{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:38:09Z","timestamp":1790746689703,"version":"4.1.0"},"reference-count":204,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T00:00:00Z","timestamp":1549843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1143974"],"award-info":[{"award-number":["APP1143974"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP112656"],"award-info":[{"award-number":["APP112656"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"James Graham Brown","award":["1077636"],"award-info":[{"award-number":["1077636"]}]},{"name":"TdKW","award":["1136300"],"award-info":[{"award-number":["1136300"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Plasmodium spp. parasites that cause malaria disease remain a significant global-health burden. With the spread of parasites resistant to artemisinin combination therapies in Southeast Asia, there is a growing need to develop new antimalarials with novel targets. Invasion of the red blood cell by Plasmodium merozoites is essential for parasite survival and proliferation, thus representing an attractive target for therapeutic development. Red blood cell invasion requires a co-ordinated series of protein\/protein interactions, protease cleavage events, intracellular signals, organelle release and engagement of an actin-myosin motor, which provide many potential targets for drug development. As these steps occur in the bloodstream, they are directly susceptible and exposed to drugs. A number of invasion inhibitors against a diverse range of parasite proteins involved in these different processes of invasion have been identified, with several showing potential to be optimised for improved drug-like properties. In this review, we discuss red blood cell invasion as a drug target and highlight a number of approaches for developing antimalarials with invasion inhibitory activity to use in future combination therapies.<\/jats:p>","DOI":"10.1093\/femsre\/fuz005","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T12:46:58Z","timestamp":1549889218000},"page":"223-238","source":"Crossref","is-referenced-by-count":92,"title":["Targeting malaria parasite invasion of red blood cells as an antimalarial strategy"],"prefix":"10.1093","volume":"43","author":[{"given":"Amy L","family":"Burns","sequence":"first","affiliation":[{"name":"Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, Australia 5005"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline G","family":"Dans","sequence":"additional","affiliation":[{"name":"Burnet Institute, Melbourne, Victoria, Australia 3004"},{"name":"Deakin University, School of Medicine, Waurn Ponds, Victoria, Australia 3216"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M","family":"Balbin","sequence":"additional","affiliation":[{"name":"Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, Australia 5005"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania F","family":"de Koning-Ward","sequence":"additional","affiliation":[{"name":"Deakin University, School of Medicine, Waurn Ponds, Victoria, Australia 3216"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R","family":"Gilson","sequence":"additional","affiliation":[{"name":"Burnet Institute, Melbourne, Victoria, Australia 3004"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G","family":"Beeson","sequence":"additional","affiliation":[{"name":"Burnet Institute, Melbourne, Victoria, Australia 3004"},{"name":"Central Clinical School and Department of Microbiology, Monash University 3004"},{"name":"Department of Medicine, University of Melbourne, Australia 3052"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle J","family":"Boyle","sequence":"additional","affiliation":[{"name":"Burnet Institute, Melbourne, Victoria, Australia 3004"},{"name":"QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia 4006"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny W","family":"Wilson","sequence":"additional","affiliation":[{"name":"Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, Australia 5005"},{"name":"Burnet Institute, Melbourne, Victoria, Australia 3004"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,2,11]]},"reference":[{"key":"2019091000282579600_bib1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s00436-005-1426-3","article-title":"Carrageenans inhibit the in vitro growth of Plasmodium falciparum and cytoadhesion to CD36","volume":"97","author":"Adams","year":"2005","journal-title":"Parasitol Res"},{"key":"2019091000282579600_bib2","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/jcb.21500","article-title":"Targeting cell signaling pathways for drug discovery: an old lock needs a new key","volume":"102","author":"Aggarwal","year":"2007","journal-title":"J Cell Biochem"},{"key":"2019091000282579600_bib3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1083\/jcb.77.1.72","article-title":"Erythrocyte entry by malarial parasites. A moving junction between erythrocyte and parasite","volume":"77","author":"Aikawa","year":"1978","journal-title":"J Cell Biol"},{"key":"2019091000282579600_bib4","doi-asserted-by":"crossref","first-page":"7285","DOI":"10.1038\/ncomms8285","article-title":"Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion","volume":"6","author":"Alam","year":"2015","journal-title":"Nat Commun"},{"key":"2019091000282579600_bib5","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1128\/EC.00040-06","article-title":"Plasmodium falciparum AMA1 binds a rhoptry neck protein homologous to TgRON4, a component of the moving junction in Toxoplasma gondii","volume":"5","author":"Alexander","year":"2006","journal-title":"Eukaryot Cell"},{"key":"2019091000282579600_bib6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev.micro.091208.073403","article-title":"Malaria parasite development in the mosquito and infection of the mammalian host","volume":"63","author":"Aly","year":"2009","journal-title":"Annu Rev Microbiol"},{"key":"2019091000282579600_bib7","doi-asserted-by":"crossref","first-page":"6032","DOI":"10.1128\/AAC.02959-14","article-title":"Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1","volume":"58","author":"Ansell","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091000282579600_bib8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature12876","article-title":"A molecular marker of artemisinin-resistant Plasmodium falciparum malaria","volume":"505","author":"Ariey","year":"2014","journal-title":"Nature"},{"key":"2019091000282579600_bib9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1314981","article-title":"Spread of artemisinin resistance in Plasmodium falciparum malaria","volume":"371","author":"Ashley","year":"2014","journal-title":"N Engl J Med"},{"key":"2019091000282579600_bib10","doi-asserted-by":"crossref","first-page":"170213","DOI":"10.1098\/rsob.170213","article-title":"Cyclic nucleotide signalling in malaria parasites","volume":"7","author":"Baker","year":"2017","journal-title":"Open Biol"},{"key":"2019091000282579600_bib11","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41467-017-00572-x","article-title":"A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission","volume":"8","author":"Baker","year":"2017","journal-title":"Nat Commun"},{"key":"2019091000282579600_bib12","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1182\/blood-2014-11-611707","article-title":"Merozoite surface protein 1 recognition of host glycophorin A mediates malaria parasite invasion of red blood cells","volume":"125","author":"Baldwin","year":"2015","journal-title":"Blood"},{"key":"2019091000282579600_bib13","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1550-7408.1989.tb05527.x","article-title":"The fine structure of secretion by Plasmodium knowlesi merozoites during red cell invasion","volume":"36","author":"Bannister","year":"1989","journal-title":"J Protozool"},{"key":"2019091000282579600_bib15","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1073\/pnas.1715443115","article-title":"PfCDPK1 is critical for malaria parasite gametogenesis and mosquito