{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:19:26Z","timestamp":1789193966079,"version":"build-2803163510"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["R21 AI185250"],"award-info":[{"award-number":["R21 AI185250"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012468","name":"Distinguished Research Professorship","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012468","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007699","name":"University of Georgia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Biofilm formation is vital for the survival and pathogenicity of the fungus Candida albicans. Expression of biofilm-promoting genes is coordinated by a transcription factor network that governs the yeast-filament transition and other processes. A second cell type transition, the white-opaque transition, is coordinated by its own transcription factor network. Initial studies suggested that the 2 transcriptional networks have a mutually exclusive relationship, driven in part by reciprocal repression of biofilm regulator Efg1 and white-opaque regulator Wor1. However, recent studies have shown that biofilm regulators and white-opaque regulators can promote one another's function in many situations. Here, we test the function of white-opaque regulator Wor2 in biofilm formation. We find that Wor2 has a functional relationship with biofilm regulator Bcr1. We characterized the phenotype of bcr1\u0394\/\u0394 wor2\u0394\/\u0394 mutants in 5 strain backgrounds and conducted RNA-sequencing (RNA-seq) analysis in the SC5314 reference strain background. The combined Bcr1-Wor2 impact is unexpected: although Bcr1 is known as a positive regulator of biofilm formation and biofilm-related genes, the bcr1\u0394\/\u0394 wor2\u0394\/\u0394 mutants have increased biofilm or filamentation capacity, depending on the strain, and increased expression of biofilm-related genes. Those properties suggest that Wor2 and Bcr1 function together as negative regulators of biofilm formation. Our findings argue that Bcr1 can act as both a positive and negative regulator of downstream effector genes in the biofilm network and establish a new connection between the biofilm and white-opaque regulatory networks.<\/jats:p>","DOI":"10.1093\/g3journal\/jkag133","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:35:13Z","timestamp":1778924113000},"source":"Crossref","is-referenced-by-count":1,"title":["Negative control of\n                    <i>Candida albicans<\/i>\n                    biofilm formation by combined action of white-opaque regulator Wor2 and biofilm regulator Bcr1"],"prefix":"10.1093","volume":"16","author":[{"given":"Katharina","family":"Goerlich","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Georgia , Athens, GA 30602 ,","place":["United 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