pneumoniae possess identical chain structures. A reinvestigation of teichoid acid (C polysaccharide)","volume":"215","author":"Fischer","year":"1993","journal-title":"Eur J Biochem\/FEBS"},{"key":"key\n\t\t\t\t20180328163942_bib76","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1365-2958.2011.07962.x","article-title":"Mutational dissection of the S\/T-kinase StkP reveals crucial roles in cell division of Streptococcus pneumoniae","volume":"83","author":"Fleurie","year":"2012","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib77","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nature13966","article-title":"MapZ marks the division sites and positions FtsZ rings in Streptococcus pneumoniae","volume":"516","author":"Fleurie","year":"2014","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180328163942_bib78","doi-asserted-by":"crossref","first-page":"e1004275","DOI":"10.1371\/journal.pgen.1004275","article-title":"Interplay of the serine\/threonine-kinase StkP and the paralogs DivIVA and GpsB in pneumococcal cell elongation and division","volume":"10","author":"Fleurie","year":"2014","journal-title":"PLos Genet"},{"key":"key\n\t\t\t\t20180328163942_bib79","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0098-2997(01)00010-3","article-title":"Redox signaling in macrophages","volume":"22","author":"Forman","year":"2001","journal-title":"Mol Aspects Med"},{"key":"key\n\t\t\t\t20180328163942_bib80","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.1365-2958.2007.05598.x","article-title":"Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC, Gram-positive bacteria","volume":"63","author":"Frees","year":"2007","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/B978-0-12-410530-0.00011-9","article-title":"Structure and Function of Choline-Binding Proteins","volume-title":"Streptococcus Pneumoniae - Molecular Mechanisms of Host-Pahtogen Interactions","author":"Galan-Bartual","year":"2015"},{"key":"key\n\t\t\t\t20180328163942_bib82","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF00425663","article-title":"Cloning and expression of the pneumococcal autolysin gene in Escherichia coli","volume":"201","author":"Garcia","year":"1985","journal-title":"Mol Gen Genet"},{"key":"key\n\t\t\t\t20180328163942_bib83","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1046\/j.1365-2958.1999.01238.x","article-title":"LytB, a novel pneumococcal murein hydrolase essential for cell separation","volume":"31","author":"Garcia","year":"1999","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib84","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1046\/j.1365-2958.1999.01455.x","article-title":"The molecular characterization of the first autolytic lysozyme of Streptococcus pneumoniae reveals evolutionary mobile domains","volume":"33","author":"Garcia","year":"1999","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib85","doi-asserted-by":"crossref","first-page":"5415","DOI":"10.1073\/pnas.87.14.5415","article-title":"A biological price of antibiotic resistance: major changes in the peptidoglycan structure of penicillin-resistant pneumococci","volume":"87","author":"Garcia-Bustos","year":"1990","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180328163942_bib86","doi-asserted-by":"crossref","first-page":"5454","DOI":"10.1128\/IAI.70.10.5454-5461.2002","article-title":"Role of RegM, a homologue of the catabolite repressor protein CcpA, in the virulence of Streptococcus pneumoniae","volume":"70","author":"Giammarinaro","year":"2002","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180328163942_bib87","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1099\/mic.0.036335-0","article-title":"The pneumococcal eukaryotic-type serine\/threonine protein kinase StkP co-localizes with the cell division apparatus and interacts with FtsZ in vitro","volume":"156","author":"Giefing","year":"2010","journal-title":"Microbiology"},{"key":"key\n\t\t\t\t20180328163942_bib88","first-page":"146","article-title":"The pneumococcal cell wall","volume-title":"Streptococcus pneumoniae - Molecular Mechanism of Host-Pathogen Interaction","author":"Gisch","year":"2015"},{"key":"key\n\t\t\t\t20180328163942_bib89","doi-asserted-by":"crossref","first-page":"15654","DOI":"10.1074\/jbc.M112.446963","article-title":"Structural reevaluation of Streptococcus pneumoniae Lipoteichoic acid and new insights into its immunostimulatory potency","volume":"288","author":"Gisch","year":"2013","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180328163942_bib90","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-84925-6","volume-title":"The Machinery of Life","author":"Goodsell","year":"2009"},{"key":"key\n\t\t\t\t20180328163942_bib91","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/bmb.20494","article-title":"Miniseries: Illustrating the machinery of life: Eukaryotic cell panorama","volume":"39","author":"Goodsell","year":"2011","journal-title":"Biochem Mol Biol Edu"},{"key":"key\n\t\t\t\t20180328163942_bib92","doi-asserted-by":"crossref","first-page":"e308","DOI":"10.1371\/journal.pbio.0050308","article-title":"Filling in the gaps: artistic license in education and outreach","volume":"5","author":"Goodsell","year":"2007","journal-title":"PLoS Biol"},{"key":"key\n\t\t\t\t20180328163942_bib93","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1365-2958.1994.tb01038.x","article-title":"A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae","volume":"12","author":"Guenzi","year":"1994","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib94","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1128\/IAI.00778-13","article-title":"Deletion of arcD in Streptococcus pneumoniae D39 impairs its capsule and attenuates virulence","volume":"81","author":"Gupta","year":"2013","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180328163942_bib95","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2217\/fmb.12.2","article-title":"Molecular mechanisms of beta-lactam resistance in Streptococcus pneumoniae","volume":"7","author":"Hakenbeck","year":"2012","journal-title":"Future Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib96","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1046\/j.1365-2958.1997.5391899.x","article-title":"SpsA, a novel pneumococcal surface protein with specific binding to secretory immunoglobulin A and secretory component","volume":"25","author":"Hammerschmidt","year":"1997","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib97","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1128\/IAI.73.8.4653-4667.2005","article-title":"Illustration of pneumococcal polysaccharide capsule during adherence and invasion