{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:29:47Z","timestamp":1779316187490,"version":"3.51.4"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012378","name":"Kavli Institute for Brain and Mind Postdoctoral Scholar award","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012378","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["NS R37 035546"],"award-info":[{"award-number":["NS R37 035546"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["NS R35 127314"],"award-info":[{"award-number":["NS R35 127314"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The conserved MAP3K DLKs are widely known for their functions in synapse formation, axonal regeneration and degeneration, and neuronal survival, notably under traumatic injury and chronic disease conditions. In contrast, their roles in other neuronal compartments are much less explored. Through an unbiased forward genetic screening in C. elegans for altered patterns of GFP-tagged DLK-1 expressed from the endogenous locus, we have recently uncovered a mechanism by which the abundance of DLK-1 is tightly regulated by intraflagellar transport in ciliated sensory neurons. Here, we report additional mutants identified from the genetic screen. Most mutants exhibit increased accumulation of GFP::DLK-1 in sensory endings, and the levels of misaccumulated GFP::DLK-1 are exacerbated by loss of function in cebp-1, the b-Zip transcription factor acting downstream of DLK-1. We identify several new mutations in genes encoding proteins functioning in intraflagellar transport and cilia assembly, in components of BBSome, MAPK-15, and DYF-5 kinases. We report a novel mutation in the chaperone HSP90 that causes misaccumulation of GFP::DLK-1 and up-regulation of CEBP-1 selectively in ciliated sensory neurons. We also find that the guanylate cyclase ODR-1 constrains GFP::DLK-1 abundance throughout cilia and dendrites of AWC neurons. Moreover, in odr-1 mutants, AWC cilia display distorted morphology, which is ameliorated by loss of function in dlk-1 or cebp-1. These data expand the landscape of DLK-1 signaling in ciliated sensory neurons and underscore a high degree of cell- and neurite- specific regulation.<\/jats:p>","DOI":"10.1093\/g3journal\/jkaf004","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T18:26:15Z","timestamp":1737743175000},"source":"Crossref","is-referenced-by-count":1,"title":["Multiple regulators constrain the abundance of <i>Caenorhabditis elegans<\/i> DLK-1 in ciliated sensory neurons"],"prefix":"10.1093","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0042-1908","authenticated-orcid":false,"given":"Yue","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Neurobiology, School of Biological Sciences, University of California San Diego , La Jolla, CA 92093, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9166-3816","authenticated-orcid":false,"given":"Junxiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, School of Biological Sciences, University of California San Diego , La Jolla, CA 92093, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arunima","family":"Debnath","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, School of Biological Sciences, University of California San Diego , La Jolla, CA 92093, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bokun","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, School of Biological Sciences, University of California San Diego , La Jolla, CA 92093, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, School of Biological Sciences, University of California San Diego , La Jolla, CA 92093, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9371-9860","authenticated-orcid":false,"given":"Yishi","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, School of Biological Sciences, University of California San Diego , La Jolla, CA 92093, USA"},{"name":"Kavli Institute for Brain and Mind, University of California San Diego , La Jolla, CA 92093, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"issue":"3","key":"2025031817093662200_jkaf004-B1","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/0092-8674(93)80053-H","article-title":"Odorant-selective genes and neurons mediate olfaction in C. elegans","volume":"74","author":"Bargmann","year":"1993","journal-title":"Cell"},{"issue":"6","key":"2025031817093662200_jkaf004-B2","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1136\/jmg.36.6.437","article-title":"New criteria for improved diagnosis of Bardet\u2013Biedl syndrome: results of a population survey","volume":"36","author":"Beales","year":"1999","journal-title":"J Med Genet."