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In Schizosaccharomyces pombe, after division, cells grow monopolarly from the old end, then transition to bipolar growth at a certain size when the new end activates. However, G1-arrested cells do not become bipolar despite continued growth, suggesting a role for the cell cycle in this process. To identify how the cell cycle impacts monopolar to bipolar transition, we performed high-throughput mRNA sequencing to detect differentially expressed genes in G1-arrested and G2-phase cells of the cell-cycle mutant cdc10-129. DESeq2 analysis identified 65 unique genes upregulated in G1 phase and 35 in G2 phase. Enrichment analysis shows that G1 phase cells upregulated the MAPK pheromone-response pathway, protein folding, rRNA processing, and heat-shock protein binding. G2 phase cells showed upregulation of plasma membrane maintenance and cell wall organization. In G2 phase cells, protein\u2013protein interaction networks identified the cdc15-hob3-rho1-bgs1 hub, known to promote bipolar growth and regulate cell wall biogenesis. In G1 phase cells, the spk1-byr2-ste11 hub involved in pheromone-response and nutritional stress-dependent G1-arrest was identified. In agreement with these findings, we find that spk1\u0394 cells are precociously bipolar, indicating a role for this kinase in preventing bipolar growth. We hypothesize that bipolar growth in G2 cells requires a combination of factors that favor cell growth. In G2, stress response pathways are downregulated while anabolic pathways are upregulated, enabling transition from monopolar to bipolar growth.<\/jats:p>","DOI":"10.1093\/g3journal\/jkag126","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T09:02:01Z","timestamp":1778490121000},"source":"Crossref","is-referenced-by-count":1,"title":["Differential gene expression drives cell-cycle-dependent transition from monopolar to bipolar growth in\n                    <i>Schizosaccharomyces pombe<\/i>"],"prefix":"10.1093","volume":"16","author":[{"given":"Samridhi","family":"Pathak","sequence":"first","affiliation":[{"name":"Department of Biology, Boston College , Chestnut Hill, MA 02467 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M","family":"Tramonte","sequence":"additional","affiliation":[{"name":"Department of Biology, Boston College , Chestnut Hill, MA 02467 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9164-0158","authenticated-orcid":false,"given":"Maitreyi","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Biology, Boston College , Chestnut Hill, MA 02467 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"2026070604324335900_jkag126-B1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000626","article-title":"The fission yeast homeodomain protein Yox1p binds to MBF and confines MBF-dependent cell-cycle transcription to G1-S via negative feedback","volume":"5","author":"Aligianni","year":"2009","journal-title":"PLoS Genet"},{"key":"2026070604324335900_jkag126-B2","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1128\/EC.4.7.1287-1297.2005","article-title":"Hyphal growth in the fission yeast Schizosaccharomyces pombe","volume":"4","author":"Amoah-Buahin","year":"2005","journal-title":"Eukaryot Cell."},{"key":"2026070604324335900_jkag126-B3","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol"},{"key":"2026070604324335900_jkag126-B4","doi-asserted-by":"publisher","first-page":"3569","DOI":"10.1242\/jcs.112.20.3569","article-title":"Schizosaccharomyces pombe protein kinase C homologues, pck1p and pck2p, are targets of rho1p and rho2p and differentially regulate cell integrity","volume":"112","author":"Arellano","year":"1999","journal-title":"J Cell Sci."},{"key":"2026070604324335900_jkag126-B5","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1002\/(SICI)1097-0029(19991001)47:1&lt;51::AID-JEMT5&gt;;3.0.CO;2-3","article-title":"RHO GTPases in the control of cell morphology, cell polarity, and actin localization in fission yeast","volume":"47","author":"Arellano","year":"1999","journal-title":"Microsc Res Tech."},{"key":"2026070604324335900_jkag126-B6","doi-asserted-by":"publisher","first-page":"4676","DOI":"10.1093\/emboj\/16.15.4676","article-title":"Control of S-phase periodic transcription in the fission yeast mitotic cycle","volume":"16","author":"Baum","year":"1997","journal-title":"EMBO J"},{"key":"2026070604324335900_jkag126-B7","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1038\/nrm2524","article-title":"Organelle positioning and cell polarity","volume":"9","author":"Bornens","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026070604324335900_jkag126-B8","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.4161\/cc.5.18.3206","article-title":"Stress-induced switch to pseudohyphal growth in S. 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