{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:00:25Z","timestamp":1793296825171,"version":"4.5.0"},"reference-count":73,"publisher":"American Physiological Society","issue":"3","license":[{"start":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T00:00:00Z","timestamp":1649376000000},"content-version":"vor","delay-in-days":97,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL084207"],"award-info":[{"award-number":["HL084207"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL144807"],"award-info":[{"award-number":["HL144807"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL134850"],"award-info":[{"award-number":["HL134850"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["18EIA33890055"],"award-info":[{"award-number":["18EIA33890055"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["15SFRN23480000"],"award-info":[{"award-number":["15SFRN23480000"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Human hypertension caused by in-frame deletion of CULLIN3 exon-9 (Cul3\u22069) is driven by renal and vascular mechanisms. We bred conditionally activatable Cul3\u22069 transgenic mice with tamoxifen-inducible Tie2-CREERT2 mice to test the importance of endothelial Cul3. The resultant mice (E-Cul3\u22069) trended towards elevated nighttime blood pressure (BP) correlated with increased nighttime activity, but displayed no difference in daytime BP or activity. Male and female E-Cul3\u22069 mice together exhibited a decline in endothelial-dependent relaxation in carotid artery. Male but not female E-Cul3\u22069 mice displayed severe endothelial dysfunction in cerebral basilar artery. There was no impairment in mesenteric artery and no difference in smooth muscle function, suggesting the effects of Cul3\u22069 are arterial bed-specific and sex-dependent. Expression of Cul3\u22069 in primary mouse aortic endothelial cells decreased endogenous Cul3 protein, phosphorylated (S1177) endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) production. Protein phosphatase (PP) 2A, a known Cul3 substrate, dephosphorylates eNOS. Cul3\u22069-induced impairment of eNOS activity was rescued by a selective PP2A inhibitor okadaic acid, but not by a PP1 inhibitor tautomycetin. Because NO deficiency contributes to salt-induced hypertension, we tested the salt-sensitivity of E-Cul3\u22069 mice. While both male and female E-Cul3\u22069 mice developed salt-induced hypertension and renal injury, the pressor effect of salt was greater in female mutants. The increased salt-sensitivity in female E-Cul3\u22069 mice was associated with decreased renovascular relaxation and impaired natriuresis in response to a sodium load. Thus, CUL3 mutations in the endothelium may contribute to human hypertension in part through decreased endothelial NO bioavailability, renovascular dysfunction, and increased salt-sensitivity of BP.<\/jats:p>","DOI":"10.1093\/function\/zqac017","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T07:24:49Z","timestamp":1649402689000},"source":"Crossref","is-referenced-by-count":18,"title":["Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension"],"prefix":"10.1152","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2013-2863","authenticated-orcid":false,"given":"Jing","family":"Wu","sequence":"first","affiliation":[{"name":"Deparment of Physiology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, 53226 Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Fang","sequence":"additional","affiliation":[{"name":"Deparment of Physiology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, 53226 Wisconsin, USA"},{"name":"Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, 52242 Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko-Ting","family":"Lu","sequence":"additional","affiliation":[{"name":"Deparment of Physiology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, 53226 Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Kumar","sequence":"additional","affiliation":[{"name":"Deparment of Physiology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, 53226 Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"Reho","sequence":"additional","affiliation":[{"name":"Deparment of Physiology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, 53226 Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T","family":"Brozoski","sequence":"additional","affiliation":[{"name":"Deparment of Physiology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, 53226 Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adokole J","family":"Otanwa","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, 52242 Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, 52242 Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand R","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, 52242 Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey K","family":"Wackman","sequence":"additional","affiliation":[{"name":"Deparment of Physiology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, 53226 Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry N","family":"Agbor","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, 52242 Iowa, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9737-0873","authenticated-orcid":false,"given":"Justin L","family":"Grobe","sequence":"additional","affiliation":[{"name":"Deparment of Physiology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, 53226 Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1453-0921","authenticated-orcid":false,"given":"Curt D","family":"Sigmund","sequence":"additional","affiliation":[{"name":"Deparment of Physiology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, 53226 Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","published-online":{"date-parts":[[2022,4,8]]},"reference":[{"issue":"9","key":"2022042722182013400_bib1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s11906-020-01076-8","article-title":"Cullin-3: Renal and Vascular Mechanisms Regulating Blood Pressure","volume":"22","author":"Wu","year":"2020","journal-title":"Curr Hypertens Rep"},{"issue":"6","key":"2022042722182013400_bib2","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.cell.2010.11.017","article-title":"Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics","volume":"143","author":"Bennett","year":"2010","journal-title":"Cell"},{"issue":"7383","key":"2022042722182013400_bib3","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/nature10814","article-title":"Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities","volume":"482","author":"Boyden","year":"2012","journal-title":"Nature"},{"issue":"11","key":"2022042722182013400_bib4","doi-asserted-by":"publisher","first-page":"4723","DOI":"10.1172\/JCI76126","article-title":"Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3","volume":"124","author":"McCormick","year":"2014","journal-title":"J Clin Invest"},{"issue":"10","key":"2022042722182013400_bib5","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.15252\/emmm.201505444","article-title":"Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia","volume":"7","author":"Schumacher","year":"2015","journal-title":"EMBO Mol Med"},{"issue":"19","key":"2022042722182013400_bib6","doi-asserted-by":"publisher","first-page":"e91015","DOI":"10.1172\/jci.insight.91015","article-title":"Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism","volume":"1","author":"Agbor","year":"2016","journal-title":"JCI Insight"},{"issue":"14","key":"2022042722182013400_bib7","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.129793","article-title":"Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension","volume":"4","author":"Agbor","year":"2019","journal-title":"JCI Insight"},{"issue":"16","key":"2022042722182013400_bib8","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.1128\/MCB.24.16.7130-7139.2004","article-title":"Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2","volume":"24","author":"Kobayashi","year":"2004","journal-title":"Mol Cell Biol"},{"issue":"2","key":"2022042722182013400_bib9","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1161\/01.hyp.37.2.444","article-title":"Endothelial dysfunction in salt-sensitive essential hypertension","volume":"37","author":"Bragulat","year":"2001","journal-title":"Hypertension"},{"issue":"10","key":"2022042722182013400_bib10","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/s0895-7061(97)00226-4","article-title":"Impairment of endothelial function in salt-sensitive hypertension in humans","volume":"10","author":"Miyoshi","year":"1997","journal-title":"Am J Hypertens"},{"issue":"4","key":"2022042722182013400_bib11","doi-asserted-by":"publisher","first-page":"R991","DOI":"10.1152\/ajpregu.00207.2005","article-title":"Renal cortical and medullary blood flow responses to L-NAME and ANG II in wild-type, nNOS null mutant, and eNOS null mutant mice","volume":"289","author":"Mattson","year":"2005","journal-title":"Am J Physiol-Regulat Integ Comp Physiol"},{"issue":"6_pt_2","key":"2022042722182013400_bib12","doi-asserted-by":"publisher","first-page":"II127","DOI":"10.1161\/01.hyp.8.6_pt_2.ii127","article-title":"Definitions and characteristics of sodium sensitivity and blood pressure resistance","volume":"8","author":"Weinberger","year":"1986","journal-title":"Hypertension"},{"issue":"3","key":"2022042722182013400_bib13","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1161\/01.hyp.27.3.481","article-title":"Salt sensitivity of blood pressure in humans","volume":"27","author":"Weinberger","year":"1996","journal-title":"Hypertension"},{"key":"2022042722182013400_bib14","doi-asserted-by":"publisher","first-page":"118377","DOI":"10.1016\/j.lfs.2020.118377","article-title":"Functional