{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:53:47Z","timestamp":1781632427215,"version":"3.54.5"},"reference-count":63,"publisher":"American Physiological Society","issue":"1","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 Research and Innovation Programs"},{"name":"Marie Sklodowska-Curie","award":["812699"],"award-info":[{"award-number":["812699"]}]},{"name":"Alexander von Humboldt Stiftung\/Foundation for an Experienced Researcher Fellowship"},{"name":"International Peritoneal Dialysis Society"},{"name":"International Cooperation Research Grant"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Olympia Morata Fellowship from Heidelberg University"},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201908080237"],"award-info":[{"award-number":["201908080237"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202108320064"],"award-info":[{"award-number":["202108320064"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003825","name":"Hungarian Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"name":"J\u00e1nos Bolyai Research Scholarship"},{"name":"Austrian Federal Ministry of Science, Research and Economy"},{"DOI":"10.13039\/100010132","name":"National Foundation for Research, Technology and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010132","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Nephrology and Dialysis Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Peritoneal dialysis (PD) is an increasingly needed, life-maintaining kidney replacement therapy; efficient solute transport is critical for patient outcome. While the role of peritoneal perfusion on solute transport in PD has been described, the role of cellular barriers is uncertain, the mesothelium has been considered irrelevant. We calculated peritoneal blood microvascular endothelial surface area (BESA) to mesothelial surface area (MSA) ratio in human peritonea in health, chronic kidney disease, and on PD, and performed molecular transport related gene profiling and single molecule localization microscopy in two mesothelial (MC) and two endothelial cell lines (EC). Molecular-weight dependent transport was studied in-vitro, ex-vivo and in mice. Peritoneal BESA is 1-3-fold higher than MSA across age groups, and increases with PD, while the mesothelium is preserved during the first 2 years of PD. Tight junction, transmembrane and transcytotic transporter expression are cell-type specifically expressed. At nanoscale, tight junction anchoring protein Zonula occludens-1 is more abundant and more continuously expressed along the MC than the EC. Ionic conductance is 3-fold lower across the MC than human microvascular EC, as is the permeability for creatinine, 4- and 10-kDa, but not for 70-kDa dextran. MC removal from sheep peritoneum abolishes ionic barrier function. Short term intraperitoneal LPS exposure in mice selectively affects peritoneal mesothelial integrity and increases transperitoneal solute transport. We provide molecular correlates and consistent functional evidence for the mesothelium as a barrier for peritoneal solute transport, ie, essential information on peritoneal transport modeling, and for interventions to improve PD efficiency and biocompatibility, and beyond.<\/jats:p>","DOI":"10.1093\/function\/zqae051","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T07:30:05Z","timestamp":1733470205000},"source":"Crossref","is-referenced-by-count":4,"title":["Molecular and Functional Characterization of the Peritoneal Mesothelium, a Barrier for Solute Transport"],"prefix":"10.1152","volume":"6","author":[{"given":"Iva","family":"Marinovic","sequence":"first","affiliation":[{"name":"Center for Pediatric and Adolescent Medicine, Department 1, Pediatric Nephrology, Medical Faculty Heidelberg, Heidelberg University , 69120 Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bartosova","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Adolescent Medicine, Department 1, Pediatric Nephrology, Medical Faculty Heidelberg, Heidelberg University , 69120 Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Levai","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Adolescent Medicine, Department 1, Pediatric Nephrology, Medical Faculty Heidelberg, Heidelberg University , 69120 Heidelberg ,","place":["Germany"]},{"name":"Pediatric Center, MTA Center of Excellence, Semmelweis University , 1083 Budapest ,","place":["Hungary"]},{"name":"HUN-REN\u2013SU Pediatrics and Nephrology Research Group , 1052 Budapest ,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Herzog","sequence":"additional","affiliation":[{"name":"Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna ,1090 Vienna ,","place":["Austria"]},{"name":"Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University Vienna , 1090 Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arslan","family":"Saleem","sequence":"additional","affiliation":[{"name":"Kirchhoff Institute for Physics, Heidelberg University , 69120 Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Du","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Adolescent