{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T14:45:59Z","timestamp":1766155559467,"version":"3.41.2"},"reference-count":41,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":299,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Clinical Discipline"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>KRAS\/BRAF mutations (mutKRAS\/mutBRAF) are unfavorable prognostic factors for colorectal cancer (CRC) metastases to the liver and lungs. However, their effects on the prognosis for patients with synchronous peritoneal metastasis (S-PM) of CRC after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are controversial. In the study, we aimed to determine the effects of mutKRAS\/mutBRAF on the prognosis for patients with S-PM who received CRS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 142 patients diagnosed with S-PM between July 2007 and July 2019 were included in this study. The demographics, mutKRAS\/mutBRAF status, overall survival (OS), and progression-free survival (PFS) of the patients were evaluated. The Kaplan\u2013Meier method and log-rank test were used to estimate the difference in survival between groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 142 patients, 68 (47.9%) showed mutKRAS and 42 (29.5%) showed mutBRAF. The median OS values were 8.4 and 34.3\u2009months for patients with mutBRAF and BRAF wild-type, respectively (P\u2009&amp;lt;\u20090.01). However, KRAS status was not significantly associated with median OS (P\u2009=\u20090.76). Multivariate analysis revealed carcinoembryonic antigen, CRS, HIPEC, and mutBRAF as independent predictors for OS. Based on these findings, a nomogram was constructed. The C-index was 0.789 (95% confidence interval, 0.742\u20130.836), indicating good predictive ability of the model. Furthermore, the 1- and 2-year survival calibration plots showed good agreement between the predicted and actual OS rates. The area under curves of the 1- and 2-year survival predictions based on the nomogram were 0.807 and 0.682, respectively. Additionally, mutBRAF was significantly associated with lower PFS (P\u2009&amp;lt;\u20090.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>mutBRAF is an independent prognostic risk factor for S-PM. The established nomogram predicted the OS of patients with CRC having S-PM with high accuracy, indicating its usefulness as a valuable prognostic tool for the designated patient cohort.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gastro\/goad061","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T10:48:20Z","timestamp":1698230900000},"source":"Crossref","is-referenced-by-count":3,"title":["Effect of <i>BRAF<\/i> mutation on the prognosis for patients with colorectal cancer undergoing cytoreductive surgery for synchronous peritoneal metastasis"],"prefix":"10.1093","volume":"11","author":[{"given":"Zhijie","family":"Wu","sequence":"first","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiusen","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zonglu","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. 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