implications of vascular endothelium in regulation of endothelial nitric oxide synthesis to control blood pressure and cardiac functions","volume":"259","author":"Kumar","year":"2020","journal-title":"Life Sci"},{"issue":"4","key":"2022042722182013400_bib15","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1161\/HYPERTENSIONAHA.114.04760","article-title":"Activation of nuclear factor erythroid 2-related factor 2 coordinates dimethylarginine dimethylaminohydrolase\/PPAR-gamma\/endothelial nitric oxide synthase pathways that enhance nitric oxide generation in human glomerular endothelial cells","volume":"65","author":"Luo","year":"2015","journal-title":"Hypertension"},{"issue":"2","key":"2022042722182013400_bib16","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1161\/CIRCRESAHA.109.210658","article-title":"GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide","volume":"106","author":"Li","year":"2010","journal-title":"Circ Res"},{"issue":"1","key":"2022042722182013400_bib17","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1093\/cvr\/cvq392","article-title":"Telmisartan inhibits vasoconstriction via PPARgamma-dependent expression and activation of endothelial nitric oxide synthase","volume":"90","author":"Yuen","year":"2011","journal-title":"Cardiovasc Res"},{"issue":"7","key":"2022042722182013400_bib18","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.2337\/db11-1399","article-title":"Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex","volume":"61","author":"Zhang","year":"2012","journal-title":"Diabetes"},{"issue":"11","key":"2022042722182013400_bib19","doi-asserted-by":"publisher","first-page":"3914","DOI":"10.2337\/db15-0244","article-title":"Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo","volume":"64","author":"Bharath","year":"2015","journal-title":"Diabetes"},{"issue":"4","key":"2022042722182013400_bib20","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.bbagen.2015.01.007","article-title":"Mechanisms of protection against diabetes-induced impairment of endothelium-dependent vasorelaxation by Tanshinone IIA","volume":"1850","author":"Li","year":"2015","journal-title":"Biochimica et Biophysica Acta (BBA) \u2013 General Subjects"},{"issue":"52","key":"2022042722182013400_bib21","doi-asserted-by":"publisher","first-page":"43378","DOI":"10.1074\/jbc.M112.420281","article-title":"Selective proteasomal degradation of the B'beta subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15","volume":"287","author":"Oberg","year":"2012","journal-title":"J Biol Chem"},{"issue":"23","key":"2022042722182013400_bib22","doi-asserted-by":"publisher","first-page":"3750","DOI":"10.4161\/15384101.2014.965068","article-title":"The role of Cullin3-mediated ubiquitination of the catalytic subunit of PP2A in TRAIL signaling","volume":"13","author":"Xu","year":"2014","journal-title":"Cell Cycle"},{"issue":"11","key":"2022042722182013400_bib23","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1161\/ATVBAHA.118.309669","article-title":"Endothelial-Specific Cre Mouse Models","volume":"38","author":"Payne","year":"2018","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"2022042722182013400_bib24","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1093\/cvr\/cvaa147","article-title":"Failure to vasodilate in response to salt loading blunts renal blood flow and causes salt-sensitive hypertension","volume":"117","author":"Wu","year":"2021","journal-title":"Cardiovasc Res"},{"issue":"4","key":"2022042722182013400_bib25","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1111\/j.1440-1681.2007.04588.x","article-title":"Identification of blood pressure control mechanisms by power spectral analysis","volume":"34","author":"Stauss","year":"2007","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"6","key":"2022042722182013400_bib26","doi-asserted-by":"publisher","first-page":"e91738","DOI":"10.1172\/jci.insight.91738","article-title":"Retinol-binding protein 7 is an endothelium-specific PPARgamma cofactor mediating an antioxidant response through adiponectin","volume":"2","author":"Hu","year":"2017","journal-title":"JCI Insight"},{"issue":"4","key":"2022042722182013400_bib27","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1161\/HYPERTENSIONAHA.119.13382","article-title":"Smooth muscle cell-specific disruption of the BB some causes vascular dysfunction","volume":"74","author":"Reho","year":"2019","journal-title":"Hypertension"},{"issue":"1","key":"2022042722182013400_bib28","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1172\/JCI80761","article-title":"Immune activation caused by vascular oxidation promotes fibrosis and hypertension","volume":"126","author":"Wu","year":"2015","journal-title":"J Clin