{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:08:42Z","timestamp":1758629322591,"version":"3.37.3"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Distal pancreatic carcinoma is one of the most lethal cancers largely due to its high incidence of distant metastasis. This study aims to assess the prognostic value of splenic-vasculature involvement in resected distal pancreatic carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective study, we collected the clinicopathologic information of 454 patients with pancreatic cancer and performed univariate and multivariate analyses to identify factors associated with progression-free survival (PFS) and overall survival (OS), with an emphasis on the prognostic value of splenic-artery and -vein involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Univariate analysis revealed that larger tumor size, non-intraductal papillary mucinous neoplasm (non-IPMN)-associated adenocarcinoma, poor differentiation, stage pT3, nodal metastasis, lymphovascular invasion, perineural invasion, and pathologic and radiographic evidence of splenic-vein invasion were significantly associated with shorter PFS and OS (all P\u2009&amp;lt;\u20090.05). Multivariate analysis confirmed non-IPMN-associated adenocarcinoma, stage pT3, stage pN1\u20132, and post-operative adjuvant chemotherapy as independent risk factors for both PFS and OS, and larger tumor size and radiographic evidence of splenic-artery invasion as predictors of PFS only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Guidelines should be developed for a uniform approach with regard to the examination and reporting of the status of the splenic vasculature when dealing with distal-pancreatic-cancer specimens.<\/jats:p><\/jats:sec>","DOI":"10.1093\/gastro\/goaa084","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T19:12:59Z","timestamp":1603221179000},"page":"139-145","source":"Crossref","is-referenced-by-count":4,"title":["Splenic-vasculature involvement is associated with poor prognosis in resected distal pancreatic cancer"],"prefix":"10.1093","volume":"9","author":[{"given":"Feng","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, MO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Pathology, Indiana University, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingmei","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Indiana University, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4200-7289","authenticated-orcid":false,"given":"Cynthia","family":"Lawson","sequence":"additional","affiliation":[{"name":"Department of Pathology, Pennsylvania State Health Milton S. 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Hershey Medical Center, Hershey, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belen Quereda","family":"Bernabeu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teena","family":"Dhir","sequence":"additional","affiliation":[{"name":"Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher W","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney L","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yale University, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuchen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yale University, New Haven, CT, 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