{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:10:40Z","timestamp":1791418240668,"version":"4.3.3"},"reference-count":23,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":325,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bromatech Inc"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Functional constipation includes a set of gastrointestinal symptoms unexplainable by an identifiable underlying physical cause or pathology. The prevalence of this condition is high and there is a need to develop strategies to reduce it. Probiotics, prebiotics, and synbiotics may be an alternative treatment for chronic functional constipation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>To compare the efficacy of dietary supplementation on symptoms of patients who suffer from chronic functional constipation. An exploratory, randomized, double-blind, placebo-controlled pilot clinical trial was conducted with 74 patients diagnosed with chronic functional constipation who were divided into four treatment groups\u2014Group A: probiotics; Group B: prebiotics; Group C: synbiotics; Group D: placebo. Each patient was treated for 8\u2009weeks. At the beginning and end of treatment, data were collected by administering questionnaires and scales, including the Bristol stool scale, on gastrointestinal symptoms, bowel movements, and sociodemographic and anthropometric characteristics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Stool frequency increased in all four study groups, and greatest difference was observed in the synbiotics group (2.8\u2009\u00b1\u20091.3 vs. 5.9\u2009\u00b1\u20092.6; P\u2009&amp;lt;\u20090.001). Stool consistency improved only in the active treatment groups. Based on the evaluation of gastrointestinal symptoms, participants treated with prebiotics, probiotics and synbiotics showed the greatest improvement in abdominal pain (8.28\u2009\u00b1\u20092.63 vs. 6.56\u2009\u00b1\u20092.62; P\u2009=\u20090.009), gastroesophageal reflux (4.60\u2009\u00b1\u20092.66 vs. 3.45\u2009\u00b1\u20092.42; P\u2009=\u20090.039) and constipation symptoms (13.00\u2009\u00b1\u20093.97 vs. 8.71\u2009\u00b1\u20093.35; P\u2009=\u20090.003), respectively. As for quality of life, the main changes were observed in physical health domains, with a placebo effect.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The present study provides evidence supporting the efficacy of dietary supplementation with probiotics, prebiotics, and synbiotics in patients with chronic functional constipation after 8\u2009weeks of treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gastro\/goae101","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T17:00:28Z","timestamp":1731344428000},"source":"Crossref","is-referenced-by-count":9,"title":["Supplementation with probiotics, prebiotics, and synbiotics in patients with chronic functional constipation: a randomized, double-blind, placebo-controlled pilot clinical trial"],"prefix":"10.1093","volume":"12","author":[{"given":"Ana","family":"Terr\u00e9n Lora","sequence":"first","affiliation":[{"name":"Research Centers in Nutrition and Health (CINUSA Group), Research Department , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno F","family":"Penad\u00e9s","sequence":"additional","affiliation":[{"name":"Research Centers in Nutrition and Health (CINUSA Group), Research Department , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"L\u00f3pez Oliva","sequence":"additional","affiliation":[{"name":"Research Centers in Nutrition and Health (CINUSA Group), Research Department , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari","family":"Arponen","sequence":"additional","affiliation":[{"name":"Slow Medicine Institute, Research Department , Alcobendas, Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl\u015fah","family":"Okutan","sequence":"additional","affiliation":[{"name":"Research Centers in Nutrition and Health (CINUSA Group), Research Department , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guerthy Melissa","family":"S\u00e1nchez Ni\u00f1o","sequence":"additional","affiliation":[{"name":"Research Centers in Nutrition and Health (CINUSA Group), Research Department , Madrid,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael","family":"San Mauro Mart\u00edn","sequence":"additional","affiliation":[{"name":"Research Centers in Nutrition and Health (CINUSA Group), Research Department , 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