{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:46:41Z","timestamp":1790725601492,"version":"4.1.0"},"reference-count":104,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":338,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2020-117983RB-I00"],"award-info":[{"award-number":["PID2020-117983RB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["CNS2022-135375"],"award-info":[{"award-number":["CNS2022-135375"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007480","name":"UCLM","doi-asserted-by":"publisher","award":["SBPLY\/23\/180225\/000029"],"award-info":[{"award-number":["SBPLY\/23\/180225\/000029"]}],"id":[{"id":"10.13039\/501100007480","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund Plus","doi-asserted-by":"publisher","award":["JDC2023-051226-I"],"award-info":[{"award-number":["JDC2023-051226-I"]}],"id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The drug-resistant pathogenic yeast Candidozyma auris (formerly named Candida auris) is considered a critical health problem of global importance. As the cell wall plays a crucial role in pathobiology, here we performed a detailed bioinformatic analysis of its biosynthesis in C. auris and related Candidozyma haemuli complex species using Candida albicans and Saccharomyces cerevisiae as references. Our data indicate that the cell wall architecture described for these reference yeasts is largely conserved in Candidozyma spp.; however, expansions or reductions in gene families point to subtle alterations, particularly with respect to \u03b2\u00ad-1,3-\u00adglucan synthesis and remodeling, phosphomannosylation, \u03b2-mannosylation, and glycosylphosphatidylinositol (GPI) proteins. In several aspects, C. auris holds a position in between C. albicans and S. cerevisiae, consistent with being classified in a separate genus. Strikingly, among the identified putative GPI proteins in C. auris are adhesins typical for both Candida (Als and Hyr\/Iff) and Saccharomyces (Flo11 and Flo5-like flocculins). Further, 26 putative C. auris GPI proteins lack homologs in Candida genus species. Phenotypic analysis of one such gene, QG37_05701, showed mild phenotypes implicating a role associated with cell wall \u03b2-1,3-glucan. Altogether, our study uncovered a wealth of information relevant for the pathogenicity of C. auris as well as targets for follow-up studies.<\/jats:p>","DOI":"10.1093\/femsyr\/foae039","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T07:21:13Z","timestamp":1733210473000},"source":"Crossref","is-referenced-by-count":15,"title":["The good, the bad, and the hazardous: comparative genomic analysis unveils cell wall features in the pathogen\n                    <i>Candidozyma auris<\/i>\n                    typical for both baker\u2019s yeast and\n                    <i>Candida<\/i>"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6879-1609","authenticated-orcid":false,"given":"Mar\u00eda","family":"Alvarado","sequence":"first","affiliation":[{"name":"Institute for Biomedicine, ETSIAMB, University of Castilla-La Mancha , 02008 Albacete ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas A","family":"G\u00f3mez-Navajas","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine, ETSIAMB, University of Castilla-La Mancha , 02008 Albacete ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Teresa","family":"Bl\u00e1zquez-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine, ETSIAMB, University of Castilla-La Mancha , 02008 Albacete ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"G\u00f3mez-Molero","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine, ETSIAMB, University of Castilla-La Mancha , 02008 Albacete ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n","family":"Fern\u00e1ndez-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine, ETSIAMB, University of Castilla-La Mancha , 02008 Albacete ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Eraso","sequence":"additional","affiliation":[{"name":"Department of Immunology, Microbiology and Parasitology, Faculty of Medicine and Nursing, University of the Basque Country (UPV\/EHU) , 48940 Bilbao ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0761-1755","authenticated-orcid":false,"given":"Carol A","family":"Munro","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences, University of Aberdeen , Aberdeen AB25 2ZD ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eulogio","family":"Valent\u00edn","sequence":"additional","affiliation":[{"name":"GMCA Research Unit, Departament of Microbiology and Ecology, University of Valencia , Burjassot, 46010 Valencia,","place":["Spain"]},{"name":"Severe Infection Research Group, Health Research