{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:39:20Z","timestamp":1793932760321,"version":"4.8.0"},"reference-count":90,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 GM130136"],"award-info":[{"award-number":["R01 GM130136"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15 GM111094"],"award-info":[{"award-number":["R15 GM111094"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mating strategies, whether sexual or asexual, confer unique costs and benefits to populations and species that facilitate evolutionary processes. In wild isolates of Caenorhabditis elegans, mating strategies are dependent on developmental history. Outcrossing significantly increases when one or both parents have transiently passed through the stress-resistant dauer diapause stage. However, the mechanisms of how life history alters mating strategies have not been systematically explored. Sex-specific responses to pheromones are a major driver of mating behaviors in C. elegans. We demonstrated previously that postdauer hermaphrodites exhibit a decreased avoidance of the pheromone ascr#3 due to the downregulation of the osm-9 TRPV channel gene in postdauer ADL neurons. Thus, we hypothesized that altered responses to pheromones in postdauer animals contribute to increased outcrossing. We conducted mating assays using wild type N2 Bristol, as well as osm-9, daf-3\/co-SMAD, and mut-16\/Mutator mutant strains that regulate the activity of hermaphrodite ADL neurons. First, we show that the outcrossing level of N2 Bristol correlated with the developmental history of males, and that postdauer males exhibited an increased ability to detect mates via pheromones compared to control males. In addition, DAF-3 plays a critical role in postdauer males to regulate mating, while playing a more minor role in hermaphrodites. Furthermore, mut-16 adults exhibited decreased outcrossing, and attempts to rescue the outcrossing phenotype resulted in transgenerational sterility due to defects in hermaphrodite and male germlines. Together, our results suggest a model whereby mating strategy is driven by male developmental history under combinatorial control of TGF-\u03b2 and RNAi pathways.<\/jats:p>","DOI":"10.1093\/g3journal\/jkag146","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:03:13Z","timestamp":1782230593000},"source":"Crossref","is-referenced-by-count":3,"title":["Mating strategies in\n                    <i>Caenorhabditis elegans<\/i>\n                    populations are determined by male developmental history"],"prefix":"10.1093","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7110-5932","authenticated-orcid":false,"given":"Rose S","family":"Al-Saadi","sequence":"first","affiliation":[{"name":"Department of Biology, Syracuse University , Syracuse, NY 13244 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Genetics, University of Rochester , Rochester, NY 14642 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra M","family":"Nichitean","sequence":"additional","affiliation":[{"name":"Department of Biology, Syracuse University , Syracuse, NY 13244 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaus R","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Biology, Syracuse University , Syracuse, NY 13244 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia G","family":"Gaytan","sequence":"additional","affiliation":[{"name":"Department of Biology, Syracuse University , Syracuse, NY 13244 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2686-8839","authenticated-orcid":false,"given":"Douglas S","family":"Portman","sequence":"additional","affiliation":[{"name":"Department of Biomedical Genetics, University of Rochester , Rochester, NY 14642 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8536-4000","authenticated-orcid":false,"given":"Sarah E","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Biology, Syracuse University , Syracuse, NY 13244 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"2026080510222017000_jkag146-B1","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/35079590","article-title":"Sexual selection and the maintenance of sexual reproduction","volume":"411","author":"Agrawal","year":"2001","journal-title":"Nature"},{"key":"2026080510222017000_jkag146-B2","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1093\/genetics\/156.3.1047","article-title":"Dauer formation induced by high temperatures in Caenorhabditis elegans","volume":"156","author":"Ailion","year":"2000","journal-title":"Genetics"},{"key":"2026080510222017000_jkag146-B3","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/cne.902190407","article-title":"Developmental alterations in sensory neuroanatomy of the Caenorhabditis elegans dauer larva","volume":"219","author":"Albert","year":"1983","journal-title":"J Comp Neurol"},{"key":"2026080510222017000_jkag146-B4","doi-asserted-by":"publisher","first-page":"iyac022","DOI":"10.1093\/genetics\/iyae049","article-title":"Updates to the Alliance of Genome Resources central