{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:34:49Z","timestamp":1755797689439,"version":"3.44.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":229,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Noncommunicable Chronic Diseases-National Science and Technology Major Project","award":["2023ZD0501600"],"award-info":[{"award-number":["2023ZD0501600"]}]},{"name":"Changhai Hospital Special Foundation for Clinical Research Program","award":["2024LYB05"],"award-info":[{"award-number":["2024LYB05"]}]},{"name":"China National Postdoctoral Program for Innovative Talents","award":["BX20230482"],"award-info":[{"award-number":["BX20230482"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Stool DNA testing based on methylated syndecan-2 (mSDC2) is a potential novel non-invasive screening test for colorectal cancer (CRC). This study aimed to assess its positive predictive value (PPV) in real-world practice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study retrospectively recruited consecutive patients with positive stool DNA-based SDC2 methylation tests from 18 hospitals between November 2016 and July 2021. Included patients were classified into the average-risk equivalent or increased-risk population and the previous-negative-colonoscopy or no-previous-colonoscopy groups. Multivariate logistic regression was conducted to investigate the risk factors that affect the detection of advanced colorectal neoplasia (ACN) in patients with a positive mSDC2 test. The primary outcome was the PPV for ACN.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The overall PPVs for ACN, CRC, and colorectal neoplasia were 28.5%, 12.8%, and 44.6%, respectively. The PPV for ACN was higher in the no-previous-colonoscopy group than in the previous-negative-colonoscopy group (30.1% vs 18.5%, P\u2009=\u20090.008) and higher in the increased-risk population than in the average-risk equivalent population (41.1% vs 21.6%, P\u2009&amp;lt;\u20090.001). However, the PPV (18.5%) was still high for patients with a previous negative colonoscopy. For ACN detection in patients with a positive mSDC2 test, old age, increased risk, and smoking history were identified as independent risk factors; previous negative colonoscopy was identified as a protective factor.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The mSDC2 test, which has a high PPV for both ACN and CRC, is expected to be an alternative CRC screening strategy. Patients with a positive mSDC2 test might require a colonoscopy as soon as possible, even if the previous colonoscopy was negative.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gastro\/goaf077","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T23:48:26Z","timestamp":1755560906000},"source":"Crossref","is-referenced-by-count":0,"title":["Stool-based methylated syndecan-2 testing has a high positive predictive value in an average\/increased-risk population: a multicenter retrospective study"],"prefix":"10.1093","volume":"13","author":[{"given":"Xinxin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology\/Digestive Endoscopy Center, Changhai Hospital, Second Military Medical University\/Naval Medical University , Shanghai, P. 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R.","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjiang","family":"Cai","sequence":"additional","affiliation":[{"name":"Center of Health Management,\u00a0Peking University Shenzhen Hospital ,Guangdong, P.R.","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuesheng","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Zheng Zhou Anorectal Hospital , Zhenzhou, Henan, P. R.","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First People\u2019s Hospital of Xiushui County , Jiujiang, Jiangxi, P. R.","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Constipation, Chengdu Anorectal Hospital , Chengdu, Sichuan, P. R.","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunting","family":"Deng","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Center, Huizhou Municipal Central Hospital , Huizhou, Guangdong, P. R.","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anorectal, Dongguan People's Hospital , Dongguan, Guangdong, P. R.","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University , Guangzhou, Guangdong, P. 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