{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T01:59:30Z","timestamp":1774922370819,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":287,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005153","name":"China National Funds for Distinguished Young Scientists","doi-asserted-by":"publisher","award":["81825013"],"award-info":[{"award-number":["81825013"]}],"id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Insufficient post-operative future liver remnant (FLR) limits the feasibility of hepatectomy for patients. Staged hepatectomy is an effective surgical approach that can improve the resection rate of hepatocellular carcinoma (HCC). This study aimed to compare the safety and efficacy of laparoscopic microwave ablation and portal vein ligation for staged hepatectomy (LAPS) and classical associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in the treatment of hepatitis B virus (HBV)-related HCC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Clinical data of patients with HBV-related HCC who underwent LAPS or ALPPS in our institute between January 2017 and May 2022 were retrospectively analysed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 18 patients with HBV-related HCC were retrospectively analysed and divided into the LAPS group (n\u2009=\u20099) and ALPPS group (n\u2009=\u20099). Eight patients in the LAPS group and eight patients in the ALPPS group proceeded to a similar resection rate (88.9% vs 88.9%, P\u2009=\u20091.000). The patients undergoing LAPS had a lower total comprehensive complication index than those undergoing ALPPS but there was not a significant different between the two groups (8.66 vs 35.87, P\u2009=\u20090.054). The hypertrophy rate of FLR induced by ALPPS tended to be more rapid than that induced by LAPS (24.29 vs 13.17\u2009mL\/d, P\u2009=\u20090.095). The 2-year recurrence-free survival (RFS) was 0% for ALPPS and 35.7% for LAPS (P\u2009=\u20090.009), whereas the 2-year overall survival for ALPPS and LAPS was 33.3% and 100.0% (P\u2009=\u20090.052), respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>LAPS tended to induce lower morbidity and FLR hypertrophy more slowly than ALPPS, with a comparable resection rate and better long-term RFS in HBV-related HCC patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gastro\/goad060","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T09:42:16Z","timestamp":1697190136000},"source":"Crossref","is-referenced-by-count":5,"title":["Comparison of clinical efficacy between LAPS and ALPPS in the treatment of hepatitis B virus-related hepatocellular carcinoma"],"prefix":"10.1093","volume":"11","author":[{"given":"Zebin","family":"Chen","sequence":"first","affiliation":[{"name":"Centre of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3133-3508","authenticated-orcid":false,"given":"Shunli","family":"Shen","sequence":"additional","affiliation":[{"name":"Centre of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxuan","family":"Xie","sequence":"additional","affiliation":[{"name":"Centre of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junbin","family":"Liao","sequence":"additional","affiliation":[{"name":"Centre of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiting","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoqiang","family":"Li","sequence":"additional","affiliation":[{"name":"Centre of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiehui","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The Third Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Kuang","sequence":"additional","affiliation":[{"name":"Centre of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,10,12]]},"reference":[{"key":"2023101309412560200_goad060-B1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s12072-017-9799-9","article-title":"Asia-pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update","volume":"11","author":"Omata","year":"2017","journal-title":"Hepatol Int"},{"key":"2023101309412560200_goad060-B2","article-title":"Liver resection versus liver transplantation for hepatocellular carcinoma within the Milan criteria based on estimated microvascular invasion risks","volume":"11","author":"Yang","year":"2023","journal-title":"Gastroenterol Rep (Oxf)"},{"key":"2023101309412560200_goad060-B3","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.jhep.2016.06.006","article-title":"Liver resection for cancer: new developments in prediction, prevention and management of postresectional liver failure","volume":"65","author":"van Mierlo","year":"2016","journal-title":"J Hepatol"},{"key":"2023101309412560200_goad060-B4","doi-asserted-by":"crossref","first-page":"goac016","DOI":"10.1093\/gastro\/goac016","article-title":"Hepatic arterial infusion of oxaliplatin plus raltitrexed in unresectable hepatocellular carcinoma with or without portal vein tumour thrombosis","volume":"10","author":"Chen","year":"2022","journal-title":"Gastroenterol Rep (Oxf)"},{"key":"2023101309412560200_goad060-B5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1477-2574.2012.00557.x","article-title":"Selection for hepatic resection of colorectal liver metastases: expert consensus statement","volume":"15","author":"Adams","year":"2013","journal-title":"HPB"},{"key":"2023101309412560200_goad060-B6","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/gastro\/goz009","article-title":"Independent risk factors for disease recurrence after surgery in patients with hepatitis B virus-related hepatocellular carcinoma \u22643 Cm in diameter","volume":"7","author":"He","year":"2019","journal-title":"Gastroenterol Rep"},{"key":"2023101309412560200_goad060-B7","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1097\/SLA.0000000000002511","article-title":"ALPPS improves resectability compared with conventional two-stage hepatectomy in patients with advanced colorectal liver metastasis: results from a Scandinavian