{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:33:16Z","timestamp":1789439596796,"version":"build-2803163510"},"reference-count":58,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":65,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010803","name":"Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR38505\/MED\/29\/1513\/2020"],"award-info":[{"award-number":["BT\/PR38505\/MED\/29\/1513\/2020"]}],"id":[{"id":"10.13039\/501100010803","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006143","name":"Department of Science and Technology","doi-asserted-by":"publisher","award":["CRG\/2022\/001047"],"award-info":[{"award-number":["CRG\/2022\/001047"]}],"id":[{"id":"10.13039\/501100006143","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["AMR\/149\/2018-ECD-II"],"award-info":[{"award-number":["AMR\/149\/2018-ECD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["Myco\/Fell\/3\/2022 ECD-II"],"award-info":[{"award-number":["Myco\/Fell\/3\/2022 ECD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012359","name":"DBT","doi-asserted-by":"publisher","award":["BT\/INF\/22\/SP45072\/2022"],"award-info":[{"award-number":["BT\/INF\/22\/SP45072\/2022"]}],"id":[{"id":"10.13039\/100012359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012359","name":"DBT","doi-asserted-by":"publisher","award":["52\/08\/2019-BIO\/BMS"],"award-info":[{"award-number":["52\/08\/2019-BIO\/BMS"]}],"id":[{"id":"10.13039\/100012359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001342","name":"DST","doi-asserted-by":"publisher","award":["SR\/PURSE Phase 2\/29\u00a9"],"award-info":[{"award-number":["SR\/PURSE Phase 2\/29\u00a9"]}],"id":[{"id":"10.13039\/501100001342","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UP Higher Education","award":["10\/2021\/281\/-4-Sattar-2021-04(2)\/2021"],"award-info":[{"award-number":["10\/2021\/281\/-4-Sattar-2021-04(2)\/2021"]}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["09\/263(1223)\/2019-EMR-I"],"award-info":[{"award-number":["09\/263(1223)\/2019-EMR-I"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"SERB","doi-asserted-by":"publisher","award":["CRG\/2020\/002107"],"award-info":[{"award-number":["CRG\/2020\/002107"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001314","name":"SRF","doi-asserted-by":"publisher","award":["CMB-BMS 2020-7196"],"award-info":[{"award-number":["CMB-BMS 2020-7196"]}],"id":[{"id":"10.13039\/100001314","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001314","name":"SRF","doi-asserted-by":"publisher","award":["Myco\/Fell\/7\/2022-ECD-II"],"award-info":[{"award-number":["Myco\/Fell\/7\/2022-ECD-II"]}],"id":[{"id":"10.13039\/100001314","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In this study, we explored the sphingolipid (SL) landscape in Candida auris, which plays pivotal roles in fungal biology and drug susceptibility. The composition of SLs exhibited substantial variations at both the SL class and molecular species levels among clade isolates. Utilizing principal component analysis, we successfully differentiated the five clades based on their SL class composition. While phytoceramide (PCer) was uniformly the most abundant SL class in all the isolates, other classes showed significant variations. These variations were not limited to SL class level only as the proportion of different molecular species containing variable number of carbons in fatty acid chains also differed between the isolates. Also a comparative analysis revealed abundance of ceramides and glucosylceramides in fluconazole susceptible isolates. Furthermore, by comparing drug-resistant and susceptible isolates within clade IV, we uncovered significant intraclade differences in key SL classes such as high PCer and low long chain base (LCB) content in resistant strains, underscoring the impact of SL heterogeneity on drug resistance development in C. auris. These findings shed light on the multifaceted interplay between genomic diversity, SLs, and drug resistance in this emerging fungal pathogen.