Institute La Fe , 46026 Valencia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estibaliz","family":"Mateo","sequence":"additional","affiliation":[{"name":"Department of Immunology, Microbiology and Parasitology, Faculty of Medicine and Nursing, University of the Basque Country (UPV\/EHU) , 48940 Bilbao ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet W J","family":"de\u00a0Groot","sequence":"additional","affiliation":[{"name":"Institute for Biomedicine, ETSIAMB, University of Castilla-La Mancha , 02008 Albacete ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"2025011616163744200_bib1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/myc.13204","article-title":"Identification of Candida auris and related species by multiplex PCR based on unique GPI protein-encoding genes","volume":"64","author":"Alvarado","year":"2021","journal-title":"Mycoses"},{"key":"2025011616163744200_bib2","doi-asserted-by":"crossref","first-page":"e1011158","DOI":"10.1371\/journal.ppat.1011158","article-title":"Integrated post-genomic cell wall analysis reveals floating biofilm formation associated with high expression of flocculins in the pathogen Pichia kudriavzevii","volume":"19","author":"Alvarado","year":"2023","journal-title":"PLoS Pathog"},{"key":"2025011616163744200_bib3","doi-asserted-by":"crossref","first-page":"e00485","DOI":"10.1128\/AAC.00485-17","article-title":"Comparison of EUCAST and CLSI Reference microdilution MICs of eight antifungal compounds for Candida auris and associated tentative epidemiological cutoff values","volume":"61","author":"Arendrup","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"2025011616163744200_bib4","doi-asserted-by":"crossref","first-page":"876","DOI":"10.3201\/eid2605.191588","article-title":"Clinical outcomes of patients treated for Candida auris infections in a multisite health system, Illinois, USA","volume":"26","author":"Arensman","year":"2020","journal-title":"Emerg Infect Dis"},{"key":"2025011616163744200_bib5","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1471-2180-8-116","article-title":"Processing of predicted substrates of fungal Kex2 proteinases from Candida albicans, C. glabrata, Saccharomyces cerevisiae and Pichia pastoris","volume":"8","author":"Bader","year":"2008","journal-title":"BMC Microbiol"},{"key":"2025011616163744200_bib6","first-page":"RP100569","article-title":"\u03b2-1,6-glucan plays a central role in the structure and remodeling of the bilaminate fungal cell wall","volume-title":"eLife","author":"Bekirian","year":"2024"},{"key":"2025011616163744200_bib7","doi-asserted-by":"crossref","first-page":"e0033022","DOI":"10.1128\/jcm.00330-22","article-title":"Name changes for fungi of medical importance, 2020 to 2021","volume":"61","author":"Borman","year":"2023","journal-title":"J Clin Microbiol"},{"key":"2025011616163744200_bib8","doi-asserted-by":"crossref","first-page":"e00189","DOI":"10.1128\/mSphere.00189-16","article-title":"Comparative pathogenicity of United Kingdom isolates of the emerging pathogen Candida auris and other key pathogenic Candida species","volume":"1","author":"Borman","year":"2016","journal-title":"mSphere"},{"key":"2025011616163744200_bib9","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.3390\/ijms25094775","article-title":"Secreted Aspartic proteinases: key factors in Candida infections and host\u2013pathogen interactions","volume":"25","author":"Bras","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2025011616163744200_bib10","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1007\/s00294-019-00976-w","article-title":"Rapid and extensive karyotype diversification in haploid clinical Candida auris isolates","volume":"65","author":"Bravo\u00a0Ruiz","year":"2019","journal-title":"Curr Genet"},{"key":"2025011616163744200_bib11","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1038\/s41564-020-0780-3","article-title":"Transcriptional and functional insights into the host immune response against the emerging fungal pathogen Candida auris","volume":"5","author":"Bruno","year":"2020","journal-title":"Nat Microbiol"},{"key":"2025011616163744200_bib12","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nature08064","article-title":"Evolution of pathogenicity and sexual reproduction in eight Candida genomes","volume":"459","author":"Butler","year":"2009","journal-title":"Nature"},{"key":"2025011616163744200_bib13","doi-asserted-by":"crossref","first-page":"e01397","DOI":"10.1128\/mBio.01397-19","article-title":"On the emergence of Candida auris: climate change, azoles, swamps, and birds","volume":"10","author":"Casadevall","year":"2019","journal-title":"mBio"},{"key":"2025011616163744200_bib14","article-title":"Antifungal