{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:02:39Z","timestamp":1784804559291,"version":"3.55.0"},"reference-count":123,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1093\/gastro\/gow047","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T13:26:19Z","timestamp":1485782779000},"page":"11-19","source":"Crossref","is-referenced-by-count":39,"title":["Irritable bowel syndrome and diet"],"prefix":"10.1093","volume":"5","author":[{"given":"Piero","family":"Portincasa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonilde","family":"Bonfrate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ornella","family":"de Bari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Lembo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Ballou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,1,20]]},"reference":[{"key":"key\n\t\t\t\t20170215055147_gow047-B1","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","article-title":"Functional bowel disorders","volume":"130","year":"2006","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B2","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cgh.2012.02.029","article-title":"Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis","volume":"10","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B3","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1053\/j.gastro.2007.06.010","article-title":"Natural history of functional gastrointestinal disorders: a 12-year longitudinal population-based study","volume":"133","year":"2007","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B4","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1111\/j.1572-0241.2007.01740.x","article-title":"Irritable bowel syndrome: a 10-yr natural history of symptoms and factors that influence consultation behavior","volume":"103","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B5","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/gastro\/gov010","article-title":"Symptomatology of irritable bowel syndrome and inflammatory bowel disease during the menstrual cycle","volume":"3","year":"2015","journal-title":"Gastroenterol Rep (Oxf)"},{"key":"key\n\t\t\t\t20170215055147_gow047-B6","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1046\/j.1365-2036.2002.01305.x","article-title":"Consensus report: clinical perspectives, mechanisms, diagnosis and management of irritable bowel syndrome","volume":"16","year":"2002","journal-title":"Aliment.Pharmacol Ther"},{"key":"key\n\t\t\t\t20170215055147_gow047-B7","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1053\/gast.2002.37095","article-title":"AGA technical review on irritable bowel syndrome","volume":"123","year":"2002","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B8","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1053\/j.gastro.2012.08.002","article-title":"Burden of gastrointestinal disease in the United States: 2012 update","volume":"143","year":"2012","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B9","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1053\/j.gastro.2016.02.031","article-title":"Bowel Disorders","volume":"150","year":"2016","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/00004836-199407000-00008","article-title":"An Office Guide to Whole-Gut Transit Time","volume":"19","year":"1994","journal-title":"J Clin Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B11","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3109\/00365529709011203","article-title":"Stool form scale as a useful guide to intestinal transit time","volume":"32","year":"1997","journal-title":"Scand J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B12","doi-asserted-by":"crossref","first-page":"816","DOI":"10.3109\/00365521.2015.1007079","article-title":"Prevalence of organic disease at colonoscopy in patients with symptoms compatible with irritable bowel syndrome: cross-sectional survey","volume":"50","year":"2015","journal-title":"Scand J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B13","doi-asserted-by":"crossref","first-page":"G775","DOI":"10.1152\/ajpgi.00155.2012","article-title":"Irritable bowel syndrome: methods, mechanisms, and pathophysiology: the confluence of increased permeability, inflammation, and pain in irritable bowel syndrome","volume":"303","year":"2012","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B14","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1056\/NEJMra1207068","article-title":"Peripheral mechanisms in irritable bowel syndrome","volume":"367","year":"2012","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170215055147_gow047-B15","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3109\/00365521.2013.799220","article-title":"Microbiota in health and irritable bowel syndrome: current knowledge, perspectives and therapeutic options","volume":"48","year":"2013","journal-title":"Scand J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B16","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/0016-5085(90)90332-U","article-title":"Tolerance for rectosigmoid distention in irritable bowel syndrome","volume":"98","year":"1990","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B17","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1053\/gast.2002.33601","article-title":"Rectal distention testing in patients with irritable bowel syndrome: sensitivity, specificity, and predictive values of pain sensory thresholds","volume":"122","year":"2002","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00535-005-1766-x","article-title":"Visceral hypersensitivity following cold water intake in subjects with irritable bowel syndrome","volume":"41","year":"2006","journal-title":"J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B19","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00535-005-1748-z","article-title":"Repetitive rectal painful distention induces rectal