{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:51:05Z","timestamp":1790178665497,"version":"4.1.0"},"reference-count":184,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":236,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Greenhouse gases drive climate change, which leads to less productive farmland and diminishing food security. Fossil oil, which is used for transport fuels and for manufacturing plastics, synthetic fabrics and other everyday products, is a major contributor to climate change. Significant greenhouse gas abatement can be achieved by replacing fossil oil with renewable biofuels. Bioethanol is proven as a road transport fuel and has potential to be converted into sustainable aviation fuel and chemicals currently made from oil. First-generation (1G) bioethanol is produced by yeast fermentation of six-carbon sugars from food crops, and it represents the major biofuel by volume. A growing second-generation (2G) industry produces bioethanol via yeast fermentation of six- and five-carbon lignocellulosic sugars. This article considers yeast-dependent aspects of 1G and 2G technologies. Critical phenotypes essential for bioethanol processes are reviewed along with classical and molecular genetic strategies for yeast strain improvements. Bioethanol production needs to be increased substantially to approach full fossil oil replacement. The future for bioethanol and the role of yeasts in mitigating climate change and improving land-use are discussed in terms of third- and fourth-generation bioethanol, and multiproduct Power-to-X biorefineries that include potential for carbon dioxide fixation by yeasts.<\/jats:p>","DOI":"10.1093\/femsyr\/foaf044","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T11:41:44Z","timestamp":1755862904000},"source":"Crossref","is-referenced-by-count":7,"title":["Perspectives on current and future yeast technologies for ethanol-based biofuels and bioproducts"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0862-2384","authenticated-orcid":false,"given":"Paul V","family":"Attfield","sequence":"first","affiliation":[{"name":"Microbiogen Pty Ltd. , Macquarie Park, NSW 2113 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Boyd","sequence":"additional","affiliation":[{"name":"Microbiogen Pty Ltd. , Macquarie Park, NSW 2113 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Purkovic","sequence":"additional","affiliation":[{"name":"Microbiogen Pty Ltd. , Macquarie Park, NSW 2113 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woon Siew","family":"Ng","sequence":"additional","affiliation":[{"name":"Microbiogen Pty Ltd. , Macquarie Park, NSW 2113 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Psyche","family":"Arcenal","sequence":"additional","affiliation":[{"name":"Microbiogen Pty Ltd. , Macquarie Park, NSW 2113 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich","family":"Kroukamp","sequence":"additional","affiliation":[{"name":"Microbiogen Pty Ltd. , Macquarie Park, NSW 2113 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J L","family":"Bell","sequence":"additional","affiliation":[{"name":"Microbiogen Pty Ltd. , Macquarie Park, NSW 2113 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"2026071609022889500_bib1","author":"Abdelilah","year":"2020","journal-title":"Renewables 2020: Analysis and Forecast to 2025"},{"key":"2026071609022889500_bib2","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1590\/S1517-83822013000300001","article-title":"Solving ethanol production problems with genetically modified yeast strains","volume":"44","author":"Abreu-Cavalheiro","year":"2014","journal-title":"Braz J Microbiol"},{"key":"2026071609022889500_bib3","doi-asserted-by":"publisher","first-page":"9152","DOI":"10.3390\/su12219152","article-title":"Projection of greenhouse gas emissions for the road transport sector based on multivariate regression and the double exponential smoothing model","volume":"12","author":"Alhindawi","year":"2020","journal-title":"Sustainability"},{"key":"2026071609022889500_bib4","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1754-6834-3-2","article-title":"Furfural induces reactive oxygen species accumulation and cellular damage in Saccharomyces cerevisiae","volume":"3","author":"Allen","year":"2010","journal-title":"Biotechnol Biofuels"},{"key":"2026071609022889500_bib5","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1002\/jctb.1676","article-title":"Increased tolerance and conversion of inhibitors in lignocellulosic hydrolysates by Saccharomyces cerevisiae","volume":"82","author":"Almeida","year":"2007","journal-title":"J Chem Tech Biotech"},{"key":"2026071609022889500_bib6","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1126\/science.1131969","article-title":"Engineering yeast transcription machinery for improved ethanol tolerance and production","volume":"314","author":"Alper","year":"2006","journal-title":"Science"},{"key":"2026071609022889500_bib7","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s13280-015-0730-0","article-title":"From first generation biofuels to advanced solar biofuels","volume":"45","author":"Aro","year":"2016","journal-title":"Ambio"},{"key":"2026071609022889500_bib8","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1186\/s13068-019-1597-2","article-title":"Saccharomyces cerevisiae exhibiting a modified route for uptake and catabolism of glycerol forms significant amounts of ethanol from this carbon source considered as \u2018non-fermentable","volume":"12","author":"A\u00dfkamp","year":"2019","journal-title":"Biotechnol Biofuels"},{"key":"2026071609022889500_bib9","doi-asserted-by":"publisher","first-page":"633","DOI":"10.3390\/fermentation9070633","article-title":"Reducing carbon intensity of food and fuel production whilst lowering land-use impacts of biofuels","volume":"9","author":"Attfield","year":"2023","journal-title":"Fermentation"},{"key":"2026071609022889500_bib10","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1111\/j.1567-1364.2006.00098.x","article-title":"Use of population genetics to derive non-recombinant Saccharomyces cerevisiae that grow using xylose as a sole carbon source","volume":"6","author":"Attfield","year":"2006","journal-title":"FEMS Yeast Res"},{"key":"2026071609022889500_bib11","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1080\/07388551.2022.2072268","article-title":"Crucial aspects of metabolism and cell biology relating to industrial production and processing of Saccharomyces biomass","volume":"43","author":"Attfield","year":"2023","journal-title":"Crit Rev Biotechnol"},{"key":"2026071609022889500_bib12","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.bbrep.2017.03.003","article-title":"Yeasts in sustainable bioethanol production: a review","volume":"10","author":"Azhar","year":"2017","journal-title":"Biochem Biophys Rep"},{"key":"2026071609022889500_bib13","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1038\/s41598-017-01141-4","article-title":"The yeast osmostress response is carbon source dependent","volume":"7","author":"Babazadeh","year":"2017","journal-title":"Sci Rep"},{"key":"2026071609022889500_bib14","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1111\/j.1567-1364.2008.00428.x","article-title":"Yeast selection for fuel ethanol production in Brazil","volume":"8","author":"Basso","year":"2008","journal-title":"FEMS Yeast Res"},{"key":"2026071609022889500_bib15","article-title":"Ethanol production in Brazil: the industrial process and its impact on\u00a0yeast