infrastructure","volume":"227","author":"Aleksander","year":"2024","journal-title":"GENETICS"},{"key":"2026080510222017000_jkag146-B5","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1534\/genetics.114.169730","article-title":"Efficient marker-free recovery of custom genetic modifications with CRISPR\/cas9 in Caenorhabditis elegans","volume":"198","author":"Arribere","year":"2014","journal-title":"Genetics"},{"key":"2026080510222017000_jkag146-B6","doi-asserted-by":"crossref","DOI":"10.1895\/wormbook.1.123.1","volume-title":"Chemosensation in C. elegans","author":"Bargmann","year":"2006"},{"key":"2026080510222017000_jkag146-B7","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1038\/nn.3253","article-title":"PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans","volume":"15","author":"Barrios","year":"2012","journal-title":"Nat Neurosci"},{"key":"2026080510222017000_jkag146-B8","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1016\/j.cub.2008.10.050","article-title":"Sensory regulation of C. elegans male mate-searching behavior","volume":"18","author":"Barrios","year":"2008","journal-title":"Curr Biol"},{"key":"2026080510222017000_jkag146-B9","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1534\/genetics.116.195438","article-title":"Endogenous RNAi pathways are required in neurons for dauer formation in Caenorhabditis elegans","volume":"205","author":"Bharadwaj","year":"2017","journal-title":"Genetics"},{"key":"2026080510222017000_jkag146-B10","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1016\/j.cell.2018.12.024","article-title":"Plasticity of the electrical connectome of C. elegans","volume":"176","author":"Bhattacharya","year":"2019","journal-title":"Cell"},{"key":"2026080510222017000_jkag146-B11","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/j.0014-3820.2000.tb00038.x","article-title":"Perspective: sex, recombination, and the efficacy of selection- was Weismann right?","volume":"54","author":"Burt","year":"2000","journal-title":"Evolution"},{"key":"2026080510222017000_jkag146-B12","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/BF00266900","article-title":"Temperature effects on self incompatibility in Lilium longiflorum","volume":"68","author":"Campbell","year":"1984","journal-title":"Theor Appl Genet"},{"key":"2026080510222017000_jkag146-B13","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/0012-1606(75)90109-8","article-title":"The dauerlarva, a post-embryonic developmental variant of the nematode Caenorhabditis elegans","volume":"46","author":"Cassada","year":"1975","journal-title":"Dev Biol"},{"key":"2026080510222017000_jkag146-B14","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/S0022-5193(80)80026-9","article-title":"The cost of sex in relation to mating system","volume":"84","author":"Charlesworth","year":"1980","journal-title":"J Theor Biol"},{"key":"2026080510222017000_jkag146-B15","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1016\/j.cub.2011.08.009","article-title":"Regulation of sexual plasticity in a nematode that produces males, females, and hermaphrodites","volume":"21","author":"Chaudhuri","year":"2011","journal-title":"Curr Biol"},{"key":"2026080510222017000_jkag146-B16","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1073\/pnas.1423333112","article-title":"Double-stranded RNA made in C. elegans neurons can enter the germline and cause transgenerational gene silencing","volume":"112","author":"Devanapally","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026080510222017000_jkag146-B17","author":"Evans","year":"2006"},{"key":"2026080510222017000_jkag146-B18","doi-asserted-by":"publisher","author":"Ewe","year":"2025","DOI":"10.1101\/2025.08.07.669182"},{"key":"2026080510222017000_jkag146-B19","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1016\/j.cub.2018.02.029","article-title":"A single-neuron chemosensory switch determines the valence of a sexually dimorphic sensory behavior","volume":"28","author":"Fagan","year":"2018","journal-title":"Curr Biol"},{"key":"2026080510222017000_jkag146-B20","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00427-003-0376-y","article-title":"Alternative morphs and plasticity of vulval development in a rhabditid nematode species","volume":"214","author":"F\u00e9lix","year":"2004","journal-title":"Dev Genes Evol"},{"key":"2026080510222017000_jkag146-B21","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1093\/genetics\/139.2.579","article-title":"gld-1, a tumor suppressor gene required for oocyte development in Caenorhabditis elegans","volume":"139","author":"Francis","year":"1995","journal-title":"Genetics"},{"key":"2026080510222017000_jkag146-B22","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05849","article-title":"C. elegans outside the Petri dish","volume":"4","author":"Fr\u00e9zal","year":"2015","journal-title":"Elife"},{"key":"2026080510222017000_jkag146-B23","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1242\/dev.01068","article-title":"Hormonal signals produced by DAF-9\/cytochrome P450 regulate C. elegans dauer diapause in response to environmental