of epithelial cells","volume":"73","author":"Hammerschmidt","year":"2005","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180328163942_bib98","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1179\/000870403235002042","article-title":"ColorBrewer.org: An online tool for selecting colour schemes for maps","volume":"40","author":"Harrower","year":"2003","journal-title":"Cartogr J"},{"key":"key\n\t\t\t\t20180328163942_bib99","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1074\/jbc.M111.304311","article-title":"Characterization of central carbon metabolism of Streptococcus pneumoniae by isotopologue profiling","volume":"287","author":"Hartel","year":"2012","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180328163942_bib100","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nature10317","article-title":"Molecular chaperones in protein folding and proteostasis","volume":"475","author":"Hartl","year":"2011","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180328163942_bib101","doi-asserted-by":"crossref","first-page":"e1002574","DOI":"10.1371\/journal.ppat.1002574","article-title":"Capsule type of Streptococcus pneumoniae determines growth phenotype","volume":"8","author":"Hathaway","year":"2012","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20180328163942_bib102","first-page":"1389","article-title":"Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors","volume":"45","author":"Hava","year":"2002","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib103","doi-asserted-by":"crossref","first-page":"11140","DOI":"10.1073\/pnas.92.24.11140","article-title":"An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae","volume":"92","author":"Havarstein","year":"1995","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180328163942_bib104","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1046\/j.1365-2958.1996.521416.x","article-title":"Identification of the streptococcal competence-pheromone receptor","volume":"21","author":"Havarstein","year":"1996","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib105","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1111\/j.1365-2958.2005.05021.x","article-title":"New insights into the pneumococcal fratricide: relationship to clumping and identification of a novel immunity factor","volume":"59","author":"Havarstein","year":"2006","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib106","doi-asserted-by":"crossref","first-page":"4707","DOI":"10.1128\/jb.174.14.4707-4717.1992","article-title":"Biosynthesis of D-alanyl-lipoteichoic acid: cloning, nucleotide sequence, and expression of the Lactobacillus casei gene for the D-alanine-activating enzyme","volume":"174","author":"Heaton","year":"1992","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib107","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/nrmicro2520","article-title":"Architects at the bacterial surface - sortases and the assembly of pili with isopeptide bonds","volume":"9","author":"Hendrickx","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib108","first-page":"1","article-title":"The pneumococcus: epidemiology, microbiology, and pathogenesis","volume":"3","author":"Henriques-Normark","year":"2013","journal-title":"Cold Spring Harbor Persp Med"},{"key":"key\n\t\t\t\t20180328163942_bib109","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nsmb940","article-title":"Insights into pneumococcal pathogenesis from the crystal structure of the modular teichoic acid phosphorylcholine esterase Pce","volume":"12","author":"Hermoso","year":"2005","journal-title":"Nat Struct Mol Biol"},{"key":"key\n\t\t\t\t20180328163942_bib110","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1128\/JB.101.2.643-648.1970","article-title":"Model for cell wall growth of Streptococcus faecalis","volume":"101","author":"Higgins","year":"1970","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib111","doi-asserted-by":"crossref","first-page":"e1000026","DOI":"10.1371\/journal.ppat.1000026","article-title":"Pneumococcal pili are composed of protofilaments exposing adhesive clusters of Rrg A","volume":"4","author":"Hilleringmann","year":"2008","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20180328163942_bib112","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1038\/emboj.2009.360","article-title":"Molecular architecture of Streptococcus pneumoniae TIGR4 pili","volume":"28","author":"Hilleringmann","year":"2009","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20180328163942_bib113","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.bbamcr.2010.01.017","article-title":"Structure and function of the molecular chaperone Trigger Factor","volume":"1803","author":"Hoffmann","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20180328163942_bib114","doi-asserted-by":"crossref","first-page":"e01700","DOI":"10.1128\/mBio.01700-14","article-title":"LocZ is a new cell division protein involved in proper septum placement in Streptococcus pneumoniae","volume":"6","author":"Holeckova","year":"2015","journal-title":"mBio"},{"key":"key\n\t\t\t\t20180328163942_bib115","doi-asserted-by":"crossref","first-page":"6552","DOI":"10.1128\/JB.181.20.6552-6555.1999","article-title":"Gene disruption studies of penicillin-binding proteins 1a, 1b, and 2a in Streptococcus pneumoniae","volume":"181","author":"Hoskins","year":"1999","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib116","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1128\/jb.173.1.372-381.1991","article-title":"Genetic transformation in Streptococcus pneumoniae: nucleotide sequence analysis shows comA, a gene required for competence induction, to be a member of the bacterial ATP-dependent transport protein family","volume":"173","author":"Hui","year":"1991","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib117","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1128\/IAI.00881-09","article-title":"The Streptococcus pneumoniae capsule inhibits complement activity and neutrophil phagocytosis by multiple mechanisms","volume":"78","author":"Hyams","year":"2010","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180328163942_bib118","doi-asserted-by":"crossref","first-page":"22635","DOI":"10.1074\/jbc.M401642200","article-title":"Crystal structure of WbpP, a genuine UDP-N-acetylglucosamine 4-epimerase from Pseudomonas aeruginosa: substrate specificity in udp-hexose 4-epimerases","volume":"279","author":"Ishiyama","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180328163942_bib119","doi-asserted-by":"crossref","first-page":"8340","DOI":"10.1128\/JB.187.24.8340-8349.2005","article-title":"Catabolite control protein A (CcpA) contributes to virulence and regulation of sugar metabolism in Streptococcus pneumoniae","volume":"187","author":"Iyer","year":"2005","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib119a","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/mi.2013.41","article-title":"Pneumococcal IgA1 protease subverts specific protection by human IgA1","volume":"7","author":"Janoff","year":"2014","journal-title":"Mucosal Immunol"},{"key":"key\n\t\t\t\t20180328163942_bib120","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.4049\/jimmunol.168.4.1886","article-title":"Streptococcus pneumoniae evades complement attack and opsonophagocytosis by expressing the pspC locus-encoded Hic protein that binds to short consensus repeats 8\u201311 of factor H","volume":"168","author":"Jarva","year":"2002","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20180328163942_bib121","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1128\/MMBR.65.2.187-207.2001","article-title":"Pneumococcal virulence factors: structure and function","volume":"65","author":"Jedrzejas","year":"2001","journal-title":"Microbiol Mol Biol R"},{"key":"key\n\t\t\t\t20180328163942_bib122","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1574-6976.2009.00167.x","article-title":"Regulation of natural genetic transformation and acquisition of transforming DNA in Streptococcus pneumoniae","volume":"33","author":"Johnsborg","year":"2009","journal-title":"FEMS Microbiol Rev"},{"key":"key\n\t\t\t\t20180328163942_bib123","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1365-2958.2008.06288.x","article-title":"A predatory mechanism dramatically increases the efficiency of lateral gene transfer in Streptococcus pneumoniae and related commensal species","volume":"69","author":"Johnsborg","year":"2008","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib124","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tim.2014.01.002","article-title":"Streptococcus pneumoniae, le transformiste","volume":"22","author":"Johnston","year":"2014","journal-title":"Trends Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib125","doi-asserted-by":"crossref","first-page":"e1003178","DOI":"10.1371\/journal.ppat.1003178","article-title":"Programmed protection of foreign DNA from restriction allows pathogenicity island exchange during pneumococcal transformation","volume":"9","author":"Johnston","year":"2013","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20180328163942_bib126","doi-asserted-by":"crossref","first-page":"e25582","DOI":"10.4161\/mge.25582","article-title":"The DpnI\/DpnII pneumococcal system, defense against foreign attack without compromising genetic exchange","volume":"3","author":"Johnston","year":"2013","journal-title":"Mob Genet Elements"},{"key":"key\n\t\t\t\t20180328163942_bib127","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nrmicro1871","article-title":"The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease","volume":"6","author":"Kadioglu","year":"2008","journal-title":"Nat Rev Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib128","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.1128\/JB.187.13.4338-4345.2005","article-title":"Choline-binding protein D (CbpD) in Streptococcus pneumoniae is essential for competence-induced cell lysis","volume":"187","author":"Kausmally","year":"2005","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib129","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1128\/IAI.71.5.2758-2765.2003","article-title":"Inactivation of the srtA gene affects localization of surface proteins and decreases adhesion of Streptococcus pneumoniae to human pharyngeal cells in vitro","volume":"71","author":"Kharat","year":"2003","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180328163942_bib130","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1128\/IAI.26.1.143-149.1979","article-title":"Pathogenic species of the genus Haemophilus and Streptococcus pneumoniae produce immunoglobulin A1 protease","volume":"26","author":"Kilian","year":"1979","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180328163942_bib130a","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1699-0463.1996.tb00724.x","article-title":"Biological significance of IgA1 proteases in bacterial colonization and pathogenesis: critical evaluation of experimental evidence","volume":"104","author":"Kilian","year":"1996","journal-title":"APMIS"},{"key":"key\n\t\t\t\t20180328163942_bib130b","doi-asserted-by":"crossref","first-page":"e01490","DOI":"10.1128\/mBio.01490-14","article-title":"Parallel evolution of Streptococcus pneumoniae and Streptococcus mitis to pathogenic and mutualistic lifestyles","volume":"5","author":"Kilian","year":"2014","journal-title":"MBio"},{"key":"key\n\t\t\t\t20180328163942_bib131","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1128\/JB.01837-08","article-title":"Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis","volume":"191","author":"Kline","year":"2009","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib132","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1007\/s00018-003-3056-1","article-title":"Lytic transglycosylases in macromolecular transport systems of Gram-negative bacteria","volume":"60","author":"Koraimann","year":"2003","journal-title":"Cell Mol Life Sci"},{"key":"key\n\t\t\t\t20180328163942_bib133","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1128\/JB.00336-06","article-title":"A functional dlt operon, encoding proteins required for incorporation of d-alanine in teichoic acids in gram-positive bacteria, confers resistance to cationic antimicrobial peptides in Streptococcus pneumoniae","volume":"188","author":"Kovacs","year":"2006","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib134","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.str.2007.06.015","article-title":"An IgG-like domain in the minor pilin GBS52 of Streptococcus agalactiae mediates lung epithelial cell adhesion","volume":"15","author":"Krishnan","year":"2007","journal-title":"Structure"},{"key":"key\n\t\t\t\t20180328163942_bib135","doi-asserted-by":"crossref","first-page":"3757","DOI":"10.1128\/IAI.71.7.3757-3765.2003","article-title":"Effect of heat shock and mutations in ClpL and ClpP on virulence gene expression in Streptococcus pneumoniae","volume":"71","author":"Kwon","year":"2003","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180328163942_bib136","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.1016\/S0021-9258(19)41386-0","article-title":"A deoxyribonuclease of Diplococcus pneumoniae specific for methylated