{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:39:41Z","timestamp":1785364781204,"version":"3.55.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The effect of transjugular intra-hepatic portosystemic shunt (TIPS) placement on renal function and the correlation of post-TIPS Cr with mortality remain unclear. This study aimed to assess the effect of TIPS placement on renal function and to examine the relationship between post-TIPS Cr and mortality risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 593 patients who underwent de novo TIPS placement between 2004 and 2017 at a single institution were included in the study. The pre-TIPS Cr level (T0; within 7\u2009days before TIPS placement) and post-TIPS Cr levels, at 1\u20132\u2009days (T1), 5\u201312\u2009days (T2), and 15\u201340\u2009days (T3), were collected. Predictors of Cr change after TIPS placement and the 1-year mortality rate were analysed using multivariable linear-regression and Cox proportional-hazards models, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 21.4% of patients (n\u2009=\u2009127) had elevated baseline Cr (\u22651.5\u2009mg\/dL; mean, 2.51\u2009\u00b1\u20091.49\u2009mg\/dL) and 78.6% (n\u2009=\u2009466) had normal baseline Cr (&amp;lt;1.5\u2009mg\/dL; mean, 0.92\u2009\u00b1\u20090.26\u2009mg\/dL). Patients with elevated pre-TIPS Cr demonstrated a decrease in post-TIPS Cr (difference, \u22120.60\u2009mg\/dL), whereas patients with normal baseline Cr exhibited no change (difference, &amp;lt;0.01\u2009mg\/dL). The 30-day, 90-day, and 1-year mortality rates were 13%, 20%, and 32%, respectively. Variceal bleeding as a TIPS-placement indication (hazard ratio = 1.731; P\u2009=\u20090.036), higher T0 Cr (hazard ratio = 1.834; P\u2009=\u20090.012), and higher T3 Cr (hazard ratio = 3.524; P\u2009&amp;lt;\u20090.001) were associated with higher 1-year mortality risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>TIPS placement improved renal function in patients with baseline renal dysfunction and the post-TIPS Cr level was a strong predictor of 1-year mortality risk.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gastro\/goaa081","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T03:38:41Z","timestamp":1601350721000},"page":"306-312","source":"Crossref","is-referenced-by-count":5,"title":["Renal-function change after transjugular intra-hepatic portosystemic shunt placement and its relationship with survival: a single-center experience"],"prefix":"10.1093","volume":"9","author":[{"given":"Min","family":"Lang","sequence":"first","affiliation":[{"name":"Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela L.","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Critical Care, and Pain Management, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian Q.","family":"Tsui","sequence":"additional","affiliation":[{"name":"Department of Radiology, UCLA Medical Center, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian 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