Susceptibility Testing for\u00a0Candida auris","author":"U.S. Centers for Disease Control and Prevention","year":"2024"},{"key":"2025011616163744200_bib15","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.3389\/fmicb.2019.02788","article-title":"Review on antifungal resistance mechanisms in the emerging pathogen Candida auris","volume":"10","author":"Chaabane","year":"2019","journal-title":"Front Microbiol"},{"key":"2025011616163744200_bib16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00134-014-3603-2","article-title":"Incidence, characteristics and outcome of ICU-acquired candidemia in India","volume":"41","author":"Chakrabarti","year":"2015","journal-title":"Intensive Care Med"},{"key":"2025011616163744200_bib17","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.3201\/eid2509.190686","article-title":"Potential fifth clade of Candida auris, Iran, 2018","volume":"25","author":"Chow","year":"2019","journal-title":"Emerg Infect Dis"},{"key":"2025011616163744200_bib18","doi-asserted-by":"crossref","first-page":"e1006290","DOI":"10.1371\/journal.ppat.1006290","article-title":"Candida auris: a rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally","volume":"13","author":"Chowdhary","year":"2017","journal-title":"PLoS Pathog"},{"key":"2025011616163744200_bib19","doi-asserted-by":"crossref","first-page":"107352","DOI":"10.1016\/j.biotechadv.2019.02.008","article-title":"The fungal cell wall as a target for the development of new antifungal therapies","volume":"37","author":"Cortes","year":"2019","journal-title":"Biotechnol Adv"},{"key":"2025011616163744200_bib20","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/jof3020022","article-title":"Fungal biofilms and polymicrobial diseases","volume":"3","author":"Costa-Orlandi","year":"2017","journal-title":"J Fungi (Basel)"},{"key":"2025011616163744200_bib21","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/yea.1790","article-title":"The Candida albicans cell wall protein Rhd3\/Pga29 is abundant in the yeast form and contributes to virulence","volume":"27","author":"de\u00a0Boer","year":"2010","journal-title":"Yeast"},{"key":"2025011616163744200_bib22","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3390\/microorganisms12050927","article-title":"Candida auris outbreaks: current status and future perspectives","volume":"12","author":"De\u00a0Gaetano","year":"2024","journal-title":"Microorganisms"},{"key":"2025011616163744200_bib23","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1128\/EC.00364-12","article-title":"Adhesins in human fungal pathogens: glue with plenty of stick","volume":"12","author":"De\u00a0Groot","year":"2013","journal-title":"Eukaryot Cell"},{"key":"2025011616163744200_bib24","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1128\/EC.3.4.955-965.2004","article-title":"Proteomic analysis of Candida albicans cell walls reveals covalently bound carbohydrate-active enzymes and adhesins","volume":"3","author":"de\u00a0Groot","year":"2004","journal-title":"Eukaryot Cell"},{"key":"2025011616163744200_bib25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.fgb.2011.12.009","article-title":"ProFASTA: a pipeline web server for fungal protein scanning with integration of cell surface prediction software","volume":"49","author":"De\u00a0Groot","year":"2012","journal-title":"Fung Genet Biol"},{"key":"2025011616163744200_bib26","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/yea.1007","article-title":"Genome-wide identification of fungal GPI proteins","volume":"20","author":"De\u00a0Groot","year":"2003","journal-title":"Yeast"},{"key":"2025011616163744200_bib27","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1128\/EC.00284-08","article-title":"The cell wall of the human pathogen Candida glabrata: differential incorporation of novel adhesin-like wall proteins","volume":"7","author":"De\u00a0Groot","year":"2008","journal-title":"Eukaryotic Cell"},{"key":"2025011616163744200_bib28","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.fgb.2005.04.002","article-title":"Features and functions of covalently linked proteins in fungal cell walls","volume":"42","author":"De\u00a0Groot","year":"2005","journal-title":"Fung Genet Biol"},{"key":"2025011616163744200_bib29","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2174\/138945006776359458","article-title":"Biofilms and their role in the resistance of pathogenic Candida to antifungal agents","volume":"7","author":"d'Enfert","year":"2006","journal-title":"Curr Drug Targets"},{"key":"2025011616163744200_bib30","doi-asserted-by":"crossref","first-page":"e428","DOI":"10.1016\/S1473-3099(23)00692-8","article-title":"Global