{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:52:14Z","timestamp":1790614334943,"version":"4.1.0"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY029659"],"award-info":[{"award-number":["R01EY029659"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Insufficient dietary intake of vitamin A causes various human diseases. For instance, chronic vitamin A deprivation causes blindness, slow growth, impaired immunity, and an increased risk of mortality in children. In contrast to these diverse effects of vitamin A deficiency (VAD) in mammals, chronic VAD in flies neither causes obvious developmental defects nor lethality. As in mammals, VAD in flies severely affects the visual system: it impairs the synthesis of the retinal chromophore, disrupts the formation of the visual pigments (Rhodopsins), and damages the photoreceptors. However, the molecular mechanisms that respond to VAD remain poorly understood. To identify genes and signaling pathways that are affected by VAD, we performed RNA-sequencing and differential gene expression analysis in Drosophila melanogaster. We found an upregulation of genes that are essential for the synthesis of the retinal chromophore, specific aminoacyl-tRNA synthetases, and major nutrient reservoir proteins. We also discovered that VAD affects several genes that are required for the termination of the light response: for instance, we found a downregulation of both arrestin genes that are essential for the inactivation of Rhodopsin. A comparison of the VAD-responsive genes with previously identified blue light stress-responsive genes revealed that the two types of environmental stress trigger largely nonoverlapping transcriptome responses. Yet, both stresses increase the expression of seven genes with poorly understood functions. Taken together, our transcriptome analysis offers insights into the molecular mechanisms that respond to environmental stresses.<\/jats:p>","DOI":"10.1093\/g3journal\/jkab297","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T13:51:45Z","timestamp":1629726705000},"source":"Crossref","is-referenced-by-count":9,"title":["Vitamin A deficiency affects gene expression in the <i>Drosophila melanogaster<\/i> head"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1022-5268","authenticated-orcid":false,"given":"Deepshe","family":"Dewett","sequence":"first","affiliation":[{"name":"Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Labaf","sequence":"additional","affiliation":[{"name":"Department of Mathematics, University of Massachusetts Boston, Boston, MA 02125, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khanh","family":"Lam-Kamath","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kourosh","family":"Zarringhalam","sequence":"additional","affiliation":[{"name":"Department of Mathematics, University of Massachusetts Boston, Boston, MA 02125, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0023-7417","authenticated-orcid":false,"given":"Jens","family":"Rister","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,23]]},"reference":[{"key":"2021120105530089300_jkab297-B1","doi-asserted-by":"crossref","first-page":"9205","DOI":"10.1074\/jbc.M510293200","article-title":"The role of drosophila ninaG oxidoreductase in visual pigment chromophore biogenesis","volume":"281","author":"Ahmad","year":"2006","journal-title":"J Biol Chem"},{"key":"2021120105530089300_jkab297-B2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0896-6273(02)00630-X","article-title":"Light-regulated subcellular translocation of Drosophila TRPL channels induces long-term adaptation and modifies the light-induced current","volume":"34","author":"Bahner","year":"2002","journal-title":"Neuron"},{"key":"2021120105530089300_jkab297-B3","doi-asserted-by":"crossref","first-page":"4886","DOI":"10.1002\/j.1460-2075.1994.tb06816.x","article-title":"The cyclophilin homolog ninaA functions as a chaperone, forming a stable complex in vivo with its protein target rhodopsin","volume":"13","author":"Baker","year":"1994","journal-title":"EMBO J"},{"key":"2021120105530089300_jkab297-B4","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1073\/pnas.90.4.1536","article-title":"A Drosophila photoreceptor cell-specific protein, calphotin, binds calcium and contains a leucine zipper","volume":"90","author":"Ballinger","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021120105530089300_jkab297-B5","doi-asserted-by":"crossref","first-page":"A822","DOI":"10.1289\/ehp.113-a822","article-title":"Focusing on vision through an environmental lens","volume":"113","author":"Barrett","year":"2005","journal-title":"Environ Health