infection","volume":"115","author":"Bansal","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019091000282579600_bib14","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1074\/jbc.M112.411934","article-title":"Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion","volume":"288","author":"Bansal","year":"2013","journal-title":"J Biol Chem"},{"key":"2019091000282579600_bib16","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/expr.1998.4349","article-title":"Plasmodium falciparum: molecular background to strain-specific rosette disruption by glycosaminoglycans and sulfated glycoconjugates","volume":"91","author":"Barragan","year":"1999","journal-title":"Exp Parasitol"},{"key":"2019091000282579600_bib17","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1126\/science.6189183","article-title":"Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)","volume":"220","author":"Barre-Sinoussi","year":"1983","journal-title":"Science"},{"key":"2019091000282579600_bib18","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1128\/AAC.00686-13","article-title":"Fucosylated chondroitin sulfate inhibits Plasmodium falciparum cytoadhesion and merozoite invasion","volume":"58","author":"Bastos","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091000282579600_bib19","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ijpara.2008.10.006","article-title":"Reticulocyte-binding protein homologue 5 - an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum","volume":"39","author":"Baum","year":"2009","journal-title":"Int J Parasitol"},{"key":"2019091000282579600_bib20","doi-asserted-by":"crossref","first-page":"5412","DOI":"10.1128\/IAI.70.10.5412-5415.2002","article-title":"Selective accumulation of mature asexual stages of Plasmodium falciparum-infected erythrocytes in the placenta","volume":"70","author":"Beeson","year":"2002","journal-title":"Infect Immun"},{"key":"2019091000282579600_bib21","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/femsre\/fuw001","article-title":"Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria","volume":"40","author":"Beeson","year":"2016","journal-title":"FEMS Microbiol Rev"},{"key":"2019091000282579600_bib22","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1083\/jcb.200505117","article-title":"Cyclic AMP and calcium interplay as second messengers in melatonin-dependent regulation of Plasmodium falciparum cell cycle","volume":"170","author":"Beraldo","year":"2005","journal-title":"J Cell Biol"},{"key":"2019091000282579600_bib24","doi-asserted-by":"crossref","first-page":"23398","DOI":"10.1074\/jbc.273.36.23398","article-title":"A subtilisin-like protein in secretory organelles of Plasmodium falciparum merozoites","volume":"273","author":"Blackman","year":"1998","journal-title":"J Biol Chem"},{"key":"2019091000282579600_bib23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0166-6851(92)90228-C","article-title":"Secondary processing of the Plasmodium falciparum merozoite surface protein-1 (MSP1) by a calcium-dependent membrane-bound serine protease: shedding of MSP133 as a noncovalently associated complex with other fragments of the MSP1","volume":"50","author":"Blackman","year":"1992","journal-title":"Mol Biochem Parasitol"},{"key":"2019091000282579600_bib4_711_254919","first-page":"8801","volume":"77","author":"Bosch"},{"key":"2019091000282579600_bib26","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.1073\/pnas.0510907103","article-title":"Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor","volume":"103","author":"Bosch","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019091000282579600_bib25","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jmb.2007.06.016","article-title":"The closed MTIP-myosin A-tail complex from the malaria parasite invasion machinery","volume":"372","author":"Bosch","year":"2007","journal-title":"J Mol Biol"},{"key":"2019091000282579600_bib27","doi-asserted-by":"crossref","first-page":"18561","DOI":"10.1074\/jbc.M113.456764","article-title":"In Silico screening on the three-dimensional model of the Plasmodium vivax SUB1 protease leads to the validation of a novel anti-parasite compound","volume":"288","author":"Bouillon","year":"2013","journal-title":"J Biol Chem"},{"key":"2019091000282579600_bib28","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1182\/blood-2009-09-243725","article-title":"Interactions with heparin-like molecules during erythrocyte invasion by Plasmodium falciparum merozoites","volume":"115","author":"Boyle","year":"2010","journal-title":"Blood"},{"key":"2019091000282579600_bib30","doi-asserted-by":"crossref","first-page":"e00709","DOI":"10.1128\/AAC.00709-17","article-title":"Identification of heparin modifications and polysaccharide inhibitors of Plasmodium falciparum merozoite invasion that have potential for novel drug development","volume":"61","author":"Boyle","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091000282579600_bib29","doi-asserted-by":"crossref","first-page":"14378","DOI":"10.1073\/pnas.1009198107","article-title":"Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development","volume":"107","author":"Boyle","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019091000282579600_bib31","doi-asserted-by":"crossref","first-page":"e1038","DOI":"10.1016\/S2214-109X(17)30333-9","article-title":"Outbreak of human malaria caused by Plasmodium simium in the Atlantic Forest in Rio de Janeiro: A molecular epidemiological investigation","volume":"5","author":"Brasil","year":"2017","journal-title":"Lancet Glob Health"},{"key":"2019091000282579600_bib32","first-page":"e00012","article-title":"UCT943, a Next-generation Plasmodium falciparum PI4K inhibitor preclinical candidate for the treatment of malaria","volume":"62","author":"Brunschwig","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091000282579600_bib33","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12936-016-1675-x","article-title":"New developments in anti-malarial target candidate and product profiles","volume":"16","author":"Burrows","year":"2017","journal-title":"Malar J"},{"key":"2019091000282579600_bib34","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.1039\/C5OB02517F","article-title":"Antimalarial activity of novel 4-cyano-3-methylisoquinoline inhibitors against Plasmodium falciparum: design, synthesis and biological evaluation","volume":"14","author":"Buskes","year":"2016","journal-title":"Org Biomol Chem"},{"key":"2019091000282579600_bib35","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/0035-9203(88)90504-4","article-title":"Inhibition of growth in vitro of Plasmodium falciparum by complex polysaccharides","volume":"82","author":"Butcher","year":"1988","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2019091000282579600_bib36","doi-asserted-by":"crossref","first-page":"8061","DOI":"10.1021\/acs.jmedchem.8b00329","article-title":"Plasmodial kinase inhibitors: license to cure?","volume":"61","author":"Cabrera","year":"2018","journal-title":"J Med Chem"},{"key":"2019091000282579600_bib37","doi-asserted-by":"crossref","first-page":"7433","DOI":"10.1073\/pnas.0307769101","article-title":"A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii","volume":"101","author":"Carey","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019091000282579600_bib38","doi-asserted-by":"crossref","first-page":"595","DOI":"10.4269\/ajtmh.1992.46.595","article-title":"Disruption of Plasmodium falciparum erythrocyte rosettes by standard heparin and heparin devoid of anticoagulant activity","volume":"46","author":"Carlson","year":"1992","journal-title":"Am J Trop Med Hyg"},{"key":"2019091000282579600_bib39","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1093\/infdis\/jiu296","article-title":"Small molecule targeting malaria merozoite surface protein-1 (MSP-1) prevents host invasion of divergent plasmodial species","volume":"210","author":"Chandramohanadas","year":"2014","journal-title":"J Infect