hypersensitivity in patients with irritable bowel syndrome","volume":"41","year":"2006","journal-title":"J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B20","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3109\/00365529609009131","article-title":"Ambulatory 24-hour jejunal motility in diarrhea-predominant irritable bowel syndrome","volume":"31","year":"1996","journal-title":"Scand J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B21","first-page":"620","article-title":"Irritable bowel syndrome: a paroxysmal motor disorder","volume":"1","year":"1986","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170215055147_gow047-B22","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1023\/A:1010770302403","article-title":"Abnormal propagation pattern of duodenal pressure waves in the irritable bowel syndrome (IBS) [correction of (IBD)]","volume":"45","year":"2000","journal-title":"Dig Dis Sci"},{"key":"key\n\t\t\t\t20170215055147_gow047-B23","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.3748\/wjg.v9.i10.2293","article-title":"Pan-enteric dysmotility, impaired quality of life and alexithymia in a large group of patients meeting the Rome II criteria for irritable bowel","volume":"9","year":"2003","journal-title":"World J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cgh.2006.11.025","article-title":"Postinfectious irritable bowel syndrome after a food-borne outbreak of acute gastroenteritis attributed to a viral pathogen","volume":"5","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B25","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1053\/j.gastro.2006.05.053","article-title":"Incidence and epidemiology of irritable bowel syndrome after a large waterborne outbreak of bacterial dysentery","volume":"131","year":"2006","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B26","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1365-2036.2007.03399.x","article-title":"Systematic review and meta-analysis: The incidence and prognosis of post-infectious irritable bowel syndrome","volume":"26","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"key\n\t\t\t\t20170215055147_gow047-B27","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1111\/j.1572-0241.2006.00654.x","article-title":"Postinfectious irritable bowel syndrome--a meta-analysis","volume":"101","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B28","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1053\/gast.2002.33579","article-title":"Activation of the mucosal immune system in irritable bowel syndrome","volume":"122","year":"2002","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B29","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1053\/j.gastro.2007.01.046","article-title":"Immune activation in patients with irritable bowel syndrome","volume":"132","year":"2007","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B30","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S1542-3565(05)00184-9","article-title":"The genetics of irritable bowel syndrome","volume":"3","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B31","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1053\/j.gastro.2014.02.054","article-title":"Loss-of-function of the voltage-gated sodium channel NaV1.5 (Channelopathies) in patients with irritable bowel syndrome","volume":"146","year":"2014","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B32","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1053\/j.gastro.2011.01.032","article-title":"The role of stress on physiological responses and clinical symptoms in irritable bowel syndrome","volume":"140","year":"2011","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B33","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0016-5085(88)80017-9","article-title":"Psychosocial factors in the irritable bowel syndrome. A multivariate study of patients and nonpatients with irritable bowel syndrome","volume":"95","year":"1988","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B34","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1046\/j.1365-2036.1997.142318000.x","article-title":"The irritable bowel severity scoring system: a simple method of monitoring irritable bowel syndrome and its progress","volume":"11","year":"1997","journal-title":"Aliment Pharmacol Ther"},{"key":"key\n\t\t\t\t20170215055147_gow047-B35","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/1471-2164-10-380","article-title":"The degree of microbiome complexity influences the epithelial response to infection","volume":"10","year":"2009","journal-title":"BMC Genomics"},{"key":"key\n\t\t\t\t20170215055147_gow047-B36","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/MEG.0000000000000374","article-title":"Effects of dietary education, followed by a tailored fructose-restricted diet in adults with fructose malabsorption","volume":"27","year":"2015","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B37","first-page":"1","article-title":"Methodology and indications of H2-breath testing in gastrointestinal diseases: the Rome Consensus Conference","volume":"29 Suppl 1","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"key\n\t\t\t\t20170215055147_gow047-B38","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1194\/jlr.R500013-JLR200","article-title":"Bile salt biotransformations by human intestinal bacteria","volume":"47","year":"2006","journal-title":"J Lipid Res"},{"key":"key\n\t\t\t\t20170215055147_gow047-B39","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1152\/physrev.00010.2008","article-title":"Role of bile acids and bile acid receptors in metabolic regulation","volume":"89","year":"2009","journal-title":"Physiol Rev"},{"key":"key\n\t\t\t\t20170215055147_gow047-B40","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.femsre.2004.09.003","article-title":"The interaction between bacteria and