{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T11:31:28Z","timestamp":1793791888538,"version":"4.6.1"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"The National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS115995"],"award-info":[{"award-number":["R01NS115995"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"The National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS107969"],"award-info":[{"award-number":["R01NS107969"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"The National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS122779"],"award-info":[{"award-number":["R01NS122779"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Animals sleep more when they are sick. In Caenorhabditis elegans, stress-induced sleep (SIS) follows cellular injury such as exposure to ultraviolet (UV) light. The genetic regulators of SIS remain incompletely defined. Using robotic automation, high-throughput imaging, and genome-wide association analysis, we performed a semi-automated screen of 940 whole-genome-sequenced Million Mutation Project (MMP) strains. We quantified behavioral activity and quiescence before and after ultraviolet (UV) radiation. We applied the Sequence Kernel Association Test (SKAT) to this behavioral data to prioritize a set of associated genes and observed significant enrichment of known SIS genetic regulators. Based on these results, we conducted a candidate validation screen for additional genes regulating SIS. We identified three genes (strd-1, cla-1, and egl-8), mutations in which reproducibly influence SIS. Further exploration of these genes holds potential for enhancing our understanding of the molecular basis of SIS. These findings establish a pipeline for automated behavioral phenotyping coupled with gene-based association to accelerate studies of C. elegans neurogenetics.<\/jats:p>","DOI":"10.1093\/g3journal\/jkag266","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:23:00Z","timestamp":1790594580000},"source":"Crossref","is-referenced-by-count":0,"title":["A semi-automated genetic screen using genome-wide association analysis identifies modulators of stress-induced sleep in\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1093","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4304-8322","authenticated-orcid":false,"given":"Zihao (John)","family":"Li","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering, The Ohio State University , Columbus, OH 43210 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helya","family":"Honarpisheh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering, The Ohio State University , Columbus, OH 43210 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreekar","family":"Kutagulla","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering, The Ohio State University , Columbus, OH 43210 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry M","family":"LeCure","sequence":"additional","affiliation":[{"name":"Department of Neurology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering, The Ohio State University , Columbus, OH 43210 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5935-0476","authenticated-orcid":false,"given":"David M","family":"Raizen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4568-3218","authenticated-orcid":false,"given":"Christopher","family":"Fang-Yen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering, The Ohio State University , Columbus, OH 43210 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"2026110406215230600_jkag266-B1","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"Adzhubei","year":"2010","journal-title":"Nat Methods"},{"key":"2026110406215230600_jkag266-B2","doi-asserted-by":"publisher","first-page":"RP87521","DOI":"10.7554\/eLife.87521","article-title":"The zebrafish mutant dreammist implicates sodium homeostasis in sleep regulation","volume":"12","author":"Barlow","year":"2023","journal-title":"elife"},{"key":"2026110406215230600_jkag266-B3","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1152\/physrev.00010.2018","article-title":"The sleep-immune crosstalk in health and disease","volume":"99","author":"Besedovsky","year":"2019","journal-title":"Physiol Rev"},{"key":"2026110406215230600_jkag266-B4","article-title":"Learning OpenCV: Computer Vision with the OpenCV Library","author":"Bradski","year":"2008"},{"key":"2026110406215230600_jkag266-B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1010665","article-title":"A sleep-active neuron can promote survival while sleep behavior is disturbed","volume":"19","author":"Busack","year":"2023","journal-title":"PLoS Genet"},{"key":"2026110406215230600_jkag266-B6","doi-asserted-by":"publisher","first-page":"iyad140","DOI":"10.1093\/genetics\/iyad140","article-title":"Forward genetic screen of Caenorhabditis elegans mutants with impaired sleep reveals a crucial role of neuronal diacylglycerol kinase DGK-1 in regulating sleep","volume":"225","author":"Chen","year":"2023","journal-title":"Genetics"},{"key":"2026110406215230600_jkag266-B7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2500356122","article-title":"The SIK3-N783Y mutation is associated with the human natural short sleep trait","volume":"122","author":"Chen","year":"2025","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026110406215230600_jkag266-B8","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.neuron.2016.01.007","article-title":"A zebrafish genetic screen identifies neuromedin U as a regulator of sleep\/wake states","volume":"89","author":"Chiu","year":"2016","journal-title":"Neuron"},{"key":"2026110406215230600_jkag266-B9","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.26652","article-title":"Longitudinal imaging of Caenorhabditis elegans in a microfabricated device reveals variation in behavioral decline during aging","volume":"6","author":"Churgin","year":"2017","journal-title":"elife"},{"key":"2026110406215230600_jkag266-B10","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1038\/s41596-019-0146-6","article-title":"Quantitative imaging of sleep behavior in Caenorhabditis elegans and larval Drosophila melanogaster","volume":"14","author":"Churgin","year":"2019","journal-title":"Nat Protoc"},{"key":"2026110406215230600_jkag266-B11","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/978-1-0716-2181-3_18","volume-title":"C. elegans: methods and applications","author":"Churgin","year":"2022"},{"key":"2026110406215230600_jkag266-B12","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1038\/nature03486","article-title":"Reduced sleep in Drosophila shaker mutants","volume":"434","author":"Cirelli","year":"2005","journal-title":"Nature"},{"key":"2026110406215230600_jkag266-B13","doi-asserted-by":"publisher","first-page":"D850","DOI":"10.1093\/nar\/gkad887","article-title":"CaeNDR, the Caenorhabditis natural diversity resource","volume":"52","author":"Crombie","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2026110406215230600_jkag266-B14","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"2026110406215230600_jkag266-B15","doi-asserted-by":"publisher","first-page":"e1010613","DOI":"10.1371\/journal.pgen.1010613","article-title":"G protein-coupled receptor kinase-2 (GRK-2) controls exploration through neuropeptide signaling in Caenorhabditis elegans","volume":"19","author":"Davis","year":"2023","journal-title":"PLoS Genet"},{"key":"2026110406215230600_jkag266-B16","doi-asserted-by":"publisher","first-page":"5415","DOI":"10.1113\/JP273009","article-title":"A mechanism for sickness sleep: lessons from invertebrates","volume":"595","author":"Davis","year":"2017","journal-title":"J Physiol"},{"key":"2026110406215230600_jkag266-B17","doi-asserted-by":"publisher","first-page":"8408","DOI":"10.1523\/JNEUROSCI.15-12-08408.1995","article-title":"Mutations in the Caenorhabditis elegans Na, K-ATPase alpha-subunit gene, eat-6, disrupt excitable cell function","volume":"15","author":"Davis","year":"1995","journal-title":"J Neurosci"},{"key":"2026110406215230600_jkag266-B18","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1534\/genetics.117.300070","article-title":"Stress-induced sleep after exposure to ultraviolet light is promoted by p53 in Caenorhabditis elegans","volume":"207","author":"DeBardeleben","year":"2017","journal-title":"Genetics"},{"key":"2026110406215230600_jkag266-B19","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1534\/genetics.115.183038","article-title":"A conserved GEF for rho-family GTPases acts in an EGF signaling pathway to promote sleep-like quiescence in Caenorhabditis elegans","volume":"202","author":"Fry","year":"2016","journal-title":"Genetics"},{"key":"2026110406215230600_jkag266-B20","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/nature20142","article-title":"Forward-genetics analysis of sleep in randomly mutagenized mice","volume":"539","author":"Funato","year":"2016","journal-title":"Nature"},{"key":"2026110406215230600_jkag266-B21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000220","article-title":"A salt-induced kinase is required for the metabolic regulation of sleep","volume":"18","author":"Grubbs","year":"2020","journal-title":"PLoS Biol"},{"key":"2026110406215230600_jkag266-B22","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1101\/gad.17420111","article-title":"AMP-activated protein kinase\u2014an energy sensor that regulates all aspects of cell function","volume":"25","author":"Hardie","year":"2011","journal-title":"Genes Dev"},{"key":"2026110406215230600_jkag266-B23","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1126\/science.1174443","article-title":"The