{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T13:48:25Z","timestamp":1792936105968,"version":"4.5.0"},"reference-count":104,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T00:00:00Z","timestamp":1689984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015814","name":"Great Lakes Bioenergy Research Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015814","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UW Department of Energy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Variation in gene copy number can alter gene expression and influence downstream phenotypes; thus copy-number variation provides a route for rapid evolution if the benefits outweigh the cost. We recently showed that genetic background significantly influences how yeast cells respond to gene overexpression, revealing that the fitness costs of copy-number variation can vary substantially with genetic background in a common-garden environment. But the interplay between copy-number variation tolerance and environment remains unexplored on a genomic scale. Here, we measured the tolerance to gene overexpression in four genetically distinct Saccharomyces cerevisiae strains grown under sodium chloride stress. Overexpressed genes that are commonly deleterious during sodium chloride stress recapitulated those commonly deleterious under standard conditions. However, sodium chloride stress uncovered novel differences in strain responses to gene overexpression. West African strain NCYC3290 and North American oak isolate YPS128 are more sensitive to sodium chloride stress than vineyard BC187 and laboratory strain BY4743. Consistently, NCYC3290 and YPS128 showed the greatest sensitivities to overexpression of specific genes. Although most genes were deleterious, hundreds were beneficial when overexpressed\u2014remarkably, most of these effects were strain specific. Few beneficial genes were shared between the sodium chloride-sensitive isolates, implicating mechanistic differences behind their sodium chloride sensitivity. Transcriptomic analysis suggested underlying vulnerabilities and tolerances across strains, and pointed to natural copy-number variation of a sodium export pump that likely contributes to strain-specific responses to overexpression of other genes. Our results reveal extensive strain-by-environment interactions in the response to gene copy-number variation, raising important implications for the accessibility of copy-number variation-dependent evolutionary routes under times of stress.<\/jats:p>","DOI":"10.1093\/g3journal\/jkad159","type":"journal-article","created":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T20:09:30Z","timestamp":1690056570000},"source":"Crossref","is-referenced-by-count":32,"title":["Gene-by-environment interactions influence the fitness cost of gene copy-number variation in yeast"],"prefix":"10.1093","volume":"13","author":[{"given":"DeElegant","family":"Robinson","sequence":"first","affiliation":[{"name":"Center for Genomic Science Innovation, University of Wisconsin-Madison , Madison, WI 53704 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Vanacloig-Pedros","sequence":"additional","affiliation":[{"name":"Center for Genomic Science Innovation, University of Wisconsin-Madison , Madison, WI 53704 , USA"},{"name":"Great Lakes Bioenergy Research Center, University of Wisconsin-Madison , Madison, WI 53704 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyi","family":"Cai","sequence":"additional","affiliation":[{"name":"Center for Genomic Science Innovation, University of Wisconsin-Madison , Madison, WI 53704 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Place","sequence":"additional","affiliation":[{"name":"Center for Genomic Science Innovation, University of Wisconsin-Madison , Madison, WI 53704 , USA"},{"name":"Great Lakes Bioenergy Research Center, University of Wisconsin-Madison , Madison, WI 53704 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Hose","sequence":"additional","affiliation":[{"name":"Center for Genomic Science Innovation, University of Wisconsin-Madison , Madison, WI 53704 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8182-257X","authenticated-orcid":false,"given":"Audrey P","family":"Gasch","sequence":"additional","affiliation":[{"name":"Center for Genomic Science Innovation, University of Wisconsin-Madison , Madison, WI 53704 , USA"},{"name":"Great Lakes Bioenergy Research Center, University of Wisconsin-Madison , Madison, WI 53704 , USA"},{"name":"Department of Medical Genetics, University of Wisconsin-Madison , Madison, WI 53704 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,22]]},"reference":[{"issue":"4","key":"2023093021265673300_jkad159-B1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1002\/yea.3355","article-title":"Monovalent cation transporters at the plasma membrane in 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