bile","volume":"29","year":"2005","journal-title":"FEMS Microbiol Rev"},{"key":"key\n\t\t\t\t20170215055147_gow047-B41","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/00004836-200603000-00015","article-title":"Colonic health: Fermentation and short chain fatty acids","volume":"40","year":"2006","journal-title":"J Clin Gastroenterol"},{"issue":"8","key":"key\n\t\t\t\t20170215055147_gow047-B42","first-page":"354","article-title":"Short chain fatty acids and colonic health","volume":"108","year":"2007","journal-title":"Bratisl Lek Listy"},{"key":"key\n\t\t\t\t20170215055147_gow047-B43","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3181\/00379727-175-41791","article-title":"Propionate may mediate the hypocholesterolemic effects of certain soluble plant fibers in cholesterol-fed rats","volume":"175","year":"1984","journal-title":"Proc Exp Biol Med"},{"key":"key\n\t\t\t\t20170215055147_gow047-B44","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1056\/NEJMra1600266","article-title":"The Human Intestinal Microbiome in Health and Disease","volume":"375","year":"2016","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170215055147_gow047-B45","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/joim.12508","article-title":"The gut microbiota and metabolic disease: current understanding and future perspectives","volume":"280","year":"2016","journal-title":"J Intern Med"},{"key":"key\n\t\t\t\t20170215055147_gow047-B46","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1053\/j.gastro.2007.04.005","article-title":"The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects","volume":"133","year":"2007","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B47","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1572-0241.2005.40312.x","article-title":"Analysis of the fecal microbiota of irritable bowel syndrome patients and healthy controls with real-time PCR","volume":"100","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B48","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1053\/j.gastro.2011.07.043","article-title":"Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome","volume":"141","year":"2011","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B49","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1053\/j.gastro.2011.06.072","article-title":"Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome","volume":"141","year":"2011","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B50","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1136\/gutjnl-2011-301501","article-title":"An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota","volume":"61","year":"2012","journal-title":"Gut"},{"key":"key\n\t\t\t\t20170215055147_gow047-B51","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.femsim.2004.08.009","article-title":"Composition and temporal stability of gastrointestinal microbiota in irritable bowel syndrome--a longitudinal study in IBS and control subjects","volume":"43","year":"2005","journal-title":"FEMS Immunol Med Microbiol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B52","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1099\/jmm.0.46134-0","article-title":"Prevalence and temporal stability of selected clostridial groups in irritable bowel syndrome in relation to predominant faecal bacteria","volume":"55","year":"2006","journal-title":"J Med Microbiol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B53","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s10620-009-0934-x","article-title":"A molecular analysis of fecal and mucosal bacterial communities in irritable bowel syndrome","volume":"55","year":"2010","journal-title":"Dig Dis Sci"},{"key":"key\n\t\t\t\t20170215055147_gow047-B54","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1111\/j.1462-2920.2007.01369.x","article-title":"Diversity of the human gastrointestinal tract microbiota revisited","volume":"9","year":"2007","journal-title":"Environ Microbiol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B55","doi-asserted-by":"crossref","first-page":"5936","DOI":"10.3748\/wjg.15.5936","article-title":"Diarrhoea-predominant irritable bowel syndrome distinguishable by 16S rRNA gene phylotype quantification","volume":"15","year":"2009","journal-title":"World J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B56","first-page":"1","article-title":"Intestinal permeability \u2013 a new target for disease prevention and therapy","volume":"14","year":"2014","journal-title":"BMC Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B57","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1136\/gutjnl-2012-302167","article-title":"Intestinal microbiota in functional bowel disorders: a Rome foundation report","volume":"62","year":"2013","journal-title":"Gut"},{"key":"key\n\t\t\t\t20170215055147_gow047-B58","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1053\/j.gastro.2013.01.049","article-title":"A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function","volume":"144","year":"2013","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B59","first-page":"S2","article-title":"American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation","volume":"109 Suppl 1","year":"2014","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B60","doi-asserted-by":"crossref","first-page":"S-194","DOI":"10.1016\/S0016-5085(14)60683-1","article-title":"Sa1079 A Meta-Analysis of the Utility of Common Serum and Fecal Biomarkers in Adults With IBS","volume":"146","year":"2014","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B61","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/j.1365-2362.2008.02035.x","article-title":"Beneficial effects of oral tilactase on patients with hypolactasia","volume":"38","year":"2008","journal-title":"Eur J Clin