fermentation","volume-title":"Biofuel Production\u2014Recent Developments and Prospects","author":"Basso","year":"2011"},{"key":"2026071609022889500_bib16","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.ymben.2011.09.005","article-title":"Engineering topology and kinetics of sucrose metabolism in Saccharomyces cerevisiae for improved ethanol yield","volume":"13","author":"Basso","year":"2011","journal-title":"Metab Eng"},{"key":"2026071609022889500_bib17","doi-asserted-by":"publisher","first-page":"e2211827119","DOI":"10.1073\/pnas.2211827119","article-title":"Conversion of CO2 into organic acids by engineered autotrophic yeast","volume":"119","author":"Baumschabl","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026071609022889500_bib18","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s12041-017-0825-4","article-title":"A Haldane perspective from a Fisher student","volume":"96","author":"Bodmer","year":"2017","journal-title":"J Genet"},{"key":"2026071609022889500_bib19","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1574-6976.1997.tb00346.x","article-title":"The molecular genetics of hexose transport in yeasts","volume":"21","author":"Boles","year":"1997","journal-title":"FEMS Microbiol Rev"},{"key":"2026071609022889500_bib20","article-title":"Life cycle assessment of ethanol production from bagasse using MicroBioGen yeast strains","author":"Bontinck","year":"2021"},{"key":"2026071609022889500_bib21","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s00253-021-11710-3","article-title":"Adaptation of Saccharomyces cerevisiae in a concentrated spent sulphite liquor waste stream for increased inhibitor resistance","volume":"106","author":"Brandt","year":"2022","journal-title":"Appl Microbiol Biotechnol"},{"key":"2026071609022889500_bib22","doi-asserted-by":"publisher","first-page":"6465","DOI":"10.1128\/AEM.71.11.6465-6472.2005","article-title":"Improvement of galactose uptake in Saccharomyces cerevisiae through overexpression of phosphoglucomutase: example of transcript analysis as a tool in inverse metabolic engineering","volume":"71","author":"Bro","year":"2005","journal-title":"Appl Environ Microb"},{"key":"2026071609022889500_bib23","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1534\/genetics.111.135731","article-title":"Nutritional control of growth and development in yeast","volume":"192","author":"Broach","year":"2012","journal-title":"Genetics"},{"key":"2026071609022889500_bib24","doi-asserted-by":"publisher","first-page":"13069","DOI":"10.1038\/s41598-018-31558-4","article-title":"Enhancement of ethanol production in very high gravity fermentation by reducing fermentation-induced oxidative stress in Saccharomyces cerevisiae","volume":"8","author":"Burphan","year":"2018","journal-title":"Sci Rep"},{"key":"2026071609022889500_bib25","doi-asserted-by":"publisher","first-page":"114766","DOI":"10.1016\/j.jenvman.2022.114766","article-title":"Managing upstream oil and gas emissions: a public health oriented approach","volume":"310","author":"Calderon","year":"2022","journal-title":"J Environ Manage"},{"key":"2026071609022889500_bib27","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1002\/ejlt.201100032","article-title":"Replacing fossil oil with fresh oil\u2014with what and for what?","volume":"113","author":"Carlsson","year":"2011","journal-title":"Euro J Lipid Sci Tech"},{"key":"2026071609022889500_bib28","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3109\/10408418609108739","article-title":"Ethanol tolerance in yeasts","volume":"13","author":"Casey","year":"1986","journal-title":"CRC Crit Rev Microbiol"},{"key":"2026071609022889500_bib29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fbioe.2015.00184","article-title":"Modifying yeast tolerance to inhibitory conditions of ethanol production processes","volume":"3","author":"Caspeta","year":"2015","journal-title":"Front Bioeng Biotechnol"},{"key":"2026071609022889500_bib30","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1126\/science.1258137","article-title":"Biofuels. Altered sterol composition renders yeast thermotolerant","volume":"346","author":"Caspeta","year":"2014","journal-title":"Science"},{"key":"2026071609022889500_bib31","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1002\/bbb.2250","article-title":"Yeast immobilization systems for second-generation ethanol production: actual trends and future perspectives","volume":"15","author":"Chac\u00f3n-Navarrete","year":"2021","journal-title":"Biofuels Bioprod Bioref"},{"key":"2026071609022889500_bib32","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.biotechadv.2007.04.001","article-title":"Genetic improvement of Saccharomyces cerevisiae for xylose fermentation","volume":"25","author":"Chu","year":"2007","journal-title":"Biotechnol Adv"},{"key":"2026071609022889500_bib33","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.ymben.2020.02.004","article-title":"Simultaneous secretion of seven lignocellulolytic enzymes by an industrial second-generation yeast strain enables efficient ethanol production from multiple polymeric substrates","volume":"59","author":"Claes","year":"2020","journal-title":"Metab Eng"},{"key":"2026071609022889500_bib34","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1111\/1574-6976.12065","article-title":"Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae","volume":"38","author":"Conrad","year":"2014","journal-title":"FEMS Microbiol Rev"},{"key":"2026071609022889500_bib35","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1186\/s13068-019-1541-5","article-title":"Construction of industrial Saccharomyces cerevisiae strains for the efficient consolidated bioprocessing of raw starch","volume":"12","author":"Cripwell","year":"2019","journal-title":"Biotechnol Biofuels"},{"key":"2026071609022889500_bib36","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1080\/21655979.2020.1801178","article-title":"Engineered Saccharomyces cerevisiae for lignocellulosic valorization: a review and perspectives on bioethanol production","volume":"11","author":"Cunha","year":"2020","journal-title":"Bioengineered"},{"key":"2026071609022889500_bib37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/7878830","article-title":"Current ethanol production requirements for the yeast Saccharomyces cerevisiae","volume":"2022","author":"da","year":"2022","journal-title":"Int J Microbiol"},{"key":"2026071609022889500_bib38","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.fob.2014.02.004","article-title":"Similarities and differences in the biochemical and enzymological properties of the four isomaltases from Saccharomyces cerevisiae","volume":"4","author":"Deng","year":"2014","journal-title":"FEBS Open Bio"},{"key":"2026071609022889500_bib39","first-page":"95","article-title":"Biostil, a continuous fermentation distillation system","volume":"15","author":"Deodhar","year":"1990","journal-title":"Bharatiya Sugar"},{"key":"2026071609022889500_bib40","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1080\/21655979.2022.2095702","article-title":"A panoramic view of technological landscape for bioethanol production from various generations of feedstocks","volume":"14","author":"Devi","year":"2023","journal-title":"Bioengineered"},{"key":"2026071609022889500_bib41","doi-asserted-by":"publisher","first-page":"6392","DOI":"10.1038\/sj.onc.1209884","article-title":"Cell growth control: little eukaryotes make big