<\/jats:p>","DOI":"10.1093\/femsyr\/foae008","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T06:59:13Z","timestamp":1709708353000},"source":"Crossref","is-referenced-by-count":18,"title":["Sphingolipid diversity in <i>Candida auris<\/i>: unraveling interclade and drug resistance fingerprints"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8266-8605","authenticated-orcid":false,"given":"Basharat","family":"Ali","sequence":"first","affiliation":[{"name":"Amity Institute of Integrative Science and Health and Amity Institute of Biotechnology, Amity University Gurgaon , Haryana, 122413 ,","place":["India"]},{"name":"School of Life Sciences, Jawaharlal Nehru University , New Delhi, 110067 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Amity Institute of Integrative Science and Health and Amity Institute of Biotechnology, Amity University Gurgaon , Haryana, 122413 ,","place":["India"]},{"name":"Yeast Biofuel Group, International Centre for Genetic Engineering and Biotechnology , New Delhi, 110067","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Kumar","sequence":"additional","affiliation":[{"name":"Amity Institute of Integrative Science and Health and Amity Institute of Biotechnology, Amity University Gurgaon , Haryana, 122413 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshu","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Amity Institute of Integrative Science and Health and Amity Institute of Biotechnology, Amity University Gurgaon , Haryana, 122413 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana Akhtar","family":"Usmani","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Lucknow , Lucknow, 226007","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivaprakash M","family":"Rudramurthy","sequence":"additional","affiliation":[{"name":"Postgraduate Institute of Medical Education and Research , Chandigarh,160012","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3253-6080","authenticated-orcid":false,"given":"Jacques F","family":"Meis","sequence":"additional","affiliation":[{"name":"Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases and Excellence Center for Medical Mycology (ECMM), University of Cologne , Cologne, 50931","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1555-3807","authenticated-orcid":false,"given":"Arunaloke","family":"Chakrabarti","sequence":"additional","affiliation":[{"name":"Postgraduate Institute of Medical Education and Research , Chandigarh,160012","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0995-6696","authenticated-orcid":false,"given":"Ashutosh","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Lucknow , Lucknow, 226007","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1224-8789","authenticated-orcid":false,"given":"Naseem A","family":"Gaur","sequence":"additional","affiliation":[{"name":"Yeast Biofuel Group, International Centre for Genetic Engineering and Biotechnology , New Delhi, 110067","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok K","family":"Mondal","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Jawaharlal Nehru University , New Delhi, 110067 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8044-7042","authenticated-orcid":false,"given":"Rajendra","family":"Prasad","sequence":"additional","affiliation":[{"name":"Amity Institute of Integrative Science and Health and Amity Institute of Biotechnology, Amity University Gurgaon , Haryana, 122413 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"2025011616161940700_bib1","doi-asserted-by":"crossref","first-page":"32028","DOI":"10.1074\/jbc.M312918200","article-title":"Newly discovered neutral glycosphingolipids in aureobasidin A-resistant zygomycetes: identification of a novel family of Gala-series glycolipids with core gal alpha 1-6\u00a0Gal beta 1-6\u00a0Gal beta sequences","volume":"279","author":"Aoki","year":"2004","journal-title":"J Biol Chem"},{"key":"2025011616161940700_bib2","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1073\/pnas.97.7.3254","article-title":"Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast","volume":"97","author":"Bagnat","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025011616161940700_bib3","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1038\/s41598-019-41513-6","article-title":"Gene duplication associated with increased fluconazole tolerance in Candida auris cells of advanced generational age","volume":"9","author":"Bhattacharya","year":"2019","journal-title":"Sci Rep"},{"key":"2025011616161940700_bib4","doi-asserted-by":"crossref","first-page":"e00498","DOI":"10.1128\/spectrum.00498-23","article-title":"High-throughput profiling of Candida auris isolates reveals clade-specific metabolic