Perspect"},{"key":"2021120105530089300_jkab297-B6","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0012-1606(90)90157-E","article-title":"Adult expression of the Drosophila Lsp-2 gene","volume":"142","author":"Benes","year":"1990","journal-title":"Dev Biol"},{"key":"2021120105530089300_jkab297-B7","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/molbev\/msg054","article-title":"Rapid divergence of the ecdysone receptor in Diptera and lepidoptera suggests coevolution between ECR and USP-RXR","volume":"20","author":"Bonneton","year":"2003","journal-title":"Mol Biol Evol"},{"key":"2021120105530089300_jkab297-B8","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1096\/fasebj.9.15.8529834","article-title":"Structure and properties of carotenoids in relation to function","volume":"9","author":"Britton","year":"1995","journal-title":"FASEB J"},{"key":"2021120105530089300_jkab297-B9","doi-asserted-by":"crossref","first-page":"E1752","DOI":"10.1073\/pnas.1306220110","article-title":"Dnr1 mutations cause neurodegeneration in Drosophila by activating the innate immune response in the brain","volume":"110","author":"Cao","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021120105530089300_jkab297-B10","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1017\/S0952523800011263","article-title":"Electrophysiological sensitivity of carotenoid deficient and replaced Drosophila","volume":"9","author":"Chen","year":"1992","journal-title":"Vis Neurosci"},{"key":"2021120105530089300_jkab297-B11","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0896-6273(01)00515-3","article-title":"Circadian regulation of gene expression systems in the Drosophila head","volume":"32","author":"Claridge-Chang","year":"2001","journal-title":"Neuron"},{"key":"2021120105530089300_jkab297-B12","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1113\/jphysiol.1994.sp020358","article-title":"Bleached pigment activates transduction in isolated rods of the salamander retina","volume":"480 (Pt 2","author":"Cornwall","year":"1994","journal-title":"J Physiol"},{"key":"2021120105530089300_jkab297-B13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ydbio.2021.03.013","article-title":"Mechanisms of vitamin A metabolism and deficiency in the mammalian and fly visual system","volume":"476","author":"Dewett","year":"2021","journal-title":"Dev Biol"},{"key":"2021120105530089300_jkab297-B14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"Star: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2021120105530089300_jkab297-B15","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1126\/science.8316831","article-title":"Arrestin function in inactivation of G protein-coupled receptor rhodopsin in vivo","volume":"260","author":"Dolph","year":"1993","journal-title":"Science"},{"key":"2021120105530089300_jkab297-B16","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1073\/pnas.44.7.648","article-title":"Vitamin A deficiency and night blindness","volume":"44","author":"Dowling","year":"1958","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021120105530089300_jkab297-B17","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1073\/pnas.46.5.587","article-title":"The biological function of vitamin A acid","volume":"46","author":"Dowling","year":"1960","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021120105530089300_jkab297-B18","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3390\/antiox7010005","article-title":"Singlet oxygen and free radical reactions of retinoids and carotenoids-a review","volume":"7","author":"Edge","year":"2018","journal-title":"Antioxidants"},{"key":"2021120105530089300_jkab297-B19","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/bies.20382","article-title":"Why photoreceptors die (and why they don't)","volume":"28","author":"Fain","year":"2006","journal-title":"Bioessays"},{"key":"2021120105530089300_jkab297-B20","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.neuron.2006.02.001","article-title":"Lazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction","volume":"49","author":"Garcia-Murillas","year":"2006","journal-title":"Neuron"},{"key":"2021120105530089300_jkab297-B21","first-page":"497","article-title":"Rhodopsin-mediated blue-light damage to the rat retina: effect of photoreversal of bleaching","volume":"42","author":"Grimm","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2021120105530089300_jkab297-B22","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.bbadis.2004.11.015","article-title":"Carotenoids as modulators of lipid membrane physical properties","volume":"1740","author":"Gruszecki","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"2021120105530089300_jkab297-B23","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.cub.2005.05.058","article-title":"Mechanisms