transcriptional repressor DEC2 regulates sleep length in mammals","volume":"325","author":"He","year":"2009","journal-title":"Science"},{"key":"2026110406215230600_jkag266-B24","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1016\/j.cub.2014.08.040","article-title":"Cellular stress induces a protective sleep-like state in C. elegans","volume":"24","author":"Hill","year":"2014","journal-title":"Curr Biol"},{"key":"2026110406215230600_jkag266-B25","doi-asserted-by":"publisher","first-page":"10886","DOI":"10.1038\/s41467-024-55252-4","article-title":"Sleep drive is coupled to tissue damage via shedding of Caenorhabditis elegans EGFR ligand SISS-1","volume":"15","author":"Hill","year":"2024","journal-title":"Nat Commun"},{"key":"2026110406215230600_jkag266-B26","doi-asserted-by":"publisher","first-page":"iyag130","DOI":"10.1093\/genetics\/iyag130","article-title":"A screen for stress-induced sleep genes in Caenorhabditis elegans reveals a role for glutamate signaling","volume":"233","author":"Howe","year":"2026","journal-title":"Genetics"},{"key":"2026110406215230600_jkag266-B27","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1534\/g3.117.300071","article-title":"Genome-wide screen for genes involved in Caenorhabditis elegans developmentally timed sleep","volume":"7","author":"Huang","year":"2017","journal-title":"G3 (Bethesda)"},{"key":"2026110406215230600_jkag266-B28","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.19837","article-title":"The RFamide receptor DMSR-1 regulates stress-induced sleep in C. elegans","volume":"6","author":"Iannacone","year":"2017","journal-title":"elife"},{"key":"2026110406215230600_jkag266-B29","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1700-22.2024","article-title":"Quiescence enhances survival during viral infection in Caenorhabditis elegans","volume":"44","author":"Iannacone","year":"2024","journal-title":"J Neurosci"},{"key":"2026110406215230600_jkag266-B30","doi-asserted-by":"publisher","first-page":"RP97503","DOI":"10.7554\/eLife.97503","article-title":"Endogenous hydrogen peroxide positively regulates secretion of a gut-derived peptide in neuroendocrine potentiation of the oxidative stress response in Caenorhabditis elegans","volume":"13","author":"Jia","year":"2024","journal-title":"elife"},{"key":"2026110406215230600_jkag266-B31","doi-asserted-by":"publisher","first-page":"5238","DOI":"10.1016\/j.cub.2021.09.049","article-title":"The dihydropyrimidine dehydrogenase gene contributes to heritable differences in sleep in mice","volume":"31","author":"Keenan","year":"2021","journal-title":"Curr Biol"},{"key":"2026110406215230600_jkag266-B32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cub.2019.10.048","article-title":"Epidermal growth factor signaling promotes sleep through a combined series and parallel neural circuit","volume":"30","author":"Konietzka","year":"2020","journal-title":"Curr Biol"},{"key":"2026110406215230600_jkag266-B33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2220856120","article-title":"C. elegans Clarinet\/CLA-1 recruits RIMB-1\/RIM-binding protein and UNC-13 to orchestrate presynaptic neurotransmitter release","volume":"120","author":"Krout","year":"2023","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026110406215230600_jkag266-B34","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1038\/nprot.2009.86","article-title":"Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm","volume":"4","author":"Kumar","year":"2009","journal-title":"Nat Protoc"},{"key":"2026110406215230600_jkag266-B35","doi-asserted-by":"publisher","first-page":"859","DOI":"10.5665\/sleep.3648","article-title":"Acute sleep deprivation enhances post-infection sleep and promotes survival during bacterial infection in Drosophila","volume":"37","author":"Kuo","year":"2014","journal-title":"Sleep"},{"key":"2026110406215230600_jkag266-B36","volume-title":"Screening whole-genome sequenced strains to investigate genetic determinants of gentle touch sensitivity in Caenorhabditis elegans","author":"Lawry","year":"2020"},{"key":"2026110406215230600_jkag266-B37","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.bbi.2014.12.028","article-title":"FMRFamide signaling promotes stress-induced sleep in Drosophila","volume":"47","author":"Lenz","year":"2015","journal-title":"Brain Behav Immun"},{"key":"2026110406215230600_jkag266-B38","doi-asserted-by":"publisher","first-page":"pgad197","DOI":"10.1093\/pnasnexus\/pgad197","article-title":"A robotic system for automated genetic manipulation and analysis of Caenorhabditis elegans","volume":"2","author":"Li","year":"2023","journal-title":"PNAS Nexus"},{"key":"2026110406215230600_jkag266-B39","doi-asserted-by":"publisher","first-page":"jeb225847","DOI":"10.1242\/jeb.225847","article-title":"Sickness