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The homologs of the Saccharomyces cerevisiae SNQ2 and PDR18 genes were identified in 171 yeast genomes, representing 68 different hemiascomycetous species. All early-divergent yeast species analyzed in this work lack Snq2\/Pdr18 homologs, suggesting that the origin of these ABC-PDR genes in hemiascomycete yeasts resulted from a horizontal transfer event. The evolutionary pathway of the Snq2\/Pdr18 protein subfamily in pathogenic Candida species was also reconstructed, revealing a main gene lineage leading to the Candida albicans SNQ2 gene. The results indicate that, after the gene duplication event at the origin of the SNQ2\/PDR18 paralogs, the PDR18 ortholog has been under strong diversifying selection and suggest that a small portion of the sequence of the SNQ2 ancestral ortholog might have been under mild positive selection. The results also showed that strong positive selection was exerted over one of the two paralogs generated by the Whole Genome Duplication (WGD) event, corresponding to the duplicate at the origin of a \u201cshort-lived\u201d WGD sublineage.<\/jats:p>","DOI":"10.1093\/femsyr\/foaf026","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T19:17:24Z","timestamp":1748373444000},"source":"Crossref","is-referenced-by-count":1,"title":["Molecular evolution of the members of the Snq2\/Pdr18 subfamily of Pdr transporters in the Hemiascomycete yeasts"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9846-6567","authenticated-orcid":false,"given":"Paulo Jorge","family":"Dias","sequence":"first","affiliation":[{"name":"iBB\u2014Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, University of Lisbon , 1049-001 Lisboa ,","place":["Portugal"]},{"name":"Associate Laboratory i4HB\u2014Institute for Health 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