of light adaptation in Drosophila photoreceptors","volume":"15","author":"Gu","year":"2005","journal-title":"Curr Biol"},{"key":"2021120105530089300_jkab297-B24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12868-018-0443-y","article-title":"Blue light induces a neuroprotective gene expression program in Drosophila photoreceptors","volume":"19","author":"Hall","year":"2018","journal-title":"BMC Neurosci"},{"key":"2021120105530089300_jkab297-B25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3109\/02713688408997198","article-title":"Basic mechanisms underlying the production of photochemical lesions in the mammalian retina","volume":"3","author":"Ham","year":"1984","journal-title":"Curr Eye Res"},{"key":"2021120105530089300_jkab297-B26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.conb.2015.01.008","article-title":"Phototransduction in Drosophila","volume":"34","author":"Hardie","year":"2015","journal-title":"Curr Opin Neurobiol"},{"key":"2021120105530089300_jkab297-B27","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/266648a0","article-title":"Vitamin A deprivation and Drosophila photopigments","volume":"266","author":"Harris","year":"1977","journal-title":"Nature"},{"key":"2021120105530089300_jkab297-B28","doi-asserted-by":"crossref","first-page":"33553","DOI":"10.1074\/jbc.M706763200","article-title":"Cmo1 deficiency abolishes vitamin A production from beta-carotene and alters lipid metabolism in mice","volume":"282","author":"Hessel","year":"2007","journal-title":"J Biol Chem"},{"key":"2021120105530089300_jkab297-B29","doi-asserted-by":"crossref","DOI":"10.3791\/4347","article-title":"Dissection and immunohistochemistry of larval, pupal and adult Drosophila retinas","author":"Hsiao","year":"2012","journal-title":"J Vis Exp"},{"key":"2021120105530089300_jkab297-B30","first-page":"219","article-title":"Opsin maturation and targeting to rhabdomeral photoreceptor membranes requires the retinal chromophore","volume":"63","author":"Huber","year":"1994","journal-title":"Eur J Cell Biol"},{"key":"2021120105530089300_jkab297-B31","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1085\/jgp.92.5.587","article-title":"Dependency on light and vitamin A derivatives of the biogenesis of 3-hydroxyretinal and visual pigment in the compound eyes of Drosophila melanogaster","volume":"92","author":"Isono","year":"1988","journal-title":"J Gen Physiol"},{"key":"2021120105530089300_jkab297-B32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2045-3701-2-11","article-title":"Retinoic acid synthesis and functions in early embryonic development","volume":"2","author":"Kam","year":"2012","journal-title":"Cell Biosci"},{"key":"2021120105530089300_jkab297-B33","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.nutres.2014.07.010","article-title":"Carotenoids, inflammation, and oxidative stress\u2013implications of cellular signaling pathways and relation to chronic disease prevention","volume":"34","author":"Kaulmann","year":"2014","journal-title":"Nutr Res"},{"key":"2021120105530089300_jkab297-B34","doi-asserted-by":"crossref","first-page":"14110","DOI":"10.1074\/jbc.M011510200","article-title":"Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A","volume":"276","author":"Kiefer","year":"2001","journal-title":"J Biol Chem"},{"key":"2021120105530089300_jkab297-B35","doi-asserted-by":"crossref","first-page":"158683","DOI":"10.1016\/j.bbalip.2020.158683","article-title":"Sterols as dietary markers for Drosophila melanogaster","volume":"1865","author":"Knittelfelder","year":"2020","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"2021120105530089300_jkab297-B36","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.mam.2005.10.001","article-title":"Carotenoid actions and their relation to health and disease","volume":"26","author":"Krinsky","year":"2005","journal-title":"Mol Aspects Med"},{"key":"2021120105530089300_jkab297-B37","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.bbrc.2008.07.011","article-title":"Circadian regulation of response to oxidative stress in Drosophila melanogaster","volume":"374","author":"Krishnan","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"2021120105530089300_jkab297-B38","doi-asserted-by":"crossref","first-page":"D809","DOI":"10.1093\/nar\/gkx976","article-title":"Flyatlas 2: a new version of the Drosophila melanogaster expression atlas with RNA-seq, miRNA-seq and sex-specific data","volume":"46","author":"Leader","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2021120105530089300_jkab297-B39","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/(SICI)1097-0029(19961215)35:6<418::AID-JEMT2>3.0.CO;2-E","article-title":"Vitamin