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We hypothesized that timing of food intake entrains circadian rhythms of blood pressure (BP) and renal excretion in mice. Male C57BL\/6J mice were fed ad libitum or reverse feeding (RF) where food was available at all times of day or only available during the 12-h lights-on period, respectively. Mice eating ad libitum had a significantly higher mean arterial pressure (MAP) during lights-off compared to lights-on (113\u2009\u00b1\u20092 mmHg vs 100\u2009\u00b1\u20092 mmHg, respectively; P\u2009&amp;lt;\u20090.0001); however, RF for 6 days inverted the diurnal rhythm of MAP (99\u2009\u00b1\u20093 vs 110\u2009\u00b1\u20093 mmHg, respectively; P\u2009&amp;lt;\u20090.0001). In contrast to MAP, diurnal rhythms of urine volume and sodium excretion remained intact after RF. Male Bmal1 knockout mice (Bmal1KO) underwent the same feeding protocol. As previously reported, Bmal1KO mice did not exhibit a diurnal MAP rhythm during ad libitum feeding (95\u2009\u00b1\u20091 mmHg vs 92\u2009\u00b1\u20093 mmHg, lights-off vs lights-on; P\u2009&amp;gt;\u20090.05); however, RF induced a diurnal rhythm of MAP (79\u2009\u00b1\u20093 mmHg vs 95\u2009\u00b1\u20092 mmHg, lights-off vs lights-on phase; P\u2009&amp;lt;\u20090.01). Transgenic PERIOD2::LUCIFERASE knock-in mice were used to assess the rhythm of the clock protein PERIOD2 in ex vivo tissue cultures. The timing of the PER2::LUC rhythm in the renal cortex and suprachiasmatic nucleus was not affected by RF; however, RF induced significant phase shifts in the liver, renal inner medulla, and adrenal gland. In conclusion, the timing of food intake controls BP rhythms in mice independent of Bmal1, urine volume, or sodium excretion.<\/jats:p>","DOI":"10.1093\/function\/zqaa034","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T20:27:08Z","timestamp":1606249628000},"source":"Crossref","is-referenced-by-count":60,"title":["Timing of Food Intake Drives the Circadian Rhythm of Blood Pressure"],"prefix":"10.1152","volume":"2","author":[{"given":"Dingguo","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson C","family":"Colson","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Jin","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of 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