multicenter randomized controlled trial (LIGRO Trial)","volume":"267","author":"Sandstr\u00f6m","year":"2018","journal-title":"Ann Surg"},{"key":"2023101309412560200_goad060-B8","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jamcollsurg.2013.03.004","article-title":"Analysis of the efficacy of portal vein embolization for patients with extensive liver malignancy and very low future liver remnant volume, including a comparison with the associating liver partition with portal vein ligation for staged hepatectomy approach","volume":"217","author":"Shindoh","year":"2013","journal-title":"J Am Coll Surg"},{"key":"2023101309412560200_goad060-B9","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1097\/SLA.0b013e318265ff44","article-title":"Laparoscopic portal vein ligation with in situ liver split for failed portal vein embolization","volume":"256","author":"Conrad","year":"2012","journal-title":"Ann Surg"},{"key":"2023101309412560200_goad060-B10","doi-asserted-by":"crossref","first-page":"e13, e16","DOI":"10.1097\/SLA.0b013e318265ff2e","article-title":"Totally laparoscopic ALPPS is feasible and may be worthwhile","volume":"256","author":"Machado","year":"2012","journal-title":"Ann Surg"},{"key":"2023101309412560200_goad060-B11","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1097\/SLA.0000000000000607","article-title":"Radio-Frequency-Assisted Liver Partition with Portal Vein Ligation (RALPP) for liver regeneration","volume":"261","author":"Gall","year":"2015","journal-title":"Ann Surg"},{"key":"2023101309412560200_goad060-B12","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/SLA.0000000000001707","article-title":"Percutaneous microwave ablation liver partition and portal vein embolization for rapid liver regeneration: a minimally invasive first step of ALPPS for hepatocellular carcinoma","volume":"264","author":"Hong","year":"2016","journal-title":"Ann Surg"},{"key":"2023101309412560200_goad060-B13","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.1097\/SLA.0000000000000606","article-title":"Laparoscopic microwave ablation and portal vein Ligation for Staged Hepatectomy (LAPS): a minimally invasive first-step approach","volume":"261","author":"Gringeri","year":"2015","journal-title":"Ann Surg"},{"key":"2023101309412560200_goad060-B14","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3390\/cancers11030302","article-title":"Rapid induction of liver regeneration for major hepatectomy (REBIRTH): a randomized controlled trial of portal vein embolisation versus ALPPS assisted with radiofrequency","volume":"11","author":"Jiao","year":"2019","journal-title":"Cancers (Basel)"},{"key":"2023101309412560200_goad060-B15","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jhep.2017.03.021","article-title":"European Association for the Study of the Liver. EASL 2017 clinical practice guidelines on the management of hepatitis B virus infection","volume":"67","year":"2017","journal-title":"J Hepatol"},{"key":"2023101309412560200_goad060-B16","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jhep.2018.03.019","article-title":"European Association for the Study of the Liver. EASL clinical practice guidelines: management of hepatocellular carcinoma","volume":"69","year":"2018","journal-title":"J Hepatol"},{"key":"2023101309412560200_goad060-B17","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1159\/000509424","article-title":"Guidelines for the diagnosis and treatment of hepatocellular carcinoma (2019 edition)","volume":"9","author":"Zhou","year":"2020","journal-title":"Liver Cancer"},{"key":"2023101309412560200_goad060-B18","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.surg.2010.10.001","article-title":"Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS)","volume":"149","author":"Rahbari","year":"2011","journal-title":"Surgery"},{"key":"2023101309412560200_goad060-B19","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/01.sla.0000133083.54934.ae","article-title":"Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey","volume":"240","author":"Dindo","year":"2004","journal-title":"Ann Surg"},{"key":"2023101309412560200_goad060-B20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/SLA.0b013e318296c732","article-title":"The comprehensive complication index: a novel continuous scale to measure surgical morbidity","volume":"258","author":"Slankamenac","year":"2013","journal-title":"Ann Surg"},{"key":"2023101309412560200_goad060-B21","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/S0041-1345(00)01583-9","article-title":"Standard liver volume in adults","volume":"32","author":"Urata","year":"2000","journal-title":"Transplant Proc"},{"key":"2023101309412560200_goad060-B22","first-page":"521","article-title":"Preoperative portal embolization to increase safety of major hepatectomy for hilar bile duct carcinoma: a preliminary report","volume":"107","author":"Makuuchi","year":"1990","journal-title":"Surgery"},{"key":"2023101309412560200_goad060-B23","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1001\/jamasurg.2015.1646","article-title":"Associating liver partition and portal vein ligation for staged hepatectomy: portal vein embolization should remain the gold standard","volume":"150","author":"Aloia","year":"2015","journal-title":"JAMA Surg"},{"key":"2023101309412560200_goad060-B24","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.bulcan.2017.03.009","article-title":"[Portal vein embolization: present and future]","volume":"104","author":"Piron","year":"2017","journal-title":"Bull Cancer"},{"key":"2023101309412560200_goad060-B25","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1245\/s10434-014-4213-5","article-title":"Systematic review and meta-analysis of feasibility, safety, and efficacy of a novel procedure: associating liver partition and portal vein ligation for staged