{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:18:44Z","timestamp":1793755124161,"version":"4.6.1"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["200-2017-96199 to M.M. and M.T.B."],"award-info":[{"award-number":["200-2017-96199 to M.M. and M.T.B."]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Georgia\u2019s President\u2019s Interdisciplinary Seed Grant Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pathogen resistance to clinical antimicrobial agents is an urgent problem. The fungus Aspergillus fumigatus causes 300,000 life-threatening infections in susceptible humans annually. Azoles, which are widely used in both clinical and agricultural settings, are currently the most effective treatment, but resistance to clinical azoles is emerging worldwide. Here, we report the isolation and analysis of azole-sensitive and azole-resistant A. fumigatus from agricultural environments in the southeastern United States (USA) and show that the USA pan-azole-resistant isolates form a clade with pan-azole-resistant isolates from the United Kingdom, the Netherlands, and India. We show that several pan-azole-resistant isolates from agricultural settings in the USA and India also carry alleles with mutations conferring resistance to agricultural fungicides from the benzimidazole (MBC) and quinone outside inhibitor (QoI) classes. We further show that pan-azole-resistant A. fumigatus isolates from patients in clinical settings in the USA, India, and the Netherlands also carry alleles conferring resistance to MBC and QoI agricultural fungicides. The presence of markers for resistance to agricultural-use fungicides in clinical A. fumigatus isolates is strong evidence for an agricultural origin of pan-azole resistance in patients. The presence of multiple fungicide-resistance alleles in agricultural and clinical isolates further suggests that the unique genetics of the pan-azole-resistant clade enables the evolution and\/or persistence of antimicrobial resistance mutations leading to the establishment of multifungicide-resistant isolates.<\/jats:p>","DOI":"10.1093\/g3journal\/jkab427","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T07:06:31Z","timestamp":1639379191000},"source":"Crossref","is-referenced-by-count":79,"title":["Evidence for the agricultural origin of resistance to multiple antimicrobials in\n                    <i>Aspergillus fumigatus<\/i>\n                    , a fungal pathogen of humans"],"prefix":"10.1093","volume":"12","author":[{"given":"S Earl","family":"Kang","sequence":"first","affiliation":[{"name":"Fungal Biology Group and Plant Biology Department, University of Georgia , Athens, GA 30602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leilani G","family":"Sumabat","sequence":"additional","affiliation":[{"name":"Fungal Biology Group and Plant Pathology Department, University of Georgia , Athens, GA 30602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Melie","sequence":"additional","affiliation":[{"name":"Fungal Biology Group and Plant Pathology Department, University of Georgia , Athens, GA 30602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Mangum","sequence":"additional","affiliation":[{"name":"Fungal Biology Group and Plant Biology Department, University of Georgia , Athens, GA 30602, USA"},{"name":"Fungal Biology Group and Plant Pathology Department, University of Georgia , Athens, GA 30602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7110-063X","authenticated-orcid":false,"given":"Michelle","family":"Momany","sequence":"additional","affiliation":[{"name":"Fungal Biology Group and Plant Biology Department, University of Georgia , Athens, GA 30602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marin T","family":"Brewer","sequence":"additional","affiliation":[{"name":"Fungal Biology Group and Plant Pathology Department, University of Georgia , Athens, GA 30602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"key":"2024042309070587500_jkab427-B1","doi-asserted-by":"crossref","first-page":"e00536-15","DOI":"10.1128\/mBio.00536-15","article-title":"Genomic context of azole resistance mutations in Aspergillus fumigatus determined using whole-genome sequencing","volume":"6","author":"Abdolrasouli","year":"2015","journal-title":"Mbio"},{"key":"2024042309070587500_jkab427-B2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J Mol Biol"},{"key":"2024042309070587500_jkab427-B3","doi-asserted-by":"crossref","first-page":"45631","DOI":"10.1038\/srep45631","article-title":"Azole-resistant Aspergillus fumigatus harboring