},{"issue":"38","key":"2025031817093662200_jkaf004-B3","doi-asserted-by":"publisher","first-page":"9288","DOI":"10.1523\/JNEUROSCI.1582-17.2017","article-title":"The atypical MAP kinase SWIP-13\/ERK8 regulates dopamine transporters through a rho-dependent mechanism","volume":"37","author":"Bermingham","year":"2017","journal-title":"J Neurosci."},{"issue":"1","key":"2025031817093662200_jkaf004-B4","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1093\/genetics\/155.1.85","article-title":"A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in Caenorhabditis elegans","volume":"155","author":"Birnby","year":"2000","journal-title":"Genetics"},{"issue":"13","key":"2025031817093662200_jkaf004-B5","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1101\/gad.1194004","article-title":"Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport","volume":"18","author":"Blacque","year":"2004","journal-title":"Genes Dev."},{"issue":"10","key":"2025031817093662200_jkaf004-B6","doi-asserted-by":"publisher","first-page":"3982","DOI":"10.1073\/pnas.1101360108","article-title":"Microtubule depolymerization in Caenorhabditis elegans touch receptor neurons reduces gene expression through a p38 MAPK pathway","volume":"108","author":"Bounoutas","year":"2011","journal-title":"Proc Natl Acad Sci USA."},{"issue":"1","key":"2025031817093662200_jkaf004-B7","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"issue":"1","key":"2025031817093662200_jkaf004-B8","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.neuron.2006.05.026","article-title":"Highwire restrains synaptic growth by attenuating a MAP kinase signal","volume":"51","author":"Collins","year":"2006","journal-title":"Neuron"},{"issue":"42","key":"2025031817093662200_jkaf004-B9","doi-asserted-by":"publisher","first-page":"31467","DOI":"10.1074\/jbc.M607612200","article-title":"Down-regulation of the mixed-lineage dual leucine zipper-bearing kinase by heat shock protein 70 and its co-chaperone CHIP","volume":"281","author":"Daviau","year":"2006","journal-title":"J Biol Chem."},{"issue":"11","key":"2025031817093662200_jkaf004-B10","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1038\/ng.248","article-title":"Single-copy insertion of transgenes in Caenorhabditis elegans","volume":"40","author":"Fr\u00f8kjaer-Jensen","year":"2008","journal-title":"Nat Genet."},{"issue":"21","key":"2025031817093662200_jkaf004-B11","doi-asserted-by":"publisher","first-page":"4839","DOI":"10.1242\/dev.126.21.4839","article-title":"A novel WD40 protein, CHE-2, acts cell-autonomously in the formation of C. elegans sensory cilia","volume":"126","author":"Fujiwara","year":"1999","journal-title":"Development"},{"issue":"9","key":"2025031817093662200_jkaf004-B12","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.1523\/JNEUROSCI.5464-09.2010","article-title":"Calcium and cyclic AMP promote axonal regeneration in Caenorhabditis elegans and require DLK-1 kinase","volume":"30","author":"Ghosh-Roy","year":"2010","journal-title":"J Neurosci."},{"issue":"10","key":"2025031817093662200_jkaf004-B13","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1101\/gr.4086505","article-title":"Galaxy: a platform for interactive large-scale genome analysis","volume":"15","author":"Giardine","year":"2005","journal-title":"Genome Res."},{"issue":"4","key":"2025031817093662200_jkaf004-B14","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.neuron.2007.07.009","article-title":"C. elegans RPM-1 regulates axon termination and synaptogenesis through the Rab GEF GLO-4 and the Rab GTPase GLO-1","volume":"55","author":"Grill","year":"2007","journal-title":"Neuron"},{"issue":"1","key":"2025031817093662200_jkaf004-B15","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13064-016-0063-0","article-title":"The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration","volume":"11","author":"Grill","year":"2016","journal-title":"Neural Dev."},{"issue":"5915","key":"2025031817093662200_jkaf004-B16","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1126\/science.1165527","article-title":"Axon regeneration requires a conserved MAP kinase pathway","volume":"323","author":"Hammarlund","year":"2009","journal-title":"Science"},{"key":"2025031817093662200_jkaf004-B17","doi-asserted-by":"publisher","first-page":"e14048","DOI":"10.7554\/eLife.14048","article-title":"An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK","volume":"5","author":"Hao","year":"2016","journal-title":"eLife"},{"issue":"2","key":"2025031817093662200_jkaf004-B18","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.cell.2009.01.057","article-title":"DEX-1 and DYF-7 establish sensory dendrite length by anchoring dendritic tips during cell migration","volume":"137","author":"Heiman","year":"2009","journal-title":"Cell"},{"issue":"3","key":"2025031817093662200_jkaf004-B19","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1073\/pnas.1514123113","article-title":"Palmitoylation controls DLK localization, interactions and activity to ensure effective axonal injury signaling","volume":"113","author":"Holland","year":"2016","journal-title":"Proc Natl Acad Sci USA."