Medicine, Department 1, Pediatric Nephrology, Medical Faculty Heidelberg, Heidelberg University , 69120 Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4296-4054","authenticated-orcid":false,"given":"Conghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Adolescent Medicine, Department 1, Pediatric Nephrology, Medical Faculty Heidelberg, Heidelberg University , 69120 Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Sacnun","sequence":"additional","affiliation":[{"name":"Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna ,1090 Vienna ,","place":["Austria"]},{"name":"Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University Vienna , 1090 Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanna","family":"Pitaraki","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, School of Health Sciences, University of Thessaly, BIOPOLIS , 41500 Larissa ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios","family":"Sinis","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine, School of Health Sciences, University of Thessaly, BIOPOLIS , 41500 Larissa ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Damgov","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Adolescent Medicine, Department 1, Pediatric Nephrology, Medical Faculty Heidelberg, Heidelberg University , 69120 Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5615-627X","authenticated-orcid":false,"given":"Damir","family":"Krunic","sequence":"additional","affiliation":[{"name":"German Cancer Research Center , 69120 Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trim","family":"Lajqi","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Adolescent Medicine, Department 1, Pediatric Nephrology, Medical Faculty Heidelberg, Heidelberg University , 69120 Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Al-Saeedi","sequence":"additional","affiliation":[{"name":"Medical Faculty Heidelberg, Department of General, Visceral and Transplantation Surgery, Heidelberg University , 69120 Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Attila","family":"Szabo","sequence":"additional","affiliation":[{"name":"Pediatric Center, MTA Center of Excellence, Semmelweis University , 1083 Budapest ,","place":["Hungary"]},{"name":"HUN-REN\u2013SU Pediatrics and Nephrology Research Group , 1052 Budapest ,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hausmann","sequence":"additional","affiliation":[{"name":"Kirchhoff Institute for Physics, Heidelberg University , 69120 Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domonkos","family":"Pap","sequence":"additional","affiliation":[{"name":"Pediatric Center, MTA Center of Excellence, Semmelweis University , 1083 Budapest ,","place":["Hungary"]},{"name":"HUN-REN\u2013SU Pediatrics and Nephrology Research Group , 1052 Budapest ,","place":["Hungary"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Kratochwill","sequence":"additional","affiliation":[{"name":"Christian Doppler Laboratory for Molecular Stress Research in Peritoneal Dialysis, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna ,1090 Vienna ,","place":["Austria"]},{"name":"Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University Vienna , 1090 Vienna ,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne M","family":"Krug","sequence":"additional","affiliation":[{"name":"Clinical Physiology\/Nutritional Medicine, Charit\u00e9- Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t and Humboldt Universit\u00e4t , 12203 Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios G","family":"Zarogiannis","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Adolescent Medicine, Department 1, Pediatric Nephrology, Medical Faculty Heidelberg, Heidelberg University , 69120 Heidelberg ,","place":["Germany"]},{"name":"Department of Physiology, Faculty of Medicine, School of Health Sciences, University of Thessaly, BIOPOLIS , 41500 Larissa ,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus Peter","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Center for Pediatric and Adolescent Medicine, Department 1, Pediatric Nephrology, Medical Faculty Heidelberg, Heidelberg University , 69120 Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"issue":"10075","key":"2025030421364919600_bib1","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic kidney disease","volume":"389","author":"Webster","year":"2017","journal-title":"The Lancet"},{"issue":"6","key":"2025030421364919600_bib2","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1177\/089686080402400616","article-title":"Analysis of the Prevalence and Causes of Ultrafiltration Failure during Long-Term Peritoneal Dialysis: A Cross-Sectional Study","volume":"24","author":"Smit","year":"2004","journal-title":"Perit Dial Int"},{"issue":"1","key":"2025030421364919600_bib3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/ndt\/gfq343","article-title":"The time course of peritoneal transport parameters in peritoneal dialysis patients who develop encapsulating