incidence and mortality of severe fungal disease","volume":"24","author":"Denning","year":"2024","journal-title":"Lancet Infect Dis"},{"key":"2025011616163744200_bib31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/mmy.39.1.55.66","article-title":"Fungal beta(1,3)-D-glucan synthesis","volume":"39 Suppl 1","author":"Douglas","year":"2001","journal-title":"Med Mycol"},{"key":"2025011616163744200_bib32","doi-asserted-by":"crossref","first-page":"11523","DOI":"10.1074\/jbc.M600314200","article-title":"Pir proteins of Saccharomyces cerevisiae are attached to \u03b2-1,3-glucan by a new protein-carbohydrate linkage","volume":"281","author":"Ecker","year":"2006","journal-title":"J Biol Chem"},{"key":"2025011616163744200_bib33","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jmb.2004.01.025","article-title":"A sensitive predictor for potential GPI lipid modification sites in fungal protein sequences and its application to genome-wide studies for Aspergillus nidulans, Candida albicans, Neurospora crassa, Saccharomyces cerevisiae and Schizosaccharomyces pombe","volume":"337","author":"Eisenhaber","year":"2004","journal-title":"J Mol Biol"},{"key":"2025011616163744200_bib34","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00284-005-0066-2","article-title":"Characterization of the CaENG1 gene encoding an endo-1,3-\u03b2-glucanase involved in cell separation in Candida albicans","volume":"51","author":"Esteban","year":"2005","journal-title":"Curr Microbiol"},{"key":"2025011616163744200_bib35","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1056\/NEJMoa1714373","article-title":"A Candida auris outbreak and its control in an intensive care setting","volume":"379","author":"Eyre","year":"2018","journal-title":"N Engl J Med"},{"key":"2025011616163744200_bib36","doi-asserted-by":"crossref","first-page":"1519 e1511","DOI":"10.1016\/j.cmi.2021.05.031","article-title":"Comparison of \u03b2-D-glucan levels between Candida auris and other Candida species at the time of candidaemia: a retrospective study","volume":"27","author":"Farooqi","year":"2021","journal-title":"Clin Microbiol Infect"},{"key":"2025011616163744200_bib37","doi-asserted-by":"crossref","first-page":"790465","DOI":"10.3389\/fcimb.2021.790465","article-title":"Characterization of Awp14, A novel cluster III Adhesin identified in a high biofilm-forming Candida glabrata isolate","volume":"11","author":"Fernandez-Pereira","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"2025011616163744200_bib38","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1021\/pr5007944","article-title":"Proteomics unravels extracellular vesicles as carriers of classical cytoplasmic proteins in Candida albicans","volume":"14","author":"Gil-Bona","year":"2015","journal-title":"J Proteome Res"},{"key":"2025011616163744200_bib39","doi-asserted-by":"crossref","first-page":"926959","DOI":"10.3389\/fmolb.2022.926959","article-title":"Structure and conservation of amyloid spines from the Candida albicans Als5 adhesin","volume":"9","author":"Golan","year":"2022","journal-title":"Front Mol Biosci"},{"key":"2025011616163744200_bib40","doi-asserted-by":"crossref","first-page":"10.1128\/microbiolspec.FUNK","DOI":"10.1128\/microbiolspec.FUNK-0035-2016","article-title":"The fungal cell wall: structure, biosynthesis, and function","volume":"5","author":"Gow","year":"2017","journal-title":"Microbiol Spectr"},{"key":"2025011616163744200_bib41","doi-asserted-by":"crossref","first-page":"e00218","DOI":"10.1128\/mSphere.00218-17","article-title":"Use of RNA-protein complexes for genome editing in non-albicans Candida species","volume":"2","author":"Grahl","year":"2017","journal-title":"mSphere"},{"key":"2025011616163744200_bib42","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1099\/mic.0.27663-0","article-title":"Yeast wall protein 1 of Candida albicans","volume":"151","author":"Granger","year":"2005","journal-title":"Microbiology"},{"key":"2025011616163744200_bib43","article-title":"Method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for yeasts","author":"Guinea","year":"2023"},{"key":"2025011616163744200_bib44","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.micinf.2016.01.002","article-title":"Candida albicans biofilms: development, regulation, and molecular mechanisms","volume":"18","author":"Gulati","year":"2016","journal-title":"Microbes Infect"},{"key":"2025011616163744200_bib45","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/mmi.12426","article-title":"Mannosylation in Candida albicans: role in cell wall function and immune recognition","volume":"90","author":"Hall","year":"2013","journal-title":"Mol