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Caenorhabditis elegans exhibits developmentally timed sleep (DTS) and stress-induced sleep (SIS), which meet the behavioral definition of sleep and are regulated by molecular mechanisms shared with other animals. Here, we studied the sleep-regulating functions of UNC-80, which forms a complex with NCA-1 and NCA-2 (hereafter collectively referred to as NCA), and UNC-79. We found that the unc-80 loss-of-function (lf) mutants experienced lower quiescence and a more fragmented and longer DTS than the wild type. The unc-80(lf) mutants also showed lower quiescence during SIS immediately after heat stress, and fragmented SIS. After that, however, quiescence remained higher for a longer time, resulting in a higher total quiescence than observed in the wild type. Similar sleep defects were observed in nca(lf) and unc-79(lf) mutants, indicating that these genes have common functions in sleep regulation. Deprivation of SIS immediately after heat stress in the wild type resulted in a sleep pattern similar to that of the unc-80(lf) mutants, suggesting that sleep immediately after stress might be essential and thus is under strong homeostatic regulation and that the prolonged DTS and SIS of the unc-80(lf) mutants might be rebound sleep. Our findings elucidated that NCA, UNC-79, and UNC-80 are necessary for stabilizing sleep and suggest the importance of the early period of sleep.<\/jats:p>","DOI":"10.1093\/g3journal\/jkag112","type":"journal-article","created":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T21:04:40Z","timestamp":1777842280000},"source":"Crossref","is-referenced-by-count":0,"title":["The NALCN channel complex is necessary for stabilizing sleep in\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1093","volume":"16","author":[{"given":"Takahiro","family":"Kamijo","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Graduate School of Science, The University of Tokyo , Bunkyo-ku, Tokyo 113-0033 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Graduate School of Science, The University of Tokyo , Bunkyo-ku, Tokyo 113-0033 ,","place":["Japan"]},{"name":"International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba , Tsukuba, Ibaraki 305-8575 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Graduate School of Science, The University of Tokyo , Bunkyo-ku, Tokyo 113-0033 ,","place":["Japan"]},{"name":"International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba Institute for Advanced Research (TIAR), University of Tsukuba , Tsukuba, Ibaraki 305-8575 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"2026070604320736900_jkag112-B1","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1186\/1471-2164-14-362","article-title":"Sleep is not just for the brain: 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