{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:26:16Z","timestamp":1787887576430,"version":"build-2784847793"},"reference-count":49,"publisher":"American Physiological Society","issue":"2","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["P0240441"],"award-info":[{"award-number":["P0240441"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["19EIA34660135"],"award-info":[{"award-number":["19EIA34660135"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32DK121424"],"award-info":[{"award-number":["F32DK121424"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Brain and muscle ARNT-like 1 (BMAL1) is a core circadian clock protein and transcription factor that regulates many physiological functions, including blood pressure (BP). Male global Bmal1 knockout (KO) mice exhibit \u223c10\u2009mmHg reduction in BP, as well as a blunting of BP rhythm. The mechanisms of how BMAL1 regulates BP remains unclear. The adrenal gland synthesizes hormones, including glucocorticoids and mineralocorticoids, that influence BP rhythm. To determine the role of adrenal BMAL1 on BP regulation, adrenal-specific Bmal1 (ASCre\/+::Bmal1) KO mice were generated using aldosterone synthase Cre recombinase to KO Bmal1 in the adrenal gland zona glomerulosa. We confirmed the localization and efficacy of the KO of BMAL1 to the zona glomerulosa. Male ASCre\/+::Bmal1 KO mice displayed a shortened BP and activity period\/circadian cycle (typically 24\u2009h) by \u223c1\u2009h and delayed peak of BP and activity by \u223c2 and 3\u2009h, respectively, compared with littermate Cre- control mice. This difference was only evident when KO mice were in metabolic cages, which acted as a stressor, as serum corticosterone was increased in metabolic cages compared with home cages. ASCre\/+::Bmal1 KO mice also displayed altered diurnal variation in serum corticosterone. Furthermore, these mice have altered eating behaviors where they have a blunted night\/day ratio of food intake, but no change in overall food consumed compared with controls. Overall, these data suggest that adrenal BMAL1 has a role in the regulation of BP rhythm and eating behaviors.<\/jats:p>","DOI":"10.1093\/function\/zqad001","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T20:36:16Z","timestamp":1673296576000},"source":"Crossref","is-referenced-by-count":22,"title":["Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior"],"prefix":"10.1152","volume":"4","author":[{"given":"Hannah M","family":"Costello","sequence":"first","affiliation":[{"name":"Department of Physiology and Aging, University of Florida , Gainesville, FL 32610 , USA"},{"name":"Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida , Gainesville, FL 32610 , USA"},{"name":"Center for Integrative Cardiovascular and Metabolic Diseases, University of Florida , Gainesville, FL 32610 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G Ryan","family":"Crislip","sequence":"additional","affiliation":[{"name":"Department of Physiology and Aging, University of Florida , Gainesville, FL 32610 , USA"},{"name":"Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida , Gainesville, FL 32610 , USA"},{"name":"Center for Integrative Cardiovascular and Metabolic Diseases, University of Florida , Gainesville, FL 32610 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kit-Yan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Physiology and Aging, University of Florida , Gainesville, FL 32610 , USA"},{"name":"Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida , Gainesville, FL 32610 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I Jeanette","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida , Gainesville, FL 32610 , USA"},{"name":"Research, North Florida\/South Georgia Malcolm Randall Veterans Affairs Medical Center , Gainesville, FL 32608 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria","family":"Juffre","sequence":"additional","affiliation":[{"name":"Department of Physiology and Aging, University of Florida , Gainesville, FL 32610 , USA"},{"name":"Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida , Gainesville, FL 32610 , USA"},{"name":"Department of Biochemistry and Molecular Biology, University of Florida , Gainesville, FL 32610 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Bratanatawira","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida , Gainesville, FL 32610 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisse","family":"Mckee","sequence":"additional","affiliation":[{"name":"Department of Physiology and Aging, University of Florida , Gainesville, FL 32610 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryanne S","family":"Thelwell","sequence":"additional","affiliation":[{"name":"Department of Physiology and Aging, University of Florida , Gainesville, FL 32610 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor M","family":"Mendez","sequence":"additional","affiliation":[{"name":"Department of Physiology and Aging, University of Florida , Gainesville, FL 32610 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles S","family":"Wingo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida , Gainesville, FL 32610 , USA"},{"name":"Research, North Florida\/South Georgia Malcolm Randall Veterans Affairs Medical Center , Gainesville, FL 32608 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren G","family":"Douma","sequence":"additional","affiliation":[{"name":"Department of Physiology and Aging, University of Florida , Gainesville, FL 32610 , USA"},{"name":"Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida , Gainesville, FL 32610 , USA"},{"name":"Center for Integrative Cardiovascular and Metabolic Diseases, University of Florida , Gainesville, FL 32610 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1342-0878","authenticated-orcid":false,"given":"Michelle L","family":"Gumz","sequence":"additional","affiliation":[{"name":"Department of Physiology and Aging, University of Florida , Gainesville, FL 32610 , USA"},{"name":"Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida , Gainesville, FL 32610 , USA"},{"name":"Center for Integrative Cardiovascular and Metabolic Diseases, University of Florida , Gainesville, FL 32610 , USA"},{"name":"Research, North Florida\/South Georgia Malcolm Randall Veterans Affairs Medical Center , Gainesville, FL 32608 , USA"},{"name":"Department of Biochemistry and Molecular Biology, University of Florida , Gainesville, FL 32610 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"issue":"8","key":"2023020909114775000_bib1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/hr.2010.111","article-title":"Diurnal blood pressure variation, risk categories and antihypertensive treatment","volume":"33","author":"de\u00a0la\u00a0Sierra","year":"2010","journal-title":"Hypertens Res"},{"key":"2023020909114775000_bib2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neubiorev.2014.01.007","article-title":"The trouble with circadian clock dysfunction: multiple deleterious effects on the brain and body","volume":"40","author":"Zelinski","year":"2014","journal-title":"Neurosci Biobehav Rev"},{"issue":"5","key":"2023020909114775000_bib3","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1161\/HYPERTENSIONAHA.121.14519","article-title":"Circadian rhythm, clock genes, and hypertension: recent advances in hypertension","volume":"78","author":"Costello","year":"2021","journal-title":"Hypertension"},{"issue":"2","key":"2023020909114775000_bib4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1257\/app.20140100","article-title":"Spring forward at your own risk: daylight saving time and fatal vehicle crashes","volume":"8","author":"Smith","year":"2016","journal-title":"Am Econ J Appl Econ"},{"issue":"10","key":"2023020909114775000_bib5","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.5664\/jcsm.8780","article-title":"Daylight saving time: an American Academy of Sleep Medicine position statement","volume":"16","author":"Rishi","year":"2020","journal-title":"J Clin Sleep Med"},{"issue":"6","key":"2023020909114775000_bib6","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1097\/HJH.0000000000002021","article-title":"The global burden of hypertension exceeds 1.4 billion people","volume":"37","author":"Egan","year":"2019","journal-title":"J Hypertens"},{"issue":"7","key":"2023020909114775000_bib7","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1097\/01.hjh.0000431740.32696.cc","article-title":"2013 ESH\/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)","volume":"31","author":"Mancia","year":"2013","journal-title":"J Hypertens"},{"key":"2023020909114775000_bib8","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.freeradbiomed.2017.11.024","article-title":"Circadian clock-mediated regulation of blood pressure","volume":"119","author":"Douma","year":"2018","journal-title":"Free Radical Biol Med"},{"issue":"7","key":"2023020909114775000_bib9","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/35081582","article-title":"Hypothalamic integration of central and peripheral clocks","volume":"2","author":"Buijs","year":"2001","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"2023020909114775000_bib10","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s12576-015-0374-7","article-title":"Comparison of light, food, and temperature as environmental synchronizers of the circadian rhythm of activity in mice","volume":"65","author":"Refinetti","year":"2015","journal-title":"J Physiol Sci"},{"issue":"1","key":"2023020909114775000_bib11","doi-asserted-by":"crossref","first-page":"20114","DOI":"10.1038\/s41598-019-56323-z","article-title":"Differentiating external zeitgeber impact on peripheral circadian clock resetting","volume":"9","author":"Heyde","year":"2019","journal-title":"Sci Rep"},{"issue":"8","key":"2023020909114775000_bib12","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nrn1177","article-title":"A clockwork web: circadian timing in brain and periphery, in health and disease","volume":"4","author":"Hastings","year":"2003","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"2023020909114775000_bib13","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nrg.2016.150","article-title":"Transcriptional architecture of the mammalian circadian clock","volume":"18","author":"Takahashi","year":"2017","journal-title":"Nat Rev Genet"},{"issue":"8","key":"2023020909114775000_bib14","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1113\/EP085781","article-title":"Molecular basis of circadian rhythmicity in renal physiology and pathophysiology","volume":"101","author":"Gumz","year":"2016","journal-title":"Exp Physiol"},{"issue":"2","key":"2023020909114775000_bib15","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.tcb.2013.07.002","article-title":"Molecular architecture of the mammalian circadian clock","volume":"24","author":"Partch","year":"2014","journal-title":"Trends Cell