peritoneal sclerosis","volume":"26","author":"Sampimon","year":"2011","journal-title":"Nephrol Dialys Transplant"},{"issue":"9","key":"2025030421364919600_bib4","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1038\/sj.ki.5000285","article-title":"Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis","volume":"69","author":"Ni","year":"2006","journal-title":"Kidney Int"},{"issue":"1","key":"2025030421364919600_bib5","doi-asserted-by":"publisher","first-page":"21344","DOI":"10.1038\/srep21344","article-title":"Quantitative histomorphometry of the healthy peritoneum","volume":"6","author":"Schaefer","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"2025030421364919600_bib6","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.kint.2018.02.022","article-title":"Neutral pH and low-glucose degradation product dialysis fluids induce major early alterations of the peritoneal membrane in children on peritoneal dialysis","volume":"94","author":"Schaefer","year":"2018","journal-title":"Kidney Int"},{"issue":"2","key":"2025030421364919600_bib7","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1681\/ASN.V132470","article-title":"Morphologic changes in the peritoneal membrane of patients with renal disease","volume":"13","author":"Williams","year":"2002","journal-title":"J Am Soc Nephrol Feb"},{"issue":"5","key":"2025030421364919600_bib8","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.121.319310","article-title":"Glucose derivative induced vasculopathy in children on chronic peritoneal dialysis","volume":"129","author":"Bartosova","year":"2021","journal-title":"Circul Res"},{"issue":"2","key":"2025030421364919600_bib9","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1093\/cvr\/cvq146","article-title":"Shear stress and the endothelial transport barrier","volume":"87","author":"Tarbell","year":"2010","journal-title":"Cardiovasc Res"},{"issue":"5","key":"2025030421364919600_bib10","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1093\/ndt\/gfy313","article-title":"Alterations of peritoneal transport characteristics in dialysis patients with ultrafiltration failure: tissue and capillary components","volume":"34","author":"Stachowska-Pietka","year":"2019","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"2025030421364919600_bib11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1177\/089686080402400409","article-title":"Does lymphatic absorption change with the duration of peritoneal dialysis?","volume":"24","author":"Michels","year":"2004","journal-title":"Perit Dial Int"},{"issue":"3","key":"2025030421364919600_bib12","doi-asserted-by":"publisher","first-page":"F425","DOI":"10.1152\/ajprenal.1985.248.3.F425","article-title":"A distributed model of peritoneal-plasma transport: tissue concentration gradients","volume":"248","author":"Flessner","year":"1985","journal-title":"American J Physiol Renal Physiol"},{"issue":"6","key":"2025030421364919600_bib13","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1177\/089686080302300605","article-title":"Is the peritoneum a significant transport barrier in peritoneal dialysis?","volume":"23","author":"Flessner","year":"2003","journal-title":"Perit Dial Int"},{"key":"2025030421364919600_bib14","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1515\/pp-2017-0010","article-title":"Pharmacological principles of intraperitoneal and bidirectional chemotherapy","volume-title":"Pleura Peritoneum.","author":"de\u00a0Bree","year":"2017"},{"issue":"1","key":"2025030421364919600_bib15","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1177\/089686088400400113","article-title":"Studies on the resistance of the peritoneal mesothelium to solute transport","volume":"4","author":"Breborowicz","year":"1984","journal-title":"Perit Dial Int"},{"issue":"2","key":"2025030421364919600_bib16","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1177\/089686088500500203","article-title":"Monolayer mesothelium from the ileal rabbit's mesentery: an experimental model for study of peritoneal kinetics in vitro","volume":"5","author":"Breborowicz","year":"1985","journal-title":"Perit Dial Int"},{"issue":"2","key":"2025030421364919600_bib17","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1152\/jappl.1998.85.2.471","article-title":"Diffusional permeability of rabbit mesothelium","volume":"85","author":"Zocchi","year":"1998","journal-title":"J Appl Physiol"},{"issue":"1","key":"2025030421364919600_bib18","doi-asserted-by":"publisher","first-page":"17429","DOI":"10.1038\/s41598-023-44466-z","article-title":"Human peritoneal tight junction, transporter and channel expression in health and kidney failure, and associated solute transport","volume":"13","author":"Levai","year":"2023","journal-title":"Sci Rep"},{"issue":"19","key":"2025030421364919600_bib19","doi-asserted-by":"publisher","first-page":"3133","DOI":"10.3390\/cells11193133","article-title":"Understanding cell model characteristics-RNA expression profiling in primary and immortalized human mesothelial cells, and in human vein and microvascular endothelial