DNA","volume":"250","author":"Lacks","year":"1975","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180328163942_bib137","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1128\/JB.123.1.222-232.1975","article-title":"Identification of a deoxyribonuclease implicated in genetic transformation of Diplococcus pneumoniae","volume":"123","author":"Lacks","year":"1975","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib138","doi-asserted-by":"crossref","first-page":"5961","DOI":"10.1128\/jb.172.10.5961-5967.1990","article-title":"Changes in composition of peptidoglycan during maturation of the cell wall in pneumococci","volume":"172","author":"Laitinen","year":"1990","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib139","doi-asserted-by":"crossref","first-page":"4166","DOI":"10.1128\/JB.05245-11","article-title":"The requirement for pneumococcal MreC and MreD is relieved by inactivation of the gene encoding PBP1a","volume":"193","author":"Land","year":"2011","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib140","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1365-2958.2004.04432.x","article-title":"Cell division in cocci: localization and properties of the Streptococcus pneumoniae FtsA protein","volume":"55","author":"Lara","year":"2005","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib141","doi-asserted-by":"crossref","first-page":"e1004835","DOI":"10.1371\/journal.ppat.1004835","article-title":"Conserved Streptococcus pneumoniae spirosomes suggest a single type of transformation pilus in competence","volume":"11","author":"Laurenceau","year":"2015","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20180328163942_bib142","doi-asserted-by":"crossref","first-page":"e1003473","DOI":"10.1371\/journal.ppat.1003473","article-title":"A type IV pilus mediates DNA binding during natural transformation in Streptococcus pneumoniae","volume":"9","author":"Laurenceau","year":"2013","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20180328163942_bib143","doi-asserted-by":"crossref","first-page":"5004","DOI":"10.1128\/JB.181.16.5004-5016.1999","article-title":"Identification of a new regulator in Streptococcus pneumoniae linking quorum sensing to competence for genetic transformation","volume":"181","author":"Lee","year":"1999","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib144","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1128\/IAI.74.4.2453-2456.2006","article-title":"RrgA and RrgB are components of a multisubunit pilus encoded by the Streptococcus pneumoniae rlrA pathogenicity islet","volume":"74","author":"LeMieux","year":"2006","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180328163942_bib145","doi-asserted-by":"crossref","first-page":"6002","DOI":"10.1128\/JB.00379-08","article-title":"Roles of the sortases of Streptococcus pneumoniae in assembly of the RlrA pilus","volume":"190","author":"LeMieux","year":"2008","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib146","doi-asserted-by":"crossref","first-page":"6402","DOI":"10.1074\/jbc.M708105200","article-title":"Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan","volume":"283","author":"Lloyd","year":"2008","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180328163942_bib147","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nj7364-359a","article-title":"Biomedical illustration: From monsters to molecules","volume":"477","author":"Lok","year":"2011","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180328163942_bib148","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-2958.1994.tb00415.x","article-title":"Membrane association and role in DNA uptake of the Bacillus subtilis PriA analogue ComF1","volume":"13","author":"Londono-Vallejo","year":"1994","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib149","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/j.1365-2958.2004.04164.x","article-title":"Molecular analysis of the psa permease complex of Streptococcus pneumoniae","volume":"53","author":"McAllister","year":"2004","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib150","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.tim.2007.10.010","article-title":"Pili in Gram-positive bacteria: assembly, involvement in colonization and biofilm development","volume":"16","author":"Mandlik","year":"2008","journal-title":"Trends Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib151","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/mmi.12425","article-title":"Complex formation and processing of the minor transformation pilins of Bacillus subtilis","volume":"90","author":"Mann","year":"2013","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib151a","doi-asserted-by":"crossref","first-page":"5055","DOI":"10.1038\/ncomms6055","article-title":"A random six-phase switch regulates pneumococcal virulence via global epigenetic changes","volume":"5","author":"Manso","year":"2014","journal-title":"Nat Commun"},{"key":"key\n\t\t\t\t20180328163942_bib152","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1016\/j.str.2008.10.007","article-title":"Sortase-mediated pilus fiber biogenesis in Streptococcus pneumoniae","volume":"16","author":"Manzano","year":"2008","journal-title":"Structure"},{"key":"key\n\t\t\t\t20180328163942_bib153","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1111\/1462-2920.12189","article-title":"From models to pathogens: how much have we learned about Streptococcus pneumoniae cell division?","volume":"15","author":"Massidda","year":"2013","journal-title":"Environ Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib154","doi-asserted-by":"crossref","first-page":"E1035","DOI":"10.1073\/pnas.1219868110","article-title":"Direct involvement of DprA, the transformation-dedicated RecA loader, in the shut-off of pneumococcal competence","volume":"110","author":"Mirouze","year":"2013","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180328163942_bib155","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1111\/j.1365-2958.1991.tb00812.x","article-title":"Complement activation and antibody binding by pneumolysin via a region of the toxin homologous to a human acute-phase protein","volume":"5","author":"Mitchell","year":"1991","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib156","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/emboj.2011.61","article-title":"Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane","volume":"30","author":"Mohammadi","year":"2011","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20180328163942_bib157","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/embor.2008.245","article-title":"Crystal structure of CbpF, a bifunctional choline-binding protein and autolysis regulator from Streptococcus