Dis"},{"key":"2019091000282579600_bib41","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1016\/j.bmcl.2013.03.017","article-title":"Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)","volume":"23","author":"Chapman","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"2019091000282579600_bib40","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1021\/jm500342d","article-title":"Optimization of an imidazopyridazine series of inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)","volume":"57","author":"Chapman","year":"2014","journal-title":"J Med Chem"},{"key":"2019091000282579600_bib42","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.bmcl.2012.11.118","article-title":"Novel in vivo active anti-malarials based on a hydroxy-ethyl-amine scaffold","volume":"23","author":"Ciana","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"2019091000282579600_bib44","doi-asserted-by":"crossref","first-page":"e1003344","DOI":"10.1371\/journal.ppat.1003344","article-title":"Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress","volume":"9","author":"Collins","year":"2013","journal-title":"PLoS Pathog"},{"key":"2019091000282579600_bib43","doi-asserted-by":"crossref","first-page":"e1000273","DOI":"10.1371\/journal.ppat.1000273","article-title":"An inhibitory antibody blocks interactions between components of the malarial invasion machinery","volume":"5","author":"Collins","year":"2009","journal-title":"PLoS Pathog"},{"key":"2019091000282579600_bib45","doi-asserted-by":"crossref","first-page":"407","DOI":"10.4269\/ajtmh.2006.74.407","article-title":"Lack of a pharmacokinetic interaction between azithromycin and chloroquine","volume":"74","author":"Cook","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"2019091000282579600_bib46","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1083\/jcb.105.4.1473","article-title":"Effects of cytochalasin and phalloidin on actin","volume":"105","author":"Cooper","year":"1987","journal-title":"J Cell Biol"},{"key":"2019091000282579600_bib47","doi-asserted-by":"crossref","first-page":"9109","DOI":"10.1073\/pnas.85.23.9109","article-title":"Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum","volume":"85","author":"Cowman","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019091000282579600_bib48","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.bcp.2006.10.030","article-title":"Sulfated cyclodextrins inhibit the entry of Plasmodium into red blood cells. Implications for malarial therapy","volume":"73","author":"Crandall","year":"2007","journal-title":"Biochem Pharmacol"},{"key":"2019091000282579600_bib49","doi-asserted-by":"crossref","first-page":"15006","DOI":"10.1038\/sigtrans.2015.6","article-title":"Announcing signal transduction and targeted therapy","volume":"1","author":"Croce","year":"2016","journal-title":"Signal Transduct Target Ther"},{"key":"2019091000282579600_bib50","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1128\/AAC.00527-07","article-title":"Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast","volume":"51","author":"Dahl","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091000282579600_bib52","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.chom.2015.09.007","article-title":"Processing of Plasmodium falciparum Merozoite surface protein MSP1 activates a spectrin-binding function enabling parasite egress from RBCs","volume":"18","author":"Das","year":"2015","journal-title":"Cell Host Microbe"},{"key":"2019091000282579600_bib51","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1056\/NEJMc1713777","article-title":"Evidence of artemisinin-resistant Plasmodium falciparum malaria in eastern India","volume":"379","author":"Das","year":"2018","journal-title":"N Engl J Med"},{"key":"2019091000282579600_bib53","doi-asserted-by":"crossref","first-page":"e1004520","DOI":"10.1371\/journal.ppat.1004520","article-title":"The central role of cAMP in regulating Plasmodium falciparum merozoite invasion of human erythrocytes","volume":"10","author":"Dawn","year":"2014","journal-title":"PLoS Pathog"},{"key":"2019091000282579600_bib55","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1039\/C4MD00090K","article-title":"A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors","volume":"5","author":"Devine","year":"2014","journal-title":"MedChemComm"},{"key":"2019091000282579600_bib54","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1039\/C6MD00495D","article-title":"Antimalarial drug discovery targeting apical membrane antigen 1","volume":"8","author":"Devine","year":"2017","journal-title":"Medchemcomm"},{"key":"2019091000282579600_bib56","doi-asserted-by":"crossref","first-page":"37502","DOI":"10.1038\/srep37502","article-title":"Identification of inhibitors that dually target the new permeability pathway and dihydroorotate dehydrogenase in the blood stage of Plasmodium falciparum","volume":"6","author":"Dickerman","year":"2016","journal-title":"Sci Rep"},{"key":"2019091000282579600_bib57","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1177\/135965350400900216","article-title":"Estimates of intracellular delay and average drug efficacy from viral load data of HIV-infected individuals under antiretroviral therapy","volume":"9","author":"Dixit","year":"2004","journal-title":"Antivir Ther"},{"key":"2019091000282579600_bib58","doi-asserted-by":"crossref","first-page":"e1002132","DOI":"10.1371\/journal.pbio.1002132","article-title":"Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance","volume":"13","author":"Dogovski","year":"2015","journal-title":"PLoS Biol"},{"issue":"Suppl 2","key":"2019091000282579600_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00003088-200241002-00001","article-title":"The pharmacokinetics of fondaparinux sodium in healthy volunteers","volume":"41","author":"Donat","year":"2002","journal-title":"Clin Pharmacokinet"},{"key":"2019091000282579600_bib60","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(05)67176-0","article-title":"Artesunate versus quinine for treatment of severe falciparum malaria: A randomised trial","volume":"366","author":"Dondorp","year":"2005","journal-title":"Lancet"},{"key":"2019091000282579600_bib61","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","article-title":"Artemisinin resistance in Plasmodium falciparum malaria","volume":"361","author":"Dondorp","year":"2009","journal-title":"N Engl J Med"},{"key":"2019091000282579600_bib62","doi-asserted-by":"crossref","first-page":"4721","DOI":"10.1128\/AAC.49.11.4721-4732.2005","article-title":"Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity","volume":"49","author":"Dorr","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091000282579600_bib63","doi-asserted-by":"crossref","first-page":"7433","DOI":"10.1016\/j.vaccine.2015.09.093","article-title":"Recent advances in recombinant protein-based malaria vaccines","volume":"33","author":"Draper","year":"2015","journal-title":"Vaccine"},{"key":"2019091000282579600_bib64","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1093\/infdis\/jix583","article-title":"Functional Conservation of the AMA1 host-cell invasion ligand between P. falciparum and P. vivax: A novel platform to accelerate vaccine and drug development","volume":"217","author":"Drew","year":"2018","journal-title":"J Infect Dis"},{"key":"2019091000282579600_bib65","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1126\/science.803712","article-title":"Invasion of erythrocytes by malaria merozoites","volume":"187","author":"Dvorak","year":"1975","journal-title":"Science"},{"key":"2019091000282579600_bib66","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0035-9203(98)90969-5","article-title":"The effect of curdlan sulphate on development in vitro of Plasmodium falciparum","volume":"92","author":"Evans","year":"1998","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2019091000282579600_bib67","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S1097-2765(05)00077-8","article-title":"Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance","volume":"6","author":"Fidock","year":"2000","journal-title":"Mol