{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:52:51Z","timestamp":1791388371877,"version":"4.3.3"},"reference-count":31,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":260,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2023YFC2507300"],"award-info":[{"award-number":["2023YFC2507300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Preventing endoscopic postoperative recurrence (ePOR) remains a major challenge in Crohn\u2019s disease (CD). This study aimed to identify the clinical and histopathological predictors of CD ePOR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This nationwide, multicenter retrospective cohort study included 389 CD patients from five tertiary Chinese IBD centers, all of whom underwent curative ileocolonic resection between July 2016 and June 2024. The primary endpoint was ePOR at 6\u201312\u2009months after surgery, defined as a modified Rutgeerts\u2019 score of\u2009\u2265\u2009i2b. Prediction models were developed based on the result of multivariate analysis of clinical and pathological data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall ePOR rate was 24.9%. Multivariate analysis showed that prior exposure to biologics [odds ratio (OR) 2.695, 95% confidence interval (CI) 1.605\u20134.525, P\u2009&amp;lt;\u20090.001] and baseline serum albumin &amp;lt; 35\u2009g\/L (OR 2.095, 95% CI 1.160\u20133.785, P\u2009=\u20090.014) were independent risk factor for ePOR, while preoperative exclusive enteral nutrition (OR 0.338, 95% CI 0.188\u20130.610, P\u2009&amp;lt;\u20090.001) and early postoperative prophylactic biologic therapy (OR 0.503, 95% CI 0.304\u20130.832, P\u2009=\u20090.007) were independently associated with a reduced risk of ePOR. Moderate-to-severe lymphoplasmacytic infiltration in the lamina propria (OR 4.924, 95% CI 2.028\u201311.957, P\u2009&amp;lt;\u20090.001) and lymphangiectasia (OR 4.916, 95% CI 2.395\u201310.092, P\u2009&amp;lt;\u20090.001) were identified as the significant histopathological predictors at the surgical margins. A prediction model integrating both clinical and pathological variables [area under the receiver operating characteristic curve (AUROC) 0.829] significantly outperformed the clinical-only model (AUROC 0.715, P\u2009=\u20090.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the era of biologics and perioperative optimization, the 6\u201312-month ePOR rate among CD patients was 24.9%. A combined clinical\u2013pathological model showed strong predictive performance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/gastro\/goag108","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:38:01Z","timestamp":1790681881000},"source":"Crossref","is-referenced-by-count":0,"title":["Prediction of endoscopic postoperative recurrence in Crohn\u2019s disease: a nationwide multicenter real-world cohort from China"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6638-8744","authenticated-orcid":false,"given":"Fan","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University , No. 58 Zhongshan Er Road, Yuexiu District, Guangzhou, Guangdong 510062, P. R.","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zicheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University , No. 26 Yuancun Erheng Road , Tianhe District, Guangzhou, Guangdong 510655, P. R.","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University , No. 26 Yuancun Erheng Road , Tianhe District, Guangzhou, Guangdong 510655, P. R.","place":["China"]},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University , No. 7 Xingdao Huanbei Road , Haizhu District, Guangzhou, Guangdong 510320, P. R.","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7372-294X","authenticated-orcid":false,"given":"Liangru","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , No. 1277 Jiefang Avenue , Jianghan District, Wuhan, Hubei 430022, P. R.","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University , No. 3 East Qingchun Road , Shangcheng District, Hangzhou, Zhejiang 310016, P. R.","place":["China"]},{"name":"Inflammatory Bowel Disease Center, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University , No. 3 East Qingchun Road , Shangcheng District, Hangzhou, Zhejiang 310016, P. R.","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7056-0586","authenticated-orcid":false,"given":"Hong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chongqing General Hospital, Chongqing University , No. 118 Xingguang Avenue , Liangjiang New Area, Chongqing 401147, P. R.","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8878-3131","authenticated-orcid":false,"given":"Yu","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , No. 1277 Jiefang Avenue , Jianghan District, Wuhan, Hubei 430022, P. R.","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjie","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University , No. 3 East Qingchun Road , Shangcheng District, Hangzhou, Zhejiang 310016, P. R.","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingya","family":"Xiang","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University , No. 3 East Qingchun Road , Shangcheng District, Hangzhou, Zhejiang 310016, P. R.","place":["China"]},{"name":"Department of Gastroenterology, Chongqing General Hospital, Chongqing University , No. 118 Xingguang Avenue , Liangjiang New Area, Chongqing 401147, P. R.","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University , No. 26 Yuancun Erheng Road , Tianhe District, Guangzhou, Guangdong 510655, P. R.","place":["China"]},{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University , No. 26 Yuancun Erheng Road , Tianhe District, Guangzhou, Guangdong 510655, P. R.","place":["China"]},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University , No. 7 Xingdao Huanbei Road , Haizhu District, Guangzhou, Guangdong 510320, P. R.","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Sixth Affiliated Hospital, Sun Yat-sen University , No. 26 Yuancun Erheng Road , Tianhe District, Guangzhou, Guangdong 510655, P. R.","place":["China"]},{"name":"Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University , No. 26 Yuancun Erheng Road , Tianhe District, Guangzhou, Guangdong 510655, P. R.","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3058-4655","authenticated-orcid":false,"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University , No. 26 Yuancun Erheng Road , Tianhe District, Guangzhou, Guangdong 510655, P. 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