pneumoniae","volume":"10","author":"Molina","year":"2009","journal-title":"EMBO Rep"},{"key":"key\n\t\t\t\t20180328163942_bib158","doi-asserted-by":"crossref","first-page":"824","DOI":"10.5301\/ijao.5000051","article-title":"Extracellular DNA in biofilms","volume":"34","author":"Montanaro","year":"2011","journal-title":"Int J Artif Organs"},{"key":"key\n\t\t\t\t20180328163942_bib159","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/mmi.12348","article-title":"Interaction of penicillin-binding protein 2x and Ser\/Thr protein kinase StkP, two key players in Streptococcus pneumoniae R6 morphogenesis","volume":"90","author":"Morlot","year":"2013","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib160","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1046\/j.1365-2958.2003.03953.x","article-title":"The D,D-carboxypeptidase PBP3 organizes the division process of Streptococcus pneumoniae","volume":"51","author":"Morlot","year":"2004","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib161","doi-asserted-by":"crossref","first-page":"15984","DOI":"10.1074\/jbc.M408446200","article-title":"Crystal structure of a peptidoglycan synthesis regulatory factor (PBP3) from Streptococcus pneumoniae","volume":"280","author":"Morlot","year":"2005","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180328163942_bib162","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1046\/j.1365-2958.2003.03767.x","article-title":"Growth and division of Streptococcus pneumoniae: localization of the high molecular weight penicillin-binding proteins during the cell cycle","volume":"50","author":"Morlot","year":"2003","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib163","doi-asserted-by":"crossref","first-page":"8505","DOI":"10.1073\/pnas.0602148103","article-title":"Attachment of capsular polysaccharide to the cell wall of Streptococcus pneumoniae type 2 is required for invasive disease","volume":"103","author":"Morona","year":"2006","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180328163942_bib164","doi-asserted-by":"crossref","first-page":"6497","DOI":"10.1128\/JB.00687-07","article-title":"Identification of the major protein component of the pneumococcal eclipse complex","volume":"189","author":"Morrison","year":"2007","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib165","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.cell.2007.07.038","article-title":"A key presynaptic role in transformation for a widespread bacterial protein: DprA conveys incoming ssDNA to RecA","volume":"130","author":"Mortier-Barriere","year":"2007","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180328163942_bib166","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0021-9258(18)63393-9","article-title":"Choline-containing teichoic acid as a structural component of pneumococcal cell wall and its role in sensitivity to lysis by an autolytic enzyme","volume":"245","author":"Mosser","year":"1970","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180328163942_bib167","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1128\/IAI.00425-08","article-title":"Isolation of Streptococcus pneumoniae biofilm mutants and their characterization during nasopharyngeal colonization","volume":"76","author":"Munoz-Elias","year":"2008","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180328163942_bib168","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/bies.201400125","article-title":"Uptake of extracellular DNA: competence induced pili in natural transformation of Streptococcus pneumoniae","volume":"37","author":"Muschiol","year":"2015","journal-title":"BioEssays"},{"key":"key\n\t\t\t\t20180328163942_bib169","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1128\/JB.181.5.1555-1561.1999","article-title":"Peptidoglycan-hydrolyzing activity of the FlgJ protein, essential for flagellar rod formation in Salmonella typhimurium","volume":"181","author":"Nambu","year":"1999","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib170","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1365-2958.2007.05908.x","article-title":"RrgA is a pilus-associated adhesin in Streptococcus pneumoniae","volume":"66","author":"Nelson","year":"2007","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib171","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1128\/IAI.01475-06","article-title":"Capsule enhances pneumococcal colonization by limiting mucus-mediated clearance","volume":"75","author":"Nelson","year":"2007","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180328163942_bib172","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1128\/MMBR.67.4.686-723.2003","article-title":"A continuum of anionic charge: structures and functions of D-alanyl-teichoic acids in gram-positive bacteria","volume":"67","author":"Neuhaus","year":"2003","journal-title":"Microbiol Mol Biol R"},{"key":"key\n\t\t\t\t20180328163942_bib173","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1365-2958.2004.04408.x","article-title":"In vitro reconstitution of a trimeric complex of DivIB, DivIC and FtsL, and their transient co-localization at the division site in Streptococcus pneumoniae","volume":"55","author":"Noirclerc-Savoye","year":"2005","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib174","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0140-6736(09)61204-6","article-title":"Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates","volume":"374","author":"O\u2019Brien","year":"2009","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180328163942_bib175","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1021\/cr9600464","article-title":"Enzymatic aspects of isoprenoid chain elongation","volume":"98","author":"Ogura","year":"1998","journal-title":"Chem Rev"},{"key":"key\n\t\t\t\t20180328163942_bib176","first-page":"98","article-title":"Postulated relationships between lysozyme and immunoglobulins as mediators of macrophage and plasma cell functions","volume":"4","author":"Osserman","year":"1976","journal-title":"Adv Pathobiol"},{"key":"key\n\t\t\t\t20180328163942_bib177","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1038\/srep02040","article-title":"Expression of the Streptococcus pneumoniae pilus-1 undergoes on and off switching during colonization in mice","volume":"3","author":"Pancotto","year":"2013","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t20180328163942_bib178","doi-asserted-by":"crossref","first-page":"e22095","DOI":"10.1371\/journal.pone.0022095","article-title":"Structure of the full-length major pilin from Streptococcus pneumoniae: implications for isopeptide bond formation in gram-positive bacterial