differences","volume":"11","author":"Brandt","year":"2023","journal-title":"Microbiol Spectr"},{"key":"2025011616161940700_bib5","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.3389\/fmicb.2019.02788","article-title":"Review on antifungal resistance mechanisms in the emerging pathogen Candida auris","volume":"10","author":"Chaabane","year":"2019","journal-title":"Front Microbiol"},{"key":"2025011616161940700_bib6","doi-asserted-by":"crossref","first-page":"e03364","DOI":"10.1128\/mBio.03364-19","article-title":"Tracing the evolutionary history and global expansion of Candida auris using population genomic analyses","volume":"11","author":"Chow","year":"2020","journal-title":"mBio"},{"key":"2025011616161940700_bib7","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1093\/jac\/dkx480","article-title":"A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009-17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance","volume":"73","author":"Chowdhary","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"2025011616161940700_bib25","article-title":"M27Ed4: Broth Dilution Antifungal Susceptibility, Yeasts","author":"CLSI","year":"2017"},{"key":"2025011616161940700_bib8","doi-asserted-by":"crossref","first-page":"1003832","DOI":"10.1371\/journal.ppat.1003832","article-title":"Synthesis and biological properties of fungal glucosylceramide","volume":"10","author":"Del\u00a0Poeta","year":"2014","journal-title":"PLoS Pathog"},{"key":"2025011616161940700_bib9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/978-1-4419-6741-1_15","article-title":"Roles for sphingolipids in Saccharomyces cerevisiae","volume-title":"Sphingolipids as Signaling and Regulatory Molecules","author":"Dickson","year":"2010"},{"key":"2025011616161940700_bib10","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1016\/j.febslet.2014.09.005","article-title":"Inositol phosphosphingolipid phospholipase C1 regulates plasma membrane ATPase (Pma1) stability in Cryptococcus neoformans","volume":"588","author":"Farnoud","year":"2014","journal-title":"FEBS Lett"},{"key":"2025011616161940700_bib11","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1083\/jcb.200105033","article-title":"Vesicular and nonvesicular transport of ceramide from ER to the Golgi apparatus in yeast","volume":"155","author":"Funato","year":"2001","journal-title":"J Cell Biol"},{"key":"2025011616161940700_bib12","doi-asserted-by":"crossref","first-page":"4495","DOI":"10.1038\/s41467-018-06944-1","article-title":"Candida albicans gains azole resistance by altering sphingolipid composition","volume":"9","author":"Gao","year":"2018","journal-title":"Nat Commun"},{"key":"2025011616161940700_bib13","doi-asserted-by":"crossref","first-page":"e0053922","DOI":"10.1128\/msystems.00539-22","article-title":"Systematic metabolic profiling identifies De Novo sphingolipid synthesis as hypha associated and essential for Candida albicans filamentation","volume":"7","author":"Garbe","year":"2022","journal-title":"mSystems"},{"key":"2025011616161940700_bib14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S1388-1981(03)00059-3","article-title":"Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism","volume":"1632","author":"Hanada","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"2025011616161940700_bib15","doi-asserted-by":"crossref","first-page":"662563","DOI":"10.3389\/fcimb.2021.662563","article-title":"Transcriptome signatures predict phenotypic variations of Candida auris","volume":"11","author":"Jenull","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"2025011616161940700_bib16","first-page":"02529","article-title":"Genetic analysis of Candida auris implicates Hsp90 in morphogenesis and azole tolerance and Cdr1 in azole resistance","volume-title":"mBio","author":"Kim","year":"2019"},{"key":"2025011616161940700_bib17","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1128\/AAC.46.4.1046-1052.2002","article-title":"In vitro low-level resistance to azoles in Candida albicans is associated with changes in membrane lipid fluidity and asymmetry","volume":"46","author":"Kohli","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"2025011616161940700_bib18","doi-asserted-by":"crossref","first-page":"158815","DOI":"10.1016\/j.bbalip.2020.158815","article-title":"Sphingolipidomics of drug resistant Candida auris clinical isolates reveal distinct sphingolipid species