},{"issue":"49","key":"2025031817093662200_jkaf004-B20","doi-asserted-by":"publisher","first-page":"30808","DOI":"10.1016\/S0021-9258(18)47353-X","article-title":"Identification, molecular cloning, and characterization of dual leucine zipper bearing kinase. A novel serine\/threonine protein kinase that defines a second subfamily of mixed lineage kinases","volume":"269","author":"Holzman","year":"1994","journal-title":"J Biol Chem."},{"issue":"3","key":"2025031817093662200_jkaf004-B21","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.cell.2016.12.044","article-title":"Apoe2, ApoE3, and ApoE4 differentially stimulate APP transcription and A\u03b2 secretion","volume":"168","author":"Huang","year":"2017","journal-title":"Cell"},{"issue":"3","key":"2025031817093662200_jkaf004-B22","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/S0014-5793(00)02432-7","article-title":"Identification and characterization of functional domains in a mixed lineage kinase LZK","volume":"488","author":"Ikeda","year":"2001","journal-title":"FEBS Lett"},{"issue":"20","key":"2025031817093662200_jkaf004-B23","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.15252\/embj.201488044","article-title":"Formation of the transition zone by Mks5\/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP2 ciliary abundance","volume":"34","author":"Jensen","year":"2015","journal-title":"EMBO J"},{"issue":"1","key":"2025031817093662200_jkaf004-B24","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1146\/annurev-cellbio-100617-062644","article-title":"Multitasking: dual leucine zipper\u2013bearing kinases in neuronal development and stress management","volume":"35","author":"Jin","year":"2019","journal-title":"Annu Rev Cell Dev Biol."},{"issue":"5","key":"2025031817093662200_jkaf004-B25","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1016\/j.cell.2019.01.044","article-title":"CCR5 is a therapeutic target for recovery after stroke and traumatic brain injury","volume":"176","author":"Joy","year":"2019","journal-title":"Cell"},{"issue":"6","key":"2025031817093662200_jkaf004-B26","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.cub.2012.01.060","article-title":"Endocytosis genes facilitate protein and membrane transport in C. elegans sensory cilia","volume":"22","author":"Kaplan","year":"2012","journal-title":"Curr Biol."},{"issue":"42","key":"2025031817093662200_jkaf004-B27","doi-asserted-by":"publisher","first-page":"E9899","DOI":"10.1073\/pnas.1805351115","article-title":"HSP90 is a chaperone for DLK and is required for axon injury signaling","volume":"115","author":"Karney-Grobe","year":"2018","journal-title":"Proc Natl Acad Sci USA."},{"issue":"4","key":"2025031817093662200_jkaf004-B28","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1534\/genetics.117.300383","article-title":"Primary cilium formation and ciliary protein trafficking is regulated by the atypical MAP kinase MAPK15 in Caenorhabditis elegans and human cells","volume":"207","author":"Kazatskaya","year":"2017","journal-title":"Genetics"},{"issue":"3","key":"2025031817093662200_jkaf004-B29","doi-asserted-by":"publisher","first-page":"iyab139","DOI":"10.1093\/genetics\/iyab139","article-title":"UNC-16 alters DLK-1 localization and negatively regulates actin and microtubule dynamics in Caenorhabditis elegans regenerating neurons","volume":"219","author":"Kulkarni","year":"2021","journal-title":"Genetics"},{"issue":"1","key":"2025031817093662200_jkaf004-B30","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1365-2443.2007.01147.x","article-title":"Caenorhabditis elegans DYF-11, an orthologue of mammalian Traf3ip1\/MIP-T3, is required for sensory cilia formation","volume":"13","author":"Kunitomo","year":"2008","journal-title":"Genes Cells"},{"issue":"3","key":"2025031817093662200_jkaf004-B31","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/S0896-6273(00)81061-2","article-title":"Olfaction and odor discrimination are mediated by the C. elegans guanylyl cyclase ODR-1","volume":"25","author":"L\u2019Etoile","year":"2000","journal-title":"Neuron"},{"issue":"4","key":"2025031817093662200_jkaf004-B32","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.neuron.2007.09.009","article-title":"The