TR34\/L98H, TR46\/Y121F\/T289A and TR53 mutations related to flower fields in Colombia","volume":"7","author":"Alvarez-Moreno","year":"2017","journal-title":"Sci Rep"},{"key":"2024042309070587500_jkab427-B4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/00275514.2018.1557796","article-title":"Fungicide-driven alterations in azole-resistant Aspergillus fumigatus are related to vegetable crops in Colombia, South America","volume":"111","author":"Alvarez-Moreno","year":"2019","journal-title":"Mycologia"},{"key":"2024042309070587500_jkab427-B5","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.3389\/fmicb.2017.01024","article-title":"Azole resistance in Aspergillus fumigatus: a consequence of antifungal use in agriculture?","volume":"8","author":"Berger","year":"2017","journal-title":"Front Microbiol"},{"key":"2024042309070587500_jkab427-B6","doi-asserted-by":"crossref","first-page":"e02240-17","DOI":"10.1128\/AAC.02240-17","article-title":"Detection of TR34\/L98H CYP51A mutation through passive surveillance for azole-resistant Aspergillus fumigatus in the United States from 2015 to 2017","volume":"62","author":"Berkow","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"2024042309070587500_jkab427-B7","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/ps.3567","article-title":"Environmental fungicides and triazole resistance in Aspergillus","volume":"70","author":"Bowyer","year":"2014","journal-title":"Pest Manag Sci"},{"key":"2024042309070587500_jkab427-B8","doi-asserted-by":"crossref","first-page":"165rv13","DOI":"10.1126\/scitranslmed.3004404","article-title":"Hidden killers: human fungal infections","volume":"4","author":"Brown","year":"2012","journal-title":"Sci Transl Med"},{"key":"2024042309070587500_jkab427-B9","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1111\/j.1365-294X.2004.02209.x","article-title":"A simple method for the calculation of microsatellite genotype distances irrespective of ploidy level","volume":"13","author":"Bruvo","year":"2004","journal-title":"Mol Ecol"},{"key":"2024042309070587500_jkab427-B10","first-page":"69","article-title":"Emergence of multi triazole-resistant Aspergillus fumigatus carrying the TR46\/Y121F\/T289A mutations in cyp51A gene from Indian environment","volume":"56","author":"Chowdhary","year":"2013","journal-title":"Mycoses"},{"key":"2024042309070587500_jkab427-B11","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/jac\/dkt397","article-title":"Azole-resistant Aspergillus fumigatus with the environmental TR46\/Y121F\/T289A mutation in India","volume":"69","author":"Chowdhary","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"2024042309070587500_jkab427-B12","author":"FRAC","year":"2010"},{"key":"2024042309070587500_jkab427-B13","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.1128\/JCM.43.8.4112-4120.2005","article-title":"Use of a novel panel of nine short tandem repeats for exact and high-resolution fingerprinting of Aspergillus fumigatus isolates","volume":"43","author":"de Valk","year":"2005","journal-title":"J Clin Microbiol"},{"key":"2024042309070587500_jkab427-B14","doi-asserted-by":"crossref","first-page":"e0180321","DOI":"10.1128\/mBio.01803-21","article-title":"Genomic diversity of azole-resistant Aspergillus fumigatus in the United States","volume":"12","author":"Etienne","year":"2021","journal-title":"mBio"},{"key":"2024042309070587500_jkab427-B15","first-page":"1","article-title":"Mechanisms of resistance to Qol fungicides in phytopathogenic fungi","volume":"11","author":"Fernandez-Ortuno","year":"2008","journal-title":"Int Microbiol"},{"key":"2024042309070587500_jkab427-B16","first-page":"203","article-title":"The QoI fungicides, the rise and fall of a successful class of agricultural fungicides","author":"Fernandez-Ortuno","year":"2010","journal-title":"Fungicides"},{"key":"2024042309070587500_jkab427-B17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.actatropica.2016.06.021","article-title":"Benzimidazole resistance in helminths: from problem to diagnosis","volume":"162","author":"Fernando","year":"2016","journal-title":"Acta Trop"},{"key":"2024042309070587500_jkab427-B18","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1126\/science.aap7999","article-title":"Worldwide emergence of resistance to antifungal drugs challenges human health and food security","volume":"360","author":"Fisher","year":"2018","journal-title":"Science"},{"key":"2024042309070587500_jkab427-B19","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/ps.1066","article-title":"Re-examination