Invest"},{"key":"key\n\t\t\t\t20170215055147_gow047-B62","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1136\/bmj.39524.439618.25","article-title":"Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome","volume":"336","year":"2008","journal-title":"BMJ"},{"key":"key\n\t\t\t\t20170215055147_gow047-B63","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.7326\/0003-4819-116-12-1009","article-title":"The irritable bowel syndrome: review and a graduated multicomponent treatment approach","volume":"116","year":"1992","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t20170215055147_gow047-B64","doi-asserted-by":"crossref","first-page":"107","DOI":"10.7326\/0003-4819-122-2-199501150-00005","article-title":"The irritable bowel syndrome: long-term prognosis and the physician-patient interaction","volume":"122","year":"1995","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t20170215055147_gow047-B65","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s10620-009-0855-8","article-title":"Irritable bowel syndrome patients' ideal expectations and recent experiences with healthcare providers: a national survey","volume":"55","year":"2010","journal-title":"Dig Dis Sci"},{"key":"key\n\t\t\t\t20170215055147_gow047-B66","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/ajg.2010.480","article-title":"Physical activity improves symptoms in irritable bowel syndrome: a randomized controlled trial","volume":"106","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B67","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1155\/2003\/532138","article-title":"Irritable bowel syndrome in primary care: the patients' and doctors' views on symptoms, etiology and management","volume":"17","year":"2003","journal-title":"Can J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B68","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000051878","article-title":"Food-related gastrointestinal symptoms in the irritable bowel syndrome","volume":"63","year":"2001","journal-title":"Digestion"},{"key":"key\n\t\t\t\t20170215055147_gow047-B69","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/sj.ejcn.1602367","article-title":"Perceived food intolerance in subjects with irritable bowel syndrome-- etiology, prevalence and consequences","volume":"60","year":"2006","journal-title":"Eur J Clin Nutr"},{"key":"key\n\t\t\t\t20170215055147_gow047-B70","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1136\/gut.2003.037697","article-title":"Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial","volume":"53","year":"2004","journal-title":"Gut"},{"key":"key\n\t\t\t\t20170215055147_gow047-B71","first-page":"128","article-title":"Food intolerance in functional bowel disorders","volume":"26 Suppl 3","year":"2011","journal-title":"J Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B72","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/j.1572-0241.2006.00672.x","article-title":"Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes","volume":"101","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B73","first-page":"89","article-title":"Significance of salicylate intolerance in diseases of the lower gastrointestinal tract","volume":"56 Suppl 5","year":"2005","journal-title":"J Physiol Pharmacol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B74","doi-asserted-by":"crossref","first-page":"b3154","DOI":"10.1136\/bmj.b3154","article-title":"Soluble or insoluble fibre in irritable bowel syndrome in primary care? Randomised placebo controlled trial","volume":"339","year":"2009","journal-title":"BMJ"},{"key":"key\n\t\t\t\t20170215055147_gow047-B75","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/apt.13167","article-title":"Systematic review: dietary fibre and FODMAP-restricted diet in the management of constipation and irritable bowel syndrome","volume":"41","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"key":"key\n\t\t\t\t20170215055147_gow047-B76","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1053\/gast.1997.v112.agast972120","article-title":"Irritable bowel syndrome: a technical review for practice guideline development","volume":"112","year":"1997","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B77","doi-asserted-by":"crossref","first-page":"e5836","DOI":"10.1136\/bmj.e5836","article-title":"Irritable bowel syndrome","volume":"345","year":"2012","journal-title":"BMJ"},{"key":"key\n\t\t\t\t20170215055147_gow047-B78","first-page":"CD003460","article-title":"Bulking agents, antispasmodics and antidepressants for the treatment of irritable bowel syndrome","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t20170215055147_gow047-B79","doi-asserted-by":"crossref","first-page":"a2313","DOI":"10.1136\/bmj.a2313","article-title":"Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis","volume":"337","year":"2008","journal-title":"BMJ"},{"key":"key\n\t\t\t\t20170215055147_gow047-B80","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1038\/ajg.2013.198","article-title":"Bloating and distention in irritable bowel syndrome: the role of gas production and visceral sensation after lactose ingestion in a population with lactase deficiency","volume":"108","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B81","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/ajg.2013.96","article-title":"Short-chain carbohydrates and functional gastrointestinal disorders","volume":"108","year":"2013","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B82","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1111\/j.1440-1746.2010.06370.x","article-title":"Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome","volume":"25","year":"2010","journal-title":"J Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B83","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1111\/j.1365-2036.2005.02506.x","article-title":"Personal view: food for thought--western lifestyle and susceptibility to Crohn's disease. The FODMAP