Cell"},{"key":"2019091000282579600_bib68","doi-asserted-by":"crossref","first-page":"47670","DOI":"10.1074\/jbc.M306603200","article-title":"Suramin and suramin analogues inhibit merozoite surface protein-1 secondary processing and erythrocyte invasion by the malaria parasite Plasmodium falciparum","volume":"278","author":"Fleck","year":"2003","journal-title":"J Biol Chem"},{"key":"2019091000282579600_bib69","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/0006-2952(92)90213-3","article-title":"Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4'-chlorophenyl) cyclohexyl]-3-hydroxy-1,4-naphthoquinone (566C80)","volume":"43","author":"Fry","year":"1992","journal-title":"Biochem Pharmacol"},{"key":"2019091000282579600_bib70","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1126\/science.6601823","article-title":"Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS)","volume":"220","author":"Gallo","year":"1983","journal-title":"Science"},{"key":"2019091000282579600_bib71","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1016\/j.bmcl.2012.06.023","article-title":"Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1","volume":"22","author":"Gemma","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"key":"2019091000282579600_bib72","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0264-410X(03)00536-X","article-title":"Safety and immunogenicity of a three-component blood-stage malaria vaccine (MSP1, MSP2, RESA) against Plasmodium falciparum in Papua New Guinean children","volume":"22","author":"Genton","year":"2003","journal-title":"Vaccine"},{"key":"2019091000282579600_bib73","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijpara.2008.09.007","article-title":"Morphology and kinetics of the three distinct phases of red blood cell invasion by Plasmodium falciparum merozoites","volume":"39","author":"Gilson","year":"2009","journal-title":"Int J Parasitol"},{"key":"2019091000282579600_bib74","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1074\/mcp.M600035-MCP200","article-title":"Identification and stoichiometry of glycosylphosphatidylinositol-anchored membrane proteins of the human malaria parasite Plasmodium falciparum","volume":"5","author":"Gilson","year":"2006","journal-title":"Mol Cell Proteomics"},{"key":"2019091000282579600_bib75","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1016\/j.bmcl.2014.05.044","article-title":"Rational design of the first difluorostatone-based PfSUB1 inhibitors","volume":"24","author":"Giovani","year":"2014","journal-title":"Bioorg Med Chem Lett"},{"key":"2019091000282579600_bib76","doi-asserted-by":"crossref","first-page":"5164","DOI":"10.1073\/pnas.0834959100","article-title":"Band 3 is a host receptor binding merozoite surface protein 1 during the Plasmodium falciparum invasion of erythrocytes","volume":"100","author":"Goel","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019091000282579600_bib77","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.molbiopara.2007.01.005","article-title":"The effects of anti-bacterials on the malaria parasite Plasmodium falciparum","volume":"152","author":"Goodman","year":"2007","journal-title":"Mol Biochem Parasitol"},{"key":"2019091000282579600_bib78","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1128\/AAC.01825-12","article-title":"Chemobiosynthesis of new antimalarial macrolides","volume":"57","author":"Goodman","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091000282579600_bib79","first-page":"163","article-title":"A phase I study of curdlan sulfate\u2013an HIV inhibitor. Tolerance, pharmacokinetics and effects on coagulation and on CD4 lymphocytes","volume":"25","author":"Gordon","year":"1994","journal-title":"J Med"},{"key":"2019091000282579600_bib80","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/mmi.13466","article-title":"Invasion of hepatocytes by Plasmodium sporozoites requires cGMP-dependent protein kinase and calcium dependent protein kinase 4","volume":"102","author":"Govindasamy","year":"2016","journal-title":"Mol Microbiol"},{"key":"2019091000282579600_bib82","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1128\/AAC.01748-15","article-title":"Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 also target cyclic GMP-dependent protein kinase and heat shock protein 90 to kill the parasite at different stages of intracellular development","volume":"60","author":"Green","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091000282579600_bib81","doi-asserted-by":"crossref","first-page":"30980","DOI":"10.1074\/jbc.M803129200","article-title":"The motor complex of Plasmodium falciparum: Phosphorylation by a calcium-dependent protein kinase","volume":"283","author":"Green","year":"2008","journal-title":"J Biol Chem"},{"key":"2019091000282579600_bib83","doi-asserted-by":"crossref","first-page":"10568","DOI":"10.1073\/pnas.1105622108","article-title":"Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion","volume":"108","author":"Hall","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019091000282579600_bib84","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nrm1679","article-title":"Plants, symbiosis and parasites: A calcium signalling connection","volume":"6","author":"Harper","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2019091000282579600_bib85","doi-asserted-by":"crossref","first-page":"6981","DOI":"10.1128\/IAI.73.10.6981-6989.2005","article-title":"Binding hot spot for invasion inhibitory molecules on Plasmodium falciparum apical membrane antigen 1","volume":"73","author":"Harris","year":"2005","journal-title":"Infect Immun"},{"key":"2019091000282579600_bib86","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1371\/journal.ppat.0010029","article-title":"Molecular identification of a malaria merozoite surface sheddase","volume":"1","author":"Harris","year":"2005","journal-title":"PLoS Pathog"},{"key":"2019091000282579600_bib87","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.pt.2010.09.005","article-title":"How artemisinin-containing combination therapies slow the spread of antimalarial drug resistance","volume":"27","author":"Hastings","year":"2011","journal-title":"Trends Parasitol"},{"key":"2019091000282579600_bib89","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.trstmh.2004.05.005","article-title":"Curdlan sulphate in human severe\/cerebral Plasmodium falciparum malaria","volume":"99","author":"Havlik","year":"2005","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2019091000282579600_bib88","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/0035-9203(94)90230-5","article-title":"The effect of curdlan sulphate on in vitro growth of Plasmodium falciparum","volume":"88","author":"Havlik","year":"1994","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2019091000282579600_bib90","doi-asserted-by":"crossref","first-page":"e1000720","DOI":"10.1371\/journal.ppat.1000720","article-title":"A Small-Molecule inhibitor of T. gondii motility induces the posttranslational modification of Myosin Light Chain-1 and Inhibits Myosin motor activity","volume":"6","author":"Heaslip","year":"2010","journal-title":"PLoS Pathog"},{"key":"2019091000282579600_bib91","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.coviro.2012.12.002","article-title":"HIV-1 entry inhibitors: Recent development and clinical use","volume":"3","author":"Henrich","year":"2013","journal-title":"Curr Opin Virol"},{"key":"2019091000282579600_bib92","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/373123a0","article-title":"Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection","volume":"373","author":"Ho","year":"1995","journal-title":"Nature"},{"key":"2019091000282579600_bib93","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1128\/IAI.69.5.3286-3294.2001","article-title":"Specificity of the protective antibody response to apical membrane antigen 1","volume":"69","author":"Hodder","year":"2001","journal-title":"Infect Immun"},{"key":"2019091000282579600_bib94","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jconrel.2006.03.020","article-title":"Oral bioavailability of a low molecular