A, visual pigments, and visual receptors in Drosophila","volume":"35","author":"Lee","year":"1996","journal-title":"Microsc Res Tech"},{"key":"2021120105530089300_jkab297-B40","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/neu.480230602","article-title":"Degeneration of photoreceptors in rhodopsin mutants of Drosophila","volume":"23","author":"Leonard","year":"1992","journal-title":"J Neurobiol"},{"key":"2021120105530089300_jkab297-B41","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"Featurecounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"2021120105530089300_jkab297-B42","doi-asserted-by":"crossref","first-page":"23942","DOI":"10.1074\/jbc.M202756200","article-title":"Biochemical properties of purified recombinant human beta-carotene 15,15'-monooxygenase","volume":"277","author":"Lindqvist","year":"2002","journal-title":"J Biol Chem"},{"key":"2021120105530089300_jkab297-B43","doi-asserted-by":"crossref","first-page":"9017","DOI":"10.1074\/jbc.M112.444240","article-title":"Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX","volume":"288","author":"Lobo","year":"2013","journal-title":"J Biol Chem"},{"key":"2021120105530089300_jkab297-B44","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with deseq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2021120105530089300_jkab297-B45","doi-asserted-by":"crossref","first-page":"12714","DOI":"10.1038\/s41598-019-48977-6","article-title":"Innate immune responses to paraquat exposure in a Drosophila model of Parkinson's disease","volume":"9","author":"Maitra","year":"2019","journal-title":"Sci Rep"},{"key":"2021120105530089300_jkab297-B46","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1073\/pnas.90.4.1531","article-title":"Calphotin: a drosophila photoreceptor cell calcium-binding protein","volume":"90","author":"Martin","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021120105530089300_jkab297-B47","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1093\/nar\/gks042","article-title":"Differential expression analysis of multifactor RNA-seq experiments with respect to biological variation","volume":"40","author":"McCarthy","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"2021120105530089300_jkab297-B48","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1016\/S0006-3495(97)78344-9","article-title":"A comparison of the efficiency of G protein activation by ligand-free and light-activated forms of rhodopsin","volume":"73","author":"Melia","year":"1997","journal-title":"Biophys J"},{"key":"2021120105530089300_jkab297-B49","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/0896-6273(89)90069-X","article-title":"Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction","volume":"2","author":"Montell","year":"1989","journal-title":"Neuron"},{"key":"2021120105530089300_jkab297-B50","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1432-1033.1997.00191.x","article-title":"Sequence, structure and evolution of the ecdysone-inducible lsp-2 gene of Drosophila melanogaster","volume":"245","author":"Mousseron-Grall","year":"1997","journal-title":"Eur J Biochem"},{"key":"2021120105530089300_jkab297-B51","doi-asserted-by":"crossref","first-page":"12670","DOI":"10.1016\/S0021-9258(17)38924-X","article-title":"Characterization of Drosophila melanogaster rhodopsin","volume":"260","author":"Nichols","year":"1985","journal-title":"J Biol Chem"},{"key":"2021120105530089300_jkab297-B52","doi-asserted-by":"crossref","first-page":"19000","DOI":"10.1073\/pnas.0807805105","article-title":"Ninab combines carotenoid oxygenase and retinoid isomerase activity in a single polypeptide","volume":"105","author":"Oberhauser","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021120105530089300_jkab297-B53","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/347298a0","article-title":"Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoid X receptor","volume":"347","author":"Oro","year":"1990","journal-title":"Nature"},{"key":"2021120105530089300_jkab297-B54","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/0896-6273(93)90059-Z","article-title":"Maturation of major Drosophila rhodopsin, ninaE, requires chromophore 3-hydroxyretinal","volume":"10","author":"Ozaki","year":"1993","journal-title":"Neuron"},{"key":"2021120105530089300_jkab297-B55","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0896-6273(92)90085-R","article-title":"Identification of a Drosophila gene encoding a calmodulin-binding protein with homology to the trp phototransduction gene","volume":"8","author":"Phillips","year":"1992","journal-title":"Neuron"},{"key":"2021120105530089300_jkab297-B56","doi-asserted-by":"crossref","first-page":"8570","DOI":"10.1523\/JNEUROSCI.1478-06.2006","article-title":"Scaffolding