Invest"},{"issue":"8","key":"2022042722182013400_bib29","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1172\/JCI24726","article-title":"Akt1\/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis","volume":"115","author":"Ackah","year":"2005","journal-title":"J Clin Invest"},{"issue":"2","key":"2022042722182013400_bib30","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1084\/jem.20082150","article-title":"Anaphylactic shock depends on endothelial Gq\/G11","volume":"206","author":"Korhonen","year":"2009","journal-title":"J Exp Med"},{"issue":"1","key":"2022042722182013400_bib31","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1186\/s13287-021-02311-y","article-title":"Identification of circulating CD31(+)CD45(+) cell populations with the potential to differentiate into erythroid cells","volume":"12","author":"Monaco","year":"2021","journal-title":"Stem Cell Res Ther"},{"issue":"31","key":"2022042722182013400_bib32","doi-asserted-by":"publisher","first-page":"19208","DOI":"10.1074\/jbc.M115.645358","article-title":"Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors","volume":"290","author":"Ibeawuchi","year":"2015","journal-title":"J Biol Chem"},{"issue":"6","key":"2022042722182013400_bib33","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/j.cell.2008.07.022","article-title":"Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation","volume":"134","author":"Duda","year":"2008","journal-title":"Cell"},{"issue":"5","key":"2022042722182013400_bib34","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1093\/cvr\/cvaa205","article-title":"High sodium intake, glomerular hyperfiltration, and protein catabolism in patients with essential hypertension","volume":"117","author":"Rossitto","year":"2021","journal-title":"Cardiovasc Res"},{"issue":"4","key":"2022042722182013400_bib35","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1161\/HYPERTENSIONAHA.120.16518","article-title":"EP3 (E-Prostanoid 3) Receptor Mediates Impaired Vasodilation in a Mouse Model of Salt-Sensitive Hypertension","volume":"77","author":"Wu","year":"2021","journal-title":"Hypertension"},{"issue":"6","key":"2022042722182013400_bib36","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1161\/HYP.0000000000000066","article-title":"ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"71","author":"Whelton","year":"2018","journal-title":"Hypertension"},{"issue":"12","key":"2022042722182013400_bib37","doi-asserted-by":"publisher","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circulation"},{"issue":"1_supplement","key":"2022042722182013400_bib38","doi-asserted-by":"publisher","first-page":"I61","DOI":"10.1161\/01.hyp.17.1_suppl.i61","article-title":"Salt sensitivity. Definition, conception, methodology, and long-term issues","volume":"17","author":"Sullivan","year":"1991","journal-title":"Hypertension"},{"issue":"2","key":"2022042722182013400_bib39","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s11906-009-0088-4","article-title":"Sodium sensitivity of blood pressure in Chinese populations","volume":"12","author":"Chen","year":"2010","journal-title":"Curr Hypertens Rep"},{"issue":"6","key":"2022042722182013400_bib40","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1084\/jem.115.6.1173","article-title":"Effects of chronia excess salt ingestion. Evidence that genetic factors play an important role in susceptibility to experimental hypertension","volume":"115","author":"Dahl","year":"1962","journal-title":"J Exp Med"},{"issue":"11","key":"2022042722182013400_bib41","doi-asserted-by":"publisher","first-page":"S68","DOI":"10.1016\/s0895-7061(01)02072-6","article-title":"Role of abnormal nitric oxide systems in salt-sensitive hypertension","volume":"14","author":"Manning","year":"2001","journal-title":"Am J Hypertens"},{"issue":"1","key":"2022042722182013400_bib42","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/ki.1994.264","article-title":"Endogenous nitric oxide synthesis determines sensitivity to the pressor effect of salt","volume":"46","author":"Tolins","year":"1994","journal-title":"Kidney Int"},{"issue":"5","key":"2022042722182013400_bib43","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1172\/JCI115467","article-title":"L-arginine abrogates salt-sensitive hypertension in Dahl\/Rapp rats","volume":"88","author":"Chen","year":"1991","journal-title":"J Clin Invest"},{"issue":"7","key":"2022042722182013400_bib44","doi-asserted-by":"publisher","first-page":"e21853","DOI":"10.1371\/journal.pone.0021853","article-title":"Soluble guanylate cyclase stimulation prevents fibrotic tissue remodeling and improves survival in salt-sensitive Dahl rats","volume":"6","author":"Geschka","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"2022042722182013400_bib45","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1161\/01.hyp.33.1.446","article-title":"Renal