{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:02:32Z","timestamp":1791378152613,"version":"4.3.2"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R21 AR077768"],"award-info":[{"award-number":["R21 AR077768"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R56 AR080718"],"award-info":[{"award-number":["R56 AR080718"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030726","name":"Department of Orthopaedics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030726","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007623","name":"Emory University School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007623","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031028","name":"Women\u2019s Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031028","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Bone homeostasis requires the balanced action of bone forming osteoblasts and bone resorbing osteoclasts. This balance is maintained through local as well as systemic factors. Loss of osteoclast resorptive activity leads to development of osteopetrosis with increased bone volume but reduced skeletal integrity. Identification of the factors that regulate such anabolic activity is hampered by the essential function of these genes in development as well as the inaccessibility of large numbers of primary osteoclasts for biochemical analyses. Here, we generated zebrafish with nonresorptive osteoclasts through CRISPR-Cas9 mediated knockout of chloride voltage-gated channel 7 (clcn7). The clcn7 mutants are adult viable, show increased vertebral bone thickness and increased bone formation. Using this in vivo model of persistent, but deficient osteoclasts, we used differential gene expression to identify putative anabolic bone regulators. Transcriptional profiling of clcn7 mutant primary osteoclasts identified differential expression of genes involved in chemotaxis and cytokine signaling. Global transgenic overexpression of a subset of the upregulated, secreted genes showed positive effects of the cytokines csf3b, cxcl19, and the glycosylated peptide progranulin 1 on skeletal parameters, while the cytokine ccl35.1 negatively impacted bone volume. Our findings suggest that the concerted function of these cytokines plays an important role in the regulation of bone homeostasis and that individual cytokines cause distinct changes in vertebral bone form and differentiation.<\/jats:p>","DOI":"10.1093\/g3journal\/jkag221","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:04:40Z","timestamp":1787223880000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>In vivo<\/i>\n                    screen for osteoclast derived osteogenic factors using non-resorptive osteoclasts in zebrafish bone"],"prefix":"10.1093","volume":"16","author":[{"given":"Joana","family":"Caetano-Lopes","sequence":"first","affiliation":[{"name":"Orthopedic Research Laboratories, Boston Children's Hospital , Boston, MA 02115 ,","place":["United States"]},{"name":"Department of Genetics, Harvard Medical School , Boston, MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-6283","authenticated-orcid":false,"given":"Valentina","family":"Daponte","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Emory University School of Medicine , Atlanta, GA 30329 ,","place":["United States"]},{"name":"VA Medical Center VA Research, , Atlanta, GA 30033 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Urso","sequence":"additional","affiliation":[{"name":"Departments of Orthopaedics and Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Emory University School of Medicine , Atlanta, GA 30329 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L","family":"Warman","sequence":"additional","affiliation":[{"name":"Orthopedic Research Laboratories, Boston Children's Hospital , Boston, MA 02115 ,","place":["United States"]},{"name":"Department of Genetics, Harvard Medical School , Boston, MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3322-281X","authenticated-orcid":false,"given":"Hicham","family":"Drissi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Emory University School of Medicine , Atlanta, GA 30329 ,","place":["United States"]},{"name":"VA Medical Center VA Research, , Atlanta, GA 30033 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia F","family":"Charles","sequence":"additional","affiliation":[{"name":"Departments of Orthopaedics and Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, MA 02115 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1282-3616","authenticated-orcid":false,"given":"Katrin","family":"Henke","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Emory University School of Medicine , Atlanta, GA 30329 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"2026100708174376200_jkag221-B1","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"Htseq\u2013a python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"2026100708174376200_jkag221-B2","author":"Andrews","year":"2010"},{"key":"2026100708174376200_jkag221-B3","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/s41413-022-00219-8","article-title":"Bone remodeling: an operational process ensuring survival and bone mechanical competence","volume":"10","author":"Bolamperti","year":"2022","journal-title":"Bone