{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T03:10:16Z","timestamp":1769310616201,"version":"3.49.0"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Placental mammals present 180 million-year-old Y chromosomes that have retained a handful of dosage-sensitive genes. However, the expression evolution of Y-linked genes across placental groups has remained largely unexplored. Here, we expanded the number of Y gametolog sequences by analyzing ten additional species from previously unexplored groups. We detected seven remarkably conserved genes across 25 placental species with known Y repertoires. We then used RNA-seq data from 17 placental mammals to unveil the expression evolution of XY gametologs. We found that Y gametologs followed, on average, a 3-fold expression loss and that X gametologs also experienced some expression reduction, particularly in primates. Y gametologs gained testis specificity through an accelerated expression decay in somatic tissues. Moreover, despite the substantial expression decay of Y genes, the combined expression of XY gametologs in males is higher than that of both X gametologs in females. Finally, our work describes several features of the Y chromosome in the last common mammalian ancestor.<\/jats:p>","DOI":"10.1093\/gbe\/evaa173","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T20:35:32Z","timestamp":1597178132000},"page":"2015-2028","source":"Crossref","is-referenced-by-count":25,"title":["Expression Evolution of Ancestral XY Gametologs across All Major Groups of Placental Mammals"],"prefix":"10.1093","volume":"12","author":[{"given":"M\u00f3nica","family":"Mart\u00ednez-Pacheco","sequence":"first","affiliation":[{"name":"Center for Genome Sciences, UNAM, Cuernavaca, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariela","family":"Tenorio","sequence":"additional","affiliation":[{"name":"Center for Genome Sciences, UNAM, Cuernavaca, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Almonte","sequence":"additional","affiliation":[{"name":"Center for Genome Sciences, UNAM, Cuernavaca, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1578-7438","authenticated-orcid":false,"given":"Vicente","family":"Fajardo","sequence":"additional","affiliation":[{"name":"Center for Genome Sciences, UNAM, Cuernavaca, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"God\u00ednez","sequence":"additional","affiliation":[{"name":"Center for Genome Sciences, UNAM, Cuernavaca, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Center for Genome Sciences, UNAM, Cuernavaca, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Cornejo-P\u00e1ramo","sequence":"additional","affiliation":[{"name":"Center for Genome Sciences, UNAM, Cuernavaca, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"D\u00edaz-Barba","sequence":"additional","affiliation":[{"name":"Center for Genome Sciences, UNAM, Cuernavaca, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Halbert","sequence":"additional","affiliation":[{"name":"Center for Integrative Genomics, University of Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelica","family":"Liechti","sequence":"additional","affiliation":[{"name":"Center for Integrative Genomics, University of Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamas","family":"Sz\u00e9kely","sequence":"additional","affiliation":[{"name":"Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Araxi O","family":"Urrutia","sequence":"additional","affiliation":[{"name":"Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom"},{"name":"Ecology Institute, UNAM, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Cortez","sequence":"additional","affiliation":[{"name":"Center for Genome Sciences, UNAM, Cuernavaca, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"issue":"9","key":"2020111900562785200_evaa173-B1","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1093\/gbe\/evz196","article-title":"Corytophanids replaced the pleurodont XY system with a new pair of XY chromosomes","volume":"11","author":"Acosta","year":"2019","journal-title":"Genome Biol Evol"},{"issue":"6209","key":"2020111900562785200_evaa173-B2","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1126\/science.1257225","article-title":"Plant genetics. 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