{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:53:16Z","timestamp":1781632396113,"version":"3.54.5"},"reference-count":51,"publisher":"American Physiological Society","issue":"1","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["PI13\/01726"],"award-info":[{"award-number":["PI13\/01726"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instituto de Salud Carlos III (ISCIII, MINECO), European Research Council"},{"name":"Horizon 2020 Research and Innovation Programme Grant","award":["ERC-CoG-2014 648936"],"award-info":[{"award-number":["ERC-CoG-2014 648936"]}]},{"name":"Horizon 2020 Research and Innovation Programme Grant","award":["RTI2018-098768-B-I00"],"award-info":[{"award-number":["RTI2018-098768-B-I00"]}]},{"name":"Spanish Ministerio de Ciencia, Innovaci\u00f3n y Universidades","award":["VA114P17"],"award-info":[{"award-number":["VA114P17"]}]},{"DOI":"10.13039\/501100014180","name":"Junta de Castilla y Le\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014180","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programa Ramon y Cajal","award":["RYC-2012-11349"],"award-info":[{"award-number":["RYC-2012-11349"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic kidney disease (CKD) significantly increases cardiovascular risk. In advanced CKD stages, accumulation of toxic circulating metabolites and mineral metabolism alterations triggers vascular calcification, characterized by vascular smooth muscle cell (VSMC) transdifferentiation and loss of the contractile phenotype. Phenotypic modulation of VSMC occurs with significant changes in gene expression. Even though ion channels are an integral component of VSMC function, the effects of uremia on ion channel remodeling has not been explored. We used an in vitro model of uremia-induced calcification of human aorta smooth muscle cells (HASMCs) to study the expression of 92 ion channel subunit genes. Uremic serum-induced extensive remodeling of ion channel expression consistent with loss of excitability but different from the one previously associated with transition from contractile to proliferative phenotypes. Among the ion channels tested, we found increased abundance and activity of voltage-dependent K+ channel Kv1.3. Enhanced Kv1.3 expression was also detected in aorta from a mouse model of CKD. Pharmacological inhibition or genetic ablation of Kv1.3 decreased the amount of calcium phosphate deposition induced by uremia, supporting an important role for this channel on uremia-induced VSMC calcification.<\/jats:p>","DOI":"10.1093\/function\/zqaa036","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T21:38:33Z","timestamp":1607117913000},"source":"Crossref","is-referenced-by-count":4,"title":["Kv1.3 Channel Inhibition Limits Uremia-Induced Calcification in Mouse and Human Vascular Smooth Muscle"],"prefix":"10.1152","volume":"2","author":[{"given":"Violeta","family":"Caza\u00f1a-P\u00e9rez","sequence":"first","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas (Fisiolog\u00eda), Instituto de Tecnolog\u00edas Biom\u00e9dicas, Universidad de La Laguna, Spain"},{"name":"Unidad de Investigaci\u00f3n y Servicio de Nefrolog\u00eda, Hospital Universitario Nuestra Se\u00f1ora de Candelaria, Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Cidad","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Fisiolog\u00eda e Instituto de Biolog\u00eda y Gen\u00e9tica Molecular (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5015-7474","authenticated-orcid":false,"given":"Juan F","family":"Navarro-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n y Servicio de Nefrolog\u00eda, Hospital Universitario Nuestra Se\u00f1ora de Candelaria, Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Rojo-Menc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Fisiolog\u00eda e Instituto de Biolog\u00eda y Gen\u00e9tica Molecular (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Jaisser","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche Scientifique 1138, Team 1, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Centre de Recherche des Cordeliers, La Laguna, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 R","family":"L\u00f3pez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Fisiolog\u00eda e Instituto de Biolog\u00eda y Gen\u00e9tica Molecular (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4324-2793","authenticated-orcid":false,"given":"Diego","family":"Alvarez