intramedullary infusion of L-arginine prevents reduction of medullary blood flow and hypertension in Dahl salt-sensitive rats","volume":"33","author":"Miyata","year":"1999","journal-title":"Hypertension"},{"issue":"3","key":"2022042722182013400_bib46","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1161\/01.HYP.27.3.643","article-title":"Renal response to L-arginine in salt-sensitive patients with essential hypertension","volume":"27","author":"Higashi","year":"1996","journal-title":"Hypertension"},{"issue":"12","key":"2022042722182013400_bib47","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1016\/j.amjhyper.2006.05.025","article-title":"Increased salt-sensitivity in endothelial nitric oxide synthase-knockout mice","volume":"19","author":"Leonard","year":"2006","journal-title":"Am J Hypertens"},{"issue":"2","key":"2022042722182013400_bib48","doi-asserted-by":"publisher","first-page":"H732","DOI":"10.1152\/ajpheart.1999.277.2.H732","article-title":"Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition","volume":"277","author":"Rudd","year":"1999","journal-title":"Am J Physiol-Heart Circulat Physiol"},{"issue":"3","key":"2022042722182013400_bib49","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.amjhyper.2005.09.012","article-title":"Sodium sensitivity of arterial blood pressure in L-NAME hypertensive but not eNOS knockout mice","volume":"19","author":"Mattson","year":"2006","journal-title":"Am J Hypertens"},{"issue":"5-6","key":"2022042722182013400_bib50","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.vph.2009.11.007","article-title":"Inhibition of endothelial nitric oxide synthase by the lipid phosphatase PTEN","volume":"52","author":"Church","year":"2010","journal-title":"Vasc Pharmacol"},{"issue":"5","key":"2022042722182013400_bib51","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1097\/MBP.0000000000000060","article-title":"Clock genes in hypertension: novel insights from rodent models","volume":"19","author":"Richards","year":"2014","journal-title":"Blood Press Monit"},{"issue":"1","key":"2022042722182013400_bib52","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1172\/JCI76881","article-title":"Smooth-muscle BMAL1 participates in blood pressure circadian rhythm regulation","volume":"125","author":"Xie","year":"2015","journal-title":"J Clin Invest"},{"issue":"10","key":"2022042722182013400_bib53","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/nsmb.3076","article-title":"Histone monoubiquitination by Clock-Bmal1 complex marks Per1 and Per2 genes for circadian feedback","volume":"22","author":"Tamayo","year":"2015","journal-title":"Nat Struct Mol Biol"},{"issue":"8","key":"2022042722182013400_bib54","doi-asserted-by":"publisher","first-page":"e1001367","DOI":"10.1371\/journal.pbio.1001367","article-title":"CULLIN-3 controls TIMELESS oscillations in the Drosophila circadian clock","volume":"10","author":"Grima","year":"2012","journal-title":"PLoS Biol"},{"issue":"6","key":"2022042722182013400_bib55","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1016\/j.neuron.2011.12.003","article-title":"insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila","volume":"72","author":"Stavropoulos","year":"2011","journal-title":"Neuron"},{"issue":"1","key":"2022042722182013400_bib56","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13293-020-00306-7","article-title":"Estrogen-related mechanisms in sex differences of hypertension and target organ damage","volume":"11","author":"Sabbatini","year":"2020","journal-title":"Biol Sex Diff"},{"issue":"364","key":"2022042722182013400_bib57","first-page":"1","article-title":"Hypertension prevalence among adults aged 18 and over: United States, 2017\u20132018","author":"Ostchega","year":"2020","journal-title":"NCHS Data Brief"},{"issue":"3","key":"2022042722182013400_bib58","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1161\/01.res.81.3.355","article-title":"Estrogen upregulates endothelial nitric oxide synthase gene expression in fetal pulmonary artery endothelium","volume":"81","author":"MacRitchie","year":"1997","journal-title":"Circ Res"},{"issue":"3","key":"2022042722182013400_bib59","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1172\/JCI5347","article-title":"Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen","volume":"103","author":"Chen","year":"1999","journal-title":"J Clin Invest"},{"key":"2022042722182013400_bib60","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jsbmb.2017.05.006","article-title":"Role of GPER in estrogen-dependent nitric oxide formation and vasodilation","volume":"176","author":"Fredette","year":"2018","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"6","key":"2022042722182013400_bib61","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1152\/japplphysiol.01197.2011","article-title":"Sex