signatures","volume":"1866","author":"Kumar","year":"2021","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"2025011616161940700_bib19","doi-asserted-by":"crossref","first-page":"e1001069","DOI":"10.1371\/journal.ppat.1001069","article-title":"PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, Calcineurin, and Hsp90","volume":"6","author":"LaFayette","year":"2010","journal-title":"PLoS Pathog"},{"key":"2025011616161940700_bib20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0014-5793(02)03067-3","article-title":"Disruption of the glucosylceramide biosynthetic pathway in Aspergillus nidulans and Aspergillus fumigatus by inhibitors of UDP-glc:ceramide glucosyltransferase strongly affects spore germination, cell cycle, and hyphal growth","volume":"525","author":"Levery","year":"2002","journal-title":"FEBS Lett"},{"key":"2025011616161940700_bib21","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1091\/mbc.11.7.2267","article-title":"Inositol phosphorylceramide synthase is located in the Golgi apparatus of Saccharomyces cerevisiae","volume":"11","author":"Levine","year":"2000","journal-title":"Mol Biol Cell"},{"key":"2025011616161940700_bib22","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02663-20","article-title":"Novel ERG11 and TAC1b mutations associated with Azole resistance in Candida auris","volume":"65","author":"Li","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"key":"2025011616161940700_bib23","doi-asserted-by":"crossref","first-page":"22679","DOI":"10.1074\/jbc.M502972200","article-title":"The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9","volume":"280","author":"Liu","year":"2005","journal-title":"J Biol Chem"},{"key":"2025011616161940700_bib24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/cid\/ciw691","article-title":"Simultaneous emergence of multidrug-resistant Candida auris on 3 continents confirmed by whole-genome sequencing and epidemiological analyses","volume":"64","author":"Lockhart","year":"2017","journal-title":"Clin Infect Dis"},{"key":"2025011616161940700_bib26","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2174\/1389557516666160118112103","article-title":"The mechanistic targets of antifungal agents: an overview","volume":"16","author":"Mazu","year":"2016","journal-title":"Mini Rev Med Chem"},{"key":"2025011616161940700_bib27","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1567-1364.2010.00656.x","article-title":"The serine\/threonine protein phosphatase Sit4p activates multidrug resistance in Saccharomyces cerevisiae","volume":"10","author":"Miranda","year":"2010","journal-title":"FEMS Yeast Res"},{"key":"2025011616161940700_bib28","doi-asserted-by":"crossref","first-page":"e00647","DOI":"10.1128\/mBio.00647-15","article-title":"Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids","volume":"6","author":"Mor","year":"2015","journal-title":"mBio"},{"key":"2025011616161940700_bib29","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.diagmicrobio.2009.11.006","article-title":"Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature","volume":"66","author":"Morio","year":"2010","journal-title":"Diagn Microbiol Infect Dis"},{"key":"2025011616161940700_bib30","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1128\/AAC.48.5.1778-1787.2004","article-title":"Membrane sphingolipid-ergosterol interactions are important determinants of multidrug resistance in Candida albicans","volume":"48","author":"Mukhopadhyay","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"2025011616161940700_bib31","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1038\/s41467-018-07779-6","article-title":"Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species","volume":"9","author":"Mu\u00f1oz","year":"2018","journal-title":"Nat Commun"},{"key":"2025011616161940700_bib32","doi-asserted-by":"crossref","first-page":"e0305222","DOI":"10.1128\/mbio.03052-22","article-title":"Directed evolution detects supernumerary centric chromosomes conferring resistance to azoles in Candida auris","volume":"13","author":"Narayanan","year":"2022","journal-title":"mBio"},{"key":"2025011616161940700_bib33","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3389\/fmicb.2011.00212","article-title":"Fungal glucosylceramides: from structural components to biologically active targets of new antimicrobials","volume":"2","author":"Nimrichter","year":"2011","journal-title":"Front