cues","volume":"131","author":"Gerisch","year":"2004","journal-title":"Development"},{"key":"2026080510222017000_jkag146-B24","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1126\/SCIENCE.6896933","article-title":"A pheromone influences larval development in the nematode Caenorhabditis elegans","volume":"218","author":"Golden","year":"1982","journal-title":"Science"},{"key":"2026080510222017000_jkag146-B25","doi-asserted-by":"publisher","first-page":"3184","DOI":"10.1073\/pnas.0409009101","article-title":"A circuit for navigation in Caenorhabditis elegans","volume":"102","author":"Gray","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026080510222017000_jkag146-B26","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.cub.2009.11.035","article-title":"A cellular memory of developmental history generates phenotypic diversity in C. elegans","volume":"20","author":"Hall","year":"2010","journal-title":"Curr Biol"},{"key":"2026080510222017000_jkag146-B27","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.21166","article-title":"Sexually dimorphic control of gene expression in sensory neurons regulates decision-making behavior in C. elegans","volume":"6","author":"Hilbert","year":"2017","journal-title":"Elife"},{"key":"2026080510222017000_jkag146-B28","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36547","article-title":"PDF-1 neuropeptide signaling regulates sexually dimorphic gene expression in shared sensory neurons of C. elegans","volume":"7","author":"Hilbert","year":"2018","journal-title":"Elife"},{"key":"2026080510222017000_jkag146-B29","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/S0960-9822(02)00813-8","article-title":"C. elegans responds to chemical repellents by integrating sensory inputs from the head and the tail","volume":"12","author":"Hilliard","year":"2002","journal-title":"Curr Biol"},{"key":"2026080510222017000_jkag146-B30","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1093\/genetics\/91.1.67","article-title":"Nondisjunction mutants of the nematode Caenorhabditis elegans","volume":"91","author":"Hodgkin","year":"1979","journal-title":"Genetics"},{"key":"2026080510222017000_jkag146-B31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006806","article-title":"Pheromone-sensing neurons regulate peripheral lipid metabolism in Caenorhabditis elegans","volume":"13","author":"Hussey","year":"2017","journal-title":"PLoS Genet"},{"key":"2026080510222017000_jkag146-B32","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.neuron.2012.06.034","article-title":"Neuromodulatory state and sex specify alternative behaviors through antagonistic synaptic pathways in C. elegans","volume":"75","author":"Jang","year":"2012","journal-title":"Neuron"},{"key":"2026080510222017000_jkag146-B33","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/BF00034212","article-title":"Factors affecting the degree of self-incompatibility in inbred lines of Brussels sprouts","volume":"20","author":"Johnson","year":"1971","journal-title":"Euphytica"},{"key":"2026080510222017000_jkag146-B34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017804","article-title":"Ascaroside expression in Caenorhabditis elegans is strongly dependent on diet and developmental stage","volume":"6","author":"Kaplan","year":"2011","journal-title":"PLoS One"},{"key":"2026080510222017000_jkag146-B35","doi-asserted-by":"crossref","DOI":"10.1895\/wormbook.1.180.1","volume-title":"Working with dauer larvae","author":"Karp","year":"2018"},{"key":"2026080510222017000_jkag146-B36","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0092-8674(00)81645-1","article-title":"Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of werner syndrome helicase and RNaseD","volume":"99","author":"Ketting","year":"1999","journal-title":"Cell"},{"key":"2026080510222017000_jkag146-B37","doi-asserted-by":"publisher","first-page":"4080","DOI":"10.1111\/febs.13393","article-title":"Males on demand: the environmental-neuro-endocrine control of male sex determination in daphnids","volume":"282","author":"LeBlanc","year":"2015","journal-title":"FEBS J"},{"key":"2026080510222017000_jkag146-B38","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.tree.2011.09.016","article-title":"The many costs of sex","volume":"27","author":"Lehtonen","year":"2012","journal-title":"Trends Ecol Evol"},{"key":"2026080510222017000_jkag146-B39","doi-asserted-by":"publisher","first-page":"17905","DOI":"10.1073\/pnas.1420439111","article-title":"Communication between oocytes and somatic cells regulates volatile pheromone production in Caenorhabditis elegans","volume":"111","author":"Leighton","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026080510222017000_jkag146-B40","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1093\/aob\/mcr159","article-title":"Mating system shifts on the trailing edge","volume":"109","author":"Levin","year":"2012","journal-title":"Ann Bot"},{"key":"2026080510222017000_jkag146-B41","doi-asserted-by":"publisher","first-page":"7427","DOI":"10.1523\/JNEUROSCI.1746-04.2004","article-title":"Mate