contributions","volume":"25","author":"De\u00a0Virgilio","year":"2006","journal-title":"Oncogene"},{"key":"2026071609022889500_bib42","doi-asserted-by":"publisher","first-page":"110149","DOI":"10.1016\/j.celrep.2021.110149","article-title":"Phosphoproteomic responses of TORC1 target kinases reveal discrete and convergent mechanisms that orchestrate the quiescence program in yeast","volume":"37","author":"Dokl\u00e1dal","year":"2021","journal-title":"Cell Rep"},{"key":"2026071609022889500_bib43","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1038\/s41467-018-05106-7","article-title":"The origin and adaptive evolution of domesticated populations of yeast from Far East Asia","volume":"9","author":"Duan","year":"2018","journal-title":"Nat Commun"},{"key":"2026071609022889500_bib44","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41570-019-0084-4","article-title":"Chemistries and processes for the conversion of ethanol into middle-distillate fuels","volume":"3","author":"Eagan","year":"2019","journal-title":"Nat Rev Chem"},{"key":"2026071609022889500_bib45","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.91565","article-title":"Bioethanol production: an overview","volume-title":"Bioethanol Technologies","author":"Edeh","year":"2021"},{"key":"2026071609022889500_bib46","doi-asserted-by":"publisher","first-page":"3381","DOI":"10.1128\/AEM.66.8.3381-3386.2000","article-title":"Anaerobic xylose fermentation by recombinant Saccharomyces cerevisiae carrying XYL1, XYL2, and XKS1 in mineral medium chemostat cultures","volume":"66","author":"Eliasson","year":"2000","journal-title":"Appl Environ Microb"},{"key":"2026071609022889500_bib47","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.copbio.2017.07.017","article-title":"A short history of RubisCO: the rise and fall (?) of Nature's predominant CO2 fixing enzyme","volume":"49","author":"Erb","year":"2018","journal-title":"Curr Opin Biotechnol"},{"key":"2026071609022889500_bib48","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1574-6976.2000.tb00551.x","article-title":"Stress-controlled transcription factors, stress-induced genes and stress tolerance in budding yeast","volume":"24","author":"Estruch","year":"2000","journal-title":"FEMS Microbiol Rev"},{"key":"2026071609022889500_bib49","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3389\/fonc.2012.00064","article-title":"Oxidative stress and programmed cell death in yeast","volume":"2","author":"Farrugia","year":"2012","journal-title":"Front Oncol"},{"key":"2026071609022889500_bib50","doi-asserted-by":"publisher","first-page":"90","DOI":"10.15698\/mic2024.03.818","article-title":"The cAMP-PKA signalling crosstalks with CWI and HOG-MAPK pathways in yeast cell response to osmotic and thermal stress","volume":"11","author":"Galello","year":"2024","journal-title":"Microb Cell"},{"key":"2026071609022889500_bib51","doi-asserted-by":"publisher","first-page":"3754","DOI":"10.1099\/mic.0.041673-0","article-title":"FSY1, a horizontally transferred gene in the Saccharomyces cerevisiae EC1118 wine yeast strain, encodes a high-affinity fructose\/H+ symporter","volume":"156","author":"Galeote","year":"2010","journal-title":"Microbiology"},{"key":"2026071609022889500_bib52","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1754-6834-3-13","article-title":"Improved xylose and arabinose utilization by an industrial recombinant Saccharomyces cerevisiae strain using evolutionary engineering","volume":"3","author":"Garcia-Sanchez","year":"2010","journal-title":"Biotechnol Biofuels"},{"key":"2026071609022889500_bib53","doi-asserted-by":"publisher","first-page":"4241","DOI":"10.1091\/mbc.11.12.4241","article-title":"Genomic expression programs in the response of yeast cells to environmental changes","volume":"11","author":"Gasch","year":"2000","journal-title":"Mol Biol Cell"},{"key":"2026071609022889500_bib54","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/s41587-019-0363-0","article-title":"The industrial yeast Pichia pastoris is converted from a heterotroph into an autotroph capable of growth on CO2","volume":"38","author":"Gassler","year":"2020","journal-title":"Nat Biotechnol"},{"key":"2026071609022889500_bib55","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1101\/gr.5750507","article-title":"Refinement and expansion of signaling pathways: the osmotic response network in yeast","volume":"17","author":"Gat-Viks","year":"2007","journal-title":"Genome Res"},{"key":"2026071609022889500_bib56","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.copbio.2014.12.012","article-title":"Improving conversion yield of fermentable sugars into fuel ethanol in 1st generation yeast-based production processes","volume":"33","author":"Gombert","year":"2015","journal-title":"Curr Opin Biotechnol"},{"key":"2026071609022889500_bib57","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/s13068-016-0583-1","article-title":"A new laboratory evolution approach to select for constitutive acetic acid tolerance in Saccharomyces cerevisiae and identification of causal mutations","volume":"9","author":"Gonz\u00e1lez-Ramos","year":"2016","journal-title":"Biotechnol Biofuels"},{"key":"2026071609022889500_bib58","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1186\/s13068-019-1610-9","article-title":"Physiological mechanism of improved tolerance of Saccharomyces cerevisiae to lignin-derived phenolic acids in lignocellulosic ethanol fermentation by short-term adaptation","volume":"12","author":"Gu","year":"2019","journal-title":"Biotechnol Biofuels"},{"key":"2026071609022889500_bib59","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1754-6834-6-125","article-title":"Carbon dioxide fixation by Calvin- Cycle enzymes improves ethanol yield in yeast","volume":"6","author":"Guadalupe-Medina","year":"2013","journal-title":"Biotechnol Biofuels"},{"key":"2026071609022889500_bib60","doi-asserted-by":"publisher","first-page":"264","DOI":"10.3390\/jof9020264","article-title":"Renewing lost genetic variability with a classical yeast genetics approach","volume":"9","author":"Gupte","year":"2023","journal-title":"J Fungi"},{"key":"2026071609022889500_bib61","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1111\/1462-2920.12866","article-title":"Surviving the heat: heterogeneity of response in Saccharomyces cerevisiae provides insight into thermal damage to the membrane","volume":"17","author":"Guyot","year":"2015","journal-title":"Environ Microbiol"},{"key":"2026071609022889500_bib62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fgene.2019.00998","article-title":"Mapping ethanol tolerance in budding yeast reveals high genetic variation in a wild isolate","volume":"10","author":"Haas","year":"2019","journal-title":"Front Genet"},{"key":"2026071609022889500_bib63","doi-asserted-by":"publisher","first-page":"88","DOI":"10.2516\/ogst\/2019061","article-title":"Is the oil industry able to support a world that consumes 105 million barrels of oil per day in 2025?","volume":"74","author":"Hacquard","year":"2019","journal-title":"Oil Gas Sci Technol\u2014Rev IFP Energies Nouvelles"},{"key":"2026071609022889500_bib64","article-title":"A market analysis for the supply of second-generation ethanol in Australia using\u00a0Microbiogen's technology","author":"Hallam","year":"2021"},{"key":"2026071609022889500_bib65","doi-asserted-by":"publisher","first-page":"631250","DOI":"10.3389\/fmicb.2021.631250","article-title":"Adaptive gene content and allele distribution variations in the wild and domesticated populations of Saccharomyces cerevisiae","volume":"12","author":"Han","year":"2021","journal-title":"Front