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During a mutation accumulation experiment in C. elegans, a 1,034-bp deletion originated spontaneously and reached an 81.7% frequency within an experimental evolution line. This heteroplasmic mtDNA deletion, designated as meuDf1, eliminated portions of 2 protein-coding genes (coxIII and nd4) and tRNA-thr in entirety. mtDNA copy number in meuDf1 heteroplasmic individuals was 35% higher than in individuals with wild-type mitochondria. After backcrossing into a common genetic background, the meuDf1 mitotype was associated with reduction in several fitness traits and independent competition experiments found a 40% reduction in composite fitness. Experiments that relaxed individual selection by single individual bottlenecks demonstrated that the deletion-bearing mtDNA possessed a strong transmission bias, thereby qualifying it as a novel selfish mitotype.<\/jats:p>","DOI":"10.1093\/g3journal\/jkae018","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T16:52:19Z","timestamp":1706028739000},"source":"Crossref","is-referenced-by-count":8,"title":["Friend turned foe: selfish behavior of a spontaneously arising mitochondrial deletion in an experimentally evolved <i>Caenorhabditis elegans<\/i> population"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4093-1654","authenticated-orcid":false,"given":"Abigail N","family":"Sequeira","sequence":"first","affiliation":[{"name":"Department of Veterinary Integrative Biosciences, Texas A&M University , 402 Raymond Stotzer Parkway, College Station, TX 77845 , USA"},{"name":"Department of Biology, Pennsylvania State University , 208 Mueller Laboratory, University Park, PA 16802 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian P","family":"O\u2019Keefe","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences, Texas A&M University , 402 Raymond Stotzer Parkway, College Station, TX 77845 , USA"},{"name":"Department of Biochemistry and Molecular Biology, University of Maryland , 655 W. 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