searching in Caenorhabditis elegans: a genetic model for sex drive in a simple invertebrate","volume":"24","author":"Lipton","year":"2004","journal-title":"J Neurosci"},{"key":"2026080510222017000_jkag146-B42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1895\/wormbook.1.155.1","volume-title":"Wormbook","author":"Ludewig","year":"2013"},{"key":"2026080510222017000_jkag146-B43","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/j.cub.2024.02.036","article-title":"C. elegans males optimize mate-preference decisions via sex-specific responses to multimodal sensory cues","volume":"34","author":"Luo","year":"2024","journal-title":"Curr Biol"},{"key":"2026080510222017000_jkag146-B44","doi-asserted-by":"publisher","first-page":"4449","DOI":"10.1016\/j.cub.2021.07.069","article-title":"Sex-specific, pdfr-1-dependent modulation of pheromone avoidance by food abundance enables flexibility in C. elegans foraging behavior","volume":"31","author":"Luo","year":"2021","journal-title":"Curr Biol"},{"key":"2026080510222017000_jkag146-B45","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1038\/nature07886","article-title":"A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans","volume":"458","author":"MacOsko","year":"2009","journal-title":"Nature"},{"key":"2026080510222017000_jkag146-B46","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1126\/science.1250598","article-title":"Neurosensory perception of environmental cues modulates sperm motility critical for fertilization","volume":"344","author":"McKnight","year":"2014","journal-title":"Science"},{"key":"2026080510222017000_jkag146-B47","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1086\/663945","article-title":"The costs of sex: facing real-world complexities","volume":"87","author":"Meirmans","year":"2012","journal-title":"Q Rev Biol"},{"key":"2026080510222017000_jkag146-B48","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1111\/j.1558-5646.2009.00652.x","article-title":"Sexual partners for the stressed: facultative outcrossing in the self-fertilizing nematode Caenorhabditis elegans","volume":"63","author":"Morran","year":"2009","journal-title":"Evolution"},{"key":"2026080510222017000_jkag146-B49","doi-asserted-by":"publisher","first-page":"E1392","DOI":"10.1073\/pnas.1600786113","article-title":"Contrasting responses within a single neuron class enable sex-specific attraction in Caenorhabditis elegans","volume":"113","author":"Narayan","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026080510222017000_jkag146-B50","first-page":"1","article-title":"Les modalites de la reproduction et le determinisme du sexe chez quelques nematodes libres","volume":"11","author":"Nigon","year":"1949","journal-title":"Ann Sci Nat Zool Biol Anim"},{"key":"2026080510222017000_jkag146-B51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphys.2014.00001","article-title":"Aphid polyphenisms: trans-generational developmental regulation through viviparity","volume":"5","author":"Ogawa","year":"2014","journal-title":"Front Physiol"},{"key":"2026080510222017000_jkag146-B52","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1086\/599084","article-title":"The evolutionary enigma of sex","volume":"174 Suppl","author":"Otto","year":"2009","journal-title":"Am Nat"},{"key":"2026080510222017000_jkag146-B53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007219","article-title":"Early experiences mediate distinct adult gene expression and reproductive programs in Caenorhabditis elegans","volume":"14","author":"Ow","year":"2018","journal-title":"PLoS Genet."},{"key":"2026080510222017000_jkag146-B54","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2024.1396587","article-title":"RNAi-dependent expression of sperm genes in ADL chemosensory neurons is required for olfactory responses in Caenorhabditis elegans","volume":"11","author":"Ow","year":"2024","journal-title":"Front Mol Biosci"},{"key":"2026080510222017000_jkag146-B55","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.61459","article-title":"Somatic aging pathways regulate reproductive plasticity in Caenorhabditis elegans","volume":"10","author":"Ow","year":"2021","journal-title":"Elife"},{"key":"2026080510222017000_jkag146-B56","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1534\/genetics.115.179382","article-title":"High efficiency, homology-directed genome editing in Caenorhabditis elegans using CRISPR-cas9 ribonucleoprotein complexes","volume":"201","author":"Paix","year":"2015","journal-title":"Genetics"},{"key":"2026080510222017000_jkag146-B57","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1126\/science.1118152","article-title":"Transitions to asexuality result in excess amino acid substitutions","volume":"311","author":"Paland","year":"2006","journal-title":"Science"},{"key":"2026080510222017000_jkag146-B58","doi-asserted-by":"publisher","first-page":"2896","DOI":"10.1242\/dev.147660","article-title":"Linking the environment, DAF-7\/TGF\u03b2 signaling and LAG-2\/DSL ligand expression in the germline stem cell