hypothesis","volume":"21","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"key\n\t\t\t\t20170215055147_gow047-B84","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1053\/j.gastro.2013.09.046","article-title":"A Diet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome","volume":"146","year":"2014","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B85","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1038\/ctg.2015.21","article-title":"The Effect of Dietary Intervention on Irritable Bowel Syndrome: A Systematic Review","volume":"6","year":"2015","journal-title":"Clin Transl Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B86","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.cgh.2008.02.058","article-title":"Dietary triggers of abdominal symptoms in patients with irritable bowel syndrome: randomized placebo-controlled evidence","volume":"6","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B87","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1053\/j.gastro.2015.07.054","article-title":"Diet low in FODMAPs reduces symptoms of irritable bowel syndrome as well as traditional dietary advice: a randomized controlled trial","volume":"149","year":"2015","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B88","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1365-277X.2012.01242.x","article-title":"British Dietetic Association evidence-based guidelines for the dietary management of irritable bowel syndrome in adults","volume":"25","year":"2012","journal-title":"J Hum Nutr Diet"},{"key":"key\n\t\t\t\t20170215055147_gow047-B89","first-page":"135","article-title":"Concordance of genetic and breath tests for lactose intolerance in a tertiary referral centre","volume":"17","year":"2008","journal-title":"J Gastrointestin Liver Dis"},{"key":"key\n\t\t\t\t20170215055147_gow047-B90","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cgh.2012.11.034","article-title":"Prevalence and presentation of lactose intolerance and effects on dairy product intake in healthy subjects and patients with irritable bowel syndrome","volume":"11","year":"2013","journal-title":"Clin Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B91","first-page":"S1","article-title":"An evidence-based position statement on the management of irritable bowel syndrome","volume":"104 Suppl 1","author":"American College of Gastroenterology Task Force on Irritable Bowel Syndrome","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B92","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1097\/00042737-200108000-00011","article-title":"The effect of a lactose-restricted diet in patients with a positive lactose tolerance test, earlier diagnosed as irritable bowel syndrome: a 5-year follow-up study","volume":"13","year":"2001","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B93","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1056\/NEJM197604012941403","article-title":"Sucrase-isomaltase deficiency. Absence of an inactive enzyme variant","volume":"294","year":"1976","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170215055147_gow047-B94","first-page":"275","article-title":"Intestinal sucrase deficiency","volume":"80","year":"1967","journal-title":"Trans Assoc Am Physicians"},{"key":"key\n\t\t\t\t20170215055147_gow047-B95","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0022-3476(73)80362-2","article-title":"Sucrase-isomaltase deficiency-a frequently misdiagnosed disease","volume":"83","year":"1973","journal-title":"J Pediatr"},{"key":"key\n\t\t\t\t20170215055147_gow047-B96","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1111\/j.1572-0241.2003.07476.x","article-title":"Fructose intolerance: an under-recognized problem","volume":"98","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B97","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/MCG.0b013e31802cbc2f","article-title":"Fructose intolerance in IBS and utility of fructose-restricted diet","volume":"42","year":"2008","journal-title":"J Clin Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B98","doi-asserted-by":"crossref","first-page":"G217","DOI":"10.1152\/ajpgi.00225.2007","article-title":"Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice","volume":"294","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B99","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/ajg.2010.487","article-title":"Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial","volume":"106","year":"2011","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B100","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1053\/j.gastro.2013.04.051","article-title":"No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates","volume":"145","year":"2013","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B101","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/biof.1079","article-title":"Curcumin, a component of turmeric: from farm to pharmacy","volume":"39","year":"2013","journal-title":"BioFactors"},{"key":"key\n\t\t\t\t20170215055147_gow047-B102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-2006-960004","article-title":"Pharmacology of curcuma longa","volume":"57","year":"1991","journal-title":"Planta Med"},{"key":"key\n\t\t\t\t20170215055147_gow047-B103","first-page":"113","article-title":"Mechanism of antiinflammatory actions of curcumine and boswellic acids","volume":"38","year":"1993","journal-title":"J Ethnopharmacol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B104","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/ecam\/neh140","article-title":"Ayurveda and traditional Chinese medicine: a comparative overview","volume":"2","year":"2005","journal-title":"Evid Based Complement Alternat Med"},{"key":"key\n\t\t\t\t20170215055147_gow047-B105","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1196\/annals.1352.010","article-title":"Curcumin: getting back to the