{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:42:12Z","timestamp":1790127732317,"version":"4.0.1"},"reference-count":102,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":68,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Postgraduate Scientific Research Innovation Project of Hunan Province","award":["CX20230531"],"award-info":[{"award-number":["CX20230531"]}]},{"name":"Leading Talents in Science and Technology Innovation in Hunan Province","award":["2024RC1051"],"award-info":[{"award-number":["2024RC1051"]}]},{"name":"Hunan Provincial People\u2019s Hospital benevolence fund key cultivation project","award":["RS2022A07"],"award-info":[{"award-number":["RS2022A07"]}]},{"name":"Natural Science Fund Hunan Province","award":["2020SK50913"],"award-info":[{"award-number":["2020SK50913"]}]},{"name":"Project of Hunan Provincial Health Commission","award":["Z2023031"],"award-info":[{"award-number":["Z2023031"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Exocrine pancreatic insufficiency (EPI) is a major cause of maldigestion and malnutrition, resulting from primary pancreatic diseases or other conditions. As the prevalence of EPI continues to rise, accurate identification of its etiology has become critical for the diagnosis and treatment of pancreatic secretory insufficiency. EPI can result from both pancreatic and non-pancreatic disorders. Pancreatic disorders include acute and chronic pancreatitis, pancreatic tumors, cystic fibrosis, procedures that involve pancreatic resection, and other rare causes. Non-pancreatic disorders of EPI include diabetes mellitus, celiac disease, inflammatory bowel disease, gastrointestinal and esophagectomy surgery, as well as advanced patient age. This review aims to provide a comprehensive analysis of the literature on EPI etiology, with a thorough overview to support its consideration as a potential diagnosis.<\/jats:p>","DOI":"10.1093\/gastro\/goaf019","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T18:47:56Z","timestamp":1741632476000},"source":"Crossref","is-referenced-by-count":5,"title":["Etiologies of exocrine pancreatic insufficiency"],"prefix":"10.1093","volume":"13","author":[{"given":"Chengji","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People\u2019s Hospital , Changsha, Hunan,","place":["P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People\u2019s Hospital , Changsha, Hunan,","place":["P. R. China"]},{"name":"Central Laboratory of Hunan Provincial People\u2019s Hospital, The First Affiliated Hospital of Hunan Normal University , Changsha, Hunan,","place":["P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Song","sequence":"additional","affiliation":[{"name":"Central Laboratory of Hunan Provincial People\u2019s Hospital, The First Affiliated Hospital of Hunan Normal University , Changsha, Hunan,","place":["P. R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People\u2019s Hospital , Changsha, Hunan,","place":["P. R. China"]},{"name":"Hunan Engineering Research Center of Digital Hepatobiliary Medicine , Changsha, Hunan,","place":["P. R. China"]},{"name":"Hunan Key Laboratory for the Prevention and Treatment of Biliary Tract Diseases , Changsha, Hunan,","place":["P. R. China"]},{"name":"Research Center for Hepatobiliary and Pancreatic Diseases of Furong Laboratory , Changsha, Hunan,","place":["P. R. 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