Microbiol"},{"key":"2025011616161940700_bib34","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1099\/mic.0.033985-0","article-title":"Candida albicans sphingolipid C9-methyltransferase is involved in hyphal elongation","volume":"156","author":"Oura","year":"2010","journal-title":"Microbiology"},{"key":"2025011616161940700_bib35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3390\/jof4020050","article-title":"Lipid biosynthesis as an antifungal target","volume":"4","author":"Pan","year":"2018","journal-title":"J Fungi"},{"key":"2025011616161940700_bib36","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1128\/AAC.00861-07","article-title":"Multidrug transporters CaCdr1p and CaMdr1p of Candida albicans display different lipid specificities: both ergosterol and sphingolipids are essential for targeting of CaCdr1p to membrane rafts","volume":"52","author":"Pasrija","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"2025011616161940700_bib37","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1128\/AAC.49.8.3442-3452.2005","article-title":"Functional analysis of CaIPT1, a sphingolipid biosynthetic gene involved in multidrug resistance and morphogenesis of Candida albicans","volume":"49","author":"Prasad","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"2025011616161940700_bib38","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1002\/1873-3468.12944","article-title":"The role of phospholipid molecular species in determining the physical properties of yeast membranes","volume":"592","author":"Renne","year":"2018","journal-title":"FEBS Lett"},{"key":"2025011616161940700_bib39","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1172\/JCI27890","article-title":"Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans","volume":"116","author":"Rittershaus","year":"2006","journal-title":"J Clin Invest"},{"key":"2025011616161940700_bib40","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3390\/pathogens10070856","article-title":"Sphingolipid inhibitors as an alternative to treat candidiasis caused by fluconazole-resistant strains","volume":"10","author":"Rollin-Pinheiro","year":"2021","journal-title":"Pathogens"},{"key":"2025011616161940700_bib41","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.4155\/fmc-2016-0053","article-title":"Sphingolipids as targets for treatment of fungal infections","volume":"8","author":"Rollin-Pinheiro","year":"2016","journal-title":"Fut Med Chem"},{"key":"2025011616161940700_bib42","doi-asserted-by":"crossref","first-page":"e01585","DOI":"10.1128\/Spectrum.01585-21","article-title":"Delineation of the direct contribution of Candida auris ERG11 mutations to clinical triazole resistance","volume":"9","author":"Rybak","year":"2021","journal-title":"Microbiol Spectr"},{"key":"2025011616161940700_bib43","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00253-005-0187-3","article-title":"Presence of glucosylceramide in yeast and its relation to alkali tolerance of yeast","volume":"71","author":"Saito","year":"2006","journal-title":"Appl Microbiol Biotechnol"},{"key":"2025011616161940700_bib44","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3390\/jof8070651","article-title":"Inositol phosphoryl transferase, Ipt1, is a critical determinant of azole resistance and virulence phenotypes in Candida glabrata","volume":"8","author":"Shahi","year":"2022","journal-title":"J Fungi"},{"key":"2025011616161940700_bib45","doi-asserted-by":"crossref","first-page":"foaa045","DOI":"10.1093\/femsyr\/foaa045","article-title":"A detailed lipidomic study of human pathogenic fungi Candida auris","volume":"20","author":"Shahi","year":"2020","journal-title":"FEMS Yeast Res"},{"key":"2025011616161940700_bib46","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1128\/AAC.02130-13","article-title":"Sphingolipid biosynthetic pathway genes FEN1 and SUR4 modulate amphotericin B resistance","volume":"58","author":"Sharma","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"2025011616161940700_bib47","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.3390\/microorganisms11082093","article-title":"Genetic characterization of the acidic and neutral glycosphingolipid biosynthetic pathways in Neurospora crassa","volume":"11","author":"Shoma","year":"2023","journal-title":"Microorganisms"},{"key":"2025011616161940700_bib48","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1194\/jlr.M078600","article-title":"Analysis