Biol"},{"issue":"9","key":"2023020909114775000_bib16","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1073\/pnas.0611680104","article-title":"Circadian variation of blood pressure and the vascular response to asynchronous stress","volume":"104","author":"Curtis","year":"2007","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"2023020909114775000_bib17","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1172\/JCI76881","article-title":"Smooth-muscle BMAL1 participates in blood pressure circadian rhythm regulation","volume":"125","author":"Xie","year":"2015","journal-title":"J Clin Invest"},{"issue":"4","key":"2023020909114775000_bib18","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1161\/HYPERTENSIONAHA.105.063636","article-title":"Kidney in hypertension","volume":"51","author":"Coffman","year":"2008","journal-title":"Hypertension"},{"issue":"10","key":"2023020909114775000_bib19","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1681\/ASN.2015091055","article-title":"Nephron-specific deletion of circadian clock gene Bmal1 alters the plasma and renal metabolome and impairs drug disposition","volume":"27","author":"Nikolaeva","year":"2016","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"2023020909114775000_bib20","doi-asserted-by":"crossref","first-page":"F710","DOI":"10.1152\/ajprenal.00364.2019","article-title":"Loss of circadian gene Bmal1 in the collecting duct lowers blood pressure in male, but not female, mice","volume":"318","author":"Zhang","year":"2020","journal-title":"Am J Physiol Renal Physiol"},{"issue":"6","key":"2023020909114775000_bib21","doi-asserted-by":"crossref","first-page":"F1463","DOI":"10.1152\/ajprenal.00014.2020","article-title":"Differences in renal BMAL1 contribution to Na+homeostasis and blood pressure control in male and female mice","volume":"318","author":"Crislip","year":"2020","journal-title":"Am J Physiol Renal Physiol"},{"issue":"7","key":"2023020909114775000_bib22","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1681\/ASN.2013060641","article-title":"Local renal circadian clocks control fluid\u2013electrolyte homeostasis and BP","volume":"25","author":"Tokonami","year":"2014","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"2023020909114775000_bib23","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1161\/HYPERTENSIONAHA.115.06977","article-title":"Glucocorticoids induce nondipping blood pressure by activating the thiazide-sensitive cotransporter","volume":"67","author":"Ivy","year":"2016","journal-title":"Hypertension"},{"issue":"10","key":"2023020909114775000_bib24","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1210\/en.2019-00357","article-title":"Sex differences in adrenal Bmal1 deletion-induced augmentation of glucocorticoid responses to stress and ACTH in mice","volume":"160","author":"Engeland","year":"2019","journal-title":"Endocrinology"},{"issue":"6","key":"2023020909114775000_bib25","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.devcel.2013.07.016","article-title":"Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells","volume":"26","author":"Freedman","year":"2013","journal-title":"Dev Cell"},{"issue":"12","key":"2023020909114775000_bib26","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1210\/en.2018-00769","article-title":"The adrenal clock prevents aberrant light-induced alterations in circadian glucocorticoid rhythms","volume":"159","author":"Engeland","year":"2018","journal-title":"Endocrinology"},{"issue":"2","key":"2023020909114775000_bib27","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1152\/physiolgenomics.2001.5.2.89","article-title":"Long-term telemetric measurement of cardiovascular parameters in awake mice: a physiological genomics tool","volume":"5","author":"Butz","year":"2001","journal-title":"Physiol Genomics"},{"issue":"6","key":"2023020909114775000_bib28","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1161\/HYPERTENSIONAHA.112.190892","article-title":"The circadian protein period 1 contributes to blood pressure control and coordinately regulates renal sodium transport genes","volume":"59","author":"Stow","year":"2012","journal-title":"Hypertension"},{"issue":"4","key":"2023020909114775000_bib29","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/09291010600903692","article-title":"Procedures for numerical analysis of circadian rhythms","volume":"38","author":"Refinetti","year":"2007","journal-title":"Biol Rhythm Res"},{"key":"2023020909114775000_bib30","first-page":"2519","article-title":"Knockout of the circadian clock protein PER1 (Period1) exacerbates hypertension and increases kidney injury in dahl salt-sensitive rats","volume-title":"Hypertension","author":"Zietara","year":"2022"},{"issue":"4","key":"2023020909114775000_bib31","doi-asserted-by":"crossref","first-page":"F449","DOI":"10.1152\/ajprenal.00385.2021","article-title":"Kidney-specific KO of the circadian clock protein PER1 alters renal sodium handling, aldosterone levels, and kidney\/adrenal gene expression","volume":"322","author":"Douma","year":"2022","journal-title":"Am J Physiol Renal Physiol"},{"issue":"1","key":"2023020909114775000_bib32","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/apha.12804","article-title":"Desoxycorticosterone pivalate-salt treatment leads to non-dipping hypertension in Per1 knockout mice","volume":"220","author":"Solocinski","year":"2017","journal-title":"Acta Physiologica"},{"issue":"1","key":"2023020909114775000_bib33","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/01.HYP.0000107401.72456.50","article-title":"Cardiovascular