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CLD frequently presents with a multitude of interrelated and intricate symptoms, including fatigue, pruritus, muscle cramps, sexual dysfunction, and falls. Increasingly, there is interest in studying and developing interventional strategies to provide a more global approach to managing these complex patients. Moreover, in addition to established guidelines for the management of conventional complications, such as ascites and hepatic encephalopathy, there have been efforts in developing evidence-based guidance for the treatment of the more subjective yet still problematic elements. This review will address the management of these less \u201cclassical\u201d but nonetheless important symptoms.<\/jats:p>","DOI":"10.1093\/gastro\/goae078","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T03:19:37Z","timestamp":1723259977000},"source":"Crossref","is-referenced-by-count":7,"title":["Symptom burden in chronic liver disease"],"prefix":"10.1093","volume":"12","author":[{"given":"Ammar","family":"Hassan","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, University of Michigan Health West, University of Michigan Medicine , Grand Rapids, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivonne","family":"Hurtado Diaz De Leon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n , Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot B","family":"Tapper","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan , Ann Arbor, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"2024081003192676900_goae078-B1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi","year":"2023","journal-title":"J Hepatol"},{"key":"2024081003192676900_goae078-B2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s11938-022-00377-y","article-title":"Symptom management in patients with cirrhosis: a practical guide","volume":"20","author":"Kaplan","year":"2022","journal-title":"Curr Treat Options 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