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While Bap1 has been shown to play key roles in metabolism, maintenance of tissue homeostasis, and immune cell development, little is known about its normal functions in the liver in vivo. Using AAV8-mediated CRISPR\/CAS9 genome editing, we generated a mouse hepatocyte-specific model of Bap1 knockout to define the changes that occur in liver biology in an in vivo system and characterize how loss of Bap1 alters the liver's response to injury. Single-cell resolution spatial transcriptomics were performed in conjunction with immunohistochemistry to analyze cell-type composition and immune cell recruitment changes. Bulk RNA-sequencing was performed to further assess the impact of Bap1 loss on transcription. Hepatocyte-specific depletion of Bap1-induced transcriptional changes shared with acute injury. We observed a strong dysregulation of inflammatory pathways associated with Bap1 loss. Moreover, the transcriptional response of Bap1 depletion in hepatocytes to damage was markedly different than in control liver, with Bap1-depleted livers showing a decreased hepatocyte identity based on gene expression. Spatial transcriptomics and quantitative texture analysis of immunohistochemistry revealed an altered immune environment prior to damage and an impaired recruitment of immune cells in Bap1-depleted livers after damage. Our data suggest Bap1 is a critical modulator in the liver's immune cell response and its loss leads to an inflammatory environment prior to damage and disrupts the recruitment immune cells. Our quantitative spatial analysis highlights the power of such approaches to characterize the spatial distribution of different cell types in a tissue.<\/jats:p>","DOI":"10.1093\/g3journal\/jkag047","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T17:39:35Z","timestamp":1771522775000},"source":"Crossref","is-referenced-by-count":0,"title":["Hepatocyte-targeted Bap1 reduction in the liver primes an inflammatory transcriptional response"],"prefix":"10.1093","volume":"16","author":[{"given":"William C","family":"Nenad","sequence":"first","affiliation":[{"name":"Bioinformatics and Computational Biology Curriculum, Department of Genetics, The University of North Carolina at Chapel Hill , Chapel Hill, NC 27599 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peyton C","family":"Kuhlers","sequence":"additional","affiliation":[{"name":"Department of Genetics, The University of North Carolina at Chapel Hill , 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