protein INAD regulates deactivation of vision by promoting phosphorylation of transient receptor potential by eye protein kinase C in Drosophila","volume":"26","author":"Popescu","year":"2006","journal-title":"J Neurosci"},{"key":"2021120105530089300_jkab297-B57","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1523\/JNEUROSCI.1150-14.2015","article-title":"Speed and sensitivity of phototransduction in Drosophila depend on degree of saturation of membrane phospholipids","volume":"35","author":"Randall","year":"2015","journal-title":"J Neurosci"},{"key":"2021120105530089300_jkab297-B58","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(95)90004-7","article-title":"Arrestin binding determines the rate of inactivation of the G protein-coupled receptor rhodopsin in vivo","volume":"81","author":"Ranganathan","year":"1995","journal-title":"Cell"},{"key":"2021120105530089300_jkab297-B59","doi-asserted-by":"crossref","first-page":"W191","DOI":"10.1093\/nar\/gkz369","article-title":"G:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)","volume":"47","author":"Raudvere","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2021120105530089300_jkab297-B60","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1242\/dev.079095","article-title":"Establishing and maintaining gene expression patterns: insights from sensory receptor patterning","volume":"140","author":"Rister","year":"2013","journal-title":"Development"},{"key":"2021120105530089300_jkab297-B61","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1432-1033.1991.tb15695.x","article-title":"The major serum protein of Drosophila larvae, larval serum protein 1, is dispensable","volume":"195","author":"Roberts","year":"1991","journal-title":"Eur J Biochem"},{"key":"2021120105530089300_jkab297-B62","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/0022-1910(77)90013-0","article-title":"The developmental profiles of two major haemolymph proteins from Drosophila melanogaster","volume":"23","author":"Roberts","year":"1977","journal-title":"J Insect Physiol"},{"key":"2021120105530089300_jkab297-B63","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"Edger: a bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"2021120105530089300_jkab297-B64","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuron.2005.12.011","article-title":"Calnexin is essential for rhodopsin maturation, ca2+ regulation, and photoreceptor cell survival","volume":"49","author":"Rosenbaum","year":"2006","journal-title":"Neuron"},{"key":"2021120105530089300_jkab297-B65","doi-asserted-by":"crossref","first-page":"445","DOI":"10.5483\/BMBRep.2015.48.8.099","article-title":"Drosophila as a model for unfolded protein response research","volume":"48","author":"Ryoo","year":"2015","journal-title":"BMB Rep"},{"key":"2021120105530089300_jkab297-B66","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/978-94-024-0945-1_9","article-title":"Vitamin a and vision","volume":"81","author":"Saari","year":"2016","journal-title":"Subcell Biochem"},{"key":"2021120105530089300_jkab297-B67","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.neuron.2010.08.024","article-title":"Arrestin translocation is stoichiometric to rhodopsin isomerization and accelerated by phototransduction in drosophila photoreceptors","volume":"67","author":"Satoh","year":"2010","journal-title":"Neuron"},{"key":"2021120105530089300_jkab297-B68","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"2021120105530089300_jkab297-B69","doi-asserted-by":"crossref","first-page":"e2427","DOI":"10.7717\/peerj.2427","article-title":"Rhodopsin 7-the unusual rhodopsin in Drosophila","volume":"4","author":"Senthilan","year":"2016","journal-title":"PeerJ"},{"key":"2021120105530089300_jkab297-B70","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1126\/science.1962207","article-title":"Photoreceptor deactivation and retinal degeneration mediated by a photoreceptor-specific protein kinase C","volume":"254","author":"Smith","year":"1991","journal-title":"Science"},{"key":"2021120105530089300_jkab297-B71","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1093\/jn\/138.10.1835","article-title":"Vitamin A deficiency and clinical disease: an historical overview","volume":"138","author":"Sommer","year":"2008","journal-title":"J Nutr"},{"key":"2021120105530089300_jkab297-B72","doi-asserted-by":"crossref","first-page":"eaat6409","DOI":"10.1126\/scisignal.aat6409","article-title":"Cells alter their tRNA abundance to selectively regulate protein synthesis during stress conditions","volume":"11","author":"Torrent","year":"2018","journal-title":"Sci