hepatectomy","volume":"22","author":"Schadde","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"2023101309412560200_goad060-B26","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/SLA.0000000000002942","article-title":"Associating liver partition and portal vein ligation for staged hepatectomy for unresectable hepatitis B virus-related hepatocellular carcinoma: a single center study of 45 patients","volume":"271","author":"Wang","year":"2020","journal-title":"Ann Surg"},{"key":"2023101309412560200_goad060-B27","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00423-016-1424-1","article-title":"Inverting the ALPPS paradigm by minimizing first stage impact: the mini-ALPPS technique","volume":"401","author":"de Santiba\u00f1es","year":"2016","journal-title":"Langenbecks Arch Surg"},{"key":"2023101309412560200_goad060-B28","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.1097\/SLA.0000000000004244","article-title":"A new surgical technique variant of partial ALPPS (tourniquet partial-ALPPS)","volume":"273","author":"Robles-Campos","year":"2021","journal-title":"Ann Surg"},{"key":"2023101309412560200_goad060-B29","first-page":"846","article-title":"Safety and efficacy of Radiofrequency-assisted ALPPS (RALPPS) in patients with cirrhosis-related hepatocellular carcinoma","volume":"33","author":"Wang","year":"2017","journal-title":"Int J Hyperthermia"},{"key":"2023101309412560200_goad060-B30","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1245\/s10434-014-4353-7","article-title":"Totally laparoscopic microwave ablation and portal vein ligation for staged hepatectomy: a new minimally invasive two-stage hepatectomy","volume":"22","author":"Cillo","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"2023101309412560200_goad060-B31","doi-asserted-by":"crossref","first-page":"287","DOI":"10.4174\/astr.2016.90.5.287","article-title":"Associating microwave ablation and portal vein ligation for staged hepatectomy for the treatment of huge hepatocellular carcinoma with cirrhosis","volume":"90","author":"Chen","year":"2016","journal-title":"Ann Surg Treat Res"},{"key":"2023101309412560200_goad060-B32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ejso.2016.05.026","article-title":"The role of portal vein embolization in the surgical management of primary hepatobiliary cancers. a systematic review","volume":"43","author":"Glantzounis","year":"2017","journal-title":"Eur J Surg Oncol"},{"key":"2023101309412560200_goad060-B33","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.hpb.2016.10.008","article-title":"High mortality after ALPPS for perihilar cholangiocarcinoma: case-control analysis including the first series from the International ALPPS Registry","volume":"19","author":"Olthof","year":"2017","journal-title":"HPB (Oxford)"},{"key":"2023101309412560200_goad060-B34","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1097\/SLA.0000000000002446","article-title":"Risk adjustment in ALPPS is associated with a dramatic decrease in early mortality and morbidity","volume":"266","author":"Linecker","year":"2017","journal-title":"Ann Surg"},{"key":"2023101309412560200_goad060-B35","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00423-012-0913-0","article-title":"A critical appraisal of the hemodynamic signal driving liver regeneration","volume":"397","author":"Abshagen","year":"2012","journal-title":"Langenbecks Arch Surg"},{"key":"2023101309412560200_goad060-B36","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1007\/s00270-013-0591-5","article-title":"Intrahepatic left to right portoportal venous collateral vascular formation in patients undergoing right portal vein ligation","volume":"36","author":"van Lienden","year":"2013","journal-title":"Cardiovasc Intervent Radiol"},{"key":"2023101309412560200_goad060-B37","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1148\/radiol.2511072175","article-title":"Radiofrequency ablation induces antigen-presenting cell infiltration and amplification of weak tumor-induced immunity","volume":"251","author":"Dromi","year":"2009","journal-title":"Radiology"},{"key":"2023101309412560200_goad060-B38","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12885-018-4011-8","article-title":"Screening for immune-potentiating antigens from hepatocellular carcinoma patients after radiofrequency ablation by serum proteomic analysis","volume":"18","author":"Shen","year":"2018","journal-title":"BMC Cancer"},{"key":"2023101309412560200_goad060-B39","doi-asserted-by":"crossref","first-page":"e20062","DOI":"10.1097\/MD.0000000000020062","article-title":"Effect of enhanced recovery after surgery program on patient-reported outcomes and function recovery in patients undergoing liver resection for hepatocellular carcinoma","volume":"99","author":"Ren","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"2023101309412560200_goad060-B40","doi-asserted-by":"crossref","first-page":"e16829","DOI":"10.2196\/16829","article-title":"Hospital costs and long-term survival of patients enrolled in an enhanced recovery program for open liver resection: prospective randomized controlled trial","volume":"4","author":"Jones","year":"2021","journal-title":"JMIR Perioper Med"}],"container-title":["Gastroenterology Report"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/gastro\/article-pdf\/doi\/10.1093\/gastro\/goad060\/52058540\/goad060.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/gastro\/article-pdf\/doi\/10.1093\/gastro\/goad060\/52058540\/goad060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T09:42:36Z","timestamp":1697190156000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/gastro\/article\/doi\/10.1093\/gastro\/goad060\/7310959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,30]]},"references-count":40,"URL":"https:\/\/doi.org\/10.1093\/gastro\/goad060","relation":{},"ISSN":["2052-0034"],"issn-type":[{"value":"2052-0034","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2022,12,30]]},"article-number":"goad060"}}