and renal phenotype in mice with one or two renin genes","volume":"43","author":"Lum","year":"2004","journal-title":"Hypertension"},{"issue":"1","key":"2023020909114775000_bib34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.33549\/physiolres.931390","article-title":"Transient hypertension and sustained tachycardia in mice housed individually in metabolism cages","volume":"58","author":"Hoppe","year":"2009","journal-title":"Physiol Res"},{"key":"2023020909114775000_bib35","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.smrv.2016.02.003","article-title":"Circadian mechanisms of 24-hour blood pressure regulation and patterning","volume":"33","author":"Smolensky","year":"2017","journal-title":"Sleep Med Rev"},{"issue":"23","key":"2023020909114775000_bib36","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1101\/gad.183500","article-title":"Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus","volume":"14","author":"Damiola","year":"2000","journal-title":"Genes Dev"},{"key":"2023020909114775000_bib37","first-page":"zqaa034","article-title":"Timing of food intake drives the circadian rhythm of blood pressure","volume-title":"Function (Oxf)","author":"Zhang","year":"2021"},{"issue":"2","key":"2023020909114775000_bib38","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1080\/13813455.2018.1441314","article-title":"Long-term metabolic cage housing increases anxiety\/depression-related behaviours in adult male rats","volume":"125","author":"Sahin","year":"2019","journal-title":"Arch Physiol Biochem"},{"issue":"3","key":"2023020909114775000_bib39","doi-asserted-by":"crossref","first-page":"e58460","DOI":"10.1371\/journal.pone.0058460","article-title":"Mice do not habituate to metabolism cage housing\u2013a three week study of male BALB\/c mice","volume":"8","author":"Kalliokoski","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"2023020909114775000_bib40","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrn2647","article-title":"Neural regulation of endocrine and autonomic stress responses","volume":"10","author":"Ulrich-Lai","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"2023020909114775000_bib41","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.physbeh.2015.02.038","article-title":"Metabolic consequences of chronic intermittent mild stress exposure","volume":"150","author":"Thompson","year":"2015","journal-title":"Physiol Behav"},{"issue":"5","key":"2023020909114775000_bib42","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-2826.1994.tb00611.x","article-title":"Adrenal steroid receptors: interactions with brain neuropeptide systems in relation to nutrient intake and metabolism","volume":"6","author":"Tempel","year":"1994","journal-title":"J Neuroendocrinol"},{"issue":"24","key":"2023020909114775000_bib43","doi-asserted-by":"crossref","first-page":"7128","DOI":"10.1093\/emboj\/20.24.7128","article-title":"Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators","volume":"20","author":"le\u00a0Minh","year":"2001","journal-title":"EMBO J"},{"issue":"1","key":"2023020909114775000_bib44","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41398-020-0694-0","article-title":"Circadian rhythm disruption and mental health","volume":"10","author":"Walker","year":"2020","journal-title":"Transl Psychiatry"},{"issue":"4","key":"2023020909114775000_bib45","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jsmc.2015.07.005","article-title":"Consequences of circadian disruption on cardiometabolic health","volume":"10","author":"Reutrakul","year":"2015","journal-title":"Sleep Med Clin"},{"issue":"10","key":"2023020909114775000_bib46","doi-asserted-by":"crossref","first-page":"E1402","DOI":"10.1073\/pnas.1516953113","article-title":"Circadian misalignment increases cardiovascular disease risk factors in humans","volume":"113","author":"Morris","year":"2016","journal-title":"Proc Natl Acad Sci"},{"issue":"2","key":"2023020909114775000_bib47","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cmet.2018.08.004","article-title":"Time-restricted feeding prevents obesity and metabolic syndrome in mice lacking a circadian clock","volume":"29","author":"Chaix","year":"2019","journal-title":"Cell Metab"},{"issue":"25","key":"2023020909114775000_bib48","doi-asserted-by":"crossref","first-page":"e2015873118","DOI":"10.1073\/pnas.2015873118","article-title":"Time-restricted feeding protects the blood pressure circadian rhythm in diabetic mice","volume":"118","author":"Hou","year":"2021","journal-title":"Proc Natl Acad Sci"},{"issue":"2","key":"2023020909114775000_bib49","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0896-6273(01)00302-6","article-title":"Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock","volume":"30","author":"Bae","year":"2001","journal-title":"Neuron"}],"container-title":["Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/full\/10.1093\/function\/zqad001","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1093\/function\/zqad001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:06:59Z","timestamp":1781629619000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/full\/10.1093\/function\/zqad001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2,9]]}},"URL":"https:\/\/doi.org\/10.1093\/function\/zqad001","relation":{},"ISSN":["2633-8823"],"issn-type":[{"value":"2633-8823","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023]]},"published":{"date-parts":[[2023]]},"article-number":"zqad001"}}