Microbiol"},{"key":"2026071609022889500_bib66","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.biortech.2008.05.027","article-title":"Pretreatments to enhance the digestibility of lignocellulosic biomass","volume":"100","author":"Hendriks","year":"2009","journal-title":"Bioresour Technol"},{"key":"2026071609022889500_bib67","doi-asserted-by":"publisher","first-page":"8108","DOI":"10.1128\/AEM.01689-15","article-title":"Increasing anaerobic acetate consumption and ethanol yields in Saccharomyces cerevisiae with NADPH-specific alcohol dehydrogenase","volume":"81","author":"Henningsen","year":"2015","journal-title":"Appl Environ Microb"},{"key":"2026071609022889500_bib68","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1042\/BST20150146","article-title":"Genome-scale modelling of microbial metabolism with temporal and spatial resolution","volume":"43","author":"Henson","year":"2015","journal-title":"Biochem Soc Trans"},{"key":"2026071609022889500_bib69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1534\/genetics.112.147850","article-title":"Applications of population genetics to animal breeding, from Wright, Fisher and Lush to genomic prediction","volume":"196","author":"Hill","year":"2014","journal-title":"Genetics"},{"key":"2026071609022889500_bib70","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1128\/AEM.64.5.1852-1859.1998","article-title":"Genetically engineered Saccharomyces yeast capable of effective cofermentation of glucose and xylose","volume":"64","author":"Ho","year":"1998","journal-title":"Appl Environ Microb"},{"key":"2026071609022889500_bib71","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1186\/s13068-021-02059-w","article-title":"Massive QTL analysis identifies pleiotropic genetic determinants for stress resistance, aroma formation, and ethanol, glycerol and isobutanol production in Saccharomyces cerevisiae","volume":"14","author":"Ho","year":"2021","journal-title":"Biotechnol Biofuels"},{"key":"2026071609022889500_bib72","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1128\/MMBR.66.2.300-372.2002","article-title":"Osmotic stress signaling and osmoadaptation in yeasts","volume":"66","author":"Hohmann","year":"2002","journal-title":"Microbiol Mol Biol Rev"},{"key":"2026071609022889500_bib73","doi-asserted-by":"publisher","first-page":"3158","DOI":"10.1128\/aem.62.9.3158-3164.1996","article-title":"Activity of the plasma membrane H+-ATPase and optimal glycolytic flux are required for rapid adaptation and growth of Saccharomyces cerevisiae in the presence of the weak-acid preservative sorbic acid","volume":"62","author":"Holyoak","year":"1996","journal-title":"Appl Environ Microb"},{"key":"2026071609022889500_bib74","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1534\/genetics.106.065292","article-title":"Genetic dissection of ethanol tolerance in the budding yeast Saccharomyces cerevisiae","volume":"175","author":"Hu","year":"2007","journal-title":"Genetics"},{"key":"2026071609022889500_bib75","doi-asserted-by":"publisher","first-page":"e41336","DOI":"10.1371\/journal.pone.0041336","article-title":"An infinitesimal model for quantitative trait genomic value prediction","volume":"7","author":"Hu","year":"2012","journal-title":"PLoS One"},{"key":"2026071609022889500_bib76","doi-asserted-by":"publisher","first-page":"7486","DOI":"10.1016\/j.biortech.2011.05.008","article-title":"Identification of crucial yeast inhibitors in bio-ethanol and improvement of fermentation at high pH and high total solids","volume":"102","author":"Huang","year":"2011","journal-title":"Bioresour Technol"},{"key":"2026071609022889500_bib77","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1534\/genetics.114.168369","article-title":"State transitions in the TORC1 signaling pathway and information processing in Saccharomyces cerevisiae","volume":"198","author":"Hughes\u00a0Hallett","year":"2014","journal-title":"Genetics"},{"key":"2026071609022889500_bib78","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1128\/AEM.02797-12","article-title":"Biomass conversion inhibitors furfural and 5-hydroxymethylfurfural induce formation of messenger RNP granules and attenuate translation activity in Saccharomyces cerevisiae","volume":"79","author":"Iwaki","year":"2013","journal-title":"Appl Environ Microb"},{"key":"2026071609022889500_bib79","doi-asserted-by":"crossref","first-page":"644089","DOI":"10.3389\/fmicb.2021.644089","article-title":"Comparative genomics supports that Brazilian bioethanol Saccharomyces cerevisiae comprise a unified group of domesticated strains related to cacha\u00e7a spirit yeasts","volume":"12","author":"Jacobus","year":"2021","journal-title":"Front Microbiol"},{"key":"2026071609022889500_bib80","doi-asserted-by":"publisher","first-page":"fox044","DOI":"10.1093\/femsyr\/fox044","article-title":"Saccharomyces cerevisiae strains for second-generation ethanol production: from academic exploration to industrial implementation","volume":"17","author":"Jansen","year":"2017","journal-title":"FEMS Yeast Res"},{"key":"2026071609022889500_bib81","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s00253-003-1450-0","article-title":"Metabolic engineering for improved fermentation of pentoses by yeasts","volume":"63","author":"Jeffries","year":"2004","journal-title":"Appl Microbiol Biotechnol"},{"key":"2026071609022889500_bib82","doi-asserted-by":"publisher","first-page":"20200351","DOI":"10.1098\/rspa.2020.0351","article-title":"Environmental sustainability of biofuels: a review","volume":"476","author":"Jeswani","year":"2020","journal-title":"Proc R Soc A"},{"key":"2026071609022889500_bib83","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12934-025-02663-7","article-title":"Response mechanism of ethanol-tolerant Saccharomyces cerevisiae strain ES-42 to increased ethanol during continuous ethanol fermentation","volume":"24","author":"Ji","year":"2025","journal-title":"Microb Cell Fact"},{"key":"2026071609022889500_bib84","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.apenergy.2018.05.076","article-title":"Is it really the end of internal combustion engines and petroleum in transport?","volume":"225","author":"Kalghatgi","year":"2018","journal-title":"Appl Energy"},{"key":"2026071609022889500_bib85","article-title":"Yield remains key to determining profitability","author":"Kelsall","year":"2008"},{"key":"2026071609022889500_bib86","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.3390\/en17112650","article-title":"Biofuels in aviation: exploring the impact of sustainable aviation fuels in aircraft engines","volume":"17","author":"Khujamberdiev","year":"2024","journal-title":"Energies"},{"key":"2026071609022889500_bib87","doi-asserted-by":"publisher","first-page":"126349","DOI":"10.1016\/j.biortech.2021.126349","article-title":"Yeast metabolic engineering for carbon dioxide fixation and its application","volume":"346","author":"Kim","year":"2021","journal-title":"Bioresour Technol"},{"key":"2026071609022889500_bib88","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1091\/mbc.e15-07-0470","article-title":"Dynamic relocation of the TORC1-Gtr1\/2-Ego1\/2\/3 complex is regulated by Gtr1 and Gtr2","volume":"27","author":"Kira","year":"2016","journal-title":"Mol Biol Cell"},{"key":"2026071609022889500_bib89","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.ymben.2016.10.008","article-title":"Towards the exploitation of glycerol's high reducing power in Saccharomyces cerevisiae-based bioprocesses","volume":"38","author":"Klein","year":"2016","journal-title":"Metab