{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:32:53Z","timestamp":1790436773731,"version":"4.1.0"},"reference-count":92,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T00:00:00Z","timestamp":1601769600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Innovative Talent Support Program of the Institution of Higher Learning in Liaoning Province","award":["2018-478"],"award-info":[{"award-number":["2018-478"]}]},{"name":"Innovative Talents of Science and Technology Support Program of Young and Middle Aged People of Shenyang","award":["RC170446"],"award-info":[{"award-number":["RC170446"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cronkhite\u2013Canada syndrome (CCS) is a rare acquired polyposis with unknown etiology. To date, &amp;gt;500 cases have been reported worldwide. CCS is typically characterized by gastrointestinal symptoms, such as diarrhea and skin changes (e.g. alopecia, pigmentation, and nail atrophy). Endoscopic features include diffuse polyps throughout the entire gastrointestinal tract, except for the esophagus. Pathological types of polyps in CCS mainly include inflammatory, hyperplastic, hamartomatous, and adenomatous polyps. CCS can be complicated by many diseases and has a canceration tendency with a high mortality rate. Moreover, there is no uniform standard treatment for CCS. A review of the reported cases of CCS is presented herein, with the goal of improving our understanding of this disease.<\/jats:p>","DOI":"10.1093\/gastro\/goaa058","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T19:24:57Z","timestamp":1597260297000},"page":"333-342","source":"Crossref","is-referenced-by-count":40,"title":["Cronkhite\u2013Canada syndrome: from clinical features to treatment"],"prefix":"10.1093","volume":"8","author":[{"given":"Ze-Yu","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, First Hospital of China Medical University, Shenyang, Liaoning, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7782-0731","authenticated-orcid":false,"given":"Li-Xuan","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, First Hospital of China Medical University, Shenyang, Liaoning, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1965-5827","authenticated-orcid":false,"given":"Bing","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, First Hospital of China Medical University, Shenyang, Liaoning, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,4]]},"reference":[{"key":"2020110115410813200_goaa058-B1","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1056\/NEJM195506162522401","article-title":"Generalized gastrointestinal polyposis; an unusual syndrome of polyposis, pigmentation, alopecia and onychotrophia","volume":"252","author":"Cronkhite","year":"1955","journal-title":"N Engl J Med"},{"key":"2020110115410813200_goaa058-B2","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1136\/jclinpath-2014-202488","article-title":"Cronkhite-Canada syndrome six decades on the many faces of an enigmatic disease","volume":"67","author":"Slavik","year":"2014","journal-title":"J Clin Pathol"},{"key":"2020110115410813200_goaa058-B3","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00535-015-1107-7","article-title":"Endoscopic and clinical evaluation of treatment and prognosis of 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