niche","volume":"144","author":"Pekar","year":"2017","journal-title":"Development"},{"key":"2026080510222017000_jkag146-B59","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1101\/gad.193904.112","article-title":"MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline","volume":"26","author":"Phillips","year":"2012","journal-title":"Genes Dev"},{"key":"2026080510222017000_jkag146-B60","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1016\/j.cell.2019.04.029","article-title":"Neuronal small RNAs control behavior transgenerationally","volume":"177","author":"Posner","year":"2019","journal-title":"Cell"},{"key":"2026080510222017000_jkag146-B61","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1016\/j.cub.2019.07.045","article-title":"Environmental programming of adult foraging behavior in C. elegans","volume":"29","author":"Pradhan","year":"2019","journal-title":"Curr Biol"},{"key":"2026080510222017000_jkag146-B62","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1242\/dev.058305","article-title":"Glia delimit shape changes of sensory neuron receptive endings in C. elegans","volume":"138","author":"Procko","year":"2011","journal-title":"Development"},{"key":"2026080510222017000_jkag146-B63","doi-asserted-by":"crossref","DOI":"10.1093\/genetics\/141.2.551","volume-title":"Enhancers of glp-1, a gene required for cell-signaling in caenorhabditis elegans, define a set of genes required for germline development","author":"Qiao","year":"1995"},{"key":"2026080510222017000_jkag146-B64","doi-asserted-by":"publisher","first-page":"4256","DOI":"10.1093\/nar\/gkaa174","article-title":"RNAi pathways repress reprogramming of C. elegans germ cells during heat stress","volume":"48","author":"Rogers","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2026080510222017000_jkag146-B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108279","article-title":"A small-RNA-mediated feedback loop maintains proper levels of 22G-RNAs in C. elegans","volume":"33","author":"Rogers","year":"2020","journal-title":"Cell Rep"},{"key":"2026080510222017000_jkag146-B66","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1016\/j.cub.2014.09.032","article-title":"Sex, age, and hunger regulate behavioral prioritization through dynamic modulation of chemoreceptor expression","volume":"24","author":"Ryan","year":"2014","journal-title":"Curr Biol."},{"key":"2026080510222017000_jkag146-B67","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Method"},{"key":"2026080510222017000_jkag146-B68","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/j.cub.2013.06.058","article-title":"Dauer-specific dendrite arborization in C. elegans is regulated by KPC-1\/furin","volume":"23","author":"Schroeder","year":"2013","journal-title":"Curr Biol"},{"key":"2026080510222017000_jkag146-B69","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000611","article-title":"Spermatogenesis-specific features of the meiotic program in Caenorhabditis elegans","volume":"5","author":"Shakes","year":"2009","journal-title":"PLoS Genet."},{"key":"2026080510222017000_jkag146-B70","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/nature02107","article-title":"Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi","volume":"426","author":"Sijen","year":"2003","journal-title":"Nature"},{"key":"2026080510222017000_jkag146-B71","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/35079578","article-title":"Sexual selection and the maintenance of sex","volume":"411","author":"Siller","year":"2001","journal-title":"Nature"},{"key":"2026080510222017000_jkag146-B72","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1073\/pnas.032225799","article-title":"Evidence of a mate-finding cue in the hermaphrodite nematode Caenorhabditis elegans","volume":"99","author":"Simon","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026080510222017000_jkag146-B73","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.11642","article-title":"Developmental programming modulates olfactory behavior in C. elegans via endogenous RNAi pathways","volume":"5","author":"Sims","year":"2016","journal-title":"Elife"},{"key":"2026080510222017000_jkag146-B74","volume-title":"The evolution of sex","author":"Smith","year":"1978"},{"key":"2026080510222017000_jkag146-B75","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1101\/gad.955702","article-title":"The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans","volume":"16","author":"Soto","year":"2002","journal-title":"Genes Dev"},{"key":"2026080510222017000_jkag146-B76","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1038\/nature07168","article-title":"A blend of small molecules regulates both mating and development in Caenorhabditis elegans","volume":"454","author":"Srinivasan","year":"2008","journal-title":"Nature"},{"key":"2026080510222017000_jkag146-B77","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0092-8674(00)81644-X","article-title":"The rde-1 gene, RNA interference, and transposon silencing in