Eng"},{"key":"2026071609022889500_bib90","doi-asserted-by":"publisher","first-page":"7521","DOI":"10.1016\/j.biortech.2011.04.094","article-title":"Techno-economic implications of improved high gravity corn mash fermentation","volume":"102","author":"Kollaras","year":"2011","journal-title":"Bioresour Technol"},{"key":"2026071609022889500_bib91","first-page":"777","article-title":"Adding value to sugarcane bagasse using a xylose metabolising yeast","volume":"113","author":"Kollaras","year":"2011","journal-title":"Int Sugar J"},{"key":"2026071609022889500_bib92","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1007\/s00253-007-0948-2","article-title":"Over-expressing GLT1 in a gpd2\u0394 mutant of Saccharomyces cerevisiae to improve ethanol production","volume":"75","author":"Kong","year":"2007","journal-title":"Appl Microbiol Biotechnol"},{"key":"2026071609022889500_bib93","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1007\/s10811-015-0633-2","article-title":"Selection of yeast strains for bioethanol production from UK seaweeds","volume":"28","author":"Kostas","year":"2016","journal-title":"J Appl Phycol"},{"key":"2026071609022889500_bib94","doi-asserted-by":"publisher","first-page":"foaf020","DOI":"10.1093\/femsyr\/foaf020","article-title":"Advancing yeast metabolism for a sustainable single carbon bioeconomy","volume":"25","author":"Kuzman","year":"2025","journal-title":"FEMS Yeast Res"},{"key":"2026071609022889500_bib95","article-title":"Canadian oil sands: life cycle assessments of greenhouse gas emissions","author":"Lattanzio","year":"2014"},{"key":"2026071609022889500_bib96","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.3390\/genes12091311","article-title":"Role of calcium\/calcineurin signalling in regulating intracellular reactive oxygen species homeostasis in Saccharomyces cerevisiae","volume":"12","author":"Li","year":"2021","journal-title":"Genes"},{"key":"2026071609022889500_bib97","doi-asserted-by":"publisher","first-page":"119843","DOI":"10.1016\/j.apenergy.2022.119843","article-title":"New approach for bio-jet fuels production by hydrodeoxygenation of higher alcohols derived from C-C coupling of bio-ethanol","volume":"324","author":"Liao","year":"2022","journal-title":"Appl Energy"},{"key":"2026071609022889500_bib98","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1007\/s43393-021-00058-4","article-title":"Overview of yeast environmental stress response pathways and the development of tolerant yeasts","volume":"2","author":"Lin","year":"2022","journal-title":"Syst Microbiol Biomanuf"},{"key":"2026071609022889500_bib99","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1186\/s13068-015-0411-z","article-title":"Engineering transcription factors to improve tolerance against alkane biofuels in Saccharomyces cerevisiae","volume":"8","author":"Ling","year":"2015","journal-title":"Biotechnol Biofuels"},{"key":"2026071609022889500_bib100","article-title":"Whey to Ethanol: a biofuel role for dairy cooperatives?","author":"Ling","year":"2008"},{"key":"2026071609022889500_bib101","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.bej.2019.02.017","article-title":"Using CRISPR\/Cas9 for multiplex genome engineering to optimize the ethanol metabolic pathway in Saccharomyces cerevisiae","volume":"145","author":"Liu","year":"2019","journal-title":"Biochem Eng J"},{"key":"2026071609022889500_bib102","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.4014\/jmb.1908.08017","article-title":"Feasibility study on long-term continuous ethanol production from cassava supernatant by immobilized yeast cells in packed bed reactor","volume":"30","author":"Liu","year":"2020","journal-title":"J Microbiol Biotechnol"},{"key":"2026071609022889500_bib103","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.bjm.2016.10.003","article-title":"Ethanol production in Brazil: a bridge between science and industry","volume":"47","author":"Lopes","year":"2016","journal-title":"Braz J Microbiol"},{"key":"2026071609022889500_bib104","doi-asserted-by":"publisher","first-page":"656","DOI":"10.3390\/genes11060656","article-title":"Extreme low cytosolic pH is a signal for cell survival in acid stressed yeast","volume":"11","author":"Lucena","year":"2020","journal-title":"Genes"},{"key":"2026071609022889500_bib105","doi-asserted-by":"publisher","first-page":"fov107","DOI":"10.1093\/femsyr\/fov107","article-title":"Sucrose and Saccharomyces cerevisiae: a relationship most sweet","volume":"16","author":"Marques","year":"2016","journal-title":"FEMS Yeast Res"},{"key":"2026071609022889500_bib106","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nclimate3347","article-title":"Climate impacts of oil extraction increase significantly with oilfield age","volume":"7","author":"Masnadi","year":"2017","journal-title":"Nat Clim Change"},{"key":"2026071609022889500_bib107","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1126\/science.aar6859","article-title":"Global carbon intensity of crude oil production","volume":"361","author":"Masnadi","year":"2018","journal-title":"Science"},{"key":"2026071609022889500_bib108","doi-asserted-by":"publisher","first-page":"112246","DOI":"10.1016\/j.yexcr.2020.112246","article-title":"Hsf1 on a leash\u2014controlling the heat shock response by chaperone titration","volume":"396","author":"Masser","year":"2020","journal-title":"Exp Cell Res"},{"key":"2026071609022889500_bib109","doi-asserted-by":"publisher","first-page":"124688","DOI":"10.1016\/j.energy.2022.124688","article-title":"Ethanol as a renewable biofuel: combustion characteristics and application in engines","volume":"257","author":"Mendiburu","year":"2022","journal-title":"Energy"},{"key":"2026071609022889500_bib110","doi-asserted-by":"publisher","first-page":"7013","DOI":"10.1007\/s00253-023-12729-4","article-title":"Engineering natural isolates of Saccharomyces cerevisiae for consolidated bioprocessing of cellulosic feedstocks","volume":"107","author":"Minnaar","year":"2023","journal-title":"Appl Microbiol Biotechnol"},{"key":"2026071609022889500_bib111","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1089\/omi.2010.0072","article-title":"Adaptive response and tolerance to weak acids in Saccharomyces cerevisiae: a genome-wide view","volume":"14","author":"Mira","year":"2010","journal-title":"OMICS"},{"key":"2026071609022889500_bib112","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1534\/genetics.111.128033","article-title":"The response to heat shock and oxidative stress in Saccharomyces cerevisiae","volume":"190","author":"Morano","year":"2012","journal-title":"Genetics"},{"key":"2026071609022889500_bib113","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0304-4157(00)00015-0","article-title":"Mutagenic study of the structure, function and biogenesis of the yeast plasma membrane H+-ATPase","volume":"1469","author":"Morsomme","year":"2000","journal-title":"Biochim Et Biophys Acta (BBA)\u2014Rev Biomemb"},{"key":"2026071609022889500_bib114","doi-asserted-by":"publisher","first-page":"100056","DOI":"10.1016\/j.engmic.2022.100056","article-title":"Challenges and opportunities for third-generation ethanol production: a critical review","volume":"3","author":"M\u00fcller","year":"2023","journal-title":"Eng Microbiol"},{"key":"2026071609022889500_bib115","doi-asserted-by":"publisher","first-page":"803","DOI":"10.3390\/jof9080803","article-title":"Improved sugarcane-based fermentation processes by an industrial fuel-ethanol yeast