{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:52:25Z","timestamp":1760647945342,"version":"3.41.2"},"reference-count":35,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":32,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Since the introduction of direct-acting antivirals, thousands of chronic hepatitis C patients have been successfully treated. However, vulnerable populations have a higher prevalence of hepatitis C virus (HCV) infection and face barriers that impede their access to antivirals. We carried out an HCV microelimination program focused on vulnerable population groups in Malaga.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>People in drug addiction treatment centers and homeless shelters in Malaga who participated in the program between October 2020 and October 2021 were included. After providing participants with educational information on HCV, a dry drop test (DDT) was used to collect blood for subsequent screening for HCV infection. The participants who were diagnosed with HCV infection were scheduled for comprehensive healthcare assessments, including blood tests, ultrasonography, elastography, and the prescription of antivirals, all conducted in a single hospital visit. Sustained viral response (SVR) was analysed 12\u2009weeks after end of treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 417 persons invited to participate, 271 (65%) agreed to participate in the program. These participants were screened for HCV infection and 28 of them were diagnosed with HCV infection (10%). These hepatitis C-infected patients had a mean age of 53\u2009\u00b1\u20099\u2009years; 86% were males and 93% were or had been drug users. Among 23 patients with HCV infection, HCV genotype 1a predominated (74%). Medical exams showed that 19% (4\/21) had advanced fibrosis (F3\u20134), and 5% (1\/21) had portal hypertension. Finally, 23 infected patients received treatment with glecaprevir\/pibrentasvir or sofosbuvir\/velpatasvir and SVR was confirmed in 22 patients (96%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Drug users and homeless people have a higher prevalence of HCV infection than the general population. The microelimination program with educational activity and screening tools achieved a high participation rate, easy healthcare access, and a high rate of SVR despite the SARS-CoV-2 pandemic.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gastro\/goad077","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T18:53:50Z","timestamp":1706036030000},"source":"Crossref","is-referenced-by-count":4,"title":["Hepatitis C virus point-of-care microelimination approach in a vulnerable population in the South of Spain"],"prefix":"10.1093","volume":"12","author":[{"given":"Jos\u00e9 Mar\u00eda","family":"Pinazo-Bandera","sequence":"first","affiliation":[{"name":"Gastroenterology Department, M\u00e1laga Biomedicine Research Institute-IBIMA BIONAND Platform, Virgen de la Victoria University Hospital, University of M\u00e1laga , M\u00e1laga, Spain"},{"name":"Biomedic Research Network in Hepatic and Digestive Diseases (CIBERehd) , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5626-5214","authenticated-orcid":false,"given":"Jes\u00fas","family":"Aranda","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, M\u00e1laga Biomedicine Research Institute-IBIMA BIONAND Platform, Virgen de la Victoria University Hospital, University of M\u00e1laga , M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto Manuel","family":"Garc\u00eda-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, M\u00e1laga Biomedicine Research Institute-IBIMA BIONAND Platform, Virgen de la Victoria University Hospital, University of M\u00e1laga , M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramiro","family":"Alc\u00e1ntara","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, M\u00e1laga Biomedicine Research Institute-IBIMA BIONAND Platform, Virgen de la Victoria University Hospital, University of M\u00e1laga , M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Ortega-Alonso","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, M\u00e1laga Biomedicine Research Institute-IBIMA BIONAND Platform, Virgen de la Victoria University Hospital, University of M\u00e1laga , M\u00e1laga, Spain"},{"name":"Biomedic Research Network in Hepatic and Digestive Diseases (CIBERehd) , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Del Campo-Herrera","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, M\u00e1laga Biomedicine Research Institute-IBIMA BIONAND Platform, Virgen de la Victoria University Hospital, University of M\u00e1laga , M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Encarnaci\u00f3n","family":"Clavijo","sequence":"additional","affiliation":[{"name":"Microbiology Department, M\u00e1laga Biomedicine Research Institute-IBIMA BIONAND Platform, Virgen de la Victoria University Hospital, University of M\u00e1laga , M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Dolores","family":"Garc\u00eda-Esca\u00f1o","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, M\u00e1laga Biomedicine Research Institute-IBIMA BIONAND Platform, Virgen de la Victoria University Hospital, University of M\u00e1laga , M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jes\u00fas","family":"Ruiz Ruiz","sequence":"additional","affiliation":[{"name":"Provincial Center for Drug Addiction, Provincial Council of M\u00e1laga , M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"Morales-Herrera","sequence":"additional","affiliation":[{"name":"Meeting and Reception Center, (CEA-Cruz Roja) , M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanesa","family":"Valle-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Meeting and Reception Center, (CEA-Cruz Roja) , M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Mart\u00edn-Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Municipal Reception Center , M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Viciana","sequence":"additional","affiliation":[{"name":"Microbiology Department, M\u00e1laga Biomedicine Research Institute-IBIMA BIONAND Platform, Virgen de la Victoria University Hospital, University of M\u00e1laga , M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Bautista","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Provincial Center for Drug Addiction, Provincial Council of M\u00e1laga , M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Fern\u00e1ndez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, M\u00e1laga Biomedicine Research Institute-IBIMA BIONAND Platform, Virgen de la Victoria University Hospital, University of M\u00e1laga , M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Pedro","family":"Toro-Ortiz","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, M\u00e1laga Biomedicine Research Institute-IBIMA BIONAND Platform, Virgen de la Victoria University Hospital, University of M\u00e1laga , M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"S\u00e1nchez-Y\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Farmacy Department, Virgen de la Victoria University Hospital , M\u00e1laga, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismael","family":"\u00c1lvarez-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, M\u00e1laga Biomedicine Research Institute-IBIMA BIONAND Platform, Virgen de la Victoria University Hospital, University of M\u00e1laga , M\u00e1laga, Spain"},{"name":"Biomedic Research Network in Hepatic and Digestive Diseases (CIBERehd) , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal J","family":"Andrade","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, M\u00e1laga Biomedicine Research Institute-IBIMA BIONAND Platform, Virgen de la Victoria University Hospital, University of M\u00e1laga , M\u00e1laga, Spain"},{"name":"Biomedic Research Network in Hepatic and Digestive Diseases (CIBERehd) , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mercedes","family":"Robles-D\u00edaz","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, M\u00e1laga Biomedicine Research Institute-IBIMA BIONAND Platform, Virgen de la Victoria University Hospital, University of M\u00e1laga , M\u00e1laga, Spain"},{"name":"Biomedic Research Network in Hepatic and Digestive Diseases (CIBERehd) , Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miren","family":"Garc\u00eda-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, M\u00e1laga Biomedicine Research Institute-IBIMA BIONAND Platform, Virgen de la Victoria University Hospital, University of M\u00e1laga , M\u00e1laga, Spain"},{"name":"Biomedic Research Network in Hepatic and Digestive Diseases (CIBERehd) , Madrid, 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