ubiquitin ligase phr1 regulates axon outgrowth through modulation of microtubule dynamics","volume":"56","author":"Lewcock","year":"2007","journal-title":"Neuron"},{"issue":"14","key":"2025031817093662200_jkaf004-B33","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows\u2013Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"issue":"3","key":"2025031817093662200_jkaf004-B34","doi-asserted-by":"crossref","first-page":"e1002416","DOI":"10.1371\/journal.pbio.1002416","article-title":"MKS5 and CEP290 dependent assembly pathway of the ciliary transition zone","volume":"14","author":"Li","year":"2016","journal-title":"PLoS Biol"},{"issue":"6997","key":"2025031817093662200_jkaf004-B35","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nature02647","article-title":"An SCF-like ubiquitin ligase complex that controls presynaptic differentiation","volume":"430","author":"Liao","year":"2004","journal-title":"Nature"},{"issue":"6","key":"2025031817093662200_jkaf004-B36","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.devcel.2008.11.001","article-title":"A BBSome subunit links ciliogenesis, microtubule stability, and acetylation","volume":"15","author":"Loktev","year":"2008","journal-title":"Dev Cell."},{"issue":"5","key":"2025031817093662200_jkaf004-B37","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.devcel.2008.03.002","article-title":"Sensory signaling-dependent remodeling of olfactory cilia architecture in C. elegans","volume":"14","author":"Mukhopadhyay","year":"2008","journal-title":"Dev Cell"},{"issue":"3","key":"2025031817093662200_jkaf004-B38","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.jmb.2004.12.005","article-title":"The dyf-3 gene encodes a novel protein required for sensory cilium formation in Caenorhabditis elegans","volume":"346","author":"Murayama","year":"2005","journal-title":"J Mol Biol."},{"issue":"6","key":"2025031817093662200_jkaf004-B39","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/j.cell.2007.03.053","article-title":"A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis","volume":"129","author":"Nachury","year":"2007","journal-title":"Cell"},{"issue":"3","key":"2025031817093662200_jkaf004-B40","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.cell.2004.12.017","article-title":"Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development","volume":"120","author":"Nakata","year":"2005","journal-title":"Cell"},{"issue":"13","key":"2025031817093662200_jkaf004-B41","doi-asserted-by":"publisher","first-page":"3447","DOI":"10.1093\/emboj\/20.13.3447","article-title":"Mixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components","volume":"20","author":"Nihalani","year":"2001","journal-title":"EMBO J."},{"issue":"10","key":"2025031817093662200_jkaf004-B42","doi-asserted-by":"publisher","first-page":"7273","DOI":"10.1074\/jbc.275.10.7273","article-title":"Identification of structural and functional domains in mixed lineage kinase dual leucine zipper-bearing kinase required for complex formation and stress-activated protein kinase activation","volume":"275","author":"Nihalani","year":"2000","journal-title":"J Biol Chem."},{"issue":"7","key":"2025031817093662200_jkaf004-B43","doi-asserted-by":"publisher","first-page":"108365","DOI":"10.1016\/j.celrep.2020.108365","article-title":"Coupled control of distal axon integrity and somal responses to axonal damage by the palmitoyl acyltransferase ZDHHC17","volume":"33","author":"Niu","year":"2020","journal-title":"Cell Rep."},{"issue":"3","key":"2025031817093662200_jkaf004-B44","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1534\/genetics.114.167841","article-title":"Systematic analyses of rpm-1 suppressors reveal roles for ESS-2 in mRNA splicing in Caenorhabditis elegans","volume":"198","author":"Noma","year":"2014","journal-title":"Genetics"},{"issue":"2","key":"2025031817093662200_jkaf004-B45","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/0012-1606(86)90314-3","article-title":"Mutant sensory cilia in the nematode Caenorhabditis elegans","volume":"117","author":"Perkins","year":"1986","journal-title":"Dev Biol."