roots","volume":"1056","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t20170215055147_gow047-B106","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11010-008-9949-4","article-title":"Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis","volume":"322","year":"2009","journal-title":"Mol Cell Biochem"},{"key":"key\n\t\t\t\t20170215055147_gow047-B107","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/ibd.20348","article-title":"Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent","volume":"14","year":"2008","journal-title":"Inflamm Bowel Dis"},{"key":"key\n\t\t\t\t20170215055147_gow047-B108","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/j.1745-7254.2006.00322.x","article-title":"Curcumin regulated shift from Th1 to Th2 in trinitrobenzene sulphonic acid-induced chronic colitis","volume":"27","year":"2006","journal-title":"Acta Pharmacol Sin"},{"key":"key\n\t\t\t\t20170215055147_gow047-B109","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/j.1365-2982.2007.00928.x","article-title":"A potential role for the vanilloid receptor TRPV1 in the therapeutic effect of curcumin in dinitrobenzene sulphonic acid-induced colitis in mice","volume":"19","year":"2007","journal-title":"Neurogastroenterol Motil"},{"key":"key\n\t\t\t\t20170215055147_gow047-B110","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1007\/s10620-006-9138-9","article-title":"Curcumin prevents the development of dextran sulfate Sodium (DSS)-induced experimental colitis","volume":"52","year":"2007","journal-title":"Dig Dis Sci"},{"key":"key\n\t\t\t\t20170215055147_gow047-B111","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/sj.bjp.0705241","article-title":"Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis","volume":"139","year":"2003","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B112","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1053\/gast.2002.37050","article-title":"Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice","volume":"123","year":"2002","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t20170215055147_gow047-B113","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1208\/s12248-012-9432-8","article-title":"Therapeutic roles of curcumin: lessons learned from clinical trials","volume":"15","year":"2013","journal-title":"AAPS J"},{"key":"key\n\t\t\t\t20170215055147_gow047-B114","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1017\/S0007114509992510","article-title":"Curcumin suppresses p38 mitogen-activated protein kinase activation, reduces IL-1beta and matrix metalloproteinase-3 and enhances IL-10 in the mucosa of children and adults with inflammatory bowel disease","volume":"103","year":"2010","journal-title":"Br J Nutr"},{"key":"key\n\t\t\t\t20170215055147_gow047-B115","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/ibd.21391","article-title":"Modulation of neutrophil motility by curcumin: implications for inflammatory bowel disease","volume":"17","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"key\n\t\t\t\t20170215055147_gow047-B116","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.4049\/jimmunol.163.6.3474","article-title":"Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity","volume":"163","year":"1999","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B117","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.cgh.2006.08.008","article-title":"Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial","volume":"4","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B118","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.cgh.2015.02.019","article-title":"Curcumin in Combination With Mesalamine Induces Remission in Patients With Mild-to-Moderate Ulcerative Colitis in a Randomized Controlled Trial","volume":"13","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B119","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1089\/acm.2004.10.1015","article-title":"Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study","volume":"10","year":"2004","journal-title":"J Altern Complement Med"},{"key":"key\n\t\t\t\t20170215055147_gow047-B120","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0378-8741(01)00249-5","article-title":"The effect of fennel essential oil on uterine contraction as a model for dysmenorrhea, pharmacology and toxicology study","volume":"76","year":"2001","journal-title":"J Ethnopharmacol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B121","first-page":"561","article-title":"Possible mechanism(s) for relaxant effects of Foeniculum vulgare on guinea pig tracheal chains","volume":"59","year":"2004","journal-title":"Pharmazie"},{"key":"key\n\t\t\t\t20170215055147_gow047-B122","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1111\/j.1572-0241.2000.02633.x","article-title":"Foeniculum vulgare therapy in irritable bowel syndrome","volume":"95","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t20170215055147_gow047-B123","doi-asserted-by":"crossref","first-page":"151","DOI":"10.15403\/jgld.2014.1121.252.ccm","article-title":"Curcumin and Fennel Essential Oil Improve Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome","volume":"25","year":"2016","journal-title":"J Gastrointestin Liver Dis"}],"container-title":["Gastroenterology Report"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/gastro\/article-pdf\/5\/1\/11\/10269860\/gow047.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T21:39:30Z","timestamp":1749937170000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/gastro\/article\/2931986\/Irritable"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,20]]},"references-count":123,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,20]]},"published-print":{"date-parts":[[2017,2]]}},"URL":"https:\/\/doi.org\/10.1093\/gastro\/gow047","relation":{},"ISSN":["2052-0034"],"issn-type":[{"value":"2052-0034","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,20]]}}}