cells","volume":"11","author":"Marinovic","year":"2022","journal-title":"Cells"},{"issue":"6","key":"2025030421364919600_bib20","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1038\/ki.1990.150","article-title":"Isolation, culture and characterization of human peritoneal mesothelial cells","volume":"37","author":"Stylianou","year":"1990","journal-title":"Kidney Int"},{"issue":"10","key":"2025030421364919600_bib21","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.3390\/ijms18102066","article-title":"Challenges for super-resolution localization microscopy and biomolecular fluorescent nano-probing in cancer research","volume":"18","author":"Hausmann","year":"2017","journal-title":"IJMS"},{"issue":"1","key":"2025030421364919600_bib22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00340-008-3152-x","article-title":"SPDM: light microscopy with single-molecule resolution at the nanoscale","volume":"93","author":"Lemmer","year":"2008","journal-title":"Appl Phys B"},{"key":"2025030421364919600_bib23","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1016\/j.csbj.2023.03.009","article-title":"Advanced image-free analysis of the nano-organization of chromatin and other biomolecules by Single Molecule Localization Microscopy (SMLM)","volume":"21","author":"Weidner","year":"2023","journal-title":"Comput Struct Biotechnol J"},{"issue":"8","key":"2025030421364919600_bib24","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.3390\/ijms19082263.","article-title":"Using persistent homology as a new approach for super-resolution localization microscopy data analysis and classification of \u03b3H2AX foci\/clusters","volume":"19","author":"Hofmann","year":"2018","journal-title":"IJMS"},{"issue":"1","key":"2025030421364919600_bib25","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3390\/cancers10010025","article-title":"Localization microscopy analyses of MRE11 clusters in 3D-conserved cell nuclei of different cell lines","volume":"10","author":"Eryilmaz","year":"2018","journal-title":"Cancers"},{"issue":"9","key":"2025030421364919600_bib26","doi-asserted-by":"publisher","first-page":"4320","DOI":"10.1039\/c7nr08145f","article-title":"Super-resolution localization microscopy of radiation-induced histone H2AX-phosphorylation in relation to H3K9-trimethylation in HeLa cells","volume":"10","author":"Hausmann","year":"2018","journal-title":"Nanoscale"},{"issue":"2","key":"2025030421364919600_bib27","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1177\/2211068214561025","article-title":"TEER measurement techniques for in vitro barrier model systems","volume":"20","author":"Srinivasan","year":"2015","journal-title":"SLAS Technol"},{"key":"2025030421364919600_bib28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-0-387-48993-3_1","article-title":"Structure and function of mesothelial cells","volume":"134","author":"Mutsaers","year":"2007","journal-title":"Cancer Treat Res"},{"issue":"2","key":"2025030421364919600_bib29","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/089686088900900212","article-title":"Permeability of different parts of the peritoneal mesothelium to solutes: an in vitro study","volume":"9","author":"Breborowicz","year":"1989","journal-title":"Perit Dial Int"},{"issue":"1-2","key":"2025030421364919600_bib30","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1111\/j.1440-1681.2007.04549.x","article-title":"Comparison of the electrophysiological properties of the sheep isolated costal and diaphragmatic parietal pleura","volume":"34","author":"Zarogiannis","year":"2007","journal-title":"Clin Exp Pharma Physio"},{"issue":"3","key":"2025030421364919600_bib31","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1097\/MAT.0b013e3180317908","article-title":"Amiloride-sensitive sodium channels on the parietal human peritoneum: evidence by ussing-type chamber experiments","volume":"53","author":"Stefanidis","year":"2007","journal-title":"ASAIO J"},{"issue":"3","key":"2025030421364919600_bib32","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.resp.2010.12.012","article-title":"Tight junction proteins contribute to barrier properties in human pleura","volume":"175","author":"Markov","year":"2011","journal-title":"Respir Physiol Neurobiol"},{"key":"2025030421364919600_bib33","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1159\/000093518","article-title":"The effect of fibrosis on peritoneal transport","volume":"150","author":"Flessner","year":"2006","journal-title":"Contribut Nephrol"},{"issue":"11","key":"2025030421364919600_bib34","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1681\/ASN.V7112385","article-title":"Peritoneal membrane transport function in children receiving long-term dialysis","volume":"7","author":"Warady","year":"1996","journal-title":"J Am Soc Nephrol Nov"},{"issue":"6","key":"2025030421364919600_bib35","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1681\/asn.2011121201","article-title":"Effects of biocompatible versus standard fluid on peritoneal dialysis