weight heparin using a polymeric delivery system","volume":"113","author":"Hoffart","year":"2006","journal-title":"J Control Release"},{"issue":"Suppl 3","key":"2019091000282579600_bib95","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1590\/S0074-02761992000700004","article-title":"A malaria merozoite surface protein (MSP1)-structure, processing and function","volume":"87","author":"Holder","year":"1992","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"2019091000282579600_bib96","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1021\/cb501004q","article-title":"Identification of potent phosphodiesterase inhibitors that demonstrate cyclic nucleotide-dependent functions in apicomplexan parasites","volume":"10","author":"Howard","year":"2015","journal-title":"ACS Chem Biol"},{"key":"2019091000282579600_bib97","doi-asserted-by":"crossref","first-page":"10994","DOI":"10.1021\/acs.jmedchem.6b01109","article-title":"Truncated latrunculins as actin inhibitors targeting Plasmodium falciparum motility and host cell invasion","volume":"59","author":"Johnson","year":"2016","journal-title":"J Med Chem"},{"key":"2019091000282579600_bib98","doi-asserted-by":"crossref","first-page":"5581","DOI":"10.1128\/AAC.00868-12","article-title":"A focused small-molecule screen identifies 14 compounds with distinct effects on Toxoplasma gondii","volume":"56","author":"Kamau","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091000282579600_bib99","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nchembio.87","article-title":"Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility","volume":"4","author":"Kato","year":"2008","journal-title":"Nat Chem Biol"},{"key":"2019091000282579600_bib100","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s12936-015-0810-4","article-title":"Measuring windows of selection for anti-malarial drug treatments","volume":"14","author":"Kay","year":"2015","journal-title":"Malar J"},{"key":"2019091000282579600_bib101","doi-asserted-by":"crossref","first-page":"6948","DOI":"10.1128\/IAI.70.12.6948-6960.2002","article-title":"In vitro studies with recombinant Plasmodium falciparum apical membrane antigen 1 (AMA1): Production and activity of an AMA1 vaccine and generation of a multiallelic response","volume":"70","author":"Kennedy","year":"2002","journal-title":"Infect Immun"},{"key":"2019091000282579600_bib102","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1016\/j.bmcl.2014.07.086","article-title":"Substrate derived peptidic alpha-ketoamides as inhibitors of the malarial protease PfSUB1","volume":"24","author":"Kher","year":"2014","journal-title":"Bioorg Med Chem Lett"},{"key":"2019091000282579600_bib103","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.ijpara.2017.05.009","article-title":"Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivo","volume":"47","author":"Khoury","year":"2017","journal-title":"Int J Parasitol"},{"key":"2019091000282579600_bib104","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/3293","article-title":"Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry","volume":"4","author":"Kilby","year":"1998","journal-title":"Nat Med"},{"key":"2019091000282579600_bib105","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1128\/AAC.46.8.2619-2626.2002","article-title":"Short-chain aliphatic polysulfonates inhibit the entry of Plasmodium into red blood cells","volume":"46","author":"Kisilevsky","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091000282579600_bib106","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2147\/TCRM.S1962","article-title":"Enfuvirtide antiretroviral therapy in HIV-1 infection","volume":"4","author":"Kitchen","year":"2008","journal-title":"Ther Clin Risk Manag"},{"key":"2019091000282579600_bib107","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1111\/j.1462-5822.2012.01812.x","article-title":"The molecular basis of HIV entry","volume":"14","author":"Klasse","year":"2012","journal-title":"Cell Microbiol"},{"key":"2019091000282579600_bib108","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1126\/science.6328660","article-title":"Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes","volume":"225","author":"Klatzmann","year":"1984","journal-title":"Science"},{"key":"2019091000282579600_bib109","doi-asserted-by":"crossref","first-page":"11405","DOI":"10.1073\/pnas.1104063108","article-title":"Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion","volume":"108","author":"Klonis","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019091000282579600_bib110","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1074\/jbc.M109.021576","article-title":"Plasmodium falciparum BAEBL binds to heparan sulfate proteoglycans on the human erythrocyte surface","volume":"285","author":"Kobayashi","year":"2010","journal-title":"J Biol Chem"},{"key":"2019091000282579600_bib111","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1038\/srep03178","article-title":"Analyses of interactions between heparin and the apical surface proteins of Plasmodium falciparum","volume":"3","author":"Kobayashi","year":"2013","journal-title":"Sci Rep"},{"key":"2019091000282579600_bib112","doi-asserted-by":"crossref","first-page":"e0163066","DOI":"10.1371\/journal.pone.0163066","article-title":"Safety and immunogenicity of EBA-175 RII-NG malaria vaccine administered intramuscularly in semi-immune adults: A phase 1, double-blinded placebo controlled dosage escalation study","volume":"11","author":"Koram","year":"2016","journal-title":"PLoS One"},{"key":"2019091000282579600_bib114","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10822-011-9420-6","article-title":"Rapid discovery of inhibitors of Toxoplasma gondii using hybrid structure-based computational approach","volume":"25","author":"Kortagere","year":"2011","journal-title":"J Comput Aided Mol Des"},{"key":"2019091000282579600_bib113","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1021\/ci100039k","article-title":"Structure-based design of novel small-molecule inhibitors of Plasmodium falciparum","volume":"50","author":"Kortagere","year":"2010","journal-title":"J Chem Inf Model"},{"key":"2019091000282579600_bib115","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/emboj.2009.22","article-title":"A multifunctional serine protease primes the malaria parasite for red blood cell invasion","volume":"28","author":"Koussis","year":"2009","journal-title":"Embo j"},{"key":"2019091000282579600_bib116","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41467-017-00053-1","article-title":"PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum","volume":"8","author":"Kumar","year":"2017","journal-title":"Nat Commun"},{"key":"2019091000282579600_bib117","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/COH.0b013e328322402e","article-title":"HIV-1 entry inhibitors: an overview","volume":"4","author":"Kuritzkes","year":"2009","journal-title":"Curr Opin HIV AIDS"},{"key":"2019091000282579600_bib118","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1128\/AAC.01216-06","article-title":"In vitro inhibition of Plasmodium falciparum rosette formation by Curdlan sulfate","volume":"51","author":"Kyriacou","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091000282579600_bib1_167_253919","first-page":"2186","volume":"1996;93","author":"Lambert"},{"key":"2019091000282579600_bib120","doi-asserted-by":"crossref","first-page":"5323","DOI":"10.1021\/pr300557m","article-title":"The Plasmodium falciparum schizont phosphoproteome reveals extensive phosphatidylinositol and cAMP-protein kinase A signaling","volume":"11","author":"Lasonder","year":"2012","journal-title":"J Proteome Res"},{"key":"2019091000282579600_bib119","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1002\/pmic.201400508","article-title":"Extensive differential protein phosphorylation as intraerythrocytic Plasmodium falciparum schizonts develop into extracellular invasive merozoites","volume":"15","author":"Lasonder","year":"2015","journal-title":"Proteomics"},{"key":"2019091000282579600_bib121","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/mmi.12765","article-title":"Diverse