Res"},{"key":"2026100708174376200_jkag221-B4","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.abb.2008.03.018","article-title":"Functions of rankl\/rank\/opg in bone modeling and remodeling","volume":"473","author":"Boyce","year":"2008","journal-title":"Arch Biochem Biophys"},{"key":"2026100708174376200_jkag221-B5","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1093\/genetics\/iyac016","article-title":"Zebrafish information network, the knowledgebase for Danio rerio research","volume":"220","author":"Bradford","year":"2022","journal-title":"Genetics"},{"key":"2026100708174376200_jkag221-B6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02182","article-title":"Chemokines in physiological and pathological bone remodeling","volume":"10","author":"Brylka","year":"2019","journal-title":"Front Immunol"},{"key":"2026100708174376200_jkag221-B7","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1111\/jai.13660","article-title":"Fluorescence-activated cell sorting (facs) of osteoblasts and osteoclasts for rna sequencing in a medaka, (temming & schlegel, 1846), osteoporosis model","volume":"34","author":"Buettner","year":"2018","journal-title":"J Appl Ichthyol"},{"key":"2026100708174376200_jkag221-B8","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1002\/jor.24539","article-title":"Zebrafish: an emerging model for orthopedic research","volume":"38","author":"Busse","year":"2020","journal-title":"J Orthop Res"},{"key":"2026100708174376200_jkag221-B9","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.15252\/embj.201490105","article-title":"Chemokine-guided cell migration and motility in zebrafish development","volume":"34","author":"Bussmann","year":"2015","journal-title":"EMBO J"},{"key":"2026100708174376200_jkag221-B10","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-6-156","article-title":"The zebrafish progranulin gene family and antisense transcripts","volume":"6","author":"Cadieux","year":"2005","journal-title":"BMC Genomics"},{"key":"2026100708174376200_jkag221-B11","doi-asserted-by":"publisher","DOI":"10.1242\/dev.181834","article-title":"Unique and non-redundant function of csf1r paralogues in regulation and evolution of post-embryonic development of the zebrafish","volume":"147","author":"Caetano-Lopes","year":"2020","journal-title":"Development"},{"key":"2026100708174376200_jkag221-B12","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41413-026-00513-9","article-title":"Spectrum and functions of ion channels and transporters in osteoclasts","volume":"14","author":"Chen","year":"2026","journal-title":"Bone Res"},{"key":"2026100708174376200_jkag221-B13","doi-asserted-by":"publisher","first-page":"D988","DOI":"10.1093\/nar\/gkab1049","article-title":"Ensembl 2022","volume":"50","author":"Cunningham","year":"2022","journal-title":"Nucleic Acids Res"},{"key":"2026100708174376200_jkag221-B14","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1182\/blood.V99.1.111","article-title":"Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects","volume":"99","author":"Dai","year":"2002","journal-title":"Blood"},{"key":"2026100708174376200_jkag221-B15","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.95083","article-title":"Current perspectives on the multiple roles of osteoclasts: mechanisms of osteoclast-osteoblast communication and potential clinical implications","volume":"13","author":"Daponte","year":"2024","journal-title":"Elife"},{"key":"2026100708174376200_jkag221-B16","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41586-018-0554-8","article-title":"Discovery of a periosteal stem cell mediating intramembranous bone formation","volume":"562","author":"Debnath","year":"2018","journal-title":"Nature"},{"key":"2026100708174376200_jkag221-B17","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"Star: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2026100708174376200_jkag221-B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2024.104936","article-title":"Osteopetrosis and related osteoclast disorders in adults: a review and knowledge gaps on behalf of the European calcified tissue society and ern bond","volume":"69","author":"Funck-Brentano","year":"2024","journal-title":"Eur J Med Genet"},{"key":"2026100708174376200_jkag221-B19","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","article-title":"Shinygo: a graphical gene-set enrichment tool for animals and plants","volume":"36","author":"Ge","year":"2020","journal-title":"Bioinformatics"},{"key":"2026100708174376200_jkag221-B20","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1186\/s12859-018-2486-6","article-title":"Idep: an integrated web application for differential expression and pathway analysis of RNA-seq data","volume":"19","author":"Ge","year":"2018","journal-title":"BMC Bioinformatics"},{"key":"2026100708174376200_jkag221-B21","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1093\/bioinformatics\/btg382","article-title":"A global test for groups of genes: testing association with a clinical outcome","volume":"20","author":"Goeman","year":"2004","journal-title":"Bioinformatics"},{"key":"2026100708174376200_jkag221-B22","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/j.1467-9868.2006.00551.x","article-title":"Testing against a high dimensional alternative","volume":"68","author":"Goeman","year":"2006","journal-title":"J