C. elegans","volume":"99","author":"Tabara","year":"1999","journal-title":"Cell"},{"key":"2026080510222017000_jkag146-B78","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1111\/j.0014-3820.2006.tb01207.x","article-title":"Genetic variation for outcrossing among Caenorhabditis elegans isolates","volume":"60","author":"Teot\u00f3nio","year":"2006","journal-title":"Evolution"},{"key":"2026080510222017000_jkag146-B79","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s12915-014-0093-1","article-title":"Reproductive assurance drives transitions to self-fertilization in experimental Caenorhabditis elegans","volume":"12","author":"Theologidis","year":"2014","journal-title":"BMC Biol"},{"key":"2026080510222017000_jkag146-B80","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1093\/genetics\/134.4.1105","article-title":"Evidence for parallel processing of sensory information controlling dauer formation in Caenorhabditis elegans","volume":"134","author":"Thomas","year":"1993","journal-title":"Genetics"},{"key":"2026080510222017000_jkag146-B81","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007542","article-title":"Distinct regions of the intrinsically disordered protein MUT-16 mediate assembly of a small RNA amplification complex and promote phase separation of mutator foci","volume":"14","author":"Uebel","year":"2018","journal-title":"PLoS Genet"},{"key":"2026080510222017000_jkag146-B82","doi-asserted-by":"publisher","first-page":"3719","DOI":"10.1534\/g3.120.401514","article-title":"Mutator foci are regulated by developmental stage, RNA, and the germline cell cycle in Caenorhabditis elegans","volume":"10","author":"Uebel","year":"2020","journal-title":"G3 (Bethesda)"},{"key":"2026080510222017000_jkag146-B83","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1534\/genetics.118.301250","article-title":"Transgenerational effects of extended dauer diapause on starvation survival and gene expression plasticity in Caenorhabditis elegans","volume":"210","author":"Webster","year":"2018","journal-title":"Genetics"},{"key":"2026080510222017000_jkag146-B84","first-page":"251","volume-title":"Essays upon heredity and kindred biological problems","author":"Weismann","year":"1889"},{"key":"2026080510222017000_jkag146-B85","doi-asserted-by":"publisher","first-page":"2695","DOI":"10.1016\/j.cub.2020.05.006","article-title":"C. elegans males integrate food signals and biological sex to modulate state-dependent chemosensation and behavioral prioritization","volume":"30","author":"Wexler","year":"2020","journal-title":"Curr Biol"},{"key":"2026080510222017000_jkag146-B86","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1111\/j.0014-3820.2000.tb01232.x","article-title":"Fixation of new alleles and the extinction of small populations: drift load, beneficial alleles, and sexual selection","volume":"54","author":"Whitlock","year":"2000","journal-title":"Evolution"},{"key":"2026080510222017000_jkag146-B87","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/j.1558-5646.2008.00558.x","article-title":"Purging the genome with sexual selection: reducing mutation load through selection on males","volume":"63","author":"Whitlock","year":"2009","journal-title":"Evolution"},{"key":"2026080510222017000_jkag146-B88","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1002\/wdev.45","article-title":"Gonad morphogenesis and distal tip cell migration in the Caenorhabditis elegans hermaphrodite","volume":"1","author":"Wong","year":"2012","journal-title":"Wiley Interdiscip Rev"},{"key":"2026080510222017000_jkag146-B89","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1038\/nmeth.2560","article-title":"A database of Caenorhabditis elegans behavioral phenotypes","volume":"10","author":"Yemini","year":"2013","journal-title":"Nat Methods"},{"key":"2026080510222017000_jkag146-B90","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1073\/pnas.1018695108","article-title":"mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans","volume":"108","author":"Zhang","year":"2011","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["G3: Genes, Genomes, Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/g3journal\/advance-article-pdf\/doi\/10.1093\/g3journal\/jkag146\/68584458\/jkag146.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/g3journal\/article-pdf\/16\/8\/jkag146\/68584458\/jkag146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/g3journal\/article-pdf\/16\/8\/jkag146\/68584458\/jkag146.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T14:22:28Z","timestamp":1785939748000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/g3journal\/article\/doi\/10.1093\/g3journal\/jkag146\/8713862"}},"subtitle":[],"editor":[{"given":"L","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":90,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,6,23]]},"published-print":{"date-parts":[[2026,8,5]]}},"URL":"https:\/\/doi.org\/10.1093\/g3journal\/jkag146","relation":{},"ISSN":["2160-1836"],"issn-type":[{"value":"2160-1836","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8]]},"published":{"date-parts":[[2026,6,23]]},"article-number":"jkag146"}}