chemotypes disrupt ion homeostasis in the Malaria parasite","volume":"94","author":"Lehane","year":"2014","journal-title":"Mol Microbiol"},{"key":"2019091000282579600_bib122","doi-asserted-by":"crossref","first-page":"e0188754","DOI":"10.1371\/journal.pone.0188754","article-title":"Inhibition of merozoite invasion and transient de-sequestration by sevuparin in humans with Plasmodium falciparum malaria","volume":"12","author":"Leitgeb","year":"2017","journal-title":"PLoS One"},{"key":"2019091000282579600_bib123","doi-asserted-by":"crossref","first-page":"6379","DOI":"10.1021\/bi9005122","article-title":"Identification and characterization of novel small molecules as potent inhibitors of the plasmodial calcium-dependent protein kinase 1","volume":"48","author":"Lemercier","year":"2009","journal-title":"Biochemistry"},{"key":"2019091000282579600_bib124","doi-asserted-by":"crossref","first-page":"e98056","DOI":"10.1371\/journal.pone.0098056","article-title":"Identification of T. gondii myosin light chain-1 as a direct target of TachypleginA-2, a small-molecule inhibitor of parasite motility and invasion","volume":"9","author":"Leung","year":"2014","journal-title":"PLoS One"},{"key":"2019091000282579600_bib125","doi-asserted-by":"crossref","first-page":"e1000941","DOI":"10.1371\/journal.ppat.1000941","article-title":"Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasite","volume":"6","author":"Leykauf","year":"2010","journal-title":"PLoS Pathog"},{"key":"2019091000282579600_bib126","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.2217\/fmb.11.108","article-title":"Gametocytogenesis in malaria parasite: Commitment, development and regulation","volume":"6","author":"Liu","year":"2011","journal-title":"Future Microbiol"},{"key":"2019091000282579600_bib127","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nature09022","article-title":"Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma","volume":"465","author":"Lourido","year":"2010","journal-title":"Nature"},{"key":"2019091000282579600_bib128","doi-asserted-by":"crossref","first-page":"10165","DOI":"10.1038\/s41598-018-28457-z","article-title":"Cellular dissection of malaria parasite invasion of human erythrocytes using viable Plasmodium knowlesi merozoites","volume":"8","author":"Lyth","year":"2018","journal-title":"Sci Rep"},{"key":"2019091000282579600_bib129","first-page":"385","article-title":"Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration","volume":"119","author":"MacPherson","year":"1985","journal-title":"Am J Pathol"},{"key":"2019091000282579600_bib130","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1128\/AAC.50.4.1470-1479.2006","article-title":"Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection","volume":"50","author":"Malakhov","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091000282579600_bib131","doi-asserted-by":"crossref","first-page":"937","DOI":"10.3389\/fimmu.2017.00937","article-title":"Primary immunodeficiency diseases: Current and emerging therapeutics","volume":"8","author":"Marciano","year":"2017","journal-title":"Front Immunol"},{"key":"2019091000282579600_bib132","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nature12782","article-title":"Targeting Plasmodium PI(4)K to eliminate malaria","volume":"504","author":"McNamara","year":"2013","journal-title":"Nature"},{"key":"2019091000282579600_bib133","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1371\/journal.pbio.0060139","article-title":"Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase","volume":"6","author":"McRobert","year":"2008","journal-title":"PLoS Biol"},{"key":"2019091000282579600_bib134","doi-asserted-by":"crossref","first-page":"12689","DOI":"10.1073\/pnas.221440898","article-title":"Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America","volume":"98","author":"Mehlotra","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019091000282579600_bib135","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1126\/science.1074553","article-title":"Role of Toxoplasma gondii myosin A in powering parasite gliding and host cell invasion","volume":"298","author":"Meissner","year":"2002","journal-title":"Science"},{"key":"2019091000282579600_bib136","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1021\/ml400412x","article-title":"Evaluation of aminohydantoins as a novel class of antimalarial agents","volume":"5","author":"Meyers","year":"2014","journal-title":"ACS Med Chem Lett"},{"key":"2019091000282579600_bib137","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1084\/jem.149.1.172","article-title":"Interaction between cytochalasin B-treated malarial parasites and erythrocytes. Attachment and junction formation","volume":"149","author":"Miller","year":"1979","journal-title":"J Exp Med"},{"key":"2019091000282579600_bib138","doi-asserted-by":"crossref","first-page":"47","DOI":"10.14238\/pi20.1-2.1980.47-50","article-title":"Heparin in the treatment of cerebral malaria","volume":"20","author":"Munir","year":"1980","journal-title":"Paediatr Indones"},{"key":"2019091000282579600_bib139","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(14)60844-8","article-title":"Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Murray","year":"2014","journal-title":"Lancet"},{"key":"2019091000282579600_bib140","doi-asserted-by":"crossref","first-page":"10798","DOI":"10.1128\/JVI.05095-11","article-title":"Timing of the components of the HIV life cycle in productively infected CD4(+) T cells in a population of HIV-infected individuals","volume":"85","author":"Murray","year":"2011","journal-title":"J Virol"},{"key":"2019091000282579600_bib141","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1126\/science.aan1478","article-title":"Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion","volume":"358","author":"Nasamu","year":"2017","journal-title":"Science"},{"key":"2019091000282579600_bib142","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3390\/ph9030037","article-title":"Strategies to overcome Heparins' low oral bioavailability","volume":"9","author":"Neves","year":"2016","journal-title":"Pharmaceuticals (Basel)"},{"key":"2019091000282579600_bib143","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.mib.2005.06.018","article-title":"The role of malaria merozoite proteases in red blood cell invasion","volume":"8","author":"O'Donnell","year":"2005","journal-title":"Curr Opin Microbiol"},{"key":"2019091000282579600_bib144","doi-asserted-by":"crossref","first-page":"e4708","DOI":"10.1371\/journal.pone.0004708","article-title":"Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in Western Kenya","volume":"4","author":"Ogutu","year":"2009","journal-title":"PLoS One"},{"key":"2019091000282579600_bib145","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/00005072-198703000-00009","article-title":"Human cerebral malaria: A pathological study","volume":"46","author":"Oo","year":"1987","journal-title":"J Neuropathol Exp Neurol"},{"key":"2019091000282579600_bib146","doi-asserted-by":"crossref","first-page":"5281","DOI":"10.1128\/AAC.00937-10","article-title":"Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum","volume":"54","author":"Painter","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091000282579600_bib147","doi-asserted-by":"crossref","first-page":"96381","DOI":"10.1172\/jci.insight.96381","article-title":"Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions","volume":"2","author":"Payne","year":"2017","journal-title":"JCI Insight"},{"key":"2019091000282579600_bib148","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.2165\/11203940-000000000-00000","article-title":"Maraviroc: A review of its use in the management of CCR5-tropic HIV-1 infection","volume":"70","author":"Perry","year":"2010","journal-title":"Drugs"},{"key":"2019091000282579600_bib149","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/cpt1974163part1514","article-title":"Heparin half-life in normal and impaired renal