of inhibitor resistance conferred by Q(o)-site mutations in cytochrome b using yeast as a model system","volume":"61","author":"Fisher","year":"2005","journal-title":"Pest Manag Sci"},{"key":"2024042309070587500_jkab427-B20","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/ps.1649","article-title":"Monitoring of Venturia inaequalis harbouring the Qol resistance G143A mutation in French orchards as revealed by PCR assays","volume":"65","author":"Fontaine","year":"2009","journal-title":"Pest Manag Sci"},{"key":"2024042309070587500_jkab427-B21","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1094\/PHYTO-09-17-0296-R","article-title":"Fitness, competitive ability, and mutation stability of isolates of Colletotrichum acutatum from strawberry resistant to QoI fungicides","volume":"108","author":"Forcelini","year":"2018","journal-title":"Phytopathology"},{"key":"2024042309070587500_jkab427-B22","doi-asserted-by":"crossref","first-page":"599233","DOI":"10.3389\/fmicb.2020.599233","article-title":"The multi-fungicide resistance status of Aspergillus fumigatus populations in arable soils and the wider European environment","volume":"11","author":"Fraaije","year":"2020","journal-title":"Front Microbiol"},{"key":"2024042309070587500_jkab427-B23","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/ps.3664","article-title":"Assessment of selection and resistance risk for demethylation inhibitor fungicides in Aspergillus fumigatus in agriculture and medicine: a critical review","volume":"70","author":"Gisi","year":"2014","journal-title":"Pest Manag Sci"},{"key":"2024042309070587500_jkab427-B24","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/ps.565","article-title":"Mechanisms influencing the evolution of resistance to Qo inhibitor fungicides","volume":"58","author":"Gisi","year":"2002","journal-title":"Pest Manag Sci"},{"key":"2024042309070587500_jkab427-B25","doi-asserted-by":"crossref","first-page":"e0064221","DOI":"10.1128\/AAC.00642-21","article-title":"Multiresistance to nonazole fungicides in Aspergillus fumigatus TR34\/L98H azole-resistant isolates","volume":"65","author":"Gonzalez-Jimenez","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"key":"2024042309070587500_jkab427-B26","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/molbev\/msp259","article-title":"SeaView Version 4: a multiplatform graphical user interface for sequence alignment and phylogenetic tree building","volume":"27","author":"Gouy","year":"2010","journal-title":"Mol Biol Evol"},{"key":"2024042309070587500_jkab427-B27","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.3389\/fmicb.2016.01814","article-title":"Predicting resistance by mutagenesis: lessons from 45 years of MBC resistance","volume":"7","author":"Hawkins","year":"2016","journal-title":"Front Microbiol"},{"key":"2024042309070587500_jkab427-B28","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1094\/PHYTO-06-12-0142-R","article-title":"The usefulness of fungicide mixtures and alternation for delaying the selection for resistance in populations of Mycosphaerella graminicola on winter wheat: a modeling analysis","volume":"103","author":"Hobbelen","year":"2013","journal-title":"Phytopathology"},{"key":"2024042309070587500_jkab427-B29","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/ps.4607","article-title":"Does agricultural use of azole fungicides contribute to resistance in the human pathogen Aspergillus fumigatus?","volume":"73","author":"Hollomon","year":"2017","journal-title":"Pest Manag Sci"},{"key":"2024042309070587500_jkab427-B30","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.3201\/eid1507.090043","article-title":"Frequency and evolution of azole resistance in Aspergillus fumigatus associated with treatment failure","volume":"15","author":"Howard","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"2024042309070587500_jkab427-B31","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1093\/jac\/dkx168","article-title":"Isolation of azole-resistant Aspergillus fumigatus from the environment in the south-eastern USA","volume":"72","author":"Hurst","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"2024042309070587500_jkab427-B33","doi-asserted-by":"crossref","first-page":"e281","DOI":"10.7717\/peerj.281","article-title":"Poppr: an R package for genetic analysis of populations with clonal, partially clonal, and\/or sexual reproduction","volume":"2","author":"Kamvar","year":"2014","journal-title":"PeerJ"},{"key":"2024042309070587500_jkab427-B34","doi-asserted-by":"crossref","first-page":"12872","DOI":"10.1073\/pnas.1717162115","article-title":"Emergence