},{"issue":"10","key":"2025031817093662200_jkaf004-B46","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1002\/cm.21387","article-title":"MAPK-15 is a ciliary protein required for PKD-2 localization and male mating behavior in Caenorhabditis elegans","volume":"74","author":"Piasecki","year":"2017","journal-title":"Cytoskeleton"},{"issue":"6","key":"2025031817093662200_jkaf004-B47","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0960-9822(01)00122-1","article-title":"An autosomal recessive polycystic kidney disease gene homolog is involved in intraflagellar transport in C. elegans ciliated sensory neurons","volume":"11","author":"Qin","year":"2001","journal-title":"Curr Biol"},{"key":"2025031817093662200_jkaf004-B48","doi-asserted-by":"publisher","first-page":"e67670","DOI":"10.7554\/eLife.67670","article-title":"Ectocytosis prevents accumulation of ciliary cargo in C. elegans sensory neurons","volume":"10","author":"Razzauti","year":"2021","journal-title":"eLife"},{"issue":"10","key":"2025031817093662200_jkaf004-B49","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/nrm3658","article-title":"Chaperone machines for protein folding, unfolding and disaggregation","volume":"14","author":"Saibil","year":"2013","journal-title":"Nat Rev Mol Cell Biol."},{"issue":"5","key":"2025031817093662200_jkaf004-B50","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1083\/jcb.201103153","article-title":"DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity","volume":"194","author":"Sengupta Ghosh","year":"2011","journal-title":"J Cell Biol."},{"issue":"11","key":"2025031817093662200_jkaf004-B51","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1038\/ncb1186","article-title":"Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons","volume":"6","author":"Snow","year":"2004","journal-title":"Nat Cell Biol."},{"issue":"39","key":"2025031817093662200_jkaf004-B52","doi-asserted-by":"publisher","first-page":"e2302801120","DOI":"10.1073\/pnas.2302801120","article-title":"An intraflagellar transport dependent negative feedback regulates the MAPKKK DLK-1 to protect cilia from degeneration","volume":"120","author":"Sun","year":"2023","journal-title":"Proc Natl Acad Sci USA."},{"key":"2025031817093662200_jkaf004-B53","doi-asserted-by":"publisher","first-page":"e87623","DOI":"10.7554\/eLife.87623","article-title":"Organization, functions, and mechanisms of the BBSome in development, ciliopathies, and beyond","volume":"12","author":"Tian","year":"2023","journal-title":"eLife"},{"issue":"5","key":"2025031817093662200_jkaf004-B54","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/j.neuron.2013.06.035","article-title":"The EBAX-type cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3\/Robo receptor in developing neurons","volume":"79","author":"Wang","year":"2013","journal-title":"Neuron"},{"issue":"3","key":"2025031817093662200_jkaf004-B55","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.neuron.2012.08.043","article-title":"Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform","volume":"76","author":"Yan","year":"2012","journal-title":"Neuron"},{"issue":"5","key":"2025031817093662200_jkaf004-B56","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.cell.2009.06.023","article-title":"The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration","volume":"138","author":"Yan","year":"2009","journal-title":"Cell"},{"issue":"12","key":"2025031817093662200_jkaf004-B57","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1016\/j.devcel.2022.05.005","article-title":"A cilia-independent function of BBSome mediated by DLK-MAPK signaling in C. elegans photosensation","volume":"57","author":"Zhang","year":"2022","journal-title":"Dev Cell."},{"issue":"12","key":"2025031817093662200_jkaf004-B58","doi-asserted-by":"publisher","first-page":"dev189886","DOI":"10.1242\/dev.189886","article-title":"Opposing effects of an F-box protein and the HSP90 chaperone network on microtubule stability and neurite growth in Caenorhabditis elegans","volume":"147","author":"Zheng","year":"2020","journal-title":"Development"}],"container-title":["G3: Genes, Genomes, Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/g3journal\/advance-article-pdf\/doi\/10.1093\/g3journal\/jkaf004\/61621802\/jkaf004.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/g3journal\/article-pdf\/15\/3\/jkaf004\/61621802\/jkaf004.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/g3journal\/article-pdf\/15\/3\/jkaf004\/61621802\/jkaf004.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T17:10:07Z","timestamp":1742317807000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/g3journal\/article\/doi\/10.1093\/g3journal\/jkaf004\/7978931"}},"subtitle":[],"editor":[{"given":"M-A","family":"F\u00e9lix","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":58,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,1,24]]},"published-print":{"date-parts":[[2025,3,18]]}},"URL":"https:\/\/doi.org\/10.1093\/g3journal\/jkaf004","relation":{},"ISSN":["2160-1836"],"issn-type":[{"value":"2160-1836","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,3]]},"published":{"date-parts":[[2025,1,24]]},"article-number":"jkaf004"}}