de la Rosa","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas (Fisiolog\u00eda), Instituto de Tecnolog\u00edas Biom\u00e9dicas, Universidad de La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4096-810X","authenticated-orcid":false,"given":"Teresa","family":"Giraldez","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias M\u00e9dicas B\u00e1sicas (Fisiolog\u00eda), Instituto de Tecnolog\u00edas Biom\u00e9dicas, Universidad de La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u00a0Teresa","family":"P\u00e9rez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular y Fisiolog\u00eda e Instituto de Biolog\u00eda y Gen\u00e9tica Molecular (IBGM), Universidad de Valladolid y Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"2021122118015960500_zqaa036-B1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.med.58.071105.111123","article-title":"Kidney disease and cardiovascular risk","volume":"58","author":"Tonelli","year":"2007","journal-title":"Annu Rev Med"},{"key":"2021122118015960500_zqaa036-B2","doi-asserted-by":"crossref","first-page":"314","DOI":"10.3389\/fcell.2019.00314","article-title":"Unraveling cardiovascular risk in renal patients: a new take on old tale","volume":"7","author":"Provenzano","year":"2019","journal-title":"Front Cell Dev Biol"},{"key":"2021122118015960500_zqaa036-B3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.carpath.2017.01.004","article-title":"Vascular inflammation and media calcification are already present in early stages of chronic kidney disease","volume":"27","author":"Benz","year":"2017","journal-title":"Cardiovasc Pathol"},{"issue":"6","key":"2021122118015960500_zqaa036-B4","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1161\/01.RES.0000141775.67189.98","article-title":"Pathophysiology of vascular calcification in chronic kidney disease","volume":"95","author":"Moe","year":"2004","journal-title":"Circ Res"},{"issue":"6","key":"2021122118015960500_zqaa036-B5","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/sj.ki.5001663","article-title":"The mechanisms of uremic serum-induced expression of bone matrix proteins in bovine vascular smooth muscle cells","volume":"70","author":"Chen","year":"2006","journal-title":"Kidney Int"},{"issue":"3","key":"2021122118015960500_zqaa036-B6","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1161\/ATVBAHA.117.310578","article-title":"Chronic kidney disease circulating calciprotein particles and extracellular vesicles promote vascular calcification: a role for GRP (Gla-rich protein)","volume":"38","author":"Viegas","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"11","key":"2021122118015960500_zqaa036-B7","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1161\/01.RES.87.11.1055","article-title":"Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies","volume":"87","author":"Proudfoot","year":"2000","journal-title":"Circ Res"},{"issue":"17","key":"2021122118015960500_zqaa036-B8","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1161\/CIRCULATIONAHA.108.783738","article-title":"Dialysis accelerates medial vascular calcification in part by triggering smooth muscle cell apoptosis","volume":"118","author":"Shroff","year":"2008","journal-title":"Circulation"},{"issue":"12","key":"2021122118015960500_zqaa036-B9","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1161\/CIRCRESAHA.108.175976","article-title":"Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration","volume":"102","author":"Clarke","year":"2008","journal-title":"Circ Res"},{"key":"2021122118015960500_zqaa036-B10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3389\/fphys.2018.00089","article-title":"Phenotypic modulation of cultured primary human aortic vascular smooth muscle cells by uremic serum","volume":"9","author":"Caza\u00f1a-Perez","year":"2018","journal-title":"Front Physiol"},{"issue":"12","key":"2021122118015960500_zqaa036-B11","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1093\/ndt\/gfl429","article-title":"High glucose increases the expression of Cbfa1 and BMP-2 and enhances the calcification of vascular smooth muscle cells","volume":"21","author":"Chen","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"2021122118015960500_zqaa036-B12","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fmed.2020.00078","article-title":"Uremic