Microbiol"},{"key":"2025011616163744200_bib46","doi-asserted-by":"crossref","first-page":"107","DOI":"10.5858\/arpa.2018-0508-RA","article-title":"Candida auris: an emerging yeast pathogen posing distinct challenges for laboratory diagnostics, treatment, and infection prevention","volume":"144","author":"Hata","year":"2020","journal-title":"Arch Pathol Lab Med"},{"key":"2025011616163744200_bib47","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.micres.2009.03.006","article-title":"Characterization of Hwp2, a Candida albicans putative GPI-anchored cell wall protein necessary for invasive growth","volume":"165","author":"Hayek","year":"2010","journal-title":"Microbiol Res"},{"key":"2025011616163744200_bib48","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1099\/mic.0.049395-0","article-title":"Hyphal induction in the human fungal pathogen Candida albicans reveals a characteristic wall protein profile","volume":"157","author":"Heilmann","year":"2011","journal-title":"Microbiology"},{"key":"2025011616163744200_bib49","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-1-0716-0270-6_3","article-title":"Using Dali for protein structure comparison","volume":"2112","author":"Holm","year":"2020","journal-title":"Methods Mol Biol"},{"key":"2025011616163744200_bib50","doi-asserted-by":"crossref","first-page":"e1011843","DOI":"10.1371\/journal.ppat.1011843","article-title":"Mechanisms of pathogenicity for the emerging fungus Candida auris","volume":"19","author":"Horton","year":"2023","journal-title":"PLoS Pathog"},{"key":"2025011616163744200_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13693780701435317","article-title":"Discovering the secrets of the Candida albicans agglutinin-like sequence (ALS) gene family\u2013a sticky pursuit","volume":"46","author":"Hoyer","year":"2008","journal-title":"Med Mycol"},{"key":"2025011616163744200_bib52","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s002030000218","article-title":"Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members","volume":"174","author":"Hube","year":"2000","journal-title":"Arch Microbiol"},{"key":"2025011616163744200_bib53","doi-asserted-by":"crossref","first-page":"e0354023","DOI":"10.1128\/spectrum.03540-23","article-title":"Emergence of the novel sixth Candida auris Clade VI in Bangladesh","volume":"12","author":"Khan","year":"2024","journal-title":"Microbiol Spectr"},{"key":"2025011616163744200_bib54","doi-asserted-by":"crossref","first-page":"836632","DOI":"10.3389\/fcimb.2022.836632","article-title":"Peering into Candida albicans Pir protein function and comparative genomics of the Pir family","volume":"12","author":"Kim","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"2025011616163744200_bib55","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1567-1364.2009.00541.x","article-title":"Covalently linked cell wall proteins of Candida albicans and their role in fitness and virulence","volume":"9","author":"Klis","year":"2009","journal-title":"FEMS Yeast Res"},{"key":"2025011616163744200_bib56","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.cmi.2019.04.024","article-title":"Morbidity and mortality of candidaemia in Europe: an epidemiologic meta-analysis","volume":"25","author":"Koehler","year":"2019","journal-title":"Clin Microbiol Infect"},{"key":"2025011616163744200_bib57","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1567-1364.2011.00727.x","article-title":"Pga26 mediates filamentation and biofilm formation and is required for virulence in Candida albicans","volume":"11","author":"Laforet","year":"2011","journal-title":"FEMS Yeast Res"},{"key":"2025011616163744200_bib58","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41572-024-00503-3","article-title":"Invasive candidiasis","volume":"10","author":"Lass-Florl","year":"2024","journal-title":"Nat Rev Dis Primers"},{"key":"2025011616163744200_bib59","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1128\/MMBR.00038-05","article-title":"Cell wall assembly in Saccharomyces cerevisiae","volume":"70","author":"Lesage","year":"2006","journal-title":"Microbiol Mol Biol Rev"},{"key":"2025011616163744200_bib60","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3767\/persoonia.2024.52.02","article-title":"Phylogenomic analysis of the Candida auris\u2013Candida haemuli clade and related taxa in the Metschnikowiaceae, and proposal of thirteen new genera, fifty-five new combinations and nine new species","volume":"52","author":"Liu","year":"2024","journal-title":"Persoonia"},{"key":"2025011616163744200_bib61","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/s41579-023-00960-9","article-title":"The rapid emergence of antifungal-resistant human-pathogenic