{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:46:08Z","timestamp":1793231168252,"version":"4.5.0"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"U.S. Department of Energy Computational Science Graduate Fellowship","award":["DE-SC0021110 (MFL)"],"award-info":[{"award-number":["DE-SC0021110 (MFL)"]}]},{"name":"UC Davis start-up funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Maize enriched in provitamin A carotenoids could be key in combatting vitamin A deficiency in human populations relying on maize as a food staple. Consumer studies indicate that orange maize may be regarded as novel and preferred. This study identifies genes of relevance for grain carotenoid concentrations and kernel color, through simultaneous dissection of these traits in 10 families of the US maize nested association mapping panel that have yellow to orange grain. Quantitative trait loci were identified via joint-linkage analysis, with phenotypic variation explained for individual kernel color quantitative trait loci ranging from 2.4% to 17.5%. These quantitative trait loci were cross-analyzed with significant marker-trait associations in a genome-wide association study that utilized \u223c27 million variants. Nine genes were identified: four encoding activities upstream of the core carotenoid pathway, one at the pathway branchpoint, three within the \u03b1- or \u03b2-pathway branches, and one encoding a carotenoid cleavage dioxygenase. Of these, three exhibited significant pleiotropy between kernel color and one or more carotenoid traits. Kernel color exhibited moderate positive correlations with \u03b2-branch and total carotenoids and negligible correlations with \u03b1-branch carotenoids. These findings can be leveraged to simultaneously achieve desirable kernel color phenotypes and increase concentrations of provitamin A and other priority carotenoids.<\/jats:p>","DOI":"10.1093\/g3journal\/jkac006","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T14:34:32Z","timestamp":1642084472000},"source":"Crossref","is-referenced-by-count":13,"title":["Simultaneous dissection of grain carotenoid levels and kernel color in biparental maize populations with yellow-to-orange grain"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5856-2901","authenticated-orcid":false,"given":"Mary-Francis","family":"LaPorte","sequence":"first","affiliation":[{"name":"Department of Plant Sciences, University of California, Davis, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3467-7242","authenticated-orcid":false,"given":"Mishi","family":"Vachev","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences, University of California, Davis, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6920-2215","authenticated-orcid":false,"given":"Matthew","family":"Fenn","sequence":"additional","affiliation":[{"name":"Plant Breeding and Genetics Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8411-0343","authenticated-orcid":false,"given":"Christine","family":"Diepenbrock","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences, University of California, Davis, Davis, CA 95616, 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