{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:22:32Z","timestamp":1793197352790,"version":"4.5.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T00:00:00Z","timestamp":1734134400000},"content-version":"vor","delay-in-days":358,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103084"],"award-info":[{"award-number":["82103084"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dongguan Science and Technology of Social Development Program","award":["20231800904303"],"award-info":[{"award-number":["20231800904303"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Colorectal cancer is the third-most common type of cancer. When peritoneal metastasis (PM) develops, diagnosing metastatic lesions is difficult and the prognosis is poor. This study aimed to compare the value of fluorine-18 fibroblast activation protein-specific inhibitor (18F-FAPI-42) and fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography\/computed tomography (PET\/CT) for detecting PM of colorectal cancer and to guide clinical decision-making.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Forty-eight patients with PM who underwent both 18F-FAPI-42 and 18F-FDG PET\/CT examinations were studied. The maximum standardized uptake value (SUV max), tumor-to-background ratios (TBRs) and peritoneal cancer index (PCI) of the PM were compared between the two imaging techniques. The intraclass correlation coefficient (ICC) was used to compare the consistency between the PET\/CT PCI score and the intraoperative PCI. A receiver-operating characteristic curve was used to predict the accuracy of CC-0 cytoreduction (complete cytoreduction with no visible disease).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The sensitivity and accuracy of 18F-FAPI-42 PET\/CT for detecting PM were higher than those of 18F-FDG PET\/CT (82.1% vs 61.1%, P\u2009&amp;lt;\u20090.01; 84.6% vs 74.5%, P\u2009&amp;lt;\u20090.01). The median SUV max and TBR of PM was greater in 18F-FAPI-42 than in 18F-FDG PET\/CT [4.8 (1.9\u201320.1) vs 4.7 (1.0\u201311.0), P\u2009=\u20090.02; 4.3 (1.4\u201314.6) vs 2.9 (0.6\u20138.0), P\u2009&amp;lt;\u20090.01, respectively]. The median PCI of PM based on 18F-FAPI-42 PET\/CT was greater than that based on 18F-FDG PET\/CT (15 vs 9, P\u2009&amp;lt;\u20090.01). The ICC for 18F-FAPI-42 PCI was greater than that for 18F-FDG PCI (0.915 vs 0.724, P\u2009&amp;lt;\u20090.01). The cut-off values of the PCI of the PM for 18F-FAPI-42 and 18F-FDG PET\/CT to predict CC-0 were &amp;lt;18 and &amp;lt;10, with areas under the curve of 0.80 and 0.79, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>18F-FAPI-42 PET\/CT has superior diagnostic efficacy for PM, particularly in the right upper epigastrium and small intestine. The PCI score of 18F-FAPI-42 PET\/CT is very close to the intraoperative PCI score and has a high value for predicting CC-0. The individualized management of PM based on the 18F-FAPI-42 PET\/CT PCI score is pivotal.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gastro\/goae104","type":"journal-article","created":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T18:40:35Z","timestamp":1734201635000},"source":"Crossref","is-referenced-by-count":11,"title":["18F-FAPI-42 PET\/CT enhances the diagnostic efficacy for peritoneal metastasis of colorectal cancer and guides treatment decisions: an original retrospective study"],"prefix":"10.1093","volume":"12","author":[{"given":"Xuneng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]},{"name":"Department of Nuclear Medicine, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center , Guangzhou, Guangdong,","place":["P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichuan","family":"He","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center , Guangzhou, Guangdong,","place":["P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keli","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong,","place":["P. R. 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