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Several alcohol-mediated mechanisms have been identified, with bioenergetic maladaptation gaining credence as an underlying pathophysiological mechanism contributing to cellular injury. This evidence-based review focuses on the current knowledge of alcohol-induced bioenergetic adaptations in metabolically active tissues: liver, cardiac and skeletal muscle, pancreas, and brain. Alcohol metabolism itself significantly interferes with bioenergetic pathways in tissues, particularly the liver. Alcohol decreases states of respiration in the electron transport chain, and activity and expression of respiratory complexes, with a net effect to decrease ATP content. In addition, alcohol dysregulates major metabolic pathways, including glycolysis, the tricarboxylic acid cycle, and fatty acid oxidation. These bioenergetic alterations are influenced by alcohol-mediated changes in mitochondrial morphology, biogenesis, and dynamics. The review highlights similarities and differences in bioenergetic adaptations according to tissue type, pattern of (acute vs. chronic) alcohol use, and energy substrate availability. The compromised bioenergetics synergizes with other critical pathophysiological mechanisms, including increased oxidative stress and accelerates cellular dysfunction, promoting senescence, programmed cell death, and end-organ injury.<\/jats:p>","DOI":"10.1093\/function\/zqac039","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T18:47:50Z","timestamp":1661366870000},"source":"Crossref","is-referenced-by-count":38,"title":["Cellular Bioenergetics: Experimental Evidence for Alcohol-induced Adaptations"],"prefix":"10.1152","volume":"3","author":[{"given":"Liz","family":"Simon","sequence":"first","affiliation":[{"name":"Department of Physiology and Comprehensive Alcohol-HIV\/AIDS Research Center, Louisiana State University Health Sciences Center , 1901 Perdido Street, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3598-384X","authenticated-orcid":false,"given":"Patricia E","family":"Molina","sequence":"additional","affiliation":[{"name":"Department of Physiology and Comprehensive Alcohol-HIV\/AIDS Research Center, Louisiana State University Health Sciences Center , 1901 Perdido Street, New Orleans, LA 70112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"issue":"7","key":"2022091314365848100_bib1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s40273-021-01031-8","article-title":"What are the economic costs to society attributable to alcohol use? 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