{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T11:31:32Z","timestamp":1793791892886,"version":"4.6.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["5R35-GM153275"],"award-info":[{"award-number":["5R35-GM153275"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Meiotic drivers are selfish elements that co-opt gametogenesis to increase their own transmission. Driving alleles may spread in a population even if harmful to overall fitness, requiring the emergence of host suppressors to ameliorate these costs. In some cases, intense coevolutionary arms races between drivers and their host genomes may occur. These conflicts have been invoked to explain the rapid evolution of karyotypes and reproduction-associated proteins across the tree of life. Despite their evolutionary importance, relatively few meiotic drivers have been well-characterized, in large part due to the difficulties inherent to detecting meiotic drivers, distinguishing them from viability effects, and performing systematic screens. To address these gaps, we present an approach to driver detection at the embryo stage in wild-derived Drosophila melanogaster. By combining fluorescent markers with a method to induce embryonic arrest at a standard developmental stage, we detect transmission of wild-derived alleles as compared to their fluorescently marked homologs in early embryos, before most fitness differences among alleles (which may mimic drive) manifest. We provide proof-of-concept for the approach and identify several areas for future improvement.<\/jats:p>","DOI":"10.1093\/g3journal\/jkag242","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:23:23Z","timestamp":1790187803000},"source":"Crossref","is-referenced-by-count":0,"title":["A method to screen for meiotic drive using embryonic markers"],"prefix":"10.1093","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4041-4852","authenticated-orcid":false,"given":"Benjamin K","family":"McCormick","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics, Cornell University , Ithaca, NY 14853 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5047-4664","authenticated-orcid":false,"given":"Daniel A","family":"Barbash","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Cornell University , 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