fungi","volume":"21","author":"Lockhart","year":"2023","journal-title":"Nat Rev Micro"},{"key":"2025011616163744200_bib62","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/cid\/ciw691","article-title":"Simultaneous emergence of multidrug-resistant Candida auris on 3 continents confirmed by whole-genome sequencing and epidemiological analyses","volume":"64","author":"Lockhart","year":"2017","journal-title":"Clin Infect Dis"},{"key":"2025011616163744200_bib63","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41592-022-01488-1","article-title":"ColabFold: making protein folding accessible to all","volume":"19","author":"Mirdita","year":"2022","journal-title":"Nat Methods"},{"key":"2025011616163744200_bib64","doi-asserted-by":"crossref","first-page":"e82395","DOI":"10.1371\/journal.pone.0082395","article-title":"Rbt1 protein domains analysis in Candida albicans brings insights into hyphal surface modifications and Rbt1 potential role during adhesion and biofilm formation","volume":"8","author":"Monniot","year":"2013","journal-title":"PLoS One"},{"key":"2025011616163744200_bib65","doi-asserted-by":"crossref","first-page":"205921","DOI":"10.1155\/2012\/205921","article-title":"Candida albicans versus Candida dubliniensis: why is C. albicans more pathogenic?","volume":"2012","author":"Moran","year":"2012","journal-title":"Int J Microbiol"},{"key":"2025011616163744200_bib66","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3390\/pathogens10040493","article-title":"High biofilm formation of non-smooth Candida parapsilosis correlates with increased incorporation of gpi-modified wall adhesins","volume":"10","author":"Moreno-Martinez","year":"2021","journal-title":"Pathogens"},{"key":"2025011616163744200_bib67","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1099\/mic.0.028902-0","article-title":"The GPI-modified proteins Pga59 and Pga62 of Candida albicans are required for cell wall integrity","volume":"155","author":"Moreno-Ruiz","year":"2009","journal-title":"Microbiology"},{"key":"2025011616163744200_bib68","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1038\/s41467-018-07779-6","article-title":"Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species","volume":"9","author":"Mu\u00f1oz","year":"2018","journal-title":"Nat Commun"},{"key":"2025011616163744200_bib69","doi-asserted-by":"crossref","first-page":"iyab029","DOI":"10.1093\/genetics\/iyab029","article-title":"Clade-specific chromosomal rearrangements and loss of subtelomeric adhesins in Candida auris","volume":"218","author":"Mu\u00f1oz","year":"2021","journal-title":"Genetics"},{"key":"2025011616163744200_bib70","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1128\/MMBR.67.3.400-428.2003","article-title":"Candida albicans secreted aspartyl proteinases in virulence and pathogenesis","volume":"67","author":"Naglik","year":"2003","journal-title":"Microbiol Mol Biol Rev"},{"key":"2025011616163744200_bib71","doi-asserted-by":"crossref","first-page":"e0305222","DOI":"10.1128\/mbio.03052-22","article-title":"Directed evolution detects supernumerary centric chromosomes conferring resistance to azoles in Candida auris","volume":"13","author":"Narayanan","year":"2022","journal-title":"mBio"},{"key":"2025011616163744200_bib72","doi-asserted-by":"crossref","first-page":"16156","DOI":"10.1038\/nmicrobiol.2016.156","article-title":"Structural basis of haem-iron acquisition by fungal pathogens","volume":"1","author":"Nasser","year":"2016","journal-title":"Nat Microbiol"},{"key":"2025011616163744200_bib73","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1046\/j.1439-0507.2001.00685.x","article-title":"Phospholipases of Candida albicans","volume":"44","author":"Niewerth","year":"2001","journal-title":"Mycoses"},{"key":"2025011616163744200_bib74","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.1099\/mic.0.26924-0","article-title":"PST1 and ECM33 encode two yeast cell surface GPI proteins important for cell wall integrity","volume":"150","author":"Pardo","year":"2004","journal-title":"Microbiology"},{"key":"2025011616163744200_bib75","doi-asserted-by":"crossref","first-page":"e1012076","DOI":"10.1371\/journal.ppat.1012076","article-title":"Candida auris undergoes adhesin-dependent and -independent cellular aggregation","volume":"20","author":"Pelletier","year":"2024","journal-title":"PLoS Pathog"},{"key":"2025011616163744200_bib76","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1093\/ofid\/ofy358","article-title":"Twenty years of the SENTRY antifungal surveillance program: results for Candida species from 1997-2016","volume":"6","author":"Pfaller","year":"2019","journal-title":"Open Forum Infect