strain","volume":"9","author":"Muller","year":"2023","journal-title":"J Fungi"},{"key":"2026071609022889500_bib116","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3390\/fermentation7030164","article-title":"Different gene expression patterns of hexose transporter genes modulate fermentation performance of four Saccharomyces cerevisiae strains","volume":"7","author":"Nadai","year":"2021","journal-title":"Fermentation"},{"key":"2026071609022889500_bib117","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s13568-016-0234-8","article-title":"Adaptation to low pH and lignocellulosic inhibitors resulting in ethanolic fermentation and growth of Saccharomyces cerevisiae","volume":"6","author":"Narayanan","year":"2016","journal-title":"AMB Expr"},{"key":"2026071609022889500_bib118","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s13568-014-0086-z","article-title":"Enhanced ethanol production and reduced glycerol formation in fps1\u2206 mutants of Saccharomyces cerevisiae engineered for improved redox balancing","volume":"4","author":"Navarrete","year":"2014","journal-title":"AMB Expr"},{"key":"2026071609022889500_bib119","doi-asserted-by":"publisher","first-page":"8824","DOI":"10.1021\/acs.est.5b01913","article-title":"Unconventional heavy oil growth and global greenhouse gas emissions","volume":"49","author":"Nduagu","year":"2015","journal-title":"Environ Sci Technol"},{"key":"2026071609022889500_bib120","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.tig.2013.09.006","article-title":"A century after Fisher: time for a new paradigm in quantitative genetics","volume":"29","author":"Nelson","year":"2013","journal-title":"Trends Genet"},{"key":"2026071609022889500_bib121","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jclepro.2018.02.220","article-title":"Business models for commercial scale second-generation bioethanol production","volume":"184","author":"Neto","year":"2018","journal-title":"J Cleaner Prod"},{"key":"2026071609022889500_bib122","doi-asserted-by":"publisher","first-page":"464","DOI":"10.3389\/fbioe.2019.00464","article-title":"Engineering of pentose transport in Saccharomyces cerevisiae for biotechnological applications","volume":"7","author":"Nijland","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"2026071609022889500_bib123","doi-asserted-by":"publisher","first-page":"126813","DOI":"10.1016\/j.micres.2021.126813","article-title":"Bio-conversion of CO2 into biofuels and other value-added chemicals via metabolic engineering","volume":"251","author":"Nisar","year":"2021","journal-title":"Microbiol Res"},{"key":"2026071609022889500_bib124","first-page":"213","article-title":"Maltose transport and metabolism in S. cerevisiae","volume":"42","author":"Novak","year":"2004","journal-title":"Food Technol Biotechnol"},{"key":"2026071609022889500_bib125","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1515\/bioeth-2016-0010","article-title":"Ethanol production from brown seaweed using non- conventional yeasts","volume":"2","author":"Obata","year":"2016","journal-title":"Bioethanol"},{"key":"2026071609022889500_bib126","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.3168\/jds.2015-10059","article-title":"Incorporation of whey permeate, a dairy effluent, in ethanol fermentation to provide a zero waste solution for the dairy industry","volume":"99","author":"Parashar","year":"2016","journal-title":"J Dairy Sci"},{"key":"2026071609022889500_bib127","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.procbio.2023.10.013","article-title":"Functional expression of RuBisCO reduces CO2 emission during fermentation by engineered Saccharomyces cerevisiae","volume":"134","author":"Park","year":"2023","journal-title":"Process Biochem"},{"key":"2026071609022889500_bib128","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1002\/yea.3429","article-title":"D-Xylose consumption by nonrecombinant Saccharomyces cerevisiae: a review","volume":"36","author":"Pati\u00f1o","year":"2019","journal-title":"Yeast"},{"key":"2026071609022889500_bib129","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/S1097-2765(03)00485-4","article-title":"TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0","volume":"12","author":"Pedruzzi","year":"2003","journal-title":"Mol Cell"},{"key":"2026071609022889500_bib130","doi-asserted-by":"publisher","first-page":"22329","DOI":"10.1038\/s41598-020-77846-w","article-title":"Differential proteomic analysis by SWATH-MS unravels the most dominant mechanisms underlying yeast adaptation to non-optimal temperatures under anaerobic conditions","volume":"10","author":"Pinheiro","year":"2020","journal-title":"Sci Rep"},{"key":"2026071609022889500_bib131","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1111\/j.1574-6976.1993.tb00005.x","article-title":"Molecular events associated with acquisition of heat tolerance by the yeast Saccharomyces cerevisiae","volume":"11","author":"Piper","year":"1993","journal-title":"FEMS Microbiol Rev"},{"key":"2026071609022889500_bib132","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3390\/biom12020210","article-title":"Interaction of TOR and PKA Signaling in S. cerevisiae","volume":"12","author":"Plank","year":"2022","journal-title":"Biomolecules"},{"key":"2026071609022889500_bib133","doi-asserted-by":"publisher","first-page":"19182","DOI":"10.1038\/s41598-023-46293-8","article-title":"Metabolic engineering of Saccharomyces cerevisiae for second- generation ethanol production from xylo-oligosaccharides and acetate","volume":"13","author":"Proc\u00f3pio","year":"2023","journal-title":"Sci Rep"},{"key":"2026071609022889500_bib134","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1038\/s41467-024-45557-9","article-title":"Increased CO2 fixation enables high carbon-yield production of 3- hydroxypropionic acid in yeast","volume":"15","author":"Qin","year":"2024","journal-title":"Nat Commun"},{"key":"2026071609022889500_bib135","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.nbt.2023.10.011","article-title":"Effective application of immobilized second generation industrial Saccharomyces cerevisiae strain on consolidated bioprocessing","volume":"78","author":"Ramos","year":"2023","journal-title":"New Biotechnol"},{"key":"2026071609022889500_bib136","article-title":"Global oil consumption hits historic 100 million barrels per day Milestone","author":"Rapier","year":"2024"},{"key":"2026071609022889500_bib137","doi-asserted-by":"publisher","first-page":"jkad104","DOI":"10.1093\/g3journal\/jkad104","article-title":"Yeast population dynamics in Brazilian bioethanol production","volume":"13","author":"Rego-Costa","year":"2023","journal-title":"G3"},{"key":"2026071609022889500_bib138","doi-asserted-by":"publisher","first-page":"392","DOI":"10.3389\/fchem.2019.00392","article-title":"Recent advances in Power-to-X technology for the production of fuels and chemicals","volume":"7","author":"Rego\u00a0de\u00a0Vasconcelos","year":"2019","journal-title":"Front Chem"},{"key":"2026071609022889500_bib139","doi-asserted-by":"publisher","first-page":"12652","DOI":"10.1038\/s41598-021-92069-3","article-title":"Yeast adaptive response to acetic acid stress involves structural alterations and increased stiffness of the cell wall","volume":"11","author":"Ribeiro","year":"2021","journal-title":"Sci Rep"},{"key":"2026071609022889500_bib140","doi-asserted-by":"publisher","first-page":"267","DOI":"10.15698\/mic2019.06.679","article-title":"Yeast AP-1 like transcription factors (Yap) and stress response: a current