function","volume":"16","author":"Perry","year":"1974","journal-title":"Clin Pharmacol Ther"},{"key":"2019091000282579600_bib150","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s10822-015-9842-7","article-title":"Computational and biophysical approaches to protein-protein interaction inhibition of Plasmodium falciparum AMA1\/RON2 complex","volume":"29","author":"Pihan","year":"2015","journal-title":"J Comput Aided Mol Des"},{"key":"2019091000282579600_bib151","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1126\/science.aaf8675","article-title":"A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress","volume":"358","author":"Pino","year":"2017","journal-title":"Science"},{"key":"2019091000282579600_bib152","doi-asserted-by":"crossref","first-page":"1c","DOI":"10.1093\/glycob\/cwi007","article-title":"Undersulfated, low-molecular-weight glycol-split heparin as an antiangiogenic VEGF antagonist","volume":"15","author":"Pisano","year":"2005","journal-title":"Glycobiology"},{"key":"2019091000282579600_bib153","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1086\/514159","article-title":"Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance","volume":"176","author":"Plowe","year":"1997","journal-title":"J Infect Dis"},{"key":"2019091000282579600_bib154","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4269\/ajtmh.2003.69.345","article-title":"An ultrastructural study of the brain in fatal Plasmodium falciparum malaria","volume":"69","author":"Pongponratn","year":"2003","journal-title":"Am J Trop Med Hyg"},{"key":"2019091000282579600_bib155","doi-asserted-by":"crossref","first-page":"e1005775","DOI":"10.1371\/journal.pcbi.1005775","article-title":"Estimating time of HIV-1 infection from next-generation sequence diversity","volume":"13","author":"Puller","year":"2017","journal-title":"PLoS Comput Biol"},{"key":"2019091000282579600_bib156","first-page":"59","article-title":"Cerebral malaria in children. Comparative study between heparin, dexamethasone and placebo","volume":"31","author":"Rampengan","year":"1991","journal-title":"Paediatr Indones"},{"key":"2019091000282579600_bib2_893_254519","first-page":"5524","volume":"1995;14","author":"Rapaport"},{"key":"2019091000282579600_bib157","doi-asserted-by":"crossref","first-page":"14815","DOI":"10.1074\/jbc.M109.080770","article-title":"Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites","volume":"285","author":"Richard","year":"2010","journal-title":"J Biol Chem"},{"key":"2019091000282579600_bib158","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1006\/expr.1994.1111","article-title":"Plasmodium falciparum: a family of sulphated glycoconjugates disrupts erythrocyte rosettes","volume":"79","author":"Rowe","year":"1994","journal-title":"Exp Parasitol"},{"key":"2019091000282579600_bib159","doi-asserted-by":"crossref","first-page":"e0172718","DOI":"10.1371\/journal.pone.0172718","article-title":"Effects of sevuparin on rosette formation and cytoadherence of Plasmodium falciparum infected erythrocytes","volume":"12","author":"Saiwaew","year":"2017","journal-title":"PLoS One"},{"key":"2019091000282579600_bib160","doi-asserted-by":"crossref","first-page":"e39769","DOI":"10.1371\/journal.pone.0039769","article-title":"Characterization of Plasmodium falciparum adenylyl cyclase-beta and its role in erythrocytic stage parasites","volume":"7","author":"Salazar","year":"2012","journal-title":"PLoS One"},{"key":"2019091000282579600_bib161","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1074\/jbc.M608615200","article-title":"In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin","volume":"282","author":"Sidhu","year":"2007","journal-title":"J Biol Chem"},{"key":"2019091000282579600_bib162","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0002-9440(10)65136-X","article-title":"A quantitative analysis of the microvascular sequestration of malaria parasites in the human brain","volume":"155","author":"Silamut","year":"1999","journal-title":"Am J Pathol"},{"key":"2019091000282579600_bib163","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1128\/IAI.00902-10","article-title":"Global identification of multiple substrates for Plasmodium falciparum SUB1, an essential malarial processing protease","volume":"79","author":"Silmon\u00a0de\u00a0Monerri","year":"2011","journal-title":"Infect Immun"},{"key":"2019091000282579600_bib164","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0140-6736(04)15836-4","article-title":"A large focus of naturally acquired Plasmodium knowlesi infections in human beings","volume":"363","author":"Singh","year":"2004","journal-title":"Lancet"},{"key":"2019091000282579600_bib165","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1021\/jm701337t","article-title":"Disruption of rosetting in Plasmodium falciparum malaria with chemically modified heparin and low molecular weight derivatives possessing reduced anticoagulant and other serine protease inhibition activities","volume":"51","author":"Skidmore","year":"2008","journal-title":"J Med Chem"},{"key":"2019091000282579600_bib166","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1136\/bmj.1.5751.714","article-title":"New concepts in treatment of malignant tertian malaria with cerebral involvement","volume":"1","author":"Smitskamp","year":"1971","journal-title":"Br Med J"},{"key":"2019091000282579600_bib167","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.pt.2004.09.009","article-title":"Molecular and functional aspects of parasite invasion","volume":"20","author":"Soldati","year":"2004","journal-title":"Trends Parasitol"},{"key":"2019091000282579600_bib168","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/ncomms1558","article-title":"Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum","volume":"2","author":"Solyakov","year":"2011","journal-title":"Nat Commun"},{"key":"2019091000282579600_bib169","doi-asserted-by":"crossref","first-page":"e62906","DOI":"10.1371\/journal.pone.0062906","article-title":"The open access malaria box: a drug discovery catalyst for neglected diseases","volume":"8","author":"Spangenberg","year":"2013","journal-title":"PLoS One"},{"key":"2019091000282579600_bib170","doi-asserted-by":"crossref","first-page":"13275","DOI":"10.1073\/pnas.1110303108","article-title":"Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion","volume":"108","author":"Srinivasan","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019091000282579600_bib171","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1038\/ncomms3261","article-title":"Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion","volume":"4","author":"Srinivasan","year":"2013","journal-title":"Nat Commun"},{"key":"2019091000282579600_bib172","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1128\/AAC.00903-07","article-title":"Pharmacokinetic determinants of the window of selection for antimalarial drug resistance","volume":"52","author":"Stepniewska","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091000282579600_bib173","doi-asserted-by":"crossref","first-page":"e00534","DOI":"10.1128\/mSphere.00534-17","article-title":"Targeted phenotypic screening in Plasmodium falciparum and Toxoplasma gondii reveals novel modes of action of medicines for malaria venture malaria box molecules","volume":"3","author":"Subramanian","year":"2018","journal-title":"mSphere"},{"key":"2019091000282579600_bib174","doi-asserted-by":"crossref","first-page":"e39444","DOI":"10.1371\/annotation\/a685ce21-d7a1-4a5b-8fe8-734a071d53cd","article-title":"Anti-tumor activity of a novel HS-mimetic-vascular endothelial growth factor binding small molecule","volume":"7","author":"Sugahara","year":"2012","journal-title":"PLoS One"},{"key":"2019091000282579600_bib175","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1086\/652240","article-title":"Two nonrecombining sympatric forms of the human malaria parasite Plasmodium ovale occur globally","volume":"201","author":"Sutherland","year":"2010","journal-title":"J Infect Dis"},{"key":"2019091000282579600_bib176","doi-asserted-by":"crossref","first-page":"4842","DOI":"10.1046\/j.1432-1327.2001.02403.x","article-title":"The