Dis"},{"key":"2025011616163744200_bib77","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.fgb.2008.08.003","article-title":"Functional analysis of Candida albicans GPI-anchored proteins: roles in cell wall integrity and caspofungin sensitivity","volume":"45","author":"Plaine","year":"2008","journal-title":"Fung Genet Biol"},{"key":"2025011616163744200_bib78","doi-asserted-by":"crossref","first-page":"e1009980","DOI":"10.1371\/journal.ppat.1009980","article-title":"A novel class of Candida glabrata cell wall proteins with \u03b2-helix fold mediates adhesion in clinical isolates","volume":"17","author":"Reithofer","year":"2021","journal-title":"PLoS Pathog"},{"key":"2025011616163744200_bib79","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.gene.2004.06.021","article-title":"The SAT1 flipper, an optimized tool for gene disruption in Candida albicans","volume":"341","author":"Reuss","year":"2004","journal-title":"Gene"},{"key":"2025011616163744200_bib80","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mib.2019.05.008","article-title":"Global epidemiology of emerging Candida auris","volume":"52","author":"Rhodes","year":"2019","journal-title":"Curr Opin Microbiol"},{"key":"2025011616163744200_bib81","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1128\/EC.00297-06","article-title":"Comprehensive analysis of glycosylphosphatidylinositol-anchored proteins in Candida albicans","volume":"6","author":"Richard","year":"2007","journal-title":"Eukaryotic Cell"},{"key":"2025011616163744200_bib82","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.ijmm.2018.06.014","article-title":"Molecular identification of Candida auris by PCR amplification of species-specific GPI protein-encoding genes","volume":"308","author":"Ruiz-Gait\u00e1n","year":"2018","journal-title":"Int J Med Microbiol"},{"key":"2025011616163744200_bib83","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1567-1364.2005.00017.x","article-title":"Molecular organization of the cell wall of Candida albicans and its relation to pathogenicity","volume":"6","author":"Ruiz-Herrera","year":"2006","journal-title":"FEMS Yeast Res"},{"key":"2025011616163744200_bib84","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1126\/science.adf8972","article-title":"A Candida auris-specific adhesin, Scf1, governs surface association, colonization, and virulence","volume":"381","author":"Santana","year":"2023","journal-title":"Science"},{"key":"2025011616163744200_bib85","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1074\/jbc.RA119.011084","article-title":"Copper-only superoxide dismutase enzymes and iron starvation stress in Candida fungal pathogens","volume":"295","author":"Schatzman","year":"2020","journal-title":"J Biol Chem"},{"key":"2025011616163744200_bib86","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1128\/EC.00210-10","article-title":"Proteolytic cleavage of covalently linked cell wall proteins by Candida albicans Sap9 and Sap10","volume":"10","author":"Schild","year":"2011","journal-title":"Euk Cell"},{"key":"2025011616163744200_bib87","doi-asserted-by":"crossref","first-page":"e00722","DOI":"10.1128\/genomeA.00722-15","article-title":"Draft genome sequence of a fluconazole-resistant Candida auris strain from a candidemia patient in India","volume":"3","author":"Sharma","year":"2015","journal-title":"Genome Announc"},{"key":"2025011616163744200_bib88","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3201\/eid2302.161320","article-title":"Biofilm-forming capability of highly virulent, multidrug-resistant Candida auris","volume":"23","author":"Sherry","year":"2017","journal-title":"Emerg Infect Dis"},{"key":"2025011616163744200_bib89","doi-asserted-by":"crossref","first-page":"e00973","DOI":"10.1128\/mSphere.00973-20","article-title":"The two-component response regulator ssk1 and the mitogen-activated protein kinase Hog1 control antifungal drug resistance and cell wall architecture of Candida auris","volume":"5","author":"Shivarathri","year":"2020","journal-title":"mSphere"},{"key":"2025011616163744200_bib90","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/myc.12947","article-title":"Biofilm formation by Candida auris isolated from colonising sites and candidemia cases","volume":"62","author":"Singh","year":"2019","journal-title":"Mycoses"},{"key":"2025011616163744200_bib91","doi-asserted-by":"crossref","first-page":"iyad024","DOI":"10.1093\/genetics\/iyad024","article-title":"Parallel expansion and divergence of an adhesin family in pathogenic yeasts","volume":"223","author":"Smoak","year":"2023","journal-title":"Genetics"},{"key":"2025011616163744200_bib92","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1128\/EC.05011-11","article-title":"Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans","volume":"10","author":"Sorgo","year":"2011","journal-title":"Euk