{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:16:17Z","timestamp":1780100177139,"version":"3.54.0"},"reference-count":93,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 GM111797, R01 GM127480, R35 GM136306, F32 GM106594, and T32 GM007133"],"award-info":[{"award-number":["R01 GM111797, R01 GM127480, R35 GM136306, F32 GM106594, and T32 GM007133"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Important uncertainties persist regarding the genetic architecture of adaptive trait evolution in natural populations, including the number of genetic variants involved, whether they are drawn from standing genetic variation, and whether directional selection drives them to complete fixation. Here, we take advantage of a unique natural population of Drosophila melanogaster from the Ethiopian highlands, which has evolved larger body size than any other known population of this species. We apply a bulk segregant quantitative trait locus mapping approach to 4 unique crosses between highland Ethiopian and lowland Zambian populations for both thorax length and wing length. Results indicated a persistently variable genetic basis for these evolved traits (with largely distinct sets of quantitative trait loci for each cross), and at least a moderately polygenic architecture with relatively strong effects present. We complemented these mapping experiments with population genetic analyses of quantitative trait locus regions and gene ontology enrichment analysis, generating strong hypotheses for specific genes and functional processes that may have contributed to these adaptive trait changes. Finally, we find that the genetic architectures indicated by our quantitative trait locus mapping results for size traits mirror those from similar experiments on other recently evolved traits in this species. Collectively, these studies suggest a recurring pattern of polygenic adaptation in this species, in which causative variants do not approach fixation and moderately strong effect loci are present.<\/jats:p>","DOI":"10.1093\/g3journal\/jkab454","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T17:33:45Z","timestamp":1641231225000},"source":"Crossref","is-referenced-by-count":9,"title":["The evolution of larger size in high-altitude <i>Drosophila melanogaster<\/i> has a variable genetic architecture"],"prefix":"10.1093","volume":"12","author":[{"given":"Quentin D","family":"Sprengelmeyer","sequence":"first","affiliation":[{"name":"Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin B","family":"Lack","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan T","family":"Braun","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"Monette","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2968-9545","authenticated-orcid":false,"given":"John E","family":"Pool","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,3]]},"reference":[{"issue":"12","key":"2022030413503032500_jkab454-B2","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/s41576-020-0250-z","article-title":"Polygenic adaptation: a unifying framework to understand positive selection","volume":"21","author":"Barghi","year":"2020","journal-title":"Nat Rev Genet"},{"issue":"2","key":"2022030413503032500_jkab454-B3","doi-asserted-by":"crossref","first-page":"e3000128","DOI":"10.1371\/journal.pbio.3000128","article-title":"Genetic redundancy fuels polygenic adaptation in Drosophila","volume":"17","author":"Barghi","year":"2019","journal-title":"PLoS Biol"},{"issue":"3","key":"2022030413503032500_jkab454-B4","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.cell.2006.04.009","article-title":"Secretion of Wnt ligands requires Evi, a conserved transmembrane 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