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However, findings from rodent studies often fail to be translated into clinical treatments. Here, we developed a novel pipeline for narrowing candidate genes from preclinical studies by translational potential and demonstrated its utility in 2 RNA-seq studies of rodent self-administration. This pipeline uses evolutionary conservation and preferential expression of genes across brain tissues to prioritize candidate genes, increasing the translational utility of RNA-seq in model organisms. Initially, we demonstrate the utility of our prioritization pipeline using an uncorrected P-value. However, we found no differentially expressed genes in either dataset after correcting for multiple testing with false discovery rate (FDR &amp;lt; 0.05 or &amp;lt;0.1). This is likely due to low statistical power that is common across rodent behavioral studies, and, therefore, we additionally illustrate the use of our pipeline on a third dataset with differentially expressed genes corrected for multiple testing (FDR &amp;lt; 0.05). We also advocate for improved RNA-seq data collection, statistical testing, and metadata reporting that will bolster the field's ability to identify reliable candidate genes and improve the translational value of bioinformatics in rodent research.<\/jats:p>","DOI":"10.1093\/g3journal\/jkad143","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T16:28:53Z","timestamp":1689092933000},"source":"Crossref","is-referenced-by-count":4,"title":["An approach for prioritizing candidate genes from RNA-seq using preclinical cocaine self-administration datasets as a test case"],"prefix":"10.1093","volume":"13","author":[{"given":"Annika","family":"Vannan","sequence":"first","affiliation":[{"name":"School of Life Sciences, Arizona State University , Tempe, AZ 85287-4501 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Dell\u2019Orco","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of New Mexico Health Science Center, University of New Mexico , Albuquerque, NM 87131-0001 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora I","family":"Perrone-Bizzozero","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, University of New Mexico Health Science Center, University of New Mexico , Albuquerque, NM 87131-0001 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet L","family":"Neisewander","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Arizona State University , Tempe, AZ 85287-4501 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa A","family":"Wilson","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Arizona State University , Tempe, AZ 85287-4501 , USA"},{"name":"Center for Evolution and Medicine, Arizona State University , Tempe, AZ 85287-4501 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,12]]},"reference":[{"issue":"5","key":"2023093021303610100_jkad143-B1","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1046\/j.1471-4159.2003.02247.x","article-title":"Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin","volume":"88","author":"Albertson","year":"2004","journal-title":"J Neurochem"},{"issue":"10","key":"2023093021303610100_jkad143-B2","doi-asserted-by":"publisher","first-page":"2304","DOI":"10.1038\/sj.npp.1301089","article-title":"Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse","volume":"31","author":"Albertson","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"2023093021303610100_jkad143-B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112708","article-title":"Cannabidiol decreases 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