of dominant multidrug-resistant bacterial clades: lessons from history and whole-genome sequencing","volume":"115","author":"Klemm","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024042309070587500_jkab427-B35","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1094\/PHP-2008-0418-01-RV","article-title":"Milestones in fungicide discovery: chemistry that changed agriculture","volume":"9","author":"Klittich","year":"2008","journal-title":"Plant Health Progress"},{"key":"2024042309070587500_jkab427-B36","doi-asserted-by":"crossref","first-page":"W256","DOI":"10.1093\/nar\/gkz239","article-title":"Interactive Tree Of Life (iTOL) v4: recent updates and new developments","volume":"47","author":"Letunic","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2024042309070587500_jkab427-B37","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"2024042309070587500_jkab427-B38","first-page":"29","volume-title":"Advances in Applied Microbiology","author":"Lucas","year":"2015"},{"key":"2024042309070587500_jkab427-B39","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3389\/fmicb.2019.00832","article-title":"Antimicrobial resistance genes, cassettes, and plasmids present in Salmonella enterica associated with United States food animals","volume":"10","author":"McMillan","year":"2019","journal-title":"Front Microbiol"},{"key":"2024042309070587500_jkab427-B40","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1128\/JCM.39.7.2431-2438.2001","article-title":"Identification of two different 14-alpha sterol demethylase-related genes (cyp51A and cyp51B) in Aspergillus fumigatus and other Aspergillus species","volume":"39","author":"Mellado","year":"2001","journal-title":"J Clin Microbiol"},{"key":"2024042309070587500_jkab427-B41","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/genetics\/151.2.557","article-title":"Aspergillus nidulans swo mutants show defects in polarity establishment, polarity maintenance and hyphal morphogenesis","volume":"151","author":"Momany","year":"1999","journal-title":"Genetics"},{"key":"2024042309070587500_jkab427-B42","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.ijantimicag.2017.01.004","article-title":"First isolation of the pan-azole-resistant Aspergillus fumigatus cyp51A TR46\/Y121F\/T289A mutant in a UK patient","volume":"49","author":"Moore","year":"2017","journal-title":"Int J Antimicrob Agents"},{"key":"2024042309070587500_jkab427-B43","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/nature04332","article-title":"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus","volume":"438","author":"Nierman","year":"2005","journal-title":"Nature"},{"key":"2024042309070587500_jkab427-B44","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1089\/cmb.2013.0084","article-title":"Assembling single-cell genomes and mini-metagenomes from chimeric MDA products","volume":"20","author":"Nurk","year":"2013","journal-title":"J Comput Biol"},{"key":"2024042309070587500_jkab427-B45","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1093\/cid\/ciw326","article-title":"Practice guidelines for the diagnosis and management of Aspergillosis: 2016 update by the Infectious Diseases Society of America","volume":"63","author":"Patterson","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2024042309070587500_jkab427-B46","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.3201\/eid2009.140142","article-title":"Passive surveillance for azole-resistant Aspergillus fumigatus, United States, 2011\u20132013","volume":"20","author":"Pham","year":"2014","journal-title":"Emerg Infect Dis"},{"key":"2024042309070587500_jkab427-B47","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cropro.2016.10.026","article-title":"The application of next-generation sequencing (NGS) for monitoring of Zymoseptoria tritici QoI resistance","volume":"92","author":"Pieczul","year":"2017","journal-title":"Crop Protection"},{"key":"2024042309070587500_jkab427-B48","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1099\/13500872-142-6-1557","article-title":"A putative cyclic peptide efflux pump encoded by the TOXA gene of the plant-pathogenic fungus Cochliobolus carbonum","volume":"142","author":"Pitkin","year":"1996","journal-title":"Microbiology-UK"},{"key":"2024042309070587500_jkab427-B49","doi-asserted-by":"publisher","author":"Rhodes","year":"2021","DOI":"10.1101\/2021.04.07.438821"},{"key":"2024042309070587500_jkab427-B50","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/jof2030021","article-title":"Triazole