of sphingolipids, sterols, and phospholipids in human pathogenic Cryptococcus strains","volume":"58","author":"Singh","year":"2017","journal-title":"J Lipid Res"},{"key":"2025011616161940700_bib58_334_015024","first-page":"e39812","article-title":"Comparative lipidomics in clinical isolates of Candida albicans reveal crosstalk between mitochondria, cell wall integrity and azole resistance","volume-title":"PLoS One","author":"Singh","year":"2012"},{"key":"2025011616161940700_bib49","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1016\/S0021-9258(19)42585-4","article-title":"Inositol phosphorylceramide, a novel substance and the chief member of a major group of yeast sphingolipids containing a single inositol phosphate","volume":"249","author":"Smith","year":"1974","journal-title":"J Biol Chem"},{"key":"2025011616161940700_bib50","doi-asserted-by":"crossref","first-page":"9975","DOI":"10.3390\/ijms23179975","article-title":"The role of ergosterol and sphingolipids in the localization and activity of Candida albicans\u2019 multidrug transporter Cdr1p and plasma membrane ATPase Pma1p","volume":"23","author":"Urbanek","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2025011616161940700_bib51","doi-asserted-by":"crossref","first-page":"104087","DOI":"10.1016\/j.resmic.2023.104087","article-title":"Beyond membrane components: uncovering the intriguing world of fungal sphingolipid synthesis and regulation","volume":"174","author":"Usmani","year":"2023","journal-title":"Res Microbiol"},{"key":"2025011616161940700_bib52","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1128\/AAC.05106-11","article-title":"Phytosphingosine-1-phosphate is a signaling molecule involved in miconazole resistance in sessile Candida albicans cells","volume":"56","author":"Vandenbosch","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"2025011616161940700_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2019.01445","article-title":"ABC transporter genes show upregulated expression in drug-resistant clinical isolates of Candida auris: a genome-wide characterization of ATP-binding cassette (ABC) transporter genes","volume":"10","author":"Wasi","year":"2019","journal-title":"Front Microbiol"},{"key":"2025011616161940700_bib54","doi-asserted-by":"crossref","first-page":"e00007","DOI":"10.1128\/JCM.00007-19","article-title":"Insights into the unique nature of the East Asian clade of the emerging pathogenic yeast Candida auris","volume":"57","author":"Welsh","year":"2019","journal-title":"J Clin Microbiol"},{"key":"2025011616161940700_bib55","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1128\/AAC.41.7.1482","article-title":"Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus","volume":"41","author":"White","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"2025011616161940700_bib56","doi-asserted-by":"crossref","first-page":"e00257","DOI":"10.1128\/mSystems.00257-19","article-title":"Multi-omics signature of Candida auris, an emerging and multidrug-resistant pathogen","volume":"4","author":"Zamith-Miranda","year":"2019","journal-title":"mSystems"},{"key":"2025011616161940700_bib57","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1128\/AAC.44.3.651-653.2000","article-title":"Inhibition of inositol phosphorylceramide synthase by Aureobasidin A in Candida and Aspergillus species","volume":"44","author":"Zhong","year":"2000","journal-title":"Antimicrob Agents Chemother"}],"container-title":["FEMS Yeast Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/femsyr\/advance-article-pdf\/doi\/10.1093\/femsyr\/foae008\/56874035\/foae008.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/femsyr\/article-pdf\/doi\/10.1093\/femsyr\/foae008\/61019844\/foae008.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/femsyr\/article-pdf\/doi\/10.1093\/femsyr\/foae008\/61019844\/foae008.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T16:16:58Z","timestamp":1737044218000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femsyr\/article\/doi\/10.1093\/femsyr\/foae008\/7623016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":58,"URL":"https:\/\/doi.org\/10.1093\/femsyr\/foae008","relation":{},"ISSN":["1567-1364"],"issn-type":[{"value":"1567-1364","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024]]},"published":{"date-parts":[[2024]]},"article-number":"foae008"}}