Roy Stat Soc B"},{"key":"2026100708174376200_jkag221-B23","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-357","article-title":"An integrative approach to ortholog prediction for disease-focused and other functional studies","volume":"12","author":"Hu","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"2026100708174376200_jkag221-B24","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.26014","article-title":"Microct-based phenomics in the zebrafish skeleton reveals virtues of deep phenotyping in a distributed organ system","volume":"6","author":"Hur","year":"2017","journal-title":"Elife"},{"key":"2026100708174376200_jkag221-B25","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nbt.2501","article-title":"Efficient genome editing in zebrafish using a crispr-cas system","volume":"31","author":"Hwang","year":"2013","journal-title":"Nat Biotechnol"},{"key":"2026100708174376200_jkag221-B26","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004903","article-title":"Overview of the matrisome\u2013an inventory of extracellular matrix constituents and functions","volume":"4","author":"Hynes","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2026100708174376200_jkag221-B27","doi-asserted-by":"publisher","first-page":"13904","DOI":"10.1073\/pnas.1308335110","article-title":"Efficient multiplex biallelic zebrafish genome editing using a crispr nuclease system","volume":"110","author":"Jao","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026100708174376200_jkag221-B28","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0092-8674(01)00206-9","article-title":"Loss of the clc-7 chloride channel leads to osteopetrosis in mice and man","volume":"104","author":"Kornak","year":"2001","journal-title":"Cell"},{"key":"2026100708174376200_jkag221-B29","author":"Krueger","year":"2012"},{"key":"2026100708174376200_jkag221-B30","doi-asserted-by":"publisher","first-page":"24113","DOI":"10.1074\/jbc.M301716200","article-title":"Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity","volume":"278","author":"Kusu","year":"2003","journal-title":"J Biol Chem"},{"key":"2026100708174376200_jkag221-B31","doi-asserted-by":"publisher","author":"Lawrence","year":"2021","DOI":"10.17504\/protocols.io.br4mm8u6"},{"key":"2026100708174376200_jkag221-B32","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.55792","article-title":"An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes","volume":"9","author":"Lawson","year":"2020","journal-title":"Elife"},{"key":"2026100708174376200_jkag221-B33","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1060187","article-title":"Zebrafish endochondral growth zones as they relate to human bone size, shape and disease","volume":"13","author":"Le Pabic","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026100708174376200_jkag221-B34","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with deseq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2026100708174376200_jkag221-B35","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s00198-022-06523-7","article-title":"Role of wnt signaling and sclerostin in bone and as therapeutic targets in skeletal disorders","volume":"34","author":"Marini","year":"2023","journal-title":"Osteoporos Int"},{"key":"2026100708174376200_jkag221-B36","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s00223-010-9337-4","article-title":"Ciliary neurotrophic factor inhibits bone formation and plays a sex-specific role in bone growth and remodeling","volume":"86","author":"McGregor","year":"2010","journal-title":"Calcif Tissue Int"},{"key":"2026100708174376200_jkag221-B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2021.101515","article-title":"G-csf, The guardian of granulopoiesis","volume":"54","author":"Mehta","year":"2021","journal-title":"Semin Immunol"},{"key":"2026100708174376200_jkag221-B38","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/j.1439-0426.2012.01990.x","article-title":"Elasmoid scales of fishes as model in biomedical bone research","volume":"28","author":"Metz","year":"2012","journal-title":"J Appl Ichthyol"},{"key":"2026100708174376200_jkag221-B39","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1242\/dev.059345","article-title":"Ubiquitous transgene expression and cre-based recombination driven by the ubiquitin promoter in zebrafish","volume":"138","author":"Mosimann","year":"2011","journal-title":"Development"},{"key":"2026100708174376200_jkag221-B40","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.matbio.2017.07.001","article-title":"The in-silico zebrafish matrisome: a new tool to study extracellular matrix gene and protein functions","volume":"65","author":"Nauroy","year":"2018","journal-title":"Matrix Biol"},{"key":"2026100708174376200_jkag221-B41","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.bbrc.2015.08.077","article-title":"Progranulin plays crucial roles in preserving bone mass by inhibiting tnf-alpha-induced osteoclastogenesis and promoting osteoblastic differentiation in mice","volume":"465","author":"Noguchi","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"2026100708174376200_jkag221-B42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/gtc.12013","article-title":"Systematic classification of vertebrate chemokines based on conserved synteny and evolutionary