resistance in Aspergillus spp.: a worldwide problem?","volume":"2","author":"Rivero-Menendez","year":"2016","journal-title":"J Fungi"},{"key":"2024042309070587500_jkab427-B51","doi-asserted-by":"crossref","first-page":"e00392-19","DOI":"10.1128\/mBio.00392-19","article-title":"Nonrandom distribution of azole resistance across the global population of Aspergillus fumigatus","volume":"10","author":"Sewell","year":"2019","journal-title":"Mbio"},{"key":"2024042309070587500_jkab427-B52","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1093\/mmy\/myx144","article-title":"Triazole resistance surveillance in Aspergillus fumigatus","volume":"56","author":"Sharpe","year":"2018","journal-title":"Med Mycol"},{"key":"2024042309070587500_jkab427-B53","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1128\/CMR.12.1.40","article-title":"Current and emerging azole antifungal agents","volume":"12","author":"Sheehan","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"2024042309070587500_jkab427-B54","doi-asserted-by":"crossref","first-page":"4053","DOI":"10.1128\/AEM.00231-09","article-title":"Possible environmental origin of resistance of Aspergillus fumigatus to medical triazoles","volume":"75","author":"Snelders","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"2024042309070587500_jkab427-B55","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1128\/jcm.31.3.572-577.1993","article-title":"The benomyl test as a fundamental diagnostic method for medical mycology","volume":"31","author":"Summerbell","year":"1993","journal-title":"J Clin Microbiol"},{"key":"2024042309070587500_jkab427-B56","author":"EUCAST","year":"2018"},{"key":"2024042309070587500_jkab427-B57","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.3201\/eid1710.110226","article-title":"Clinical implications of azole resistance in Aspergillus fumigatus, the Netherlands, 2007\u20132009","volume":"17","author":"van der Linden","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"2024042309070587500_jkab427-B58","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1128\/AAC.01130-15","article-title":"Molecular characterization of a voriconazole-resistant, posaconazole-susceptible Aspergillus fumigatus isolate in a lung transplant recipient in the United States","volume":"60","author":"Vazquez","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"2024042309070587500_jkab427-B59","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1094\/PDIS-12-11-1037-RE","article-title":"A rapid resazurin-based microtiter assay to evaluate Qol sensitivity for Alternaria alternata isolates and their molecular characterization","volume":"96","author":"Vega","year":"2012","journal-title":"Plant Dis"},{"key":"2024042309070587500_jkab427-B60","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/cid\/civ885","article-title":"Azole resistance in Aspergillus fumigatus: can we retain the clinical use of mold-active antifungal azoles?","volume":"62","author":"Verweij","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2024042309070587500_jkab427-B61","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1128\/JCM.02478-15","article-title":"First detection of TR34 L98H and TR46 Y121F T289A Cyp51 mutations in Aspergillus fumigatus Isolates in the United States","volume":"54","author":"Wiederhold","year":"2016","journal-title":"J Clin Microbiol"}],"container-title":["G3"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/g3journal\/advance-article-pdf\/doi\/10.1093\/g3journal\/jkab427\/42087292\/jkab427.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/g3journal\/article-pdf\/12\/2\/jkab427\/57307719\/jkab427.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/g3journal\/article-pdf\/12\/2\/jkab427\/57307719\/jkab427.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T05:08:15Z","timestamp":1713848895000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/g3journal\/article\/doi\/10.1093\/g3journal\/jkab427\/6460338"}},"subtitle":[],"editor":[{"given":"J","family":"Heitman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,12,13]]},"references-count":60,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,12,13]]},"published-print":{"date-parts":[[2022,2,4]]}},"URL":"https:\/\/doi.org\/10.1093\/g3journal\/jkab427","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.05.24.113787","asserted-by":"object"}]},"ISSN":["2160-1836"],"issn-type":[{"value":"2160-1836","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,2,1]]},"published":{"date-parts":[[2021,12,13]]},"article-number":"jkab427"}}