pili","volume":"6","author":"Paterson","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180328163942_bib179","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1128\/IAI.43.3.1085-1087.1984","article-title":"Activation of human complement by the pneumococcal toxin pneumolysin","volume":"43","author":"Paton","year":"1984","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180328163942_bib180","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0966-842X(02)02333-8","article-title":"How do bacteria resist human antimicrobial peptides?","volume":"10","author":"Peschel","year":"2002","journal-title":"Trends Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib181","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1007\/s00134-003-1961-2","article-title":"Factors determining the appearance of glucose in upper and lower respiratory tract secretions","volume":"29","author":"Philips","year":"2003","journal-title":"Intensive Care Med"},{"key":"key\n\t\t\t\t20180328163942_bib182","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/j.1574-6976.2011.00323.x","article-title":"From meadows to milk to mucosa\u2014adaptation of Streptococcus and Lactococcus species to their nutritional environments","volume":"36","author":"Price","year":"2012","journal-title":"FEMS Microbiol Rev"},{"key":"key\n\t\t\t\t20180328163942_bib183","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00018-008-8477-4","article-title":"Pili in Gram-negative and Gram-positive bacteria\u2014structure, assembly and their role in disease","volume":"66","author":"Proft","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"key\n\t\t\t\t20180328163942_bib184","doi-asserted-by":"crossref","first-page":"E2466","DOI":"10.1073\/pnas.1205638109","article-title":"Structure-function analysis of pneumococcal DprA protein reveals that dimerization is crucial for loading RecA recombinase onto DNA during transformation","volume":"109","author":"Quevillon-Cheruel","year":"2012","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180328163942_bib185","doi-asserted-by":"crossref","first-page":"L743","DOI":"10.1152\/ajplung.00146.2004","article-title":"Surfactant lipid synthesis and lamellar body formation in glycogen-laden type II cells","volume":"287","author":"Ridsdale","year":"2004","journal-title":"Am J Physiol-Lung C"},{"key":"key\n\t\t\t\t20180328163942_bib186","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/bioinformatics\/btr652","article-title":"Using Sybil for interactive comparative genomics of microbes on the web","volume":"28","author":"Riley","year":"2012","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20180328163942_bib187","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1128\/MMBR.58.2.211-232.1994","article-title":"The bacterial nucleoid revisited","volume":"58","author":"Robinow","year":"1994","journal-title":"Microbiol Rev"},{"key":"key\n\t\t\t\t20180328163942_bib188","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S1095-6433(01)00320-8","article-title":"Regulation of surfactant secretion","volume":"129","author":"Rooney","year":"2001","journal-title":"Comp Biochem Phys C"},{"key":"key\n\t\t\t\t20180328163942_bib189","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.1365-2958.1997.mmi494.x","article-title":"Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae","volume":"25","author":"Rosenow","year":"1997","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib190","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0022-2143(98)90073-7","article-title":"Pneumolysin: a multifunctional pneumococcal virulence factor","volume":"131","author":"Rubins","year":"1998","journal-title":"J Lab Clin Med"},{"key":"key\n\t\t\t\t20180328163942_bib191","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1111\/febs.13240","article-title":"Modeling the ComD\/ComE\/comcde interaction network using small angle X-ray scattering","volume":"282","author":"Sanchez","year":"2015","journal-title":"FEBS J"},{"key":"key\n\t\t\t\t20180328163942_bib192","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1574-6976.2008.00105.x","article-title":"The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis","volume":"32","author":"Sauvage","year":"2008","journal-title":"FEMS Microbiol Rev"},{"key":"key\n\t\t\t\t20180328163942_bib193","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/nature08403","article-title":"What recent ribosome structures have revealed about the mechanism of translation","volume":"461","author":"Schmeing","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180328163942_bib194","volume-title":"The PyMOL Molecular Graphics System, Version 1.8","author":"Schr\u00f6dinger","year":"2015"},{"key":"key\n\t\t\t\t20180328163942_bib195","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1093\/nar\/gkg520","article-title":"SWISS-MODEL: An automated protein homology-modeling server","volume":"31","author":"Schwede","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20180328163942_bib196","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1128\/JB.187.12.3969-3979.2005","article-title":"Pneumococcal HtrA protease mediates inhibition of competence by the CiaRH two-component signaling system","volume":"187","author":"Sebert","year":"2005","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib197","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1128\/JB.01795-07","article-title":"A new model of pneumococcal lipoteichoic acid structure resolves biochemical, biosynthetic, and serologic inconsistencies of the current model","volume":"190","author":"Seo","year":"2008","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib198","doi-asserted-by":"crossref","first-page":"16988","DOI":"10.1074\/jbc.M114.555854","article-title":"Structural basis of pilus anchoring by the ancillary pilin RrgC of Streptococcus pneumoniae","volume":"289","author":"Shaik","year":"2014","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180328163942_bib199","doi-asserted-by":"crossref","first-page":"E1061","DOI":"10.1073\/pnas.1108323108","article-title":"Essential PcsB putative peptidoglycan hydrolase interacts with the essential FtsXSpn cell division protein in Streptococcus pneumoniae D39","volume":"108","author":"Sham","year":"2011","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180328163942_bib200","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1089\/mdr.1996.2.95","article-title":"Bacterial walls, peptidoglycan hydrolases, autolysins, and autolysis","volume":"2","author":"Shockman","year":"1996","journal-title":"Microb Drug Resist"},{"key":"key\n\t\t\t\t20180328163942_bib201","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1128\/IAI.56.8.1890-1896.1988","article-title":"Ultrastructural