{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:50:21Z","timestamp":1758361821850,"version":"3.44.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":254,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Drug Regulatory Science Project of Gansu Provincial Drug Administration","award":["2022GSMPA0016"],"award-info":[{"award-number":["2022GSMPA0016"]}]},{"name":"Talent Introduction Program of Lanzhou University Second Hospital","award":["yjrckyqdj-2024\u201303"],"award-info":[{"award-number":["yjrckyqdj-2024\u201303"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Current techniques for monitoring gastroesophageal reflux are limited to measuring physicochemical parameters. We presented a novel pH-integrated ultrathin endoscope (the EndoMonitor System) for simultaneous acquisition of reflux images and pH data. This preclinical study evaluated the performance of the latest version of the EndoMonitor System.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The stability and hydrogen ion selectivity of the pH electrode in the EndoMonitor System were evaluated. Subsequently, six types of reflux events were simulated in an isolated organ (porcine esophagus-stomach). Complete duodenal ligation was used to create porcine gastroesophageal reflux models. The number of reflux episodes and acid exposure time were assessed and compared with the pH-impedance catheter results.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The detection rates for distal acid reflux, distal mixed reflux, and horizontal acid reflux events of the EndoMonitor System were significantly higher than those of the pH-impedance catheter (100% vs 18.6%, 100% vs 32.7%, and 100% vs 49.1%, respectively; all P\u2009&amp;lt;\u20090.001). Furthermore, the EndoMonitor System demonstrated superior detection performance in proximal acid and mixed reflux events compared with the pH-impedance catheter (100% vs 90.9% and 100% vs 88.1%, respectively; both P\u2009&amp;lt;\u20090.05). In vivo reflux monitoring demonstrated statistically higher detection rates of reflux events with the EndoMonitor System in two-thirds of the experimental groups (P\u2009&amp;lt;\u20090.05), with a more remarkable overall detection advantage (100% vs 82.0%; P\u2009&amp;lt;\u20090.001). The acid exposure time measurement results for these two devices were comparable (mean \u00b1 standard deviation: 2.62\u2009\u00b1\u20091.82 vs 2.52\u2009\u00b1\u20091.74\u2009min; P\u2009=\u20090.161).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The EndoMonitor System improves the accuracy of identifying reflux events and simplifies the monitoring process. It was also highly operable. This study provided important preclinical experience for clinical trials.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/gastro\/goaf085","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T11:23:05Z","timestamp":1755516185000},"source":"Crossref","is-referenced-by-count":0,"title":["Feasibility and efficacy of pH-integrated ultrathin endoscopy for ambulatory gastroesophageal reflux monitoring (with videos)"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6106-265X","authenticated-orcid":false,"given":"Xiaoyu","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Lanzhou University Second Hospital , Lanzhou, Gansu, P. R.","place":["China"]},{"name":"Gansu Provincial Digestive Endoscopy Engineering Research Center , Lanzhou, Gansu, P. 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R.","place":["China"]},{"name":"Department of Digestive Diseases, Second Affiliated Hospital of Baotou Medical College , Baotou, Inner Mongolia Autonomous Region, P. R.","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Information Science and Engineering, Lanzhou University , Lanzhou, Gansu, P. R.","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1196-9381","authenticated-orcid":false,"given":"Xiaojun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Lanzhou University Second Hospital , Lanzhou, Gansu, P. R.","place":["China"]},{"name":"Gansu Provincial Digestive Endoscopy Engineering Research Center , Lanzhou, Gansu, P. 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