Cell"},{"key":"2025011616163744200_bib93","first-page":"1799","article-title":"The yeast genus tardiomyces gen. nov. With one new species and two new combinations","volume-title":"Infection","author":"Spruijtenburg","year":"2024"},{"key":"2025011616163744200_bib94","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1046\/j.1462-5822.2002.00206.x","article-title":"Adhesion in Candida spp","volume":"4","author":"Sundstrom","year":"2002","journal-title":"Cell Microbiol"},{"key":"2025011616163744200_bib95","doi-asserted-by":"crossref","first-page":"100878","DOI":"10.1016\/S2666-5247(24)00101-0","article-title":"Detection and characterisation of a sixth Candida auris clade in Singapore: a genomic and phenotypic study","volume":"5","author":"Suphavilai","year":"2024","journal-title":"Lancet Microbe"},{"key":"2025011616163744200_bib96","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1080\/13693780802206435","article-title":"Adherence mechanisms in human pathogenic fungi","volume":"46","author":"Tronchin","year":"2008","journal-title":"Med Mycol"},{"key":"2025011616163744200_bib97","doi-asserted-by":"crossref","first-page":"e36952","DOI":"10.1371\/journal.pone.0036952","article-title":"Candida albicans-epithelial interactions: dissecting the roles of active penetration, induced endocytosis and host factors on the infection process","volume":"7","author":"Wachtler","year":"2012","journal-title":"PLoS One"},{"key":"2025011616163744200_bib98","doi-asserted-by":"crossref","first-page":"9212","DOI":"10.1038\/s41467-024-53588-5","article-title":"Functional redundancy in Candida auris cell surface adhesins crucial for cell\u2013cell interaction and aggregation","volume":"15","author":"Wang","year":"2024","journal-title":"Nat Commun"},{"key":"2025011616163744200_bib99","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1038\/s41467-022-31201-x","article-title":"Innate immune responses against the fungal pathogen Candida auris","volume":"13","author":"Wang","year":"2022","journal-title":"Nat Commun"},{"key":"2025011616163744200_bib100","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1128\/JCM.00921-17","article-title":"Survival, persistence, and isolation of the emerging multidrug-resistant pathogenic yeast Candida auris on a plastic health care surface","volume":"55","author":"Welsh","year":"2017","journal-title":"J Clin Microbiol"},{"key":"2025011616163744200_bib101","doi-asserted-by":"crossref","first-page":"e00007","DOI":"10.1128\/JCM.00007-19","article-title":"Insights into the unique nature of the east asian clade of the emerging pathogenic yeast Candida auris","volume":"57","author":"Welsh","year":"2019","journal-title":"J Clin Microbiol"},{"key":"2025011616163744200_bib102","article-title":"WHO fungal priority pathogens list to guide research, development and public health action","author":"World Health Organization","year":"2022"},{"key":"2025011616163744200_bib103","doi-asserted-by":"crossref","first-page":"20894","DOI":"10.1074\/jbc.M500334200","article-title":"Comprehensive proteomic analysis of Saccharomyces cerevisiae cell walls: identification of proteins covalently attached via glycosylphosphatidylinositol remnants or mild alkali-sensitive linkages","volume":"280","author":"Yin","year":"2005","journal-title":"J Biol Chem"},{"key":"2025011616163744200_bib104","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41426-018-0187-x","article-title":"Filamentation in Candida auris, an emerging fungal pathogen of humans: passage through the mammalian body induces a heritable phenotypic switch","volume":"7","author":"Yue","year":"2018","journal-title":"Emerg Microbes Infect"}],"container-title":["FEMS Yeast Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/femsyr\/advance-article-pdf\/doi\/10.1093\/femsyr\/foae039\/60952472\/foae039.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/femsyr\/article-pdf\/doi\/10.1093\/femsyr\/foae039\/60952472\/foae039.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/femsyr\/article-pdf\/doi\/10.1093\/femsyr\/foae039\/60952472\/foae039.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T11:17:29Z","timestamp":1737026249000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femsyr\/article\/doi\/10.1093\/femsyr\/foae039\/7916657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":104,"URL":"https:\/\/doi.org\/10.1093\/femsyr\/foae039","relation":{},"ISSN":["1567-1364"],"issn-type":[{"value":"1567-1364","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024]]},"published":{"date-parts":[[2024]]},"article-number":"foae039"}}