localization of capsules, cell wall polysaccharide, cell wall proteins, and F antigen in pneumococci","volume":"56","author":"Skov Sorensen","year":"1988","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180328163942_bib202","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/j.1365-2958.2011.07887.x","article-title":"Sortase enzymes in Gram-positive bacteria","volume":"82","author":"Spirig","year":"2011","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib203","doi-asserted-by":"crossref","first-page":"e10919","DOI":"10.1371\/journal.pone.0010919","article-title":"Supramolecular organization of the repetitive backbone unit of the Streptococcus pneumoniae pilus","volume":"5","author":"Spraggon","year":"2010","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180328163942_bib204","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1006\/abbi.2000.2029","article-title":"Purification and characterization of the RecA protein from Streptococcus pneumoniae","volume":"382","author":"Steffen","year":"2000","journal-title":"Arch Biochem Biophys"},{"key":"key\n\t\t\t\t20180328163942_bib204a","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.meegid.2014.10.020","article-title":"Natural transformation and genome evolution in Streptococcus pneumoniae","volume":"33","author":"Straume","year":"2015","journal-title":"Infect Genet Evol"},{"key":"key\n\t\t\t\t20180328163942_bib205","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1128\/JB.187.9.3052-3061.2005","article-title":"Two distinct functions of ComW in stabilization and activation of the alternative sigma factor ComX in Streptococcus pneumoniae","volume":"187","author":"Sung","year":"2005","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib206","doi-asserted-by":"crossref","first-page":"4689","DOI":"10.1128\/jb.179.15.4689-4698.1997","article-title":"Characterization of a gene cluster for glycogen biosynthesis and a heterotetrameric ADP-glucose pyrophosphorylase from Bacillus stearothermophilus","volume":"179","author":"Takata","year":"1997","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib207","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1126\/science.1061217","article-title":"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae","volume":"293","author":"Tettelin","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20180328163942_bib208","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.sbi.2006.03.008","article-title":"The mechanism of pore formation by bacterial toxins","volume":"16","author":"Tilley","year":"2006","journal-title":"Curr Opin Struct Biol"},{"key":"key\n\t\t\t\t20180328163942_bib209","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.cell.2005.02.033","article-title":"Structural basis of pore formation by the bacterial toxin pneumolysin","volume":"121","author":"Tilley","year":"2005","journal-title":"Cell"},{"key":"key\n\t\t\t\t20180328163942_bib210","article-title":"Todar's Online Textbook of Bacteriology (2008-2012) Streptococcus pneumoniae","author":"Todar","year":"2016"},{"key":"key\n\t\t\t\t20180328163942_bib211","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1126\/science.157.3789.694","article-title":"Choline in the cell wall of a bacterium: novel type of polymer-linked choline in Pneumococcus","volume":"157","author":"Tomasz","year":"1967","journal-title":"Science"},{"key":"key\n\t\t\t\t20180328163942_bib212","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1073\/pnas.59.1.86","article-title":"Biological consequences of the replacement of choline by ethanolamine in the cell wall of Pneumococcus: chanin formation, loss of transformability, and loss of autolysis","volume":"59","author":"Tomasz","year":"1968","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180328163942_bib213","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1073\/pnas.51.3.480","article-title":"Regulation of the transformability of pheumococcal cultures by macromolecular cell products","volume":"51","author":"Tomasz","year":"1964","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180328163942_bib214","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0021-9258(19)42020-6","article-title":"Coordinated incorporation of nascent peptidoglycan and teichoic acid into pneumococcal cell walls and conservation of peptidoglycan during growth","volume":"250","author":"Tomasz","year":"1975","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180328163942_bib215","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1073\/pnas.68.11.2627","article-title":"Abnormal autolytic enzyme in a pneumococus with altered teichoic acid composition","volume":"68","author":"Tomasz","year":"1971","journal-title":"P Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180328163942_bib216","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1046\/j.1365-2958.2003.03782.x","article-title":"Assembly of pili on the surface of Corynebacterium diphtheriae","volume":"50","author":"Ton-That","year":"2003","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib217","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1128\/IAI.68.2.921-924.2000","article-title":"Evaluation of the virulence of a Streptococcus pneumoniae neuraminidase-deficient mutant in nasopharyngeal colonization and development of otitis media in the chinchilla model","volume":"68","author":"Tong","year":"2000","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180328163942_bib218","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1177\/1075547099020004004","article-title":"Visual literacy and science communication","volume":"20","author":"Trumbo","year":"1999","journal-title":"Sci Commun"},{"key":"key\n\t\t\t\t20180328163942_bib219","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00202-11","article-title":"Dynamic distribution of the SecA and SecY translocase subunits and septal localization of the HtrA surface chaperone\/protease during Streptococcus pneumoniae D39 cell division","volume":"2","author":"Tsui","year":"2011","journal-title":"mBio"},{"key":"key\n\t\t\t\t20180328163942_bib220","article-title":"Elongation factor P - entry P64042","author":"UniProt","year":"2015"},{"key":"key\n\t\t\t\t20180328163942_bib221","article-title":"SP_1945","author":"UniProt","year":"2016"},{"key":"key\n\t\t\t\t20180328163942_bib222","volume-title":"Streptococcus Pneumoniae Comparative System","author":"University of Maryland Baltimore","year":"2015"},{"key":"key\n\t\t\t\t20180328163942_bib223","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nsmb1187","article-title":"Identification and structural basis of binding to host lung glycogen by streptococcal