outcomes","volume":"23","author":"Johnson","year":"2012","journal-title":"J Am Soc Nephrol"},{"issue":"12","key":"2025030421364919600_bib36","doi-asserted-by":"publisher","first-page":"4445","DOI":"10.1093\/ndt\/gfs314","article-title":"The effect of low glucose degradation product, neutral pH versus standard peritoneal dialysis solutions on peritoneal membrane function: the balANZ trial","volume":"27","author":"Johnson","year":"2012","journal-title":"Nephrol Dialys Transplant"},{"issue":"2","key":"2025030421364919600_bib37","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1681\/ASN.V132470","article-title":"Morphologic changes in the peritoneal membrane of patients with renal disease","volume":"13","author":"Williams","year":"2002","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"2025030421364919600_bib38","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3747\/pdi.2014.00038","article-title":"Biocompatible dialysis solutions preserve peritoneal mesothelial cell and vessel wall integrity. a case-control study on human biopsies","volume":"36","author":"Del\u00a0Peso","year":"2016","journal-title":"Perit Dial Int"},{"issue":"10","key":"2025030421364919600_bib39","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1097\/01.ASN.0000086475.83211.DF","article-title":"Improved acidosis correction and recovery of mesothelial cell mass with neutral-pH bicarbonate dialysis solution among children undergoing automated peritoneal dialysis","volume":"14","author":"Haas","year":"2003","journal-title":"J Am Soc Nephrol. Oct"},{"issue":"1","key":"2025030421364919600_bib40","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1111\/j.1523-1755.2004.00747.x","article-title":"The Euro-Balance Trial: the effect of a new biocompatible peritoneal dialysis fluid (balance) on the peritoneal membrane","volume":"66","author":"Williams","year":"2004","journal-title":"Kidney Int"},{"issue":"1","key":"2025030421364919600_bib41","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1080\/0886022x.2019.1686018","article-title":"Tight junction protein expression from peritoneal dialysis Effluent. Renal failure","volume":"41","author":"Kim","year":"2019","journal-title":"Renal Failure"},{"issue":"10","key":"2025030421364919600_bib42","doi-asserted-by":"publisher","first-page":"Cd007554","DOI":"10.1002\/14651858.CD007554.pub3","article-title":"Biocompatible dialysis fluids for peritoneal dialysis","volume":"2018","author":"Htay","year":"2018","journal-title":"Cochrane Database System Rev"},{"issue":"6","key":"2025030421364919600_bib43","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1177\/089686080602600610","article-title":"Improved in vitro biocompatibility of bicarbonate-buffered peritoneal dialysis fluid","volume":"26","author":"Grossin","year":"2006","journal-title":"Perit Dial Int"},{"issue":"7","key":"2025030421364919600_bib44","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1093\/ndt\/gfh814","article-title":"Glucose degradation products downregulate ZO-1 expression in human peritoneal mesothelial cells: the role of VEGF","volume":"20","author":"Leung","year":"2005","journal-title":"Nephrol Dial Transplant"},{"issue":"8","key":"2025030421364919600_bib45","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.3390\/biom10081178","article-title":"Alanyl-glutamine restores tight junction organization after disruption by a conventional peritoneal dialysis fluid","volume":"10","author":"Bartosova","year":"2020","journal-title":"Biomolecules"},{"issue":"15","key":"2025030421364919600_bib46","doi-asserted-by":"publisher","first-page":"8178","DOI":"10.3390\/ijms22158178","article-title":"An experimental workflow for studying barrier integrity, permeability, and tight junction composition and localization in a single endothelial cell monolayer: proof of concept","volume":"22","author":"Bartosova","year":"2021","journal-title":"IJMS"},{"issue":"Pt 7","key":"2025030421364919600_bib47","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1242\/jcs.113399","article-title":"Epithelial barrier assembly requires coordinated activity of multiple domains of the tight junction protein ZO-1","volume":"126","author":"Rodgers","year":"1 2013","journal-title":"J Cell Sci"},{"issue":"1","key":"2025030421364919600_bib48","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/2040-2384-2-14","article-title":"Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeability","volume":"2","author":"Sarin","year":"2010","journal-title":"J Angiogenesis Res"},{"issue":"3","key":"2025030421364919600_bib49","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1515\/pp-2016-0015","article-title":"Functional vascular anatomy of the peritoneum in health and disease","volume":"1","author":"Solass","year":"1 2016","journal-title":"Pleura Peritoneum."