Signal"},{"key":"2021120105530089300_jkab297-B73","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1074\/jbc.R111.303990","article-title":"Metabolism of carotenoids and retinoids related to vision","volume":"287","author":"von Lintig","year":"2012","journal-title":"J Biol Chem"},{"key":"2021120105530089300_jkab297-B74","first-page":"1130","article-title":"Analysis of the blind Drosophila mutant ninaB identifies the gene encoding the key enzyme for vitamin A formation in vivo","volume":"98","author":"von Lintig","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021120105530089300_jkab297-B75","doi-asserted-by":"crossref","first-page":"11915","DOI":"10.1074\/jbc.275.16.11915","article-title":"Filling the gap in vitamin A research. Molecular identification of an enzyme cleaving beta-carotene to retinal","volume":"275","author":"von Lintig","year":"2000","journal-title":"J Biol Chem"},{"key":"2021120105530089300_jkab297-B76","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/abbi.2000.2096","article-title":"Molecular analysis of vitamin A formation: Cloning and characterization of beta-carotene 15,15'-dioxygenases","volume":"385","author":"von Lintig","year":"2001","journal-title":"Arch Biochem Biophys"},{"key":"2021120105530089300_jkab297-B77","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1074\/jbc.M109.056101","article-title":"NinaB is essential for Drosophila vision but induces retinal degeneration in opsin-deficient photoreceptors","volume":"285","author":"Voolstra","year":"2010","journal-title":"J Biol Chem"},{"key":"2021120105530089300_jkab297-B78","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neuron.2007.11.020","article-title":"The socs box protein stops is required for phototransduction through its effects on phospholipase C","volume":"57","author":"Wang","year":"2008","journal-title":"Neuron"},{"key":"2021120105530089300_jkab297-B79","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cub.2009.12.022","article-title":"Requirement for an enzymatic visual cycle in Drosophila","volume":"20","author":"Wang","year":"2010","journal-title":"Curr Biol"},{"key":"2021120105530089300_jkab297-B80","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fnmol.2017.00057","article-title":"Molecular chaperone calnexin regulates the function of Drosophila sodium channel paralytic","volume":"10","author":"Xiao","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"2021120105530089300_jkab297-B81","first-page":"394","article-title":"CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells","volume":"129","author":"Xu","year":"2016","journal-title":"J Cell Sci"},{"key":"2021120105530089300_jkab297-B82","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/genetics\/138.2.413","article-title":"Mutations in calphotin, the gene encoding a Drosophila photoreceptor cell-specific calcium-binding protein, reveal roles in cellular morphogenesis and survival","volume":"138","author":"Yang","year":"1994","journal-title":"Genetics"},{"key":"2021120105530089300_jkab297-B83","doi-asserted-by":"crossref","first-page":"19692","DOI":"10.1038\/srep19692","article-title":"The amino acid transporter Jhi-21 coevolves with glutamate receptors, impacts NMJ physiology, and influences locomotor activity in Drosophila larvae","volume":"6","author":"Ziegler","year":"2016","journal-title":"Sci Rep"},{"key":"2021120105530089300_jkab297-B84","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1038\/s41598-018-20394-1","article-title":"Jhi-21 plays a role in Drosophila insulin-like peptide release from larval IPCs via leucine transport","volume":"8","author":"Ziegler","year":"2018","journal-title":"Sci Rep"}],"container-title":["G3 Genes|Genomes|Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/g3journal\/advance-article-pdf\/doi\/10.1093\/g3journal\/jkab297\/40530883\/jkab297.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/g3journal\/article-pdf\/11\/11\/jkab297\/41293831\/jkab297.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/g3journal\/article-pdf\/11\/11\/jkab297\/41293831\/jkab297.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T08:17:47Z","timestamp":1638346667000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/g3journal\/article\/doi\/10.1093\/g3journal\/jkab297\/6356515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,23]]},"references-count":84,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,8,23]]},"published-print":{"date-parts":[[2021,10,19]]}},"URL":"https:\/\/doi.org\/10.1093\/g3journal\/jkab297","relation":{},"ISSN":["2160-1836"],"issn-type":[{"value":"2160-1836","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,11,1]]},"published":{"date-parts":[[2021,8,23]]},"article-number":"jkab297"}}