history","volume":"18","author":"Nomiyama","year":"2013","journal-title":"Genes Cells"},{"key":"2026100708174376200_jkag221-B43","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s11914-018-0415-2","article-title":"Genetics of osteopetrosis","volume":"16","author":"Palagano","year":"2018","journal-title":"Curr Osteoporos Rep"},{"key":"2026100708174376200_jkag221-B44","volume-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2021"},{"key":"2026100708174376200_jkag221-B45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003537","article-title":"Osteoclasts control osteoblast chemotaxis via pdgf-bb\/pdgf receptor beta signaling","volume":"3","author":"Sanchez-Fernandez","year":"2008","journal-title":"PLoS One"},{"key":"2026100708174376200_jkag221-B46","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"Nih image to imagej: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"2026100708174376200_jkag221-B47","first-page":"827","article-title":"Overexpression of the granulocyte colony-stimulating factor gene leads to osteoporosis in mice","volume":"74","author":"Takahashi","year":"1996","journal-title":"Lab Invest"},{"key":"2026100708174376200_jkag221-B48","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s00223-014-9865-4","article-title":"A comparison of osteoclast-rich and osteoclast-poor osteopetrosis in adult mice sheds light on the role of the osteoclast in coupling bone resorption and bone formation","volume":"95","author":"Thudium","year":"2014","journal-title":"Calcif Tissue Int"},{"key":"2026100708174376200_jkag221-B49","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.bone.2019.06.002","article-title":"A role for g protein-coupled receptor 137b in bone remodeling in mouse and zebrafish","volume":"127","author":"Urso","year":"2019","journal-title":"Bone"},{"key":"2026100708174376200_jkag221-B50","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.70385","article-title":"Progranulin protects against osteoporosis by regulating osteoclast and osteoblast balance via tnfr pathway","volume":"29","author":"Wang","year":"2025","journal-title":"J Cell Mol Med"},{"key":"2026100708174376200_jkag221-B51","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1553794","article-title":"Molecular mechanisms and targeted therapy of progranulin in metabolic diseases","volume":"16","author":"Wang","year":"2025","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026100708174376200_jkag221-B52","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/jmor.1065","article-title":"Features of mono- and multinucleated bone resorbing cells of the zebrafish danio rerio and their contribution to skeletal development, remodeling, and growth","volume":"250","author":"Witten","year":"2001","journal-title":"J Morphol"},{"key":"2026100708174376200_jkag221-B53","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/j.1469-185X.2009.00077.x","article-title":"A comparative view on mechanisms and functions of skeletal remodelling in teleost fish, with special emphasis on osteoclasts and their function","volume":"84","author":"Witten","year":"2009","journal-title":"Biol Rev Camb Philos Soc"},{"key":"2026100708174376200_jkag221-B54","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1038\/nm.3668","article-title":"Pdgf-bb secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis","volume":"20","author":"Xie","year":"2014","journal-title":"Nat Med"},{"key":"2026100708174376200_jkag221-B55","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0145-305X(79)80006-3","article-title":"Ultrastructural study of the teleost fish kidney","volume":"3","author":"Zapata","year":"1979","journal-title":"Dev Comp Immunol"},{"key":"2026100708174376200_jkag221-B56","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030366","article-title":"The role of the lysosomal cl(-)\/h(+) antiporter clc-7 in osteopetrosis and neurodegeneration","volume":"11","author":"Zifarelli","year":"2022","journal-title":"Cells"},{"key":"2026100708174376200_jkag221-B57","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.818462","article-title":"Cathepsin k(+) non-osteoclast cells in the skeletal system: function, models, identity, and therapeutic implications","volume":"10","author":"Zou","year":"2022","journal-title":"Front Cell Dev Biol"}],"container-title":["G3: Genes, Genomes, Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/g3journal\/advance-article-pdf\/doi\/10.1093\/g3journal\/jkag221\/70722125\/jkag221.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/g3journal\/article-pdf\/16\/10\/jkag221\/70722125\/jkag221.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/g3journal\/article-pdf\/16\/10\/jkag221\/70722125\/jkag221.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:18:13Z","timestamp":1791375493000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/g3journal\/article\/doi\/10.1093\/g3journal\/jkag221\/8766973"}},"subtitle":[],"editor":[{"given":"B","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":57,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,8,20]]},"published-print":{"date-parts":[[2026,10,7]]}},"URL":"https:\/\/doi.org\/10.1093\/g3journal\/jkag221","relation":{},"ISSN":["2160-1836"],"issn-type":[{"value":"2160-1836","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,8,20]]},"article-number":"jkag221"}}