H89 cAMP-dependent protein kinase inhibitor blocks Plasmodium falciparum development in infected erythrocytes","volume":"268","author":"Syin","year":"2001","journal-title":"Eur J Biochem"},{"key":"2019091000282579600_bib177","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1086\/605635","article-title":"Azithromycin plus artesunate versus artemether-lumefantrine for treatment of uncomplicated malaria in Tanzanian children: A randomized, controlled trial","volume":"49","author":"Sykes","year":"2009","journal-title":"Clin Infect Dis"},{"key":"2019091000282579600_bib178","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1083\/jcb.201605100","article-title":"Reassessing the mechanics of parasite motility and host-cell invasion","volume":"214","author":"Tardieux","year":"2016","journal-title":"J Cell Biol"},{"key":"2019091000282579600_bib179","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1128\/EC.00186-09","article-title":"The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony","volume":"9","author":"Taylor","year":"2010","journal-title":"Eukaryot Cell"},{"key":"2019091000282579600_bib180","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1056\/NEJMoa1008115","article-title":"A field trial to assess a blood-stage malaria vaccine","volume":"365","author":"Thera","year":"2011","journal-title":"N Engl J Med"},{"key":"2019091000282579600_bib181","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1126\/science.1204988","article-title":"Host cell invasion by apicomplexan parasites: Insights from the co-structure of AMA1 with a RON2 peptide","volume":"333","author":"Tonkin","year":"2011","journal-title":"Science"},{"key":"2019091000282579600_bib182","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0764-4469(98)80009-7","article-title":"Impact of chloroquine resistance on malaria mortality","volume":"321","author":"Trape","year":"1998","journal-title":"C R Acad Sci III"},{"key":"2019091000282579600_bib183","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S1473-3099(15)70032-0","article-title":"Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: A cross-sectional survey of the K13 molecular marker","volume":"15","author":"Tun","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"2019091000282579600_bib184","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1084\/jem.169.5.1835","article-title":"Plasmodium falciparum-infected erythrocytes form spontaneous erythrocyte rosettes","volume":"169","author":"Udomsangpetch","year":"1989","journal-title":"J Exp Med"},{"key":"2019091000282579600_bib185","doi-asserted-by":"crossref","first-page":"e100","DOI":"10.1371\/journal.ppat.0020100","article-title":"Release of sequestered malaria parasites upon injection of a glycosaminoglycan","volume":"2","author":"Vogt","year":"2006","journal-title":"PLoS Pathog"},{"key":"2019091000282579600_bib186","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1128\/AAC.01148-08","article-title":"A Small-Molecule Dengue Virus Entry Inhibitor","volume":"53","author":"Wang","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091000282579600_bib3_546_254719","first-page":"10194","volume":"2000;74","author":"Watanabe"},{"key":"2019091000282579600_bib187","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.pt.2015.12.007","article-title":"Overlaying molecular and temporal aspects of malaria parasite invasion","volume":"32","author":"Weiss","year":"2016","journal-title":"Trends Parasitol"},{"key":"2019091000282579600_bib188","doi-asserted-by":"crossref","first-page":"e1004670","DOI":"10.1371\/journal.ppat.1004670","article-title":"Revealing the sequence and resulting cellular morphology of receptor-ligand interactions during Plasmodium falciparum invasion of erythrocytes","volume":"11","author":"Weiss","year":"2015","journal-title":"PLoS Pathog"},{"key":"2019091000282579600_bib189","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.ijpara.2008.05.016","article-title":"Cyclic nucleotide-specific phosphodiesterases of Plasmodium falciparum: PfPDEalpha, a non-essential cGMP-specific PDE that is an integral membrane protein","volume":"38","author":"Wentzinger","year":"2008","journal-title":"Int J Parasitol"},{"key":"2019091000282579600_bib190","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0140-6736(13)60024-0","article-title":"Malaria","volume":"383","author":"White","year":"2014","journal-title":"Lancet"},{"key":"2019091000282579600_bib191","volume-title":"World Malaira Report","author":"WHO","year":"2017"},{"key":"2019091000282579600_bib193","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12915-015-0162-0","article-title":"Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum","volume":"13","author":"Wilson","year":"2015","journal-title":"BMC Biol"},{"key":"2019091000282579600_bib192","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1128\/AAC.01881-12","article-title":"Defining the timing of action of antimalarial drugs against Plasmodium falciparum","volume":"57","author":"Wilson","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"2019091000282579600_bib194","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.ijpara.2012.04.005","article-title":"Plasmodium subtilisin-like protease 1 (SUB1): Insights into the active-site structure, specificity and function of a pan-malaria drug target","volume":"42","author":"Withers-Martinez","year":"2012","journal-title":"Int J Parasitol"},{"key":"2019091000282579600_bib195","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0079-6468(05)43007-6","article-title":"The discovery of the CCR5 receptor antagonist, UK-427,857, a new agent for the treatment of HIV infection and AIDS","volume":"43","author":"Wood","year":"2005","journal-title":"Prog Med Chem"},{"key":"2019091000282579600_bib196","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1128\/IAI.64.4.1373-1378.1996","article-title":"Sulfated polyanions inhibit invasion of erythrocytes by plasmodial merozoites and cytoadherence of endothelial cells to parasitized erythrocytes","volume":"64","author":"Xiao","year":"1996","journal-title":"Infect Immun"},{"key":"2019091000282579600_bib197","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.cell.2007.10.049","article-title":"Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes","volume":"131","author":"Yeoh","year":"2007","journal-title":"Cell"},{"key":"2019091000282579600_bib199","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1042\/BJ20050425","article-title":"PfPDE1, a novel cGMP-specific phosphodiesterase from the human malaria parasite Plasmodium falciparum","volume":"392","author":"Yuasa","year":"2005","journal-title":"Biochem J"},{"key":"2019091000282579600_bib198","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2174\/156800910791054176","article-title":"Antitumor effect of butanoylated heparin with low anticoagulant activity on lung cancer growth in mice and rats","volume":"10","author":"Yu","year":"2010","journal-title":"Curr Cancer Drug Targets"},{"key":"2019091000282579600_bib200","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1084\/jem.20150032","article-title":"Basigin is a druggable target for host-oriented antimalarial interventions","volume":"212","author":"Zenonos","year":"2015","journal-title":"J Exp Med"}],"container-title":["FEMS Microbiology Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/femsre\/article-pdf\/43\/3\/223\/29938714\/fuz005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T14:23:54Z","timestamp":1720967034000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femsre\/article\/43\/3\/223\/5315754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,11]]},"references-count":204,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,2,11]]},"published-print":{"date-parts":[[2019,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/femsre\/fuz005","relation":{},"ISSN":["1574-6976"],"issn-type":[{"value":"1574-6976","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,5]]},"published":{"date-parts":[[2019,2,11]]}}}