overview","volume":"6","author":"Rodrigues-Pousada","year":"2019","journal-title":"Microb Cell"},{"key":"2026071609022889500_bib141","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1038\/s41467-018-04157-0","article-title":"Heterozygous diploid and interspecies SCRaMbLEing","volume":"9","author":"Shen","year":"2018","journal-title":"Nat Commun"},{"key":"2026071609022889500_bib142","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s10295-008-0481-z","article-title":"Genome shuffling to improve thermotolerance, ethanol tolerance and ethanol productivity of Saccharomyces cerevisiae","volume":"36","author":"Shi","year":"2009","journal-title":"J Ind Microbiol Biotechnol"},{"key":"2026071609022889500_bib143","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1002\/bit.20094","article-title":"Fermentation performance of engineered and evolved xylose-fermenting Saccharomyces cerevisiae strains","volume":"87","author":"Sonderegger","year":"2004","journal-title":"Biotech Bioeng"},{"key":"2026071609022889500_bib144","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2672.2009.04657.x","article-title":"The ethanol stress response and ethanol tolerance of Saccharomyces cerevisiae","volume":"109","author":"Stanley","year":"2010","journal-title":"J App Microbiol"},{"key":"2026071609022889500_bib145","article-title":"Production of Biofuels Worldwide in 2023, With a Forecast until 2030","author":"Statista Reports","year":"2025"},{"key":"2026071609022889500_bib146","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.3390\/pr8101310","article-title":"Process strategies for the transition of 1\u00a0G to advanced bioethanol production","volume":"8","author":"Susmozas","year":"2020","journal-title":"Processes"},{"key":"2026071609022889500_bib147","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s12192-016-0667-7","article-title":"Cross-stress resistance in Saccharomyces cerevisiae yeast-new insight into an old phenomenon","volume":"21","author":"\u015awi\u0119ci\u0142o","year":"2016","journal-title":"Cell Stress Chaperones"},{"key":"2026071609022889500_bib148","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s00253-008-1698-5","article-title":"Proline as a stress protectant in yeast: physiological functions, metabolic regulations, and biotechnological applications","volume":"81","author":"Takagi","year":"2008","journal-title":"Appl Microbiol Biotechnol"},{"key":"2026071609022889500_bib149","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1093\/bbb\/zbab022","article-title":"Molecular mechanisms and highly functional development for stress tolerance of the yeast Saccharomyces cerevisiae","volume":"85","author":"Takagi","year":"2021","journal-title":"Biosci Biotechnol Biochem"},{"key":"2026071609022889500_bib150","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1111\/1751-7915.13270","article-title":"Using gas mixtures of CO, CO2 and H2 as microbial substrates: the do's and don'ts of successful technology transfer from laboratory to production scale","volume":"11","author":"Takors","year":"2018","journal-title":"Microb Biotechnol"},{"key":"2026071609022889500_bib151","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.landusepol.2015.11.015","article-title":"Food versus fuel? Going beyond biofuels","volume":"56","author":"Tomei","year":"2016","journal-title":"Land Use Policy"},{"key":"2026071609022889500_bib152","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s13068-019-1641-2","article-title":"Improved simultaneous co-fermentation of glucose and xylose by Saccharomyces cerevisiae for efficient lignocellulosic biorefinery","volume":"13","author":"Tran","year":"2020","journal-title":"Biotechnol Biofuels"},{"key":"2026071609022889500_bib153","doi-asserted-by":"publisher","first-page":"268","DOI":"10.3390\/fermentation7040268","article-title":"Production of bioethanol\u2014a review of factors affecting ethanol yield","volume":"7","author":"Tse","year":"2021","journal-title":"Fermentation"},{"key":"2026071609022889500_bib154","doi-asserted-by":"publisher","first-page":"1466644","DOI":"10.3389\/fbioe.2024.1466644","article-title":"Saccharomyces cerevisiae for lignocellulosic ethanol production: a look at key attributes and genome shuffling","volume":"12","author":"Tsegaye","year":"2024","journal-title":"Front Bioeng Biotechnol"},{"key":"2026071609022889500_bib155","doi-asserted-by":"publisher","first-page":"1061667","DOI":"10.3389\/fbioe.2022.1061667","article-title":"Microbial detoxification of lignocellulosic biomass hydrolysates: biochemical and molecular aspects, challenges, exploits and future perspectives","volume":"10","author":"Ujor","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"2026071609022889500_bib156","doi-asserted-by":"publisher","first-page":"142","DOI":"10.3389\/fmicb.2013.00142","article-title":"Yeast adaptation to weak acids prevents futile energy expenditure","volume":"4","author":"Ullah","year":"2013","journal-title":"Front Microbiol"},{"key":"2026071609022889500_bib157","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.synbio.2021.12.010","article-title":"Pathway engineering strategies for improved product yield in yeast-based industrial ethanol production","volume":"7","author":"van\u00a0Aalst","year":"2022","journal-title":"Synthetic Syst Biotechnol"},{"key":"2026071609022889500_bib158","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.bpj.2011.12.038","article-title":"Role of unsaturated lipid and ergosterol in ethanol tolerance of model yeast biomembranes","volume":"102","author":"Vanegas","year":"2012","journal-title":"Biophys J"},{"key":"2026071609022889500_bib159","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/10_2007_061","article-title":"Consolidated bioprocessing for bioethanol production using Saccharomyces cerevisiae","volume":"108","author":"Van\u00a0Zyl","year":"2007","journal-title":"Adv Biochem Eng Biotechnol"},{"key":"2026071609022889500_bib160","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1128\/mmbr.05018-11","article-title":"Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system","volume":"76","author":"Verghese","year":"2012","journal-title":"Microbiol Mol Biol Rev"},{"key":"2026071609022889500_bib161","doi-asserted-by":"publisher","first-page":"foy075","DOI":"10.1093\/femsyr\/foy075","article-title":"Fermentation of glucose-xylose-arabinose mixtures by a synthetic consortium of single-sugar-fermenting Saccharomyces cerevisiae strains","volume":"18","author":"Verhoeven","year":"2018","journal-title":"FEMS Yeast Res"},{"key":"2026071609022889500_bib162","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3390\/beverages2040030","article-title":"Saccharomyces cerevisiae in the production of fermented beverages","volume":"2","author":"Walker","year":"2016","journal-title":"Beverages"},{"key":"2026071609022889500_bib163","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1021\/acssynbio.3c00289","article-title":"Engineering all-round cellulase for bioethanol production","volume":"12","author":"Wang","year":"2023","journal-title":"ACS Synth Biol"},{"key":"2026071609022889500_bib164","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1002\/jctb.2634","article-title":"Improvement of ethanol production in Saccharomyces cerevisiae by hetero-expression of GAPN and FPS1 deletion","volume":"86","author":"Wang","year":"2011","journal-title":"J Chem Technol Biotechnol"},{"key":"2026071609022889500_bib165","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s40643-021-00375-5","article-title":"Reducing glucoamylase