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The traits that contribute to its ubiquity as an opportunistic pest, such as long lifespan, expansive neurosensory capacity, and nutritional flexibility, also make P. americana an excellent invertebrate model organism as evidenced by its long history in neuroscience and physiological research. Current genetic resources available for P. americana highlight its large, complex genome and richly diverse transcriptional capabilities, but fall short of producing a complete, chromosome-level genome. Here, we present a high-quality de novo genome assembly of a laboratory-raised adult female P. americana using a combination of high fidelity PacBio long reads and Hi-C sequencing. The final 3.23\u2005Gb genome was assembled with chromosomal resolution into 17 scaffolds, consistent with previous karyotype analysis, and has a scaffold N50 of 188.1\u2005Mb and genome Benchmarking Universal Single-Copy Ortholog (BUSCO) score of 99.7%. This assembly includes a chromosome that was missing from the previous reference genome for this species. Protein prediction and annotation were performed via the NCBI Eukaryotic Genome Annotation Pipeline, which identified 16,750 protein-coding genes and generated an annotation BUSCO score of 97.8%. Ortholog comparisons with available Blattodea assemblies highlight the expanded chemosensory and immune capabilities of P. americana compared to termite relatives. This genome assembly is a valuable tool for facilitating future research on the biology and evolution of this remarkable insect.<\/jats:p>","DOI":"10.1093\/g3journal\/jkaf247","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T14:38:57Z","timestamp":1761143937000},"source":"Crossref","is-referenced-by-count":2,"title":["Improved chromosome-level genome assembly of the American cockroach,\n                    <i>Periplaneta americana<\/i>"],"prefix":"10.1093","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7422-6868","authenticated-orcid":false,"given":"Rachel L","family":"Dockman","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Georgia , Athens, GA 30602 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler J","family":"Simmonds","sequence":"additional","affiliation":[{"name":"Tropical Pest Genetics and Molecular Biology Research Unit, Daniel K Inouye U.S. Pacific Basin Agricultural Research Center, USDA-ARS , Hilo, HI 96720 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2612-109X","authenticated-orcid":false,"given":"Kevin J","family":"Vogel","sequence":"additional","affiliation":[{"name":"Department of Entomology, University of Georgia , Athens, GA 30602 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott M","family":"Geib","sequence":"additional","affiliation":[{"name":"Tropical Pest Genetics and Molecular Biology Research Unit, Daniel K Inouye U.S. Pacific Basin Agricultural Research Center, USDA-ARS , Hilo, HI 96720 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7898-2425","authenticated-orcid":false,"given":"Elizabeth A","family":"Ottesen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Georgia , Athens, GA 30602 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"2026010621530174500_jkaf247-B1","doi-asserted-by":"publisher","first-page":"e21390","DOI":"10.1002\/arch.21390","article-title":"Purification and functional characterization of lectin with phenoloxidase activity from the hemolymph of cockroach, Periplaneta americana","volume":"95:","author":"Arumugam","year":"2017","journal-title":"Arch Insect Biochem Physiol"},{"key":"2026010621530174500_jkaf247-B2","doi-asserted-by":"publisher","first-page":"e4717","DOI":"10.7717\/peerj.4717","article-title":"The role of gut microbiota in the regulation of standard metabolic rate in female Periplaneta americana","volume":"6","author":"Ayayee","year":"2018","journal-title":"PeerJ"},{"key":"2026010621530174500_jkaf247-B3","doi-asserted-by":"crossref","DOI":"10.1007\/978-94-009-5827-2","volume-title":"The American cockroach","author":"Bell","year":"1982"},{"key":"2026010621530174500_jkaf247-B4","unstructured":"Brown M, Gonz\u00e1lez De la Rosa PM, Mark B. \u00a02023. 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