differences in salt sensitivity to nitric oxide dependent vasodilation in healthy young adults","volume":"112","author":"Eisenach","year":"2012","journal-title":"J Appl Physiol"},{"issue":"6","key":"2022042722182013400_bib62","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1161\/HYPERTENSIONAHA.117.11087","article-title":"Biological Sex Modulates the Adrenal and Blood Pressure Responses to Angiotensin II","volume":"71","author":"Shukri","year":"2018","journal-title":"Hypertension"},{"issue":"4","key":"2022042722182013400_bib63","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1111\/jch.13509","article-title":"Sex-specific patterns in the association between salt intake and blood pressure: The ELSA-Brasil study","volume":"21","author":"Mill","year":"2019","journal-title":"J Clin Hypert"},{"issue":"12","key":"2022042722182013400_bib64","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.7326\/0003-4819-135-12-200112180-00005","article-title":"Effects of diet and sodium intake on blood pressure: subgroup analysis of the DASH-sodium trial","volume":"135","author":"Vollmer","year":"2001","journal-title":"Ann Intern Med"},{"issue":"3","key":"2022042722182013400_bib65","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1081\/ceh-100102663","article-title":"The role of gender in salt-induced hypertension","volume":"23","author":"Bayorh","year":"2001","journal-title":"Clin Exp Hypertens"},{"issue":"2","key":"2022042722182013400_bib66","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1161\/HYPERTENSIONAHA.119.13822","article-title":"New Mechanism for the Sex Differences in Salt-Sensitive Hypertension: The Role of Macula Densa NOS1beta-Mediated Tubuloglomerular Feedback","volume":"75","author":"Zhang","year":"2020","journal-title":"Hypertension"},{"issue":"2","key":"2022042722182013400_bib67","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1097\/MNH.0000000000000394","article-title":"The pivotal role of renal vasodysfunction in salt sensitivity and the initiation of salt-induced hypertension","volume":"27","author":"Kurtz","year":"2018","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"3","key":"2022042722182013400_bib68","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1161\/HYPERTENSIONAHA.111.170175","article-title":"Salt sensitivity in blacks: evidence that the initial pressor effect of NaCl involves inhibition of vasodilatation by asymmetrical dimethylarginine","volume":"58","author":"Schmidlin","year":"2011","journal-title":"Hypertension"},{"issue":"2","key":"2022042722182013400_bib69","doi-asserted-by":"publisher","first-page":"H508","DOI":"10.1152\/ajpheart.1990.258.2.H508","article-title":"Role of blood volume expansion in Dahl rat model of hypertension","volume":"258","author":"Greene","year":"1990","journal-title":"Am J Physiol-Heart Circul Physiol"},{"issue":"6","key":"2022042722182013400_bib70","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1161\/01.hyp.18.6.805","article-title":"Abnormal renal hemodynamics in black salt-sensitive patients with hypertension","volume":"18","author":"Campese","year":"1991","journal-title":"Hypertension"},{"issue":"3","key":"2022042722182013400_bib71","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1161\/01.hyp.2.3.274","article-title":"Determinants of renal vascular resistance in the Dahl strain of genetically hypertensive rat","volume":"2","author":"Fink","year":"1980","journal-title":"Hypertension"},{"issue":"5","key":"2022042722182013400_bib72","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1161\/HYPERTENSIONAHA.114.04147","article-title":"Oligoclonal CD8+ T cells play a critical role in the development of hypertension","volume":"64","author":"Trott","year":"2014","journal-title":"Hypertension"},{"issue":"2","key":"2022042722182013400_bib73","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.cmet.2015.11.013","article-title":"Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron","volume":"23","author":"Zhang","year":"2016","journal-title":"Cell Metab"}],"container-title":["Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/full\/10.1093\/function\/zqac017","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1093\/function\/zqac017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:06:52Z","timestamp":1781629612000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/full\/10.1093\/function\/zqac017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":73,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,4,27]]}},"URL":"https:\/\/doi.org\/10.1093\/function\/zqac017","relation":{},"ISSN":["2633-8823"],"issn-type":[{"value":"2633-8823","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022]]},"published":{"date-parts":[[2022]]},"article-number":"zqac017"}}