virulence factors","volume":"14","author":"van Bueren","year":"2007","journal-title":"Nat Struct Mol Biol"},{"key":"key\n\t\t\t\t20180328163942_bib224","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1111\/j.1462-5822.2007.00981.x","article-title":"Macrophage complement receptors and pathogen clearance","volume":"9","author":"van Lookeren Campagne","year":"2007","journal-title":"Cell Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib225","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1574-6976.2007.00088.x","article-title":"Structural variation in the glycan strands of bacterial peptidoglycan","volume":"32","author":"Vollmer","year":"2008","journal-title":"FEMS Microbiol Rev"},{"key":"key\n\t\t\t\t20180328163942_bib226","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.bbamem.2007.06.007","article-title":"Murein (peptidoglycan) structure, architecture and biosynthesis in Escherichia coli","volume":"1778","author":"Vollmer","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20180328163942_bib227","doi-asserted-by":"crossref","first-page":"20496","DOI":"10.1074\/jbc.M910189199","article-title":"The pgdA gene encodes for a peptidoglycan N-acetylglucosamine deacetylase in Streptococcus pneumoniae","volume":"275","author":"Vollmer","year":"2000","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180328163942_bib228","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nrg3375","article-title":"Organization and segregation of bacterial chromosomes","volume":"14","author":"Wang","year":"2013","journal-title":"Nat Rev Genet"},{"key":"key\n\t\t\t\t20180328163942_bib228a","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1128\/IAI.64.10.3967-3974.1996","article-title":"Identification, cloning, and sequencing of the immunoglobulin A1 protease gene of Streptococcus pneumoniae","volume":"64","author":"Wani","year":"1996","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180328163942_bib229","first-page":"198","article-title":"A brief history of the pneumococcus in biomedical research","volume":"14","author":"Watson","year":"1999","journal-title":"Semin Respir Infect"},{"key":"key\n\t\t\t\t20180328163942_bib230","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrmicro1861","article-title":"Teichoic acids and related cell-wall glycopolymers in Gram-positive physiology and host interactions","volume":"6","author":"Weidenmaier","year":"2008","journal-title":"Nat Rev Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib230a","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1073\/pnas.0637469100","article-title":"Antibody-enhanced pneumococcal adherence requires IgA1 protease","volume":"100","author":"Weiser","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20180328163942_bib231","doi-asserted-by":"crossref","first-page":"e64197","DOI":"10.1371\/journal.pone.0064197","article-title":"Exit from competence for genetic transformation in Streptococcus pneumoniae is regulated at multiple levels","volume":"8","author":"Weng","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180328163942_bib232","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1574-6968.1996.tb08147.x","article-title":"Incorporation of choline into Streptococcus pneumoniae cell wall antigens: evidence for choline kinase activity","volume":"138","author":"Whiting","year":"1996","journal-title":"FEMS Microbiol Lett"},{"key":"key\n\t\t\t\t20180328163942_bib233","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1574-6968.1996.tb08493.x","article-title":"Investigation of a choline phosphate synthesis pathway in Streptococcus pneumoniae: evidence for choline phosphate cytidylyltransferase activity","volume":"143","author":"Whiting","year":"1996","journal-title":"FEMS Microbiol Lett"},{"key":"key\n\t\t\t\t20180328163942_bib234","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1111\/j.1574-6976.2010.00220.x","article-title":"Regulation of glycogen metabolism in yeast and bacteria","volume":"34","author":"Wilson","year":"2010","journal-title":"FEMS Microbiol Rev"},{"key":"key\n\t\t\t\t20180328163942_bib235","article-title":"Pneumococcal disease","author":"World Health Organization","year":"2011"},{"key":"key\n\t\t\t\t20180328163942_bib236","article-title":"Pneumonia","author":"World Health Organization","year":"2014"},{"key":"key\n\t\t\t\t20180328163942_bib237","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1128\/JB.01938-06","article-title":"Mutations blocking side chain assembly, polymerization, or transport of a Wzy-dependent Streptococcus pneumoniae capsule are lethal in the absence of suppressor mutations and can affect polymer transfer to the cell wall","volume":"189","author":"Xayarath","year":"2007","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180328163942_bib238","doi-asserted-by":"crossref","first-page":"5418","DOI":"10.1128\/IAI.00178-09","article-title":"Pyruvate formate lyase is required for pneumococcal fermentative metabolism and virulence","volume":"77","author":"Yesilkaya","year":"2009","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20180328163942_bib239","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev.micro.62.081307.162944","article-title":"Capsules of Streptococcus pneumoniae and other bacteria: paradigms for polysaccharide biosynthesis and regulation","volume":"65","author":"Yother","year":"2011","journal-title":"Annu Rev Microbiol"},{"key":"key\n\t\t\t\t20180328163942_bib240","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1574-6976.2007.00098.x","article-title":"The different shapes of cocci","volume":"32","author":"Zapun","year":"2008","journal-title":"FEMS Microbiol Rev"},{"key":"key\n\t\t\t\t20180328163942_bib241","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1046\/j.1365-2958.1999.01291.x","article-title":"Pneumococcal licD2 gene is involved in phosphorylcholine metabolism","volume":"31","author":"Zhang","year":"1999","journal-title":"Mol Microbiol"}],"container-title":["FEMS Microbiology Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/femsre\/article-pdf\/41\/6\/854\/21652576\/fux037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T14:04:53Z","timestamp":1719410693000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femsre\/article\/41\/6\/854\/4345647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,5]]},"references-count":248,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,10,5]]},"published-print":{"date-parts":[[2017,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/femsre\/fux037","relation":{},"ISSN":["1574-6976"],"issn-type":[{"value":"1574-6976","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,11]]},"published":{"date-parts":[[2017,10,5]]}}}