},{"issue":"1","key":"2025030421364919600_bib50","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1152\/physrev.00025.2013","article-title":"The organic anion transporter (OAT) family: a systems biology perspective","volume":"95","author":"Nigam","year":"2015","journal-title":"Physiolog Rev"},{"issue":"2","key":"2025030421364919600_bib51","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/089686080902900217","article-title":"HPMCs induce greater intercellular delocalization of tight junction-associated proteins due to a higher susceptibility to H2O2 compared with HUVECs","volume":"29","author":"Horiuchi","year":"2009","journal-title":"Perit Dial Int"},{"issue":"3","key":"2025030421364919600_bib52","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/s41569-022-00770-1","article-title":"Vascular endothelial cell development and diversity","volume":"20","author":"Trimm","year":"2023","journal-title":"Nat Rev Cardiol"},{"key":"2025030421364919600_bib53","doi-asserted-by":"publisher","first-page":"31","DOI":"10.25259\/cmas_02_02_2021","article-title":"The panorama of different faces of mesothelial cells","volume":"18","author":"Shidham","year":"2021","journal-title":"Cytojournal"},{"issue":"1","key":"2025030421364919600_bib54","doi-asserted-by":"publisher","first-page":"G308","DOI":"10.1152\/ajpgi.00582.2006","article-title":"Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism","volume":"293","author":"Sheth","year":"2007","journal-title":"Am J Physiol Gastrointestin Liver Physiol"},{"issue":"4","key":"2025030421364919600_bib55","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1046\/j.1523-1755.2002.00255.x","article-title":"Effects of pH-neutral, bicarbonate-buffered dialysis fluid on peritoneal transport kinetics in children","volume":"61","author":"Schmitt","year":"2002","journal-title":"Kidney Int"},{"issue":"2","key":"2025030421364919600_bib56","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1177\/089686089701700208","article-title":"Analysis of ultrafiltration failure in peritoneal dialysis patients by means of standard peritoneal permeability analysis","volume":"17","author":"Ho-dac-Pannekeet","year":"1997","journal-title":"Perit Dial Int"},{"issue":"11","key":"2025030421364919600_bib57","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1111\/j.1525-1594.2005.00157.x","article-title":"Enhancement of the transmesothelial resistance of the parietal sheep peritoneum by epinephrine in vitro: ussing-type chamber experiments","volume":"29","author":"Stefanidis","year":"2005","journal-title":"Artificial Organs"},{"issue":"2","key":"2025030421364919600_bib58","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1681\/asn.v132480","article-title":"Hemodynamic effects of peritoneal dialysis solutions on the rat peritoneal membrane: role of acidity, buffer choice, glucose concentration, and glucose degradation products","volume":"13","author":"Mortier","year":"2002","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"2025030421364919600_bib59","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.3390\/molecules28031086","article-title":"Dextran formulations as effective delivery systems of therapeutic agents","volume":"28","author":"Petrovici","year":"2023","journal-title":"Molecules"},{"issue":"2","key":"2025030421364919600_bib60","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1159\/000520894","article-title":"Peritoneal expression of SGLT-2, GLUT1, and GLUT3 in peritoneal dialysis patients","volume":"47","author":"Schricker","year":"2022","journal-title":"Kidney Blood Pressure Res"},{"issue":"2","key":"2025030421364919600_bib61","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1177\/08968608221080170","article-title":"Dual SGLT1\/SGLT2 inhibitor phlorizin reduces glucose transport in experimental peritoneal dialysis","volume":"43","author":"Martus","year":"2023","journal-title":"Perit Dial Int"},{"issue":"11","key":"2025030421364919600_bib62","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.3390\/biom10111573","article-title":"SGLT2 Inhibition by Intraperitoneal Dapagliflozin Mitigates Peritoneal Fibrosis and Ultrafiltration Failure in a Mouse Model of Chronic Peritoneal Exposure to High-Glucose Dialysate","volume":"10","author":"Balzer","year":"2020","journal-title":"Biomolecules"},{"issue":"3","key":"2025030421364919600_bib63","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1177\/089686088600600303","article-title":"Transmesothelial Ultrafiltration IN VITRO","volume":"6","author":"Breborowicz","year":"1986","journal-title":"Perit Dial Int"}],"container-title":["Function"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/full\/10.1093\/function\/zqae051","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1093\/function\/zqae051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T17:07:16Z","timestamp":1781629636000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/full\/10.1093\/function\/zqae051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,10]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2,12]]}},"URL":"https:\/\/doi.org\/10.1093\/function\/zqae051","relation":{},"ISSN":["2633-8823"],"issn-type":[{"value":"2633-8823","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025]]},"published":{"date-parts":[[2024,12,10]]},"article-number":"zqae051"}}