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The medial prefrontal cortex (mPFC) is a core region in the brain that modulates emotions and is directly involved in the cardiovascular response to stress by increasing vascular resistance. In the present study we examined the relationship between ACEs, mPFC and peripheral vascular function. Forty-five, adults (33\u00b15\u00a0yrs.) participated in the present study to evaluate cerebral hemodynamics and peripheral vascular function. The impact of adverse experiences was evaluated through the ACE questionnaire. Among those that experienced ACEs (ACE group, n\u00a0=\u00a022), there was a significantly (P &amp;lt; 0.001) reduced activation of the mPFC as well as greater peripheral vascular resistance observed in the small (P\u00a0\u2264\u00a00.035), conduit (P\u00a0\u2264\u00a00.042) and large (P\u00a0\u2264\u00a00.001) blood vessels, when compared to those that did not report ACEs (Control group, n\u00a0=\u00a023). In addition, relationships between the number of ACEs and mPFC activation (rs = \u22120.428; P = 0.003) and peripheral vascular function (rs\u2264 \u22120.373; P\u00a0\u2264\u00a00.009) were observed. Findings from the present study support that adults who experienced ACEs exhibit a reduced activation of the mPFC along with systemic vascular dysfunction. In addition, individuals exposed to more childhood traumatic events exhibited a progressively greater inactivation of the mPFC and an increased peripheral vasoconstriction in a dose-dependent manner. These findings provide novel insights into the potential role that the brain and the peripheral vasculature may have in connecting adverse childhood events to the increased risk of CVD.<\/jats:p>","DOI":"10.1093\/function\/zqac029","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T14:51:14Z","timestamp":1654008674000},"source":"Crossref","is-referenced-by-count":20,"title":["The Link Between Childhood Adversity and Cardiovascular Disease Risk: Role of Cerebral and Systemic Vasculature"],"prefix":"10.1152","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3582-4483","authenticated-orcid":false,"given":"Paula","family":"Rodriguez-Miguelez","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Health Sciences, Virginia Commonwealth University , Richmond 23284, VA, USA"},{"name":"Division of Pulmonary and Critical Care, Virginia Commonwealth University , Richmond 23284, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Looney","sequence":"additional","affiliation":[{"name":"Georgia Prevention Institute, Augusta University , Augusta 30912, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marsha","family":"Blackburn","sequence":"additional","affiliation":[{"name":"Georgia Prevention Institute, Augusta University , Augusta 30912, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Thomas","sequence":"additional","affiliation":[{"name":"Georgia Prevention Institute, Augusta University , Augusta 30912, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1956-0449","authenticated-orcid":false,"given":"Jennifer S","family":"Pollock","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Alabama at Birmingham , Birmingham 35294, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan A","family":"Harris","sequence":"additional","affiliation":[{"name":"Georgia Prevention Institute, Augusta University , Augusta 30912, Georgia, USA"},{"name":"Sport and Exercise Science Research Institute, University of Ulster , Jordanstown BT37 0QB, Northern Ireland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"issue":"2","key":"2022062411331392800_bib1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/apha.12189","article-title":"A mechanistic look at the effects of adversity early in life on cardiovascular disease risk during adulthood","volume":"210","author":"Loria","year":"2014","journal-title":"Acta Physiologica"},{"issue":"5","key":"2022062411331392800_bib2","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1161\/CIR.0000000000000536","article-title":"Childhood and adolescent adversity and cardiometabolic outcomes: a scientific statement from the American Heart Association","volume":"137","author":"Suglia","year":"2018","journal-title":"Circulation"},{"issue":"13","key":"2022062411331392800_bib3","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1161\/01.CIR.0000143074.54995.7F","article-title":"Insights into causal pathways for ischemic heart disease: adverse childhood experiences study","volume":"110","author":"Dong","year":"2004","journal-title":"Circulation"},{"issue":"4","key":"2022062411331392800_bib4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0749-3797(98)00017-8","article-title":"Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. 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