{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:48:50Z","timestamp":1773283730127,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["16ykjc25"],"award-info":[{"award-number":["16ykjc25"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yat-sen University Clinical Research 5010 Program","award":["2016005"],"award-info":[{"award-number":["2016005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Total mesorectum excision (TME) is considered the standard surgical procedure for rectal-cancer treatment. Transanal TME (taTME) is a new procedure to treat low rectal cancer. Some published studies have proven that taTME can provide a better-quality resected specimen in low-rectal-cancer patients in comparison to the transabdominal procedure, yet long-term outcomes must be investigated. We designed this non-inferiority trial (TaLaR trial) to compare short-term and long-term outcomes between taTME and laparoscopic TME (lapTME) for rectal cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The TaLaR trial is a phase III open-labeled multicenter randomized\u2013controlled trial. Patients who are diagnosed with rectal cancer with no more than T3N2 stage, and with the tumor location below the peritoneal reflection by magnetic resonance imaging scan, digital rectal examination, or colonoscopy, qualify for this study. After calculating, a total of 1,114 patients (557 per group) will be randomly allocated to either the taTME or the lapTME group. Primary endpoints are the 3-year disease-free survival (DFS) rate and the 5-year overall survival (OS) rate. Secondary endpoints include specimen quality, perioperative results, pelvic and anal function, and quality of life.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>The TaLaR trial is expected to clarify whether taTME can achieve comparable oncological outcomes, as well as improve specimen quality and recovery conditions in rectal-cancer patients compared with lapTME.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gastro\/goaa083","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T12:07:08Z","timestamp":1602590828000},"page":"71-76","source":"Crossref","is-referenced-by-count":13,"title":["Transanal vs laparoscopic total mesorectal excision for rectal cancer: a multicenter randomized phase III clinical trial (TaLaR trial) protocol"],"prefix":"10.1093","volume":"9","author":[{"given":"Liang","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. China"},{"name":"Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziwei","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. China"},{"name":"Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangling","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. China"},{"name":"Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, Jilin, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyang","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, The Affiliated Nanchong Central Hospital of North Sichuan Medical College, Nanchong, Sichuan, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, The Second People\u2019s Hospital of Yibin, Yibin, Sichuan, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Daping Hospital, Army Medical university, Chongqing, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4309-1227","authenticated-orcid":false,"given":"Yi","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiwen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Peking University Cancer Hospital, Beijing, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Guang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Feng","sequence":"additional","affiliation":[{"name":"Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanlong","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Peking University People\u2019s Hospital, Beijing, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. China"},{"name":"Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. China"},{"name":"Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. 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