behaviors across vertebrate taxa: proximate and ultimate mechanisms","volume":"224","author":"Lopes","year":"2021","journal-title":"J Exp Biol"},{"key":"2026110406215230600_jkag266-B40","doi-asserted-by":"publisher","first-page":"e0005058","DOI":"10.1371\/journal.pntd.0005058","article-title":"Using C. elegans forward and reverse genetics to identify new compounds with anthelmintic activity","volume":"10","author":"Mathew","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"2026110406215230600_jkag266-B41","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/S0896-6273(00)80847-8","article-title":"Go\u03b1 and diacylglycerol kinase negatively regulate the Gq\u03b1 pathway in C. elegans","volume":"24","author":"Miller","year":"1999","journal-title":"Neuron"},{"key":"2026110406215230600_jkag266-B42","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1242\/dev.042044","article-title":"Differential requirements for STRAD in LKB1-dependent functions in C. elegans","volume":"137","author":"Narbonne","year":"2010","journal-title":"Development"},{"key":"2026110406215230600_jkag266-B43","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.1016\/j.cub.2016.07.048","article-title":"C. elegans stress-induced sleep emerges from the collective action of multiple neuropeptides","volume":"26","author":"Nath","year":"2016","journal-title":"Curr Biol"},{"key":"2026110406215230600_jkag266-B44","doi-asserted-by":"publisher","first-page":"2406","DOI":"10.1016\/j.cub.2014.08.037","article-title":"FMRFamide-like FLP-13 neuropeptides promote quiescence following heat stress in Caenorhabditis elegans","volume":"24","author":"Nelson","year":"2014","journal-title":"Curr Biol"},{"key":"2026110406215230600_jkag266-B45","doi-asserted-by":"publisher","first-page":"3200","DOI":"10.1038\/s41467-025-58478-y","article-title":"Pathogen infection induces sickness behaviors through neuromodulators linked to stress and satiety in C. elegans","volume":"16","author":"Pradhan","year":"2025","journal-title":"Nat Commun"},{"key":"2026110406215230600_jkag266-B46","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1038\/nature06535","article-title":"Lethargus is a Caenorhabditis elegans sleep-like state","volume":"451","author":"Raizen","year":"2008","journal-title":"Nature"},{"key":"2026110406215230600_jkag266-B47","doi-asserted-by":"publisher","first-page":"10","DOI":"10.17912\/micropub.biology.000112","article-title":"UNC-108\/RAB-2 is required for C. elegans stress-induced sleep","volume":"2019","author":"Robinson","year":"2019","journal-title":"MicroPubl Biol"},{"key":"2026110406215230600_jkag266-B48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075853","article-title":"Reduced sleep-like quiescence in both hyperactive and hypoactive mutants of the Galphaq gene egl-30 during lethargus in Caenorhabditis elegans","volume":"8","author":"Schwarz","year":"2013","journal-title":"PLoS One"},{"key":"2026110406215230600_jkag266-B49","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.neuron.2019.07.026","article-title":"A rare mutation of \u03b21-adrenergic receptor affects sleep\/wake behaviors","volume":"103","author":"Shi","year":"2019","journal-title":"Neuron"},{"key":"2026110406215230600_jkag266-B50","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.cub.2020.09.071","article-title":"Mutations in metabotropic glutamate receptor 1 contribute to natural short sleep trait","volume":"31","author":"Shi","year":"2021","journal-title":"Curr Biol"},{"key":"2026110406215230600_jkag266-B51","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.cub.2020.10.076","article-title":"Innate immunity promotes sleep through epidermal antimicrobial peptides","volume":"31","author":"Sinner","year":"2021","journal-title":"Curr Biol"},{"key":"2026110406215230600_jkag266-B52","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.isci.2019.08.050","article-title":"NPR-1 modulates plasticity in C. elegans stress-induced sleep","volume":"19","author":"Soto","year":"2019","journal-title":"Iscience"},{"key":"2026110406215230600_jkag266-B53","doi-asserted-by":"publisher","author":"Stiernagle","year":"2021","DOI":"10.1895\/wormbook.1.101.1"},{"key":"2026110406215230600_jkag266-B54","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1101\/gr.157651.113","article-title":"The million mutation project: a new approach to genetics in Caenorhabditis elegans","volume":"23","author":"Thompson","year":"2013","journal-title":"Genome Res"},{"key":"2026110406215230600_jkag266-B55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006235","article-title":"Accelerating gene discovery by phenotyping whole-genome sequenced multi-mutation strains and using the sequence kernel association test (SKAT)","volume":"12","author":"Timbers","year":"2016","journal-title":"PLoS Genet"},{"key":"2026110406215230600_jkag266-B56","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1126\/science.aat1650","article-title":"A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila","volume":"363","author":"Toda","year":"2019","journal-title":"Science"},{"key":"2026110406215230600_jkag266-B57","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.tins.2015.12.005","article-title":"Call it worm sleep","volume":"39","author":"Trojanowski","year":"2016","journal-title":"Trends Neurosci"},{"key":"2026110406215230600_jkag266-B58","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12499","article-title":"Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep","volume":"5","author":"Turek","year":"2016","journal-title":"elife"},{"key":"2026110406215230600_jkag266-B59","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1016\/j.cub.2013.09.028","article-title":"An AP2 transcription factor is required for a sleep-active neuron to induce sleep-like quiescence in C. elegans","volume":"23","author":"Turek","year":"2013","journal-title":"Curr Biol"},{"key":"2026110406215230600_jkag266-B60","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1038\/nn1981","article-title":"Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans","volume":"10","author":"Van Buskirk","year":"2007","journal-title":"Nat Neurosci"},{"key":"2026110406215230600_jkag266-B61","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1242\/dev.040881","article-title":"Paired and LIM class homeodomain proteins coordinate differentiation of the C. elegans ALA neuron","volume":"137","author":"Van Buskirk","year":"2010","journal-title":"Development"},{"key":"2026110406215230600_jkag266-B62","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ajhg.2011.05.029","article-title":"Rare-variant association testing for sequencing data with the sequence kernel association test","volume":"89","author":"Wu","year":"2011","journal-title":"Am J Hum Genet"},{"key":"2026110406215230600_jkag266-B63","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1093\/sleep\/31.4.465","article-title":"A genetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila","volume":"31","author":"Wu","year":"2008","journal-title":"Sleep"},{"key":"2026110406215230600_jkag266-B64","doi-asserted-by":"publisher","first-page":"eaax2014","DOI":"10.1126\/scitranslmed.aax2014","article-title":"Mutant neuropeptide S receptor reduces sleep duration with preserved memory consolidation","volume":"11","author":"Xing","year":"2019","journal-title":"Sci Transl Med"},{"key":"2026110406215230600_jkag266-B65","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.29276","article-title":"Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release","volume":"6","author":"Xuan","year":"2017","journal-title":"elife"},{"key":"2026110406215230600_jkag266-B66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3002030","article-title":"The active zone protein Clarinet regulates synaptic sorting of ATG-9 and presynaptic autophagy","volume":"21","author":"Xuan","year":"2023","journal-title":"PLoS Biol"},{"key":"2026110406215230600_jkag266-B67","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1038\/nmeth.2560","article-title":"A database of Caenorhabditis elegans behavioral phenotypes","volume":"10","author":"Yemini","year":"2013","journal-title":"Nat Methods"},{"key":"2026110406215230600_jkag266-B68","doi-asserted-by":"publisher","first-page":"2790","DOI":"10.1039\/C5LC00305A","article-title":"High-throughput, motility-based sorter for microswimmers such as C. elegans","volume":"15","author":"Yuan","year":"2015","journal-title":"Lab Chip"}],"container-title":["G3: Genes, Genomes, Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/g3journal\/advance-article-pdf\/doi\/10.1093\/g3journal\/jkag266\/71437647\/jkag266.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/g3journal\/article-pdf\/16\/11\/jkag266\/71437647\/jkag266.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/g3journal\/article-pdf\/16\/11\/jkag266\/71437647\/jkag266.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T11:22:13Z","timestamp":1793791333000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/g3journal\/article\/doi\/10.1093\/g3journal\/jkag266\/8841152"}},"subtitle":[],"editor":[{"given":"R","family":"Baugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":68,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,9,28]]},"published-print":{"date-parts":[[2026,11,4]]}},"URL":"https:\/\/doi.org\/10.1093\/g3journal\/jkag266","relation":{},"ISSN":["2160-1836"],"issn-type":[{"value":"2160-1836","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,11]]},"published":{"date-parts":[[2026,9,28]]},"article-number":"jkag266"}}