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Skeletal homeostasis, which includes aspects such as bone density, structural integrity, and regenerative processes, is essential for normal skeletal function. Autophagy, an intricate intracellular mechanism for degrading and recycling cellular components, plays a multifaceted role in bone metabolism. It involves sequestering cellular waste, damaged proteins, and organelles within autophagosomes, which are then degraded and recycled. Autophagy\u2019s impact on bone health varies depending on factors such as regulation, cell type, environmental cues, and physiological context. Despite being traditionally considered a cytoplasmic process, autophagy is subject to transcriptional and epigenetic regulation within the nucleus. However, the precise influence of epigenetic regulation, including DNA methylation, histone modifications, and non-coding RNA expression, on cellular fate remains incompletely understood. The interplay between autophagy and epigenetic modifications adds complexity to bone cell regulation. This article provides an in-depth exploration of the intricate interplay between these two regulatory paradigms, with a focus on the epigenetic control of autophagy in bone metabolism. Such an understanding enhances our knowledge of bone metabolism-related disorders and offers insights for the development of targeted therapeutic strategies.<\/jats:p>","DOI":"10.1093\/function\/zqae004","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T23:28:56Z","timestamp":1706138936000},"source":"Crossref","is-referenced-by-count":16,"title":["Epigenetic Regulation of Autophagy in Bone Metabolism"],"prefix":"10.1152","volume":"5","author":[{"given":"Yazhou","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Foot and Ankle Surgery, Tengzhou Central People\u2019s Hospital , Tengzhou 277500 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, Tengzhou Central People\u2019s Hospital , Tengzhou 277500 , 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