usage for commercial-scale ethanol production from starch using glucoamylase expressing Saccharomyces cerevisiae","volume":"8","author":"Wang","year":"2021","journal-title":"Bioresour Bioprocess"},{"key":"2026071609022889500_bib166","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.3390\/molecules29102275","article-title":"Composition of lignocellulose hydrolysate in different biorefinery strategies: nutrients and inhibitors","volume":"29","author":"Wang","year":"2024","journal-title":"Molecules"},{"key":"2026071609022889500_bib167","doi-asserted-by":"publisher","first-page":"6908","DOI":"10.1128\/AEM.01906-14","article-title":"Flocculation causes inhibitor tolerance in Saccharomyces cerevisiae for second-generation bioethanol production","volume":"80","author":"Westman","year":"2014","journal-title":"Appl Environ Microb"},{"key":"2026071609022889500_bib168","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s13068-020-01823-8","article-title":"Rapid optimisation of cellulolytic enzymes ratios in Saccharomyces cerevisiae using in vitro SCRaMbLE","volume":"13","author":"Wightman","year":"2020","journal-title":"Biotechnol Biofuels"},{"key":"2026071609022889500_bib169","doi-asserted-by":"publisher","first-page":"4881","DOI":"10.1128\/AEM.00177-07","article-title":"Engineering of Saccharomyces cerevisiae for efficient anaerobic alcoholic fermentation of l-arabinose","volume":"73","author":"Wisselink","year":"2007","journal-title":"Appl Environ Microb"},{"key":"2026071609022889500_bib170","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3390\/su17010287","article-title":"Review of lignocellulosic biomass pretreatment using physical, thermal and chemical methods for higher yields in bioethanol production","volume":"17","author":"Wo\u017aniak","year":"2025","journal-title":"Sustainability"},{"key":"2026071609022889500_bib171","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1039\/C9RA08673K","article-title":"Enhanced ethanol production from sugarcane molasses by industrially engineered Saccharomyces cerevisiae via replacement of the PHO4 gene","volume":"10","author":"Wu","year":"2020","journal-title":"RSC Adv"},{"key":"2026071609022889500_bib172","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1016\/j.biortech.2005.01.010","article-title":"Coordinated development of leading biomass pretreatment technologies","volume":"96","author":"Wyman","year":"2005","journal-title":"Bioresour Technol"},{"key":"2026071609022889500_bib173","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.ces.2017.10.016","article-title":"Improving the thermo-tolerance of yeast base on the antioxidant defense system","volume":"175","author":"Xu","year":"2018","journal-title":"Chem Eng Sci"},{"key":"2026071609022889500_bib174","doi-asserted-by":"publisher","first-page":"703","DOI":"10.3390\/jof8070703","article-title":"CRISPR-Cas9 approach constructed engineered Saccharomyces cerevisiae with the deletion of GPD2, FPS1 and ADH2 to enhance the production of ethanol","volume":"8","author":"Yang","year":"2022","journal-title":"J Fungi"},{"key":"2026071609022889500_bib175","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s12934-022-01885-3","article-title":"Ethanol yield improvement in Saccharomyces cerevisiae GPD2 Delta FPS1 Delta ADH2 Delta DLD3 Delta mutant and molecular mechanism exploration based on the metabolic flux and transcriptomics approaches","volume":"21","author":"Yang","year":"2022","journal-title":"Microb Cell Fact"},{"key":"2026071609022889500_bib176","doi-asserted-by":"publisher","first-page":"5698","DOI":"10.1038\/s41467-019-13638-9","article-title":"CO2 hydrogenation to high-value products via heterogeneous catalysis","volume":"10","author":"Ye","year":"2019","journal-title":"Nat Commun"},{"key":"2026071609022889500_bib177","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.mimet.2016.06.012","article-title":"Genome shuffling of Saccharomyces cerevisiae for enhanced glutathione yield and relative gene expression analysis using fluorescent quantitation reverse transcription polymerase chain reaction","volume":"127","author":"Yin","year":"2016","journal-title":"J Microbiol Methods"},{"key":"2026071609022889500_bib178","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1128\/AEM.69.3.1499-1503.2003","article-title":"Ethanol tolerance in the yeast Saccharomyces cerevisiae is dependent on cellular oleic acid content","volume":"69","author":"You","year":"2003","journal-title":"Appl Environ Microb"},{"key":"2026071609022889500_bib179","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/j.1472-765X.2006.02041.x","article-title":"Effect of FPS1 deletion on the fermentation properties of Saccharomyces cerevisiae","volume":"44","author":"Zhang","year":"2007","journal-title":"Lett App Microbiol"},{"key":"2026071609022889500_bib180","doi-asserted-by":"publisher","first-page":"36254","DOI":"10.1039\/d3ra05216h","article-title":"Improving thermo-tolerance of Saccharomyces cerevisiae by precise regulation of the expression of small HSP","volume":"13","author":"Zhang","year":"2023","journal-title":"RSC Adv"},{"key":"2026071609022889500_bib181","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1038\/s41589-024-01771-6","article-title":"Engineering a xylose fermenting yeast for lignocellulosic ethanol production","volume":"21","author":"Zhang","year":"2025","journal-title":"Nat Chem Biol"},{"key":"2026071609022889500_bib182","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1007\/s10295-014-1421-8","article-title":"Improvement of oxidative stress tolerance in Saccharomyces cerevisiae through global transcriptional machinery engineering","volume":"41","author":"Zhao","year":"2014","journal-title":"J Ind Microb Biotech"},{"key":"2026071609022889500_bib183","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.biotechadv.2009.06.006","article-title":"Yeast flocculation: new story in fuel ethanol production","volume":"27","author":"Zhao","year":"2009","journal-title":"Biotechnol Adv"},{"key":"2026071609022889500_bib184","doi-asserted-by":"publisher","first-page":"874","DOI":"10.3389\/fchem.2019.00874","article-title":"Lignocellulosic biomass: understanding recalcitrance and predicting hydrolysis","volume":"7","author":"Zoghlami","year":"2019","journal-title":"Front Chem"},{"key":"2026071609022889500_bib185","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1128\/EC.4.1.63-71.2005","article-title":"Tor and cyclic AMP-protein kinase A: two parallel pathways regulating expression of genes required for cell growth","volume":"4","author":"Zurita-Martinez","year":"2005","journal-title":"Euk Cell"}],"container-title":["FEMS Yeast Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/femsyr\/advance-article-pdf\/doi\/10.1093\/femsyr\/foaf044\/64120689\/foaf044.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/femsyr\/article-pdf\/doi\/10.1093\/femsyr\/foaf044\/64120689\/foaf044.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/femsyr\/article-pdf\/doi\/10.1093\/femsyr\/foaf044\/64120689\/foaf044.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T13:02:56Z","timestamp":1784206976000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/femsyr\/article\/doi\/10.1093\/femsyr\/foaf044\/8240784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":184,"URL":"https:\/\/doi.org\/10.1093\/femsyr\/foaf044","relation":{},"ISSN":["1567-1364"],"issn-type":[{"value":"1567-1364","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025]]},"published":{"date-parts":[[2025]]},"article-number":"foaf044"}}