vascular calcification is correlated with oxidative elastic lamina injury, contractile smooth muscle cell loss, osteogenesis, and apoptosis: the human pathobiological evidence","volume":"7","author":"Chang","year":"2020","journal-title":"Front Med (Lausanne)"},{"issue":"4","key":"2021122118015960500_zqaa036-B13","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1172\/JCI116391","article-title":"Bone morphogenetic protein expression in human atherosclerotic lesions","volume":"91","author":"Bostrom","year":"1993","journal-title":"J Clin Invest"},{"issue":"4","key":"2021122118015960500_zqaa036-B14","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/ije\/31.4.737","article-title":"Vascular calcification and osteoporosis: inflammatory responses to oxidized lipids","volume":"31","author":"Demer","year":"2002","journal-title":"Int J Epidemiol"},{"issue":"5","key":"2021122118015960500_zqaa036-B15","doi-asserted-by":"crossref","first-page":"e000481","DOI":"10.1161\/JAHA.113.000481","article-title":"Medial and intimal calcification in chronic kidney disease: stressing the contributions","volume":"2","author":"Rogers","year":"2013","journal-title":"J Am Heart Assoc"},{"issue":"2","key":"2021122118015960500_zqaa036-B16","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/ndt\/15.2.218","article-title":"Morphology of coronary atherosclerotic lesions in patients with end-stage renal failure","volume":"15","author":"Schwarz","year":"2000","journal-title":"Nephrol Dial Transplant"},{"key":"2021122118015960500_zqaa036-B17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/978-1-4939-3353-2_13","article-title":"Vascular calcification in uremia: new-age concepts about an old-age problem","volume":"1397","author":"Smith","year":"2016","journal-title":"Methods Mol Biol"},{"issue":"4","key":"2021122118015960500_zqaa036-B18","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/cvr\/cvy010","article-title":"Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness","volume":"114","author":"Durham","year":"2018","journal-title":"Cardiovasc Res"},{"issue":"20","key":"2021122118015960500_zqaa036-B19","doi-asserted-by":"crossref","first-page":"19966","DOI":"10.1074\/jbc.M500917200","article-title":"Patterns of gene expression differentially regulated by platelet-derived growth factor and hypertrophic stimuli in vascular smooth muscle cells: markers for phenotypic modulation and response to injury","volume":"280","author":"Kaplan-Albuquerque","year":"2005","journal-title":"J Biol Chem"},{"key":"2021122118015960500_zqaa036-B20","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/bs.apha.2016.07.001","article-title":"Potassium channels in regulation of vascular smooth muscle contraction and growth","volume":"78","author":"Jackson","year":"2017","journal-title":"Adv Pharmacol"},{"issue":"1","key":"2021122118015960500_zqaa036-B21","doi-asserted-by":"crossref","DOI":"10.1111\/micc.12427","article-title":"Kv channels and vascular smooth muscle cell proliferation","volume":"25","author":"Lopez-Lopez","year":"2018","journal-title":"Microcirculation"},{"issue":"6","key":"2021122118015960500_zqaa036-B22","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s10557-014-6554-5","article-title":"K+ channels expression in hypertension after arterial injury, and effect of selective Kv1.3 blockade with PAP-1 on intimal hyperplasia formation","volume":"28","author":"Cidad","year":"2014","journal-title":"Cardiovasc Drugs Ther"},{"issue":"5","key":"2021122118015960500_zqaa036-B23","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1124\/mol.105.015669","article-title":"Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases","volume":"68","author":"Schmitz","year":"2005","journal-title":"Mol Pharmacol"},{"issue":"5","key":"2021122118015960500_zqaa036-B24","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1161\/ATVBAHA.111.242727","article-title":"Kv1.3 channels can modulate cell proliferation during phenotypic switch by an ion-flux independent mechanism","volume":"32","author":"Cidad","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"12","key":"2021122118015960500_zqaa036-B25","doi-asserted-by":"crossref","first-page":"e273","DOI":"10.1161\/ATVBAHA.119.313492","article-title":"Myocardin-dependent Kv1.5 channel expression prevents phenotypic modulation of human vessels in organ culture","volume":"39","author":"Arevalo-Martinez","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1\u20132","key":"2021122118015960500_zqaa036-B26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ddmod.2010.08.002","article-title":"Models of chronic kidney disease","volume":"7","author":"Yang","year":"2010","journal-title":"Drug Discov Today Dis Models"},{"issue":"6","key":"2021122118015960500_zqaa036-B27","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1161\/ATVBAHA.110.205187","article-title":"Characterization of ion channels involved in the proliferative response of femoral artery smooth muscle cells","volume":"30","author":"Cidad","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"2021122118015960500_zqaa036-B28","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1113\/jphysiol.2008.165217","article-title":"De novo expression of Kv6.3 contributes to changes in vascular smooth muscle cell excitability in a hypertensive mice strain","volume":"587","author":"Moreno-Dominguez","year":"2009","journal-title":"J Physiol"},{"issue":"6","key":"2021122118015960500_zqaa036-B29","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"issue":"8","key":"2021122118015960500_zqaa036-B30","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1007\/s00424-014-1607-y","article-title":"Kv1.3 channels modulate human vascular smooth muscle cells proliferation independently of mTOR signaling pathway","volume":"467","author":"Cidad","year":"2015","journal-title":"Pflugers Arch"},{"issue":"7","key":"2021122118015960500_zqaa036-B31","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"issue":"1","key":"2021122118015960500_zqaa036-B32","doi-asserted-by":"crossref","first-page":"C27","DOI":"10.1152\/ajpcell.00136.2017","article-title":"The secret life of ion channels: Kv1.3 potassium channels and proliferation","volume":"314","author":"Perez-Garcia","year":"2018","journal-title":"Am J Physiol Cell Physiol"},{"issue":"12","key":"2021122118015960500_zqaa036-B33","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1161\/01.RES.0000194322.91255.13","article-title":"Contribution of Kv channels to phenotypic remodeling of human uterine artery smooth muscle cells","volume":"97","author":"Miguel-Velado","year":"2005","journal-title":"Circ Res"},{"issue":"1","key":"2021122118015960500_zqaa036-B34","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0014-2999(99)00188-0","article-title":"Effects of paxilline on K+ channels in rat mesenteric arterial cells","volume":"372","author":"Li","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"2021122118015960500_zqaa036-B35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.atherosclerosis.2015.11.005","article-title":"A novel organ culture model of aorta for vascular calcification","volume":"244","author":"Akiyoshi","year":"2016","journal-title":"Atherosclerosis"},{"key":"2021122118015960500_zqaa036-B36","first-page":"30170","article-title":"Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation","author":"Cidad","year":"2020","journal-title":"J Cell Physiol"},{"key":"2021122118015960500_zqaa036-B37","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.atherosclerosis.2016.12.022","article-title":"Uremia modulates the phenotype of aortic smooth muscle cells","volume":"257","author":"Madsen","year":"2017","journal-title":"Atherosclerosis"},{"issue":"5","key":"2021122118015960500_zqaa036-B38","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1517\/14728222.2016.1112792","article-title":"The voltage-gated potassium channel Kv1.3 is a promising multitherapeutic target against human pathologies","volume":"20","author":"Perez-Verdaguer","year":"2016","journal-title":"Expert Opin Ther Targets"},{"key":"2021122118015960500_zqaa036-B39","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13223-016-0168-3","article-title":"Lymphocyte Kv1.3-channels in the pathogenesis of chronic obstructive pulmonary disease: novel therapeutic implications of targeting the channels by commonly used drugs","volume":"12","author":"Kazama","year":"2016","journal-title":"Allergy Asthma Clin Immunol"},{"issue":"1","key":"2021122118015960500_zqaa036-B40","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12576-014-0331-x","article-title":"Physiological significance of delayed rectifier K(+) channels (Kv1.3) expressed in T lymphocytes and their pathological significance in chronic kidney disease","volume":"65","author":"Kazama","year":"2015","journal-title":"J Physiol Sci"},{"issue":"4","key":"2021122118015960500_zqaa036-B41","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ccell.2017.03.003","article-title":"Direct pharmacological targeting of a mitochondrial ion channel selectively kills tumor cells in vivo","volume":"31","author":"Leanza","year":"2017","journal-title":"Cancer Cell"},{"issue":"3","key":"2021122118015960500_zqaa036-B42","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3390\/ijms17030407","article-title":"The role of KV7.3 in regulating osteoblast maturation and mineralization","volume":"17","author":"Yang","year":"2016","journal-title":"Int J Mol Sci"},{"key":"2021122118015960500_zqaa036-B43","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.yjmcc.2019.12.006","article-title":"Oxidative stress contributes to vascular calcification in patients with chronic kidney disease","volume":"138","author":"Huang","year":"2020","journal-title":"J Mol Cell Cardiol"},{"issue":"10","key":"2021122118015960500_zqaa036-B44","doi-asserted-by":"crossref","DOI":"10.3390\/toxins12100624","article-title":"Uremic toxins and vascular calcification-missing the forest for all the trees","volume":"12","author":"Rapp","year":"2020","journal-title":"Toxins (Basel)"},{"issue":"5236","key":"2021122118015960500_zqaa036-B45","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1126\/science.270.5236.633","article-title":"Relaxation of arterial smooth muscle by calcium sparks","volume":"270","author":"Nelson","year":"1995","journal-title":"Science"},{"issue":"7","key":"2021122118015960500_zqaa036-B46","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.1073\/pnas.96.7.4137","article-title":"Molecular basis of fast inactivation in voltage and Ca2+-activated K+ channels: a transmembrane beta-subunit homolog","volume":"96","author":"Wallner","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"issue":"13","key":"2021122118015960500_zqaa036-B47","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.1523\/JNEUROSCI.19-13-05255.1999","article-title":"Molecular basis for the inactivation of Ca2+- and voltage-dependent BK channels in adrenal chromaffin cells and rat insulinoma tumor cells","volume":"19","author":"Xia","year":"1999","journal-title":"J Neurosci"},{"issue":"Pt 1","key":"2021122118015960500_zqaa036-B48","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1113\/jphysiol.1996.sp021288","article-title":"Calcium-activated potassium channels in the endothelium of intact rat aorta","volume":"492","author":"Marchenko","year":"1996","journal-title":"J Physiol"},{"issue":"9","key":"2021122118015960500_zqaa036-B49","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1161\/01.CIR.0000086464.04719.DD","article-title":"Blockade of the intermediate-conductance calcium-activated potassium channel as a new therapeutic strategy for restenosis","volume":"108","author":"Kohler","year":"2003","journal-title":"Circulation"},{"issue":"6","key":"2021122118015960500_zqaa036-B50","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1161\/ATVBAHA.107.155796","article-title":"Local delivery of the KCa3.1 blocker, TRAM-34, prevents acute angioplasty-induced coronary smooth muscle phenotypic modulation and limits stenosis","volume":"28","author":"Tharp","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"2021122118015960500_zqaa036-B51","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s00424-008-0491-8","article-title":"The non-excitable smooth muscle: calcium signaling and phenotypic switching during vascular disease","volume":"456","author":"House","year":"2008","journal-title":"Pflugers Arch"}],"container-title":["Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/full\/10.1093\/function\/zqaa036","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1093\/function\/zqaa036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:06:37Z","timestamp":1781629597000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/full\/10.1093\/function\/zqaa036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,9]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,11,9]]}},"URL":"https:\/\/doi.org\/10.1093\/function\/zqaa036","relation":{},